Review
Obstetrics & Gynecology
Yakir S. Levin
Summary: Skin changes due to aging lead to a desire for treatments that restore a more youthful appearance. This work discusses common concerns and their anatomical causes, highlighting evidence for the role of menopause-associated hormonal changes. It also explores various treatment options, emphasizing minimally invasive approaches, such as botulinum toxins, fillers, lasers, and thread lifts. These interventions, used in combination, can help patients achieve aesthetic rejuvenation.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Dermatology
Kira Minkis, Diana Bolotin, M. Laurin Council, Anna Bar, Ronda S. Farah, Nour Kibbi, Rachel Y. N. Miest, Jeffrey S. Orringer, Arisa Ortiz, Kathleen C. Suozzi, Neelam A. Vashi, Simon S. Yoo, Joerg Albrecht, Travis W. Blalock, Alison J. Bruce, Min Deng, Shraddha Desai, Milad Eshaq, Lori A. Fiessinger, Erica Ghareeb, Tanya Greywal, Adelaide A. Hebert, Deirdre Hooper, Maria Hordinsky, Jenny C. Hu, Atieh Jibbe, Jayne Joo, Kristen M. Kelly, Sonya Kenkare, Shilpi Khetarpal, Lauren C. S. Kole, A. Shadi Kourosh, Helena Kuhn, Kachiu C. Lee, Roberta Lucas, Janiene Luke, Mariam Mafee, Tiffany T. Mayo, Zeena Y. Nawas, Edit B. Olasz Harken, Michelle Pearlstein, Vesna Petronic-Rosic, Carolyn A. Robinson, Megan N. Rogge, Dana L. Sachs, Sami K. Saikaly, Olivia L. Schenck, Cynthia A. Schlick, Ladan Shahabi, Desmond M. Shipp, Melissa Shive, Sirunya Silapunt, Amanda K. Suggs, Leila Tolaymat, Kimberley H. M. Ward, Mara Weinstein Velez, Joshua Zeichner, Bianca Y. Kang, Sarah A. Ibrahim, Rachel E. Christensen, Noor Anvery, McKenzie A. Dirr, Naomi Lawrence, Murad Alam
Summary: Cosmetic and laser procedures are popular among patients and dermatologists are well trained in these skills. Most dermatology residents want to incorporate cosmetic procedures into their practice and prefer to learn them during residency. However, there are challenges in how residents are trained in cosmetic and laser dermatology. To address these barriers, the Association of Academic Cosmetic Dermatology (AACD) was founded in 2021 as a professional society for dermatologists who educate resident trainees in cosmetic and laser dermatology. The AACD aims to improve cosmetic dermatology education through collaboration, research, and advocacy.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Review
Computer Science, Information Systems
Pat Vatiwutipong, Sirawich Vachmanus, Thanapon Noraset, Suppawong Tuarob
Summary: In the past decade, dermatology has made significant advancements through the use of artificial intelligence (AI) technologies. AI has been utilized for screening, diagnosis, treatment, and prediction of treatment outcomes. While previous systematic reviews have focused on medical dermatology, the adoption of AI in cosmetic dermatology has not been comprehensively reviewed. This systematic review aims to analyze existing research and recent advancements in AI applications within the field of cosmetic dermatology.
Article
Chemistry, Multidisciplinary
Qian An, Shengze Su, Wei Hu, Yanying Wang, Tao Liang, Xianghong Li, Chunya Li
Summary: Combining photothermal therapy (PTT) with photodynamic therapy (PDT) and other therapeutic tools can significantly enhance tumor-killing ability. Copper sulfide nanoparticle (CuS NP) photothermal reagents, when combined with PDT photosensitizers, can effectively construct a PTT/PDT combination therapeutic platform. The CuS@COF nanosheets prepared with a dual-ligand assistant strategy exhibit excellent photothermal conversion performance, high singlet oxygen yield, and high photothermal conversion efficiency.
