Article
Oncology
Lei Zhang, Yuqing Li, Lingli Zhou, Houhong Zhou, Liefu Ye, Tong Ou, Huaishan Hong, Shiwen Zheng, Ziyu Zhou, Kang Wu, Zeqin Yan, Jean Paul Thiery, Jun Cui, Song Wu
Summary: YTHDF2 is upregulated in bladder cancer and promotes tumor growth by inhibiting RIG-I-mediated immune signaling, highlighting the significance of m(6)A modifications in bladder cancer and providing therapeutic opportunities.
Article
Immunology
Takashi Ishikawa, Masashi Okai, Emi Mochizuki, Toru Uchiyama, Masafumi Onodera, Toshinao Kawai
Summary: Despite X-CGD patients developing severe infections at a younger age than AR-CGD patients, our data suggests that BCG infections occur at a high frequency in both AR-CGD and X-CGD patients, regardless of genotype and mutant forms.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Qiong Liao, Yangming Zheng, Yanchun Wang, Leping Ye, Xiaomei Liu, Weiwei Jiao, Yang Liu, Yu Zhu, Jihang Jia, Lin Sun, Adong Shen, Chaomin Wan
Summary: BCG vaccination in Chinese children can reduce the risk of severe tuberculosis. Children who received BCG vaccination at birth, regardless of the presence of a BCG scar, have a lower risk of severe tuberculosis.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biotechnology & Applied Microbiology
Jinmiao Lu, Xunjie Zhang, Hong Xu, Zhiping Li
Summary: The Bacillus Calmette-Guerin (BCG) vaccine is provided free of charge in China, and over 300 million newborns have been vaccinated. Rare adverse events have been reported, including pneumonia, lymphadenitis, and septicemia. The mortality rate is higher for preterm infants compared to full-term infants.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Maria A. Duarte C., Jeismar M. Carballo O., Yetsenia M. De Gouveia, Angie Garcia, Diana Ruiz, Teresa Gledhill, Eglys Gonzalez-Marcano, Ana F. Convit
Summary: ConvitVax is a personalized vaccine for breast cancer treatment, which has been shown to be safe and effective in preclinical studies on BALB/c mice.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Boli Ma, Xueyi Nie, Lei Liu, Mengyuan Li, Qi Chen, Yueyang Liu, Yuxin Hou, Yi Yang, Jinrui Xu
Summary: The inhibition of PERK alleviated pyroptosis induced by BCG infection, showing an effect of resistance against infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Arti Nanda, Humoud Al-Sabah, Anwar Al-Sumait, Nadia AlNaqi, Mohammad Al-Otaibi, Atlal AlLafi
Summary: A 3-year-old girl presented with a delayed nontuberculous granulomatous reaction on a bacillus Calmette-Guerin injection site, which showed dissemination to distant sites. A favorable response was observed after 12 weeks of treatment with clarithromycin, and there was no recurrence during a follow-up of over 2 years.
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2021)
Article
Immunology
Karin Dijkman, Thomas Lindenstrom, Ida Rosenkrands, Rikke Soe, Joshua S. S. Woodworth, Cecilia S. Lindestam S. Arlehamn, Rasmus Mortensen
Summary: The licensed TB vaccine, BCG, is inadequate in protecting adolescents and adults from pulmonary TB, leading to millions of deaths each year. Subunit vaccines have shown potential against TB, but their multiple administrations pose logistical challenges. Co-administration of BCG with a single dose of the expression-optimized H107e/CAF((R))01 vaccine improved protection and triggered BCG-specific immune responses. This supports the strategy of combining BCG with subunit vaccines for an improved TB vaccine with fewer vaccination visits.
