Formulation, Delivery and Stability of Bone Morphogenetic Proteins for Effective Bone Regeneration
出版年份 2017 全文链接
标题
Formulation, Delivery and Stability of Bone Morphogenetic Proteins for Effective Bone Regeneration
作者
关键词
Bone morphogenetic proteins, Growth factor, Protein formulation, Protein stability, Regenerative medicine
出版物
PHARMACEUTICAL RESEARCH
Volume 34, Issue 6, Pages 1152-1170
出版商
Springer Nature
发表日期
2017-03-25
DOI
10.1007/s11095-017-2147-x
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Peptides for bone tissue engineering
- (2016) Rick Visser et al. JOURNAL OF CONTROLLED RELEASE
- No Touching! Abrasion of Adsorbed Protein Is the Root Cause of Subvisible Particle Formation During Stirring
- (2016) Ahmad S. Sediq et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- RhBMP-2-induced radiculitis in patients undergoing transforaminal lumbar interbody fusion: relationship to dose
- (2016) Alan T. Villavicencio et al. Spine Journal
- Bone regenerative efficacy of biphasic calcium phosphate collagen composite as a carrier of rhBMP-2
- (2015) Eun-Ung Lee et al. CLINICAL ORAL IMPLANTS RESEARCH
- Hydrogel-based Delivery of rhBMP-2 Improves Healing of Large Bone Defects Compared With Autograft
- (2015) Laxminarayanan Krishnan et al. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
- Nanofibrous yet injectable polycaprolactone-collagen bone tissue scaffold with osteoprogenitor cells and controlled release of bone morphogenetic protein-2
- (2015) Gayathri Subramanian et al. Materials Science & Engineering C-Materials for Biological Applications
- Complications with the use of bone morphogenetic protein 2 (BMP-2) in spine surgery
- (2014) Chadi A. Tannoury et al. Spine Journal
- Safety and Effectiveness of Recombinant Human Bone Morphogenetic Protein-2 for Spinal Fusion
- (2013) Mark C. Simmonds et al. ANNALS OF INTERNAL MEDICINE
- Low dose BMP-2 treatment for bone repair using a PEGylated fibrinogen hydrogel matrix
- (2013) Dror Ben-David et al. BIOMATERIALS
- Cancer Risk After Use of Recombinant Bone Morphogenetic Protein-2 for Spinal Arthrodesis
- (2013) Eugene J Carragee et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences
- (2013) Riccardo Torosantucci et al. PHARMACEUTICAL RESEARCH
- Quantitative Assessment of Retrograde Ejaculation Using Semen Analysis, Comparison With a Standardized Qualitative Questionnaire, and Investigating the Impact of rhBMP-2
- (2013) Gil Tepper et al. SPINE
- Analytical approaches to assess the degradation of therapeutic proteins
- (2013) Vasco Filipe et al. TRAC-TRENDS IN ANALYTICAL CHEMISTRY
- Subcutaneous tissue response and osteogenic performance of calcium phosphate nanoparticle-enriched hydrogels in the tibial medullary cavity of guinea pigs
- (2012) Matilde Bongio et al. Acta Biomaterialia
- Studies of bone morphogenetic protein-based surgical repair
- (2012) Kevin W.-H. Lo et al. ADVANCED DRUG DELIVERY REVIEWS
- BMP2 promotes migration and invasion of breast cancer cells via cytoskeletal reorganization and adhesion decrease: an AFM investigation
- (2012) Hua Jin et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Prediction of heparin binding sites in bone morphogenetic proteins (BMPs)
- (2012) Neha S. Gandhi et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Injectable and thermo-sensitive PEG-PCL-PEG copolymer/collagen/n-HA hydrogel composite for guided bone regeneration
- (2012) ShaoZhi Fu et al. BIOMATERIALS
- Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds
- (2012) Sungsoo S. Lee et al. BIOMATERIALS
- BMP-13 Emerges as a Potential Inhibitor of Bone Formation
- (2012) Bojiang Shen et al. International Journal of Biological Sciences
- Effect of Bone Morphogenetic Protein-2 on Proliferation and Apoptosis of Gastric Cancer Cells
- (2012) Junjie Zhang et al. International Journal of Medical Sciences
- Facilitating the mineralization of oligo(poly(ethylene glycol) fumarate) hydrogel by incorporation of hydroxyapatite nanoparticles
- (2012) M. Reza Nejadnik et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- Critical assessment of rhBMP-2 mediated bone induction: An in vitro and in vivo evaluation
- (2012) Marta Kisiel et al. JOURNAL OF CONTROLLED RELEASE
- Retrograde Ejaculation After Anterior Lumbar Spine Surgery
- (2012) Emily M. Lindley et al. SPINE
