Characterizing protein–protein-interaction in high-concentration monoclonal antibody systems with the quartz crystal microbalance

High-concentration protein formulations: How high is high?

(2017) Patrick Garidel et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Role of Buffers in Protein Formulations

(2017) Teddy J. Zbacnik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Effect of Hierarchical Cluster Formation on the Viscosity of Concentrated Monoclonal Antibody Formulations Studied by Neutron Scattering

(2016) P. Douglas Godfrin et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Macromolecular Crowding In Vitro , In Vivo , and In Between

(2016) Germán Rivas et al.   TRENDS IN BIOCHEMICAL SCIENCES

Squeeze flow rheometry as a novel tool for the characterization of highly concentrated protein solutions

(2015) Marie-Therese Schermeyer et al.   BIOTECHNOLOGY AND BIOENGINEERING

Charge-Induced Patchy Attractions between Proteins

(2015) Weimin Li et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Observation of Small Cluster Formation in Concentrated Monoclonal Antibody Solutions and Its Implications to Solution Viscosity

(2014) Eric J. Yearley et al.   BIOPHYSICAL JOURNAL

Role of Anisotropic Interactions for Proteins and Patchy Nanoparticles

(2014) Christopher J. Roberts et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Immunoactive two-dimensional self-assembly of monoclonal antibodies in aqueous solution revealed by atomic force microscopy

(2014) Shinichiro Ido et al.   NATURE MATERIALS

Prediction of colloidal stability of high concentration protein formulations

(2014) Patrick Garidel et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Do Clustering Monoclonal Antibody Solutions Really Have a Concentration Dependence of Viscosity?

(2013) Jai A. Pathak et al.   BIOPHYSICAL JOURNAL

Buffer capacity of biologics-from buffer salts to buffering by antibodies

(2013) Anne R. Karow et al.   BIOTECHNOLOGY PROGRESS

Temperature-Induced Ultradense PEG Polyelectrolyte Surface Grafting Provides Effective Long-Term Bioresistance against Mammalian Cells, Serum, and Whole Blood

(2012) Ryosuke Ogaki et al.   BIOMACROMOLECULES

Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

(2012) Brian D. Connolly et al.   BIOPHYSICAL JOURNAL

The electrokinetic potential of therapeutic proteins and its modulation: Impact on protein stability

(2012) Michael Wagner et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Hard Quasispherical Particle Models for the Viscosity of Solutions of Protein Mixtures

(2012) Allen P. Minton   JOURNAL OF PHYSICAL CHEMISTRY B

Viscosity of concentrated therapeutic protein compositions

(2011) Jan Jezek et al.   ADVANCED DRUG DELIVERY REVIEWS

Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development

(2011) Tim J. Kamerzell et al.   ADVANCED DRUG DELIVERY REVIEWS

Assessment of Net Charge and Protein–Protein Interactions of Different Monoclonal Antibodies

(2011) Christian Lehermayr et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Viscosity Behavior of High-Concentration Protein Mixtures

(2011) William J. Galush et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Diffusion and Sedimentation Interaction Parameters for Measuring the Second Virial Coefficient and Their Utility as Predictors of Protein Aggregation

(2010) Atul Saluja et al.   BIOPHYSICAL JOURNAL

A critical evaluation of self-interaction chromatography as a predictive tool for the assessment of protein–protein interactions in protein formulation development: A case study of a therapeutic monoclonal antibody

(2010) Virginie Le Brun et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Factors Affecting the Viscosity in High Concentration Solutions of Different Monoclonal Antibodies

(2010) Sandeep Yadav et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Intermolecular Interactions of IgG1 Monoclonal Antibodies at High Concentrations Characterized by Light Scattering

(2010) Thomas M. Scherer et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Specific interactions in high concentration antibody solutions resulting in high viscosity

(2009) Sandeep Yadav et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Carboxylate-Dependent Gelation of a Monoclonal Antibody

(2009) Osigwe Esue et al.   PHARMACEUTICAL RESEARCH

QCM-D and Reflectometry Instrument: Applications to Supported Lipid Structures and Their Biomolecular Interactions

(2008) Malin Edvardsson et al.   ANALYTICAL CHEMISTRY

Reversible Self-Association of a Concentrated Monoclonal Antibody Solution Mediated by Fab–Fab Interaction That Impacts Solution Viscosity

(2008) Sonoko Kanai et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Viscoelastic characterization of high concentration antibody formulations using quartz crystal microbalance with dissipation monitoring

(2008) Ankit R. Patel et al.   JOURNAL OF PHARMACEUTICAL SCIENCES