Article
Public, Environmental & Occupational Health
Ola Nakken, Trygve Holmoy, Hein Stigum, Kjell-Morten Myhr, Jesper Dahl, Einar Heldal, Haakon E. Meyer
Summary: The study found that a strong in vivo immune response to BCG vaccine is associated with a reduced risk of developing MS more than 30 years later. The strength of TST reactivity is linked to decreased MS risk, suggesting a potential protective mechanism against the disease.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Susan Martins Pereira, Florisneide Rodrigues Barreto, Ramon Andrade de Souza, Carlos Antonio de Souza Teles Santos, Marcos Pereira, Enny Santos da Paixao, Carla Cristina Oliveira de Jesus Lima, Marcio Santos da Natividade, Ana Angelica Bulcao Portela Lindoso, Eder Gatti Fernandes, Evonio Barros Campelo Campelo Junior, Julia Moreira Pescarini, Kaio Vinicius Freitas de Andrade, Fernanda Mattos de Souza, Elisangela Alves de Britto, Ceuci Nunes, Maria Yuri Ichihara, Margareth Dalcolmo, Anete Trajman, Manoel Barral-Netto, Ibrahim Abubakar, Mauricio Lima Barreto, Ricardo Arraes de Alencar Ximenes, Laura Cunha Rodrigues
Summary: This study investigated the association between previous BCG vaccination and the severity of COVID-19 clinical progression. The results showed that BCG vaccination was highly protective against clinical progression of COVID-19, especially in individuals aged 60 or younger.
Article
Multidisciplinary Sciences
Christina Gillezeau, Naimisha Movva, Maaike van Gerwen, Karma Rabon-Stith, Norah Shire, Philip Zachary Brohawn, Emanuela Taioli, Jon Fryzek
Summary: The study suggests that the IFN-gamma signature status is associated with a decreased risk of mortality in patients with urinary bladder cancer, particularly in those with muscle-invasive bladder cancer. This may serve as a prognostic marker for survival assessment.
Letter
Dermatology
Aika Shionoya, Yuko Yoto, Tokimasa Hida, Aki Ishikawa, Tadashi Hasegawa, Takeshi Tsugawa, Hisashi Uhara
Summary: In this article, we present a case of lupus vulgaris caused by BCG vaccination in a patient with Mendelian susceptibility to mycobacterial disease (MSMD) due to a novel STAT1 gene variation. Dermatologists should consider MSMD as a possible diagnosis in patients who develop cutaneous tuberculosis after BCG vaccination. This helps to ensure proper vaccination in individuals with inborn errors of immunity.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Immunology
Wei Huang, Nan-Chang Chiu, Hsin Chi, Fu-Yuan Huang, Ching-Ying Huang
Summary: A study on BCG vaccine adverse reactions found that osteitis/osteomyelitis occurred less frequently when vaccination was done after 5 months of age, but injection site reactions and lymphadenitis were more common, with shorter onset durations of mild adverse reactions observed in older vaccinees above 5 months of age.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biotechnology & Applied Microbiology
Pati Aji Achdiat, Oki Suwarsa, Yudi Mulyana Hidayat, Mohamad Nasir Shafiee, Reiva Farah Dwiyana, Hendra Gunawan, Rasmia Rowawi, Reyshiani Johan
Summary: Anogenital warts (AGWs) are benign proliferations caused by Human Papillomavirus (HPV) infection on the genital or anal areas. Various therapeutic options are available for the treatment of AGWs but there is no best or ideal therapy, and the recurrence of AGWs is significantly high. A promising new therapy that is currently being evaluated is immunotherapy with the intralesional Bacillus Calmette-Guerin (BCG) vaccine.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Leontine van Balveren, Eugene P. van Puijenbroek, Linda Davidson, Florence van Hunsel
Summary: Reactivation of BCG scar is observed after COVID-19 vaccination with mRNA and viral vector vaccines, characterized by erythema and pain within a few days. The exact mechanism remains unknown, but heat shock protein 65 may be involved.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Respiratory System
Rebekka Faber Thudium, Andreas Ronit, Shoaib Afzal, Yunus Colak, Julie Lyng Forman, Fernando Mendo, Fabian Chen, Vicente Estrada, Nagalingeswaran Kumarasamy, Borge G. Nordestgaard, Jens Lundgren, Jorgen Vestbo, Ken M. Kunisaki, Susanne Dam Nielsen
Summary: This study compared the decline in lung function between people living with HIV who receive antiretroviral therapy and matched controls, and found that well-treated PLWH have faster lung function decline than controls. Smoking seems to modify this association, suggesting that smoking may lead to more rapid lung function decline in PLWH than in controls.