Article
Chemistry, Analytical
Ke Zheng, Xinxin Liu, Mengyuan Li, Shangmei Zhou, Caifeng Ding
Summary: Switchable theranostics have been developed using smart nanoengineering to construct nanostructured phthalocyanines self-assembled by amphiphilic zinc phthalocyanines and hydrophobic copper phthalocyanines, enabling accurate tumor imaging and targeted therapy.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Shunxin Tang, Bo Zhou, Wanying Sun, Chengyuan Zhu, Yue Tang, Bang-Ping Jiang, Xing-Can Shen
Summary: A novel glutathione (GSH) depletion-mediated in situ transformation strategy is proposed, which can transform the precursors of Berlin green nanocubes into Prussian blue nanocubes (t-PB NCs). This strategy significantly enhances the accuracy of tumor-specific three-dimensional photoacoustic imaging and tumor regional phototherapy, reducing cytotoxic effects towards healthy cells.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Zilin Zhu, Li Wei, Yidan Lai, Oliver W. L. Carter, Samya Banerjee, Peter J. Sadler, Huaiyi Huang
Summary: Rationally-designed glucose-appended Ir(III) photocatalysts were found to exhibit visible light-induced catalytic NAD(P)H oxidation in aqueous solution. Among them, the highly in vivo biocompatible complex Ir3 showed lysosome and mitochondria targeting necro-apoptotic photo-cytotoxicity against various cancer cell lines and multicellular spheroids while remaining non-toxic in the dark.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Weiwei Wu, Yan Yang, Zhuoying Liang, Xiling Song, Yadong Huang, Lin Qiu, Xiaozhong Qiu, Siming Yu, Wei Xue
Summary: This study demonstrated the effective strategy of utilizing near-infrared laser-induced simultaneous release of NO and alkyl radicals to inhibit tumor growth, achieved through the elaborately fabricated biocompatible free radical nanogenerator. Under NIR II laser irradiation, the nanogenerator can precisely control the release profiles of NO and alkyl radicals, displaying synergistic anticancer effects on breast tumors.
Review
Medicine, Research & Experimental
Shilang Liao, Mengru Cai, Rongyue Zhu, Tingting Fu, Yuji Du, Jiahui Kong, Yongqiang Zhang, Changhai Qu, Xiaoxv Dong, Jian Ni, Xingbin Yin
Summary: Chlorin e6 (Ce6), a highly effective photosensitizer and sonosensitizer, has been extensively researched and developed for antitumor therapy. It shows promising future applications in photodynamic therapy, dynamic acoustic therapy, and combined acoustic and light therapy for tumors. Ce6 is also being studied for other applications such as fluorescence navigation, antibacterials, and plant growth regulation. Despite the challenges in clinical applications, Ce6 offers significant advantages in photodynamic therapy/sonodynamic therapy against cancer and has potential clinical utility.
