Article
Fisheries
Ru-Yi Chen, Jie Chen, Zi-Ming Liu, Zhi-Hua Lin, Zhi-Ping Guo
Summary: The study revealed that the NKL in barbel steed exhibits immunomodulatory effects in fish and protects the host from pathogenic infections independently of direct bacterial clearance.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Immunology
Christian Binder, Felix Sellberg, Filip Cvetkovski, Stefan Berg, Erik Berglund, David Berglund
Summary: The study showed that siplizumab increased NK cell activation by binding to Fc gamma RIIIA, suggesting potential application in inhibiting NK cell activation. However, the inhibitory effects of CD2 blockade on natural cytotoxicity and antibody-dependent cytotoxicity remain unclear.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hang Xu, Zihao Yuan, Li Sun
Summary: This study identified a non-canonical NK-lysin protein in Japanese flounder, which plays an important role in immune defense against bacterial infection. A peptide derived from this protein, P35, exhibits antimicrobial effects by targeting both bacteria and fish cells through multiple mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Yujun Zhang, Ping Deng, Caijiao Dai, Mengke Wu, Xueqin Liu, Lijuan Li, Xiaoyi Pan, Junfa Yuan
Summary: In this study, 18 antimicrobial peptides (AMPs) were identified from the genome of Carassius auratus, and their tissue distribution and expression patterns were investigated. The results showed that these AMPs were widely distributed in all tested tissues, and their expression levels were upregulated in response to bacterial and viral infection. Furthermore, a synthetic peptide caNKL2102-119 was found to effectively inhibit the growth of several pathogens.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Carolina Munoz-Flores, Ivan Gonzalez-Chavarria, Felipe Sandoval, Francisco J. Roa, Paulo Palacios, Allisson Astuya, Khaterina Fernandez, Claudia Altamirano, Alex Romero, Jannel Acosta, Jorge R. Toledo
Summary: Intensive salmon farming has led to outbreaks of infections, and the use of antibiotics for prevention and control has negative impacts on the environment and human health. Therefore, antimicrobial peptides (AMPs) have been proposed as an alternative. However, the main challenges for their large-scale clinical application are high production costs and complex chemical synthesis. Recombinant DNA technology offers a more sustainable and scalable option, and the designed chimeric peptide demonstrated immunomodulatory activity.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Cell Biology
Hanna Kim, Jae-Eun Byun, Suk Ran Yoon, Hashem Koohy, Haiyoung Jung, Inpyo Choi
Summary: The study found that SARS-CoV-2 S protein peptides can bind to the NKG2D receptor on NK cells, enhancing immune responses by increasing NK cytotoxicity towards lung cancer cells and stimulating IFN-gamma production. This novel interaction between SARS-CoV-2 and NK cells may have potential clinical applications as a therapeutic target for COVID-19.
CELLULAR IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fernanda Scopelliti, Valentina Dimartino, Caterina Cattani, Andrea Cavani
Summary: This study found that TRPA1 channels are highly expressed in the CD56(dim)CD16(+) subpopulation of NK cells, and their activation can increase cell-mediated cytotoxicity against tumors while also regulating the survival of NK cells to limit excessive cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Ziming Hu, Xiuxiu Xu, Haiming Wei
Summary: NK cells are essential components of innate immunity, playing a key role in defending against tumors and viral infections. They express a diverse range of receptors and exhibit phenotypic and functional diversity influenced by various factors such as developmental origins, tumors, and viral infections. Understanding NK cells in the tumor microenvironment is crucial for the development of NK cell immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shean-Jaw Chiou, Huey-Jiun Ko, Chi-Ching Hwang, Yi-Ren Hong
Summary: Beta2-microglobulin (B2M) plays a crucial role in both immune response and antimicrobial activity, functioning primarily in innate defense. B2M acts as an antimicrobial peptide under acidic conditions, disrupting a wide range of microbes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Nico van Os, Ali Javed, Femke Broere, Albert van Dijk, Melanie D. Balhuizen, Martin van Eijk, Suzan H. M. Rooijakkers, Bart W. Bardoel, Dani A. C. Heesterbeek, Henk P. Haagsman, Edwin Veldhuizen
Summary: CR-163 and CR-172 exhibit broad-spectrum antimicrobial activity by disrupting bacterial membranes. Additionally, PepBiotics can bind to LPS and LTA, replacing the role of polymyxin B. The study also demonstrates that bacteria killed by PepBiotics are less likely to stimulate immune cells compared to gentamicin and heat-killed bacteria, which still elicit a strong immune response.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Multidisciplinary Sciences
Csilla Sebok, Stephanie Walmsley, Patrik Traj, Mate Mackei, Julia Voroshazi, Janka Petrilla, Laszlo Kovacs, Agnes Kemeny, Zsuzsanna Neogrady, Gabor Matis
Summary: The study suggests that Cathelicidin-2 could be a promising candidate for future immunomodulating drug development to combat infection and inflammation. It plays a substantial role in modulating the hepatic immune response, affecting cell viability, membrane integrity, and redox homeostasis, while also possessing anti-inflammatory effects.