Article
Immunology
Marco Gelpi, Luanna Uchoa Karvig, Andreas Dehlbaek Knudsen, Edith Wolder Sorensen, Thomas Benfield, Shoaib Afzal, Susanne Dam Nielsen
Summary: Cardiovascular diseases are the leading cause of morbidity and mortality in people with HIV. This study found that body mass index and central obesity were associated with incident hypertension in well-treated HIV patients, suggesting the importance of lifestyle changes and weight loss in preventing hypertension, rather than focusing solely on HIV-specific factors.
Article
Infectious Diseases
Moises Alberto Suarez-Zdunek, Sunil Kumar Saini, Christian Ross Pedersen, Sebastian Rask Hamm, Annemette Hald, Allan Rasmussen, Jens Georg Hillingso, Sine Reker Hadrup, Susanne Dam Nielsen
Summary: This study aims to explore the cellular immune response against CMV and VZV infections in liver transplant recipients and identify potential risk factors for infection. Through an epidemiological substudy and an immunological substudy, the incidence and clinical risk factors for CMV and VZV infections will be determined, and the frequency, T cell receptor sequences, and phenotypic characteristics of CMV- and VZV-specific T cells will be examined. The study has the potential to develop a prediction model and proof-of-concept for adoptive T cell therapy against CMV and VZV to reduce the burden and consequence of infections in liver transplant recipients.
BMC INFECTIOUS DISEASES
(2023)
Article
Hematology
Line Dam Heftdal, Sebastian Rask Hamm, Laura Perez-Alos, Johannes Roth Madsen, Jose Juan Almagro Armenteros, Kamille Fogh, Christoffer Cronwald Kronborg, Anders Pommer Vallentin, Rasmus Bo Hasselbalch, Dina Leth Moller, Cecilie Bo Hansen, Mia Pries-Heje, Anne Ortved Gang, Sisse Rye Ostrowski, Ruth Frikke-Schmidt, Erik Sorensen, Linda Hilsted, Henning Bundgaard, Kasper Iversen, Peter Garred, Susanne Dam Nielsen, Kirsten Gronbaek
Summary: The initial responses to COVID-19 vaccination are impaired in patients with blood cancers. This study examined the immune responses of patients with myeloid and lymphoid malignancies who received three or four doses of the BNT162b2 vaccine, compared to controls. Risk factors for humoral and cellular nonresponse one year after vaccination were also identified.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Anesthesiology
Pernille D. K. Diasso, Dalia Abou-Kassem, Susanne D. Nielsen, Katharina M. Main, Per Sjogren, Geana P. Kurita
Summary: Long-term opioid treatment (L-TOT) for chronic non-cancer pain (CNCP) may result in endocrine dysfunction, including changes in testosterone, growth hormone, and prolactin levels. This study found that compared to CNCP patients not receiving opioids, those on L-TOT had lower testosterone and growth hormone levels, as well as higher prolactin levels. Additionally, a correlation was observed between high opioid dose and low growth hormone levels.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Biology
Flora Mikaeloff, Marco Gelpi, Rui Benfeitas, Andreas D. Knudsen, Beate Vestad, Julie Hogh, Johannes R. Hov, Thomas Benfield, Daniel Murray, Christian G. Giske, Adil Mardinoglu, Marius Troseid, Susanne D. Nielsen, Ujjwal Neogi, Niel Hens
Summary: Multiomics technologies were used to stratify and characterize the metabolic risk profile in people living with HIV (PWH) on antiretroviral therapy. Through network analysis and similarity network fusion (SNF), three groups of PWH were identified: healthy-like, mild at-risk, and severe at-risk. PWH in the severe at-risk group had a high incidence of metabolic syndrome and dysregulated metabolic traits, despite having higher CD4(+) T-cell counts. The microbiome profile differed between the healthy-like group and the at-risk groups, potentially contributing to systemic inflammation and cardiometabolic risk.