MOLECULAR PHARMACEUTICS
(2023)
Article
Dermatology
Harry Burton, Adam Daunton
Summary: A 62-year-old woman presented with a mass over the dorsal aspect of her left index finger distal interphalangeal joint that she reported had been present for at least 6 months.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Review
Chemistry, Inorganic & Nuclear
Manjunatha Ankathatti Munegowda, Angelica Manalac, Madrigal Weersink, Sherri A. McFarland, Lothar Lilge
Summary: Ruthenium(II)-based coordination complexes have great potential as photosensitizers for photodynamic therapy. The modular architectures of these complexes allow for tuning of various properties such as cellular uptake, subcellular targeting, solubility, and light absorption. Many studies focus on systematic variation of ligands to investigate their impact on photophysical and photobiological performance. However, comparisons between Ru(II)-based PSs and other generations of PSs are scarce. Nonetheless, quantitative models based on PDT dose metrics are available for qualitative comparisons. This review summarizes the relevant studies on Ru(II)-containing PSs and their potential efficacy.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Manjunatha Ankathatti Munegowda, Angelica Manalac, Madrigal Weersink, Sherri A. McFarland, Lothar Lilge
Summary: Ruthenium(II)-based coordination complexes are promising photosensitizers for photodynamic therapy with potential in oncology and antimicrobial fields. These complexes can be tuned for different photophysical properties and studies comparing their efficacy to other PSs are limited but possible using PDT dose metrics.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Multidisciplinary Sciences
Wenping Zhu, Ying Li, Shaoxun Guo, Wu-Jie Guo, Tuokai Peng, Hui Li, Bin Liu, Hui-Qing Peng, Ben Zhong Tang
Summary: This study demonstrates the development of stereoisomeric photosensitizers using supramolecular assembly and their effectiveness in photodynamic therapy against fungal infections. It showcases the potential and importance of aggregation-induced photodynamic action.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Qihang Ding, Ling Mei, Yu Liu, Shan Zhou, Lu Chen, Yuying Liang, Mingle Li, Hui Zhou, Chao Yin, Jong Seung Kim
Summary: Researchers constructed a D-A type-based NIR-II fluorophore with mitochondria targeting, which demonstrated both photothermal effect and photodynamic performance. They further fabricated nanodots with DSPE-mPEG for in vivo experiments, achieving strong NIR-II fluorescence tracing of tumors and impressive NIR-II image-guided photodynamic therapy and photothermal therapy.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Xiangjie Luo, Xiaoqin Chi, Yaying Lin, Zhaoxuan Yang, Hongyu Lin, Jinhao Gao
Summary: The photosensitizer-conjugated camptothecin-based prodrug effectively targets cancer cell mitochondria, triggers ROS-responsive release of CPT, and induces mitochondrial damage, achieving high therapeutic efficacy for solid tumors.
CHEMICAL COMMUNICATIONS
(2021)
Review
Food Science & Technology
Amirhossein Sheida, Tarannomsadat Taghavi, Rana Shafabakhsh, Amirreza Ostadian, Zahra Razaghi Bahabadi, Mahmood Khaksary Mahabady, Michael R. Hamblin, Hamed Mirzaei
Summary: Concerns about long-term side effects have led to a decline in the use of conventional drugs for cardiovascular disease, with renewed interest in medicinal plant products as potential alternatives. Increased levels of free radicals and oxidative stress contribute to myocardial damage after heart attack, and treatment approaches aim to reduce free radicals and enhance antioxidant defense mechanisms. Bioactive natural products such as curcumin, resveratrol, quercitin, berberine, and tanshinone have been shown to protect the heart muscle in myocardial infarction and have potential molecular mechanisms of action.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Neurosciences
Mahnaz Kahuripour, Zahra Behroozi, Behnaz Rahimi, Michael R. Hamblin, Fatemeh Ramezani
Summary: This study conducted a meta-analysis on the effect of curcumin on functional recovery after SCI and found that daily administration of curcumin can significantly improve recovery and reduce the expression of GFAP marker.