- Retrograde ejaculation after anterior lumbar interbody fusion with and without bone morphogenetic protein-2 augmentation: a 10-year cohort controlled study
- (2012) Garet C. Comer et al. Spine Journal
- The use of injectable sonication-induced silk hydrogel for VEGF165 and BMP-2 delivery for elevation of the maxillary sinus floor
- (2011) Wenjie Zhang et al. BIOMATERIALS
- Spatiotemporal delivery of bone morphogenetic protein enhances functional repair of segmental bone defects
- (2011) Yash M. Kolambkar et al. BONE
- Activity of bone morphogenetic protein-7 after treatment at various temperatures: Freezing vs. pasteurization vs. allograft
- (2011) Munetomo Takata et al. CRYOBIOLOGY
- Use and efficacy of bone morphogenetic proteins in fracture healing
- (2011) Suzanne N. Lissenberg-Thunnissen et al. INTERNATIONAL ORTHOPAEDICS
- Bone Formation Induced by Growth Factors Embedded into the Nanostructured Particles
- (2011) S. Facca et al. Journal of Biomedical Nanotechnology
- Recombinant Human Bone Morphogenetic Protein-2: A Randomized Trial in Open Tibial Fractures Treated with Reamed Nail Fixation
- (2011) Hannu T Aro et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- Exaggerated Inflammatory Response After Use of Recombinant Bone Morphogenetic Protein in Recurrent Unicameral Bone Cysts
- (2011) Kevin M. MacDonald et al. JOURNAL OF PEDIATRIC ORTHOPAEDICS
- Forced Degradation of Therapeutic Proteins
- (2011) Andrea Hawe et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Protein Instability and Immunogenicity: Roadblocks to Clinical Application of Injectable Protein Delivery Systems for Sustained Release
- (2011) Wim Jiskoot et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Inflammatory response to recombinant human bone morphogenetic protein-2 use in the treatment of a proximal humeral fracture: a case report
- (2011) Abhishek Julka et al. JOURNAL OF SHOULDER AND ELBOW SURGERY
- rhBMP-2 has adverse effects on human oral carcinoma cell lines in vivo
- (2011) Natalia A. Kokorina et al. LARYNGOSCOPE
- A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned
- (2011) Eugene J. Carragee et al. Spine Journal
- Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats
- (2011) Ji-Woong Jang et al. Oral Surgery Oral Medicine Oral Pathology Oral Radiology
- Experimental Study of Nano-Hydroxyapatite/Recombinant Human Bone Morphogenetic Protein-2 Composite Artificial Bone
- (2010) Weimin Zhu et al. ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY
- Perioperative complications with rhBMP-2 in transforaminal lumbar interbody fusion
- (2010) Kirk Owens et al. EUROPEAN SPINE JOURNAL
- Physical instability, aggregation and conformational changes of recombinant human bone morphogenetic protein-2 (rhBMP-2)
- (2010) Ludmila Luca et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Highly porous titanium scaffolds for orthopaedic applications
- (2010) Bogdan Dabrowski et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
- Segmental bone defects: from cellular and molecular pathways to the development of novel biological treatments
- (2010) Spyros G. Pneumaticos et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- The effects of carrier nature and pH on rhBMP-2-induced ectopic bone formation
- (2010) Ludmila Luca et al. JOURNAL OF CONTROLLED RELEASE
- Bone Morphogenetic Proteins and Cancer
- (2010) Jayesh P. Thawani et al. NEUROSURGERY
- Stability of Protein Pharmaceuticals: An Update
- (2010) Mark Cornell Manning et al. PHARMACEUTICAL RESEARCH
- Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development
- (2010) John den Engelsman et al. PHARMACEUTICAL RESEARCH
- Recombinant human bone morphogenetic protein-2 and pancreatic cancer: a retrospective cohort study
- (2010) Daniel Mines et al. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
- Complications Related to Osteobiologics Use in Spine Surgery
- (2010) Thomas E. Mroz et al. SPINE
- Off-Label Use of Bone Morphogenetic Proteins in the United States Using Administrative Data
- (2010) Kevin L. Ong et al. SPINE
- Histopathologic inflammatory response induced by recombinant bone morphogenetic protein-2 causing radiculopathy after transforaminal lumbar interbody fusion
- (2010) Ryan D. Muchow et al. Spine Journal
- Promoting fusion in minimally invasive lumbar interbody stabilization with low-dose bone morphogenic protein-2—but what is the cost?