Article
Immunology
Andreas D. Knudsen, Andreas Fuchs, Thomas Benfield, Jan Gerstoft, Lars Kober, Marius Troseid, Klaus F. Kofoed, Susanne D. Nielsen
Summary: Almost half of virologically suppressed persons with human immunodeficiency virus had atherosclerosis, and 18% had obstructive coronary artery disease. Interleukin 6 was associated with coronary artery disease but adjusting for cardiovascular risk factors attenuated the association.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Selina Kikkenborg Berg, Helle Wallach-Kildemoes, Line Ryberg Rasmussen, Ulrikka Nygaard, Nina Marie Birk, Henning Bundgaard, Annette Kjaer Ersboll, Lau Caspar Thygesen, Susanne Dam Nielsen, Anne Vinggaard Christensen
Summary: This study investigated the changes in symptom-specific hospital contacts among 12-18-year-olds following two doses of BNT162b2 COVID-19 vaccine compared to unvaccinated peers. National register data was used to match vaccinated and unvaccinated adolescents based on sex and age. Differences between the vaccinated and unvaccinated were found in symptom-specific hospital contacts, with higher rates observed for some symptoms among the vaccinated and higher rates for others among the unvaccinated. Monitoring of specific symptoms is important post-vaccination, considering the risk of infection and symptoms following COVID-19 infection.
Article
Immunology
Mads-Holger B. Jacobsen, Andreas D. Knudsen, Thomas Benfield, Sisse R. Ostrowski, Shoaib Afzal, Edith W. Sorensen, Susanne D. Nielsen, Marco Gelpi
Summary: This study investigated the association between soluble CD40 ligand, soluble thrombomodulin, and syndecan-1 with metabolic syndrome in people with HIV, and their association with HIV-specific variables. The results indicated that high levels of soluble CD40 ligand were associated with an increased risk of metabolic syndrome.
Article
Infectious Diseases
Sebastian Rask Hamm, Sunil Kumar Saini, Annemette Hald, Anna V. Vaaben, Natasja Wulff Pedersen, Moises Alberto Suarez-Zdunek, Zitta Barrella Harboe, Helle Bruunsgaard, Isik Somuncu Johansen, Carsten Schade Larsen, Claus Bistrup, Henrik Birn, Soren Schwartz Sorensen, Sine Reker Hadrup, Susanne Dam Nielsen
Summary: This study aims to characterize the immune response to RZV vaccination in kidney transplant candidates and recipients. The study will provide new knowledge and potentially enhance preventive strategies against herpes zoster in a population at increased risk.
BMC INFECTIOUS DISEASES
(2023)
Article
Immunology
Zitta Barrella Harboe, Annemette Hald, Christina Ekenberg, Neval Ete Wareham, Lene Fogt Lundbo, Jon Gitz Holler, Tavs Qvist, Sebastian Rask Hamm, Stephanie Bjerrum, Omid Rezahosseini, Paul Suno Krohn, Finn Gustafsson, Michael Perch, Allan Rasmussen, Susanne Dam Nielsen
Summary: This study describes the experience of implementing a vaccination clinic targeting different organ transplantation in a transplantation center in Denmark. The study found a low proportion of documented recommended vaccinations before transplantation, with higher serological protection against measles, mumps, or rubella. Most candidates required multiple vaccinations, including some needing live attenuated vaccines.