NUTRITIONAL NEUROSCIENCE
(2023)
Review
Dermatology
Jan Kyselovic, Jozef Masarik, Hayet Kechemir, Eva Koscova, Iva Igracki Turudic, Michael Richard Hamblin
Summary: Infrared light therapy has positive effects on relieving musculoskeletal pain through several mechanisms, including increasing nitric oxide availability and reducing inflammation.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Hamed Kowsari, Amirhossein Davoodvandi, Fatemeh Dashti, Seyed Mohamad Ali Mirazimi, Zahra Razaghi Bahabadi, Michael Aschner, Amirhossein Sahebkar, Hamid Reza Gilasi, Michael R. Hamblin, Hamed Mirzaei
Summary: Acute liver injury (ALI) is a critical and fatal disorder associated with excessive alcohol consumption. Despite advances in the early diagnosis and treatment of breast cancer, it remains a leading cause of cancer-related death in women worldwide. Phytochemicals, such as resveratrol, have shown promise in preventing and treating breast cancer. While resveratrol can affect various signaling pathways in vitro, its efficacy in animal models of breast cancer has been disappointing.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Review
Oncology
Nasim Ebrahimi, Maral Afshinpour, Siavash Seifollahy Fakhr, Paniz Ghasempour Kalkhoran, Vida Shadman-Manesh, Samaneh Adelian, Sheida Beiranvand, Fatemeh Rezaei-Tazangi, Roya Khorram, Michael R. Hamblin, Amir Reza Aref
Summary: Colorectal cancer (CRC) is a major cause of cancer death worldwide. The presence of cancer stem cells (CSCs) contributes to therapy resistance and recurrence. This review examines the role of signaling pathways in colorectal CSCs and discusses potential drugs for treatment of resistant CRC.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ming Zhong, Ghanbar Mahmoodi Chalbatani, Meifang Deng, Qiuyi Li, Elahe Gharagouzloo, Michael R. Hamblin, Eloah Rabello Suarez, Lili Hu, Dingding Wang
Summary: This study investigates the potential of CAR-T cells modified with a chimeric antigen receptor (CAR) targeting the vascular endothelial growth factor 2 receptor/kinase insert domain receptor (KDR) to destroy tumors. The results demonstrate the effectiveness of this CAR construct in inhibiting the growth of lung cancer and suggest its applicability as a new treatment strategy for other vascularized solid tumors.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Neurosciences
Omid Mohamadzadeh, Mahsasadat Hajinouri, Farzaneh Moammer, Seyed Saeed Tamehri Zadeh, Ghoncheh Omid Shafiei, Ameneh Jafari, Amirreza Ostadian, Sayyed Alireza Talaei Zavareh, Michael R. Hamblin, Arezoo Jafarian Yazdi, Amirhossein Sheida, Hamed Mirzaei
Summary: Nowadays, traumatic brain injury (TBI) is a global concern due to its significant morbidity and long-term consequences that are not fully understood. Cellular pathways such as free radical production, excitotoxicity, apoptosis, and neuroinflammatory responses have been identified in TBI. Non-coding RNAs (ncRNAs) have been found to play a crucial role in post-transcriptional regulation in the brain, and altered levels of ncRNA expression have been observed in both traumatic and non-traumatic brain injuries. This review provides an overview of the primary molecular mechanisms involved in TBI and discusses the latest findings on changes and the role of ncRNAs in TBI from both clinical and experimental research.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pathology
Seyed Mojtaba Mousavi, Saereh Hosseindoost, Seyed Mohammad Amin Mahdian, Nasim Vousooghi, Ali Rajabi, Ameneh Jafari, Amirreza Ostadian, Michael R. Hamblin, MahmoudReza Hadjighassem, Hamed Mirzaei
Summary: This study investigated the therapeutic benefits of exosomes generated from U87 cells treated with curcumin and/or temozolomide, which can function as a new type of targeted therapy by increasing cell apoptosis and reducing the side effects of anti-tumor drugs.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Genetics & Heredity
Alireza Farokhian, Ali Rajabi, Amirhossein Sheida, Amirhossein Abdoli, Moein Rafiei, Zahra Hadian Jazi, Sahar Ahmadi Asouri, Mohammad Amin Morshedi, Michael R. Hamblin, Parisa Adib-Hajbagheri, Hamed Mirzaei
Summary: ncRNAs, particularly miRNAs, lncRNAs, and circRNAs, play a significant role in regulating gene expression and affecting multiple cellular processes, especially apoptosis. Apoptosis has recently gained great interest as a therapeutic target to improve myocardial infarction outcomes. This review summarizes studies on ncRNAs that can promote or suppress apoptosis in the context of myocardial infarction, potentially introducing new therapeutic targets for its treatment.