- (2010) Richard J. Mannion et al. Spine Journal
- Chemically-Conjugated Bone Morphogenetic Protein-2 on Three-Dimensional Polycaprolactone Scaffolds Stimulates Osteogenic Activity in Bone Marrow Stromal Cells
- (2010) Huina Zhang et al. TISSUE ENGINEERING PART A
- Slow-Release Human Recombinant Bone Morphogenetic Protein-2 Embedded Within Electrospun Scaffolds for Regeneration of Bone Defect: In Vitro and In Vivo Evaluation
- (2010) Samer Srouji et al. TISSUE ENGINEERING PART A
- Biomimetic apatite-coated alginate/chitosan microparticles as osteogenic protein carriers
- (2009) Min Lee et al. BIOMATERIALS
- Bioceramics of calcium orthophosphates
- (2009) Sergey V. Dorozhkin BIOMATERIALS
- Response of a concentrated monoclonal antibody formulation to high shear
- (2009) Jared S. Bee et al. BIOTECHNOLOGY AND BIOENGINEERING
- Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering
- (2009) Ziyad S. Haidar et al. BIOTECHNOLOGY LETTERS
- Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: Current challenges in BMP delivery
- (2009) Ziyad S. Haidar et al. BIOTECHNOLOGY LETTERS
- The Role of Thiols and Disulfides on Protein Stability
- (2009) Maulik Trivedi et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Prevalence, Complications, and Hospital Charges Associated With Use of Bone-Morphogenetic Proteins in Spinal Fusion Procedures
- (2009) Kevin S. Cahill JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Bone morphogenetic protein receptors and signal transduction
- (2009) K. Miyazono et al. JOURNAL OF BIOCHEMISTRY
- Recombinant Human Bone Morphogenetic Protein-2 on an Absorbable Collagen Sponge with an Osteoconductive Bulking Agent in Posterolateral Arthrodesis with Instrumentation
- (2009) Edgar Dawson et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- Clinical and Radiographic Analysis of an Optimized rhBMP-2 Formulation as an Autograft Replacement in Posterolateral Lumbar Spine Arthrodesis
- (2009) John R Dimar et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- Immunogenicity of bone morphogenetic proteins
- (2009) Chang Ju Hwang et al. JOURNAL OF NEUROSURGERY-SPINE
- Posterolateral Intertransverse Spinal Fusion Possible in Osteoporotic Rats With BMP-7 in a Higher Dose Delivered on a Composite Carrier
- (2009) Jike Lu et al. SPINE
- Recombinant Human Bone Morphogenetic Protein-2-Induced Radiculitis in Elective Minimally Invasive Transforaminal Lumbar Interbody Fusions
- (2009) Stefan A. Mindea et al. SPINE
- Complications associated with single-level transforaminal lumbar interbody fusion
- (2009) Jeffrey A. Rihn et al. Spine Journal
- Silk Fibroin Microparticles as Carriers for Delivery of Human Recombinant Bone Morphogenetic Protein-2: In Vitro and In Vivo Bioactivity
- (2009) Paulo César Bessa et al. TISSUE ENGINEERING PART C-METHODS
- Biodegradable gelatin microparticles as delivery systems for the controlled release of bone morphogenetic protein-2
- (2008) Zarana S. Patel et al. Acta Biomaterialia
- Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model
- (2008) Borhane H. Fellah et al. BIOMATERIALS
- The Structure of Glycosaminoglycans and their Interactions with Proteins
- (2008) Neha S. Gandhi et al. Chemical Biology & Drug Design
- Enhancement of posterolateral lumbar spine fusion using low-dose rhBMP-2 and cultured marrow stromal cells
- (2008) Tsai-Sheng Fu et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery)
- (2008) P. C. Bessa et al. Journal of Tissue Engineering and Regenerative Medicine
- Effect of Autologous Bone Marrow Stromal Cell Seeding and Bone Morphogenetic Protein-2 Delivery on Ectopic Bone Formation in a Microsphere/Poly(Propylene Fumarate) Composite
- (2008) Diederik H.R. Kempen et al. TISSUE ENGINEERING PART A
- Chitosan Film as rhBMP2 Carrier: Delivery Properties for Bone Tissue Application
- (2007) Ander Abarrategi et al. BIOMACROMOLECULES
- Mandibular bone repair by implantation of rhBMP-2 in a slow release carrier of polylactic acid—An experimental study in rats
- (2007) Henning Schliephake et al. BIOMATERIALS
- The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: minimum 4-year follow-up of a pilot study
- (2007) Alexander R. Vaccaro et al. Spine Journal
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