Article
Multidisciplinary Sciences
Laura Perez-Alos, Cecilie Bo Hansen, Jose Juan Almagro Armenteros, Johannes Roth Madsen, Line Dam Heftdal, Rasmus Bo Hasselbalch, Mia Marie Pries-Heje, Rafael Bayarri-Olmos, Ida Jarlhelt, Sebastian Rask Hamm, Dina Leth Moller, Erik Sorensen, Sisse Rye Ostrowski, Ruth Frikke-Schmidt, Linda Maria Hilsted, Henning Bundgaard, Susanne Dam Nielsen, Kasper Karmark Iversen, Peter Garred
Summary: The complexity of immune responses to SARS-CoV-2 has increased over time, with diverse immune imprinting observed in vaccinated individuals. Our study found that both humoral and cellular responses were generally higher after SARS-CoV-2 infection compared to infection-naive individuals. Pre-vaccination viral exposure was crucial for achieving a robust IgA response. Lower IgG, IgA, and neutralizing antibody responses post-vaccination were associated with a significantly higher risk of reinfection and future Omicron infections. However, T-cell responses did not show the same association. Primary infection before Omicron and subsequent reinfection dampened the humoral and cellular responses compared to a primary Omicron infection, consistent with immune imprinting.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Line Dam Heftdal, Laura Perez-Alos, Rasmus Bo Hasselbalch, Cecilie Bo Hansen, Sebastian Rask Hamm, Dina Leth Moller, Mia Pries-Heje, Kamille Fogh, Jan Gerstoft, Kirsten Gronbaek, Sisse Rye Ostrowski, Ruth Frikke-Schmidt, Erik Sorensen, Linda Hilsted, Henning Bundgaard, Peter Garred, Kasper Iversen, Caroline Sabin, Susanne Dam Nielsen
Summary: This study investigated the long-term durability of humoral and cellular immune responses to the third dose of BNT162b2 in people with HIV and controls. The results showed that before the third dose, HIV patients had lower concentrations of SARS-CoV-2 antibodies compared to controls, but there were no differences in antibody concentrations between the two groups after four and eleven months of the third dose. Additionally, there were no differences in cellular immune response between the two groups four months after the third dose.
Article
Immunology
Omid Rezahosseini, Sebastian Rask Hamm, Line Dam Heftdal, Laura Perez-Alos, Dina Leth Moller, Michael Perch, Johannes Roth Madsen, Annemette Hald, Cecilie Bo Hansen, Jose Juan Almagro Armenteros, Mia Marie Pries-Heje, Rasmus Bo Hasselbalch, Kamille Fogh, Ruth Frikke-Schmidt, Linda Maria Hilsted, Erik Sorensen, Sisse Rye Ostrowski, Zitta Barrella Harboe, Kasper Iversen, Henning Bundgaard, Soren Schwartz Sorensen, Allan Rasmussen, Peter Garred, Susanne Dam Nielsen
Summary: We found that within 12 months after receiving at least three doses of the BNT162b2 vaccine, solid organ transplant (SOT) recipients had lower humoral and T-cell responses compared to controls, especially those without previous SARS-CoV-2 infection. However, SOT recipients with previous infection had comparable immune responses to controls.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Ida Jarlhelt, Laura Perez-Alos, Rafael Bayarri-Olmos, Cecilie Bo Hansen, Maria Skaalum Petersen, Pal Weihe, Jose Juan Almagro Armenteros, Johannes Roth Madsen, Jacob Pohl Stangerup Nielsen, Linda Maria Hilsted, Kasper Karmark Iversen, Henning Bundgaard, Susanne Dam Nielsen, Peter Garred
Summary: The prediction of durability of immunity against COVID-19 is crucial, and longitudinal studies are necessary for understanding the details of protective SARS-CoV-2 antibody responses. The study developed an ELISA test based on the N protein to distinguish between infection- and vaccine-induced immune responses.
MICROBIOLOGY SPECTRUM
(2023)