Article
Oncology
Grace Lee, Sheela Karunanithi, Bruce Posner, Hanspeter Niederstrasser, Hong Cheng, Yuriy Federov, Shivaprasad Manjappa, Karam Musaitif, Huaiyu Wang, Zachary Jackson, David Wald
Summary: Our work led to the identification of a promising compound that potently increases NK cell-mediated killing of a variety of different cancer cells, but has no impact on the killing of normal cells. This compound demonstrates the utility of this screening assay.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Agriculture, Dairy & Animal Science
Samiru S. Wickramasuriya, Inkyung Park, Youngsub Lee, Luciana M. Richer, Chris Przybyszewski, Cyril G. Gay, Jolieke G. van Oosterwijk, Hyun S. Lillehoj
Summary: We investigated the effects of a higher dose of oral B. subtilis-cNK-2 treatment on coccidiosis, intestinal health, and gut microbiota composition in broiler chickens. The results showed that the NK treatment significantly improved growth performance, gut integrity, and mucosal immunity, while reducing fecal oocyst shedding. The gut microbiota composition in the NK group exhibited a distinct shift compared to the infected control group, indicating the restoration of dysbiosis caused by E. acervulina infection.
Article
Chemistry, Multidisciplinary
Weipan Xu, Zheng Ma, Geetika Dhanda, Jayanta Haldar, Hexin Xie
Summary: The expression of B-lactamase in bacteria has led to significant resistance to clinically important B-lactam antibiotics. Antimicrobial peptides (AMPs) have emerged as potential therapeutic agents to combat antibiotic resistance, but their cytotoxicity has been a major concern. This study reports a novel cephalosporin-caged AMP that shows reduced cytotoxicity and hemolytic activity, but becomes highly active against bacteria upon specific hydrolysis by antimicrobial resistance-causing B-lactamase. Further investigations demonstrate that this B-lactamase-activatable AMP selectively inactivates resistant bacterial pathogens. This strategy could be applicable to other AMPs for the treatment of infectious diseases caused by B-lactamase-expressing pathogenic bacteria.
CHINESE CHEMICAL LETTERS
(2023)
Review
Cell & Tissue Engineering
Hans Klingemann
Summary: The NK-92 cell line is a highly active blood natural killer (NK) cell that exhibits broader and greater cytotoxicity. It has significant implications in both research and clinical treatment, showing great potential in the treatment of cancer and infections.
Article
Medicine, Research & Experimental
Marina Z. Jovanovic, David A. Geller, Nevena M. Gajovic, Milena M. Jurisevic, Nebojsa N. Arsenijevic, Milan M. Jovanovic, Gordana M. Supic, Danilo V. Vojvodic, Ivan P. Jovanovic
Summary: Co-blockage of IL33/ST2 and PD-L/PD-1 axes impedes tumor progression more efficiently than single blockage of either axes, thus offering potential new approach to immunotherapy of tumors.
