Article
Nanoscience & Nanotechnology
Yao Chen, Shuya Liu, Yin Liao, Hanshan Yang, Zhuo Chen, Yuru Hu, Shaozhi Fu, Jingbo Wu
Summary: In this study, albumin-modified gold nanoparticles (Alb-GNPs) were prepared and their radiosensitizing effects and biotoxicity in human non-small-cell lung carcinoma tumor-bearing mice models were observed. The prepared nanoparticles (Alb-GNPs) showed excellent colloidal stability and biocompatibility with a mean size of 205.06 +/- 1.03 nm. Clone formation experiments demonstrated that Alb-GNPs exerted excellent radiosensitization with a higher sensitization enhancement ratio (SER) of 1.432 compared to X-ray alone. Alb-GNPs could accumulate favorably in tumors and their combination with radiotherapy exhibited a greater radiosensitizing effect and anti-tumor activity. Additionally, no toxicity or abnormal irritating response was observed with the application of Alb-GNPs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Inorganic & Nuclear
Reem Darwesh, Samia Faisal Aboushoushah, Sahar Almarhabi, Alia M. Aldahlawi, Nihal S. Elbialy
Summary: The study aimed to enhance the efficacy of radiotherapy against human breast cancer cells using TurboBeads magnetic nanoparticles functionalized with gold as a nano-radiosensitizer. The combination of MNPs-Au with radiation significantly increased cancer cell death compared to radiation alone.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Xiao-xiao Guo, Zhen-hu Guo, Jing-song Lu, Wen-sheng Xie, Qiu-zi Zhong, Xiao-dan Sun, Xiu-mei Wang, Jian-ye Wang, Ming Liu, Ling-yun Zhao
Summary: A versatile nanostrategy based on dose deposition enhancement, cell cycle arrest, and ROS production was proposed as a potential radiosensitizer for prostate cancer treatment. The synthesis of docetaxel-loaded gold nanoparticles with PSMA ligand conjugation successfully achieved enhanced cellular uptake and cell cycle arrest in G2/M phases. The nano-system was found to effectively promote ROS generation and double strand breaks under irradiation, making it an ideal and safe radiosensitizer for PCa.
Article
Pharmacology & Pharmacy
Marika Musielak, Agnieszka Bos-Liedke, Oliwia Piwocka, Katarzyna Kowalska, Roksana Markiewicz, Barbara Szymkowiak, Pawel Bakun, Wiktoria M. Suchorska
Summary: In this study, the role of gold nanoparticles in enhancing the response of breast cancer cells to ionizing radiation was assessed by comparing 2D and 3D models. It was found that the PEG chain plays an important role in the efficiency of gold nanoparticles in sensitizing cells to ionizing radiation, indicating that gold nanoparticles are a promising agent for combined treatment with radiotherapy.
Review
Nanoscience & Nanotechnology
Anqi Zhang, Lei Gao
Summary: Radiotherapy is an important method for treating malignant tumors. Enhancing its therapeutic gain ratio through physical techniques is the current direction of radiotherapy. The combination of hyperthermia and radiotherapy can improve the radiosensitivity of tumor cells and has significant clinical value. Nanomaterials have attracted widespread attention in tumor hyperthermia research and show great potential. This article summarizes the sensitizing mechanisms and effects of gold nanotechnology and provides an overview of the advancements of other nanoparticles in radiation therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Ioanna Tremi, Sophia Havaki, Sofia Georgitsopoulou, Nefeli Lagopati, Vasilios Georgakilas, Vassilis G. Gorgoulis, Alexandros G. Georgakilas
Summary: The article discusses the combined effects of ionizing radiation with high-Z metallic nanoparticles, particularly gold, on DNA damage. It highlights the use of transmission electron microscopy (TEM) to study these effects at a detailed cellular level, focusing on the uptake and damage of nanoparticles in cells. The goal is to better understand the radiosensitization mechanisms of nanoparticles.
Article
Nanoscience & Nanotechnology
Lijie Yang, Jinhua Wang, Liying Sun, Yisi Zhang, Peng Huang, Junfeng Guo
Summary: This study synthesized gold nanoparticles of different shapes to investigate their effects on combined photothermal/radiotherapy. Among the nanoparticles, gold nanoflowers showed the highest cellular uptake efficiency and photothermal conversion ability, leading to the strongest anticancer effect in combined treatment. This suggests that gold nanoflowers may be more desirable dual agents for highly efficient combined photothermal-radiotherapy compared to nanoparticles with other shapes.
Article
Chemistry, Multidisciplinary
Jiahao Liu, Lina Guo, Ze Mi, Zhenguo Liu, Pengfei Rong, Wenhu Zhou
Summary: A two-step low-dose radiotherapy strategy combined with spherical nucleic acids-based nanomedicine was used to enhance the accumulation and penetration of nanoparticles in tumors. The strategy successfully recruited macrophages into the tumor, which not only served as drug depots but also enhanced extravasation to improve nanoparticle accumulation. Through optimized timing and administration, the delivered nanoparticles promoted a phenotype switch in macrophages, resulting in increased phagocytosis and further enhancing accumulation and penetration. This approach showed significant enhancement of nanoparticles accumulation compared to passive targeting, with efficient deep penetration throughout the tumor tissue.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Floriane Poignant, Caterina Monini, Etienne Testa, Michael Beuve
Summary: In this study, a new quantity called the probability enhancement ratio (PER) was introduced to estimate the probability of imparting specific energy to nanotargets. The results showed that the PER varied significantly with various factors, and the highest enhancement could lead to severe damages for biological nanotargets located near gold nanoparticles.