Correction
Nanoscience & Nanotechnology
Navid Rabiee, Mojtaba Bagherzadeh, Amir Mohammad Ghadiri, Yousef Fatahi, Abdullah Aldhaher, Pooyan Makvandi, Rassoul Dinarvand, Maryam Jouyandeh, Mohammad Reza Saeb, Masoud Mozafari, Mohammadreza Shokouhimehr, Michael R. Hamblin, Rajender S. Varma
ACS APPLIED BIO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Arefeh Ebadati, Mojgan Oshaghi, Sara Saeedi, Parastoo Parsa, Vahid Pirhajati Mahabadi, Morteza Karimi, Atefeh Jahandideh Hajiebrahimdehi, Michael R. Hamblin, Mahdi Karimi
Summary: Multi-drug resistant bacteria pose a significant challenge in the treatment of infectious diseases. Cationic nanopolymers, specifically poly(DABCO-BBAC) nanoparticles, exhibit high efficiency as antimicrobial agents. These nanoparticles effectively inhibit and kill multi-drug resistant Pseudomonas aeruginosa, making them a potential therapeutic option for drug-resistant clinical pathogens.
BIOORGANIC CHEMISTRY
(2023)
Article
Immunology
Mohammad Hasan Jafari Najaf Abadi, Fahimeh Abdi Abyaneh, Noushid Zare, Javad Zamani, Amirhossein Abdoli, Fatemeh Aslanbeigi, Michael R. Hamblin, Hossein Tarrahimofrad, Mohammadreza Rahimi, Seyed Mohammadreza Hashemian, Hamed Mirzaei
Summary: Currently, there is a lack of recombinant vaccine for preventing or treating Salmonella infection. In this study, a multi-epitope vaccine against Salmonella was designed using in silico approach. The vaccine was predicted to be non-allergenic and antigenic, and it could interact with human TLR5, potentially inducing an immune response for the prevention and treatment of Salmonella infection.
MICROBIAL PATHOGENESIS
(2023)
Article
Oncology
Przemys law Gnatowski, Edyta Pilat, Justyna Kucinska-Lipka, Mohammad Reza Saeb, Michael R. Hamblin, Masoud Mozafari
Summary: Cancerous tumors are highly fatal, claiming almost 10 million lives in 2020 worldwide. Accurately modeling tumors is a challenging task due to their complex and dynamic nature. Hydrogel-based 3D bioprinting is emerging as a promising approach to overcome the limitations of current models and mimic cancer development and behavior.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Dermatology
Sebastiaan J. W. van Kraaij, Michael R. Hamblin, Gisele Pickering, Bill Giannokopoulos, Hayet Kechemir, Moritz Heinz, Iva Igracki-Turudic, Yalcin Yavuz, Robert Rissmann, Pim Gal
Summary: This study evaluated the local effects of the FIRTECH patch on skin perfusion, microcirculation, and oxygenation. The results showed that the patch had a slight increase in skin perfusion, but not significant; the treated areas had significantly higher oxygen consumption and skin temperature compared to the untreated areas. The study also found that the FIRTECH patch was well tolerated and had a non-thermal vasodilatory effect.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Neurosciences
Sareh Kazmi, Fereshteh Farajdokht, Reza Meynaghizadeh-Zargar, Saeed Sadigh-Eteghad, Amir Pasokh, Mohammad Farzipour, Narmin Farazi, Michael R. Hamblin, Javad Mahmoudi
Summary: Prolonged microgravity exposure leads to cognitive impairment through oxidative stress and neuroinflammation. In this study, transcranial near-infrared photobiomodulation (PBM) was found to be effective in improving cognitive deficits in a mouse model of simulated microgravity. PBM treatment reduced latency time and errors, decreased hippocampal lipid peroxidation, increased antioxidant defense systems, and activated the Sirt1/Nrf2 signaling pathway and up-regulated BDNF, while reducing neuroinflammation and oxidative stress.