Article
Multidisciplinary Sciences
Sofija Sekulic Markovic, Nevena Gajovic, Milena Jurisevic, Marina Jovanovic, Biljana Popovska Jovicic, Nebojsa Arsenijevic, Zeljko Mijailovic, Zana Dolicanin, Ivan Jovanovic
Summary: This study aimed to investigate the levels of Gal-1 and its correlation with proinflammatory cytokines and clinical parameters in COVID-19 patients. The study found that Gal-1 and proinflammatory cytokines were significantly elevated in severe stages of COVID-19. Gal-1 positively correlated with IL-1β, IL-6, IL-10, IL-23, and IL-33, implicating its role in immune modulation during COVID-19. Linear regression model and ROC curve analysis suggested Gal-1 as a significant predictor for COVID-19 severity.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Andjela A. Franich, Milena M. Jurisevic, Nevena M. Gajovic, Nebojsa N. Arsenijevic, Ivan P. Jovanovic, Bojan S. Stojanovic, Jakob Kljun, Snezana Rajkovic, Marija D. Zivkovic, Milica Dimitrijevic Stojanovic, Slobodanka Lj Mitrovic
Summary: In this study, four novel Pt(II) complexes were synthesized and investigated for their anticancer activity. The Pt3 complex showed potent cytotoxic activity against breast and colorectal cancer cells, with stronger selectivity and lower toxicity compared to other complexes tested.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Immunology
Ana Divjak, Ivan Jovanovic, Aleksandar Matic, Aleksandra Tomic Lucic, Nevena Gajovic, Milena Jurisevic, Aleksandra Jurisic Skevin, Mirjana Veselinovic
Summary: This trial suggests that vitamin D3 has potential therapeutic and immunomodulatory effects in patients with knee osteoarthritis. Oral supplementation of vitamin D3 can significantly reduce pain and improve the quality of life in knee osteoarthritis patients. Vitamin D3 supplementation also increases systemic values of IL-33.
IMMUNOLOGIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Nevena Gajovic, Sofija Sekulic Markovic, Milena Jurisevic, Marina Jovanovic, Nebojsa Arsenijevic, Zeljko Mijailovic, Marina Jovanovic, Ivan Jovanovic
Summary: Gal-3 is associated with COVID-19 severity and immune response. Patients in critical stage have higher levels of Gal-3, cytokines, and CCR5 expression, indicating more severe inflammation. Gal-3 also correlates with clinical and radiographic findings, as well as peripheral blood immune cell composition.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Jelena Nesic, Biljana Ljujic, Vesna Rosic, Aleksandar Djukic, Milenko Rosic, Ivica Petrovic, Nenad Zornic, Ivan P. Jovanovic, Sara Petrovic, Svetlana Djukic
Summary: Adiponectin and interleukin-33 are associated in patients with metabolic syndrome, with adiponectin potentially serving as an early marker and interleukin-33 being a potential predictor of inflammatory status in the early stage.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Milica M. M. Borovcanin, Katarina Vesic, Dragana Arsenijevic, Maja Milojevic-Rakic, Natasa R. Mijailovic, Ivan P. P. Jovanovic
Summary: In modern clinical practice and research, there are one-sided approaches to behavioral changes in patients with oncological problems. Early detection strategies must consider the specifics of the disease. Behavioral changes may be related to systemic proinflammatory changes. The review provides an overview of similar inflammatory disturbances in both oncological disease and depression.
Review
Cell Biology
Bojan Stojanovic, Ivan P. Jovanovic, Milica Dimitrijevic Stojanovic, Marina Jovanovic, Berislav Vekic, Bojan Milosevic, Aleksandar Cvetkovic, Marko Spasic, Bojana S. Stojanovic
Summary: Acute pancreatitis is a complex inflammatory condition of the pancreas, mediated by various T cell subsets and B cells. The immune response, involving pro-inflammatory and anti-inflammatory cytokines, plays a crucial role in the pathogenesis of acute pancreatitis. Understanding the roles of immune cells, such as Treg, CD8(+) T cells, and B cells, may lead to the development of novel immunotherapies for better patient outcomes. However, more research is needed to determine the precise roles of these cells and their potential as therapeutic targets in acute pancreatitis.