Article
Biology
Miguel Angel Perez-Amor, Leonardo Barrios, Gemma Armengol, Joan Francesc Barquinero
Summary: This study evaluated the radiosensitizing effect of 50 nm gold nanoparticles (GNPs) on two neoplastic cell lines. The GNPs were found to increase the sensitivity of tumor cells to radiation, with functionalized GNPs exhibiting a higher effect. However, the heterogeneity between cell lines makes it difficult to describe the magnitude of this effect.
Article
Pharmacology & Pharmacy
Sandeep B. Shelar, K. C. Barick, Bijaideep Dutta, Manidipa Basu, Puthusserickal A. Hassan
Summary: The aim of this study was to functionalize gold nanoparticles with Lanreotide peptide (LP) to promote their selective delivery in SSTR2-expressing cancer cells and enhance radiosensitization. The LP was coupled with negatively charged citrate-stabilized gold nanoparticles (GNP) through electrostatic interaction. The GNP-LP conjugates showed higher cellular uptake and toxicity in SSTR2-expressing AR42J cells, resulting in enhanced radiosensitization.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Boyi Yu, Xuanyi Lu, Xianglong Feng, Ting Zhao, Jiaxin Li, Yudie Lu, Fei Ye, Xiongxiong Liu, Xiaogang Zheng, Zheyu Shen, Xiaodong Jin, Weiqiang Chen, Qiang Li
Summary: This study found that GONs can be used as radiosensitizers to enhance the sensitivity of 4T1 breast cancer cells to X-ray irradiation, improving the killing effect and immune activation of radiotherapy. Fractionated X-ray irradiation combined with GONs demonstrated the most significant tumor growth inhibition and activation of the antitumor immune response.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Acoustics
J. A. Fuentes-Garcia, J. Santoyo-Salzar, E. Rangel-Cortes, G. F. Goya, V Cardozo-Mata, J. A. Pescador-Rojas
Summary: The optimized synthesis of gold nanoparticles with different shapes and sizes was achieved using ultrasonic irradiation assisted Turkevich-Frens method. The effects of different ultrasound powers and continuous irradiation time were studied to control the size and shape of the GNPs colloidal solutions. The resulting quasi-spherical GNPs showed sizes ranging from 12 to 16 nm, with different shapes such as pentakis dodecahedron, triakis icosahedron, and tetrakis hexahedron.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Engineering, Biomedical
Hamed Nosrati, Farzad Seidi, Ali Hosseinmirzaei, Navid Mousazadeh, Ali Mohammadi, Mohammadreza Ghaffarlou, Hossein Danafar, Joao Conde, Ali Sharafi
Summary: Utilizing all-in-one nanoparticles for synchronous chemoradiotherapy significantly enhances cancer therapy efficacy, as demonstrated by studies on cell viability, proliferation, and ROS production. In vivo anticancer experiments show that the mPEG-CUR@Au system improves radiation sensitivity in 4T1 mammary carcinoma and completely eradicates breast cancer.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Meena Bhandari, Seema Raj, Ashwani Kumar, Dilraj Preet Kaur
Summary: Multifunctional nanoparticles show promising characteristics for overcoming side effects in cancer treatment. Despite numerous studies supporting the advantages of eco-friendly nanoparticles, they have yet to find their way into clinical translation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Somayeh Sadat Mehrnia, Bijan Hashemi, Seyed Javad Mowla, Maryam Nikkhah, Azim Arbabi
Summary: This study demonstrated that AS1411 aptamer enhanced the delivery of gold nanoparticles to cancer cells, leading to increased radiation-induced cancer cell death. The sensitization effect was particularly significant for breast cancer cells and mammosphere cells, suggesting potential for future clinical applications in cancer treatment.
RADIATION ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Parichehr Maleki, Seyed Javad Mowla, Mohammad Taheri, Soudeh Ghafouri-Fard, Jamshid Raheb
Summary: The study evaluated the impact of down-regulation of LINK-A in non-small cell lung carcinoma cell lines, revealing that LINK-A significantly affects cell survival, proliferation, and migration, and may act as an oncogene in NSCLC.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Arman Moradi, Majid Maleki, Zahra Ghaemmaghami, Zahra Khajali, Feridoun Noohi, Maryam Hosseini Moghadam, Samira Kalyinia, Seyed Javad Mowla, Nabil G. Seidah, Mahshid Malakootian
Summary: Genetic mutations in LDLR and PCSK9 genes exhibit diversity in Iranian patients with FH, potentially leading to the development of FH and early-onset CAD. A pathogenic mutation in the LDLR gene was found to be cosegregated in a family. Genetic testing and reports on nucleotide alterations are limited in the Iranian population.