Review
Biochemistry & Molecular Biology
Ana Bogut, Bojan Stojanovic, Marina Jovanovic, Milica Dimitrijevic Stojanovic, Nevena Gajovic, Bojana S. Stojanovic, Goran Balovic, Milan Jovanovic, Aleksandar Lazovic, Milos Mirovic, Milena Jurisevic, Ivan Jovanovic, Violeta Mladenovic
Summary: This review provides a comprehensive overview of the multifaceted role of Galectin-1 in Pancreatic Ductal Adenocarcinoma (PDAC), including its contributions to tumor stroma remodeling, angiogenesis, metabolic reprogramming, and potential implications for therapeutic interventions. The challenges associated with targeting Galectin-1 are discussed, and the promising prospects of Gal-1 inhibition, including the utilization of nanotechnology and theranostics, are highlighted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Bojan Milosevic, Bojan Stojanovic, Aleksandar Cvetkovic, Ivan Jovanovic, Marko Spasic, Milica Dimitrijevic Stojanovic, Vesna Stankovic, Marija Sekulic, Bojana S. Stojanovic, Natasa Zdravkovic, Minja Mitrovic, Jasmina Stojanovic, Darko Laketic, Maja Vulovic, Danijela Cvetkovic
Summary: This review aims to unravel the enigmatic aspects of mammaglobin and elucidate its potential role in redefining the paradigm of breast carcinoma biomarkers. The expression of mammaglobin in tumoral and peritumoral tissues and its circulating levels in the blood will be thoroughly examined, providing insights into its possible function in cancer progression and metastasis. Furthermore, the potential application of mammaglobin as a non-invasive diagnostic tool and a target for personalized treatment strategies will be discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Borge S. Petrovic, Sandra S. Jovicic Milic, Maja B. Dukic, Ivana D. Radojevic, Milena M. Jurisevic, Nevena M. Gajovic, Angela Petrovic, Nebojsa N. Arsenijevic, Ivan P. Jovanovic, Edina Avdovic, Danijela Lj. Stojkovic, Verica V. Jevtic
Summary: Four new ligands and their corresponding palladium(II) complexes were synthesized and characterized. The interaction between the complexes and human serum albumin (HSA) was studied using fluorescence spectroscopy. The most active and selective compound, ligand L4, showed potential for future in vivo testing and induced cell death mainly by apoptosis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Milica Dimitrijevic Stojanovic, Bojan Stojanovic, Ivan Radosavljevic, Vojin Kovacevic, Ivan Jovanovic, Bojana S. Stojanovic, Nikola Prodanovic, Vesna Stankovic, Miodrag Jocic, Marina Jovanovic
Summary: This review comprehensively examines the role of Galectin-3 in pancreatic ductal adenocarcinoma (PDAC), including its expression, interaction with immune cells, signaling pathways, effects on apoptosis, and therapeutic resistance. The prognostic significance of serum levels of Galectin-3 and its potential utilization as a biomarker are also discussed. Additionally, the review critically analyzes the inhibitors of Galectin-3 and their potential therapeutic applications in PDAC, offering new avenues for targeted treatments.
Article
Oncology
Andjela R. Petrovic, Ivan P. Jovanovic, Milena M. Jurisevic, Marina Z. Jovanovic, Marina M. Jovanovic, Sladjana P. Pavlovic, Nebojsa N. Arsenijevic, Gordana M. Supic, Danilo V. Vojvodic, Milan M. Jovanovic, Nevena M. Gajovic
Summary: The study found that metformin can directly enhance the activation and cytotoxicity of natural killer (NK) cells. This finding may contribute to dissecting key mechanisms of metformin exerting antitumor activity and advancing the use of metformin as an antitumor agent.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, General & Internal
Marina Jovanovic, Sofija Sekulic, Miodrag Jocic, Milena Jurisevic, Nevena Gajovic, Marina Jovanovic, Nebojsa Arsenijevic, Milan Jovanovic, Milan Mijailovic, Milos Milosavljevic, Ivan Jovanovic
Summary: This study aimed to determine the transcriptional activity and functional phenotype of T cells and the relationship between pro-and anti-inflammatory cytokines and clinical parameters of COVID-19 severity. The results showed a significant elevation of IL-12, IFN-gamma, IL-17, and IL-23 in stage IV of the disease, with a strong intercorrelation between these cytokines. CD4+ T cells displayed increased transcriptional activity and an increased percentage of IFN-gamma and IL-17 producing T cells.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Bojan Stojanovic, Nevena Gajovic, Milena Jurisevic, Milica Dimitrijevic Stojanovic, Marina Jovanovic, Ivan Jovanovic, Bojana S. Stojanovic, Bojan Milosevic
Summary: IL-33 plays a critical role in breast cancer biology, influencing cancer progression and immune response, and may serve as a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)