FRONTIERS IN GENETICS
(2021)
Editorial Material
Biochemistry & Molecular Biology
Leila Montazeri, Maryam Mohajeri, Hossein Baharvand, Rouhollah Fathi, Valeria Poli, Sara Kazemi, Fattaneh Pahlavan, Solmaz Kouhestani, Firoozeh Ahmadi, Seyed Javad Mowla
Summary: This report showcases the successful experiences of the Executive Boards of these two congresses in overcoming the challenges brought about by the COVID-19 pandemic. By utilizing different virtual setting components, they have created a suitable model for future virtual events, inspiring people to turn threats into opportunities.
Review
Biochemistry & Molecular Biology
Naeim Ehtesham, Shahnaz Shahrbanian, Mohammad Valadiathar, Seyed Javad Mowla
Summary: This study investigates the impact of exercise on miRNA expression in individuals with obesity, highlighting the role of miRNAs in obesity and exercise adaptation mechanisms. Further research is needed to fully understand the underlying molecular pathways.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Afsaneh Malekzadeh Shafaroudi, Ali Sharifi-Zarchi, Saeid Rahmani, Nahid Nafissi, Seyed Javad Mowla, Andrea Lauria, Salvatore Oliviero, Maryam M. Matin
Summary: Studies have revealed the significant downregulation of the C1orf132 long transcript in breast cancer, along with the identification of its promoter that has a notable impact on the expression of miR-29c, subsequently influencing cell migration ability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Sogol Ghanbari, Adel Salimi, Saeid Rahmani, Nahid Nafissi, Ali Sharifi-Zarchi, Seyed Javad Mowla
Summary: In this study, a multi-component scoring system was used to identify the most stable miRNA, hsa-miR-361-5p, in breast tissues using TCGA miRNA-Seq data. This miRNA was recommended as a suitable reference gene for miRNA expression studies in breast cancer. Furthermore, the commonly used IC hsa-miR-16-5p was shown to be unsuitable for breast cancer studies.
Article
Oncology
Seyed Masoud Rezaeijo, Bijan Hashemi, Bahram Mofid, Mohsen Bakhshandeh, Arash Mahdavi, Mohammad Saber Hashemi
Summary: The study evaluated the feasibility of dose painting procedure for treating prostate cancer based on mpMR images and machine learning techniques. The results showed promising potential of the DP procedure in achieving effective dose escalation and treatment for prostate cancer.
RADIATION ONCOLOGY
(2021)
Article
Oncology
Amin Banaei, Bijan Hashemi, Mohsen Bakhshandeh
Summary: The study compared four different radiotherapy techniques for treating COVID-19 patients and found that the risks induced by IMRT and VMAT techniques were lower, making them suitable for younger patients or those with greater concerns about radiation-induced cancers.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Saman Moradi, Bijan Hashemi, Mohsen Bakhshandeh, Amin Banaei, Bahram Mofid
Summary: This study aimed to evaluate the conformity and homogeneity of prostate IMRT dose painting plans based on tumoral cell density and relative volumes of each lesion. The new plan evaluation indices considering cellular density showed significantly lower values compared to conventional indices. Furthermore, there was a stronger relationship between the evaluated indices and tumor control probability.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Milad Hatamian, Bijan Hashemi, Seied Rabi Mahdavi, Masoud Soleimani, Leila Khalafi
Summary: The study investigated the effect of time interval between hyperthermia and radiotherapy on the cell cycle arrest of MCF7 breast cancer cells. The results showed that a 24-hour time interval had the most significant effect on the cell population at S and G2/M phases, suggesting it as the most appropriate time for combinational therapy.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gh Sharbo, B. Hashemi, M. Bakhshandeh, A. Rakhsha
Summary: This study evaluated the effectiveness of various IMRT and 3D-CRT protocols for the treatment of nasopharyngeal cancer. The results showed that the IMRT protocol with a collimator angle of 10 degrees and a couch angle of 8 degrees had the lowest normal tissue complication probability, while the 3D-CRT protocol performed better in patients with a lower common volume between the total planning target volume and organs at risk.
INTERNATIONAL JOURNAL OF RADIATION RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
S. M. Rezaeijo, B. Hashemi, B. Mofid, M. Bakhshandeh, A. Rostami, S. H. Molana
Summary: The study compared three whole pelvic radiotherapy (WPRT) procedures and two local radiotherapy (LRT) procedures for prostate cancer patients, showing the importance of considering a balance between dosimetric and radiobiological evaluation when selecting the appropriate treatment technique.
INTERNATIONAL JOURNAL OF RADIATION RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
G. Sharbo, B. Hashemi, M. Bakhshandeh, A. Rakhsha
Summary: The study evaluated the clinical efficacy and radiobiological outcome of IMRT modalities for NPC, finding no significant effects on HI, CN, and TCP, but significant impacts on some OARs. Using appropriate IMRT protocols could potentially reduce the dose to the OARs and the probability of inducing secondary cancer in patients.
JOURNAL OF RADIOTHERAPY IN PRACTICE
(2021)
