期刊
PEDIATRIC PULMONOLOGY
卷 52, 期 -, 页码 S29-S36出版社
WILEY
DOI: 10.1002/ppul.23825
关键词
cystic fibrosis; mycobacteria; Mycobacterium abscessus; Mycobacterium avium; nontuberculous; transmission
资金
- National Institute of Allergy and Infectious Diseases [1K01AI125726-02]
- Cystic Fibrosis Foundation [NICK13A0, NICK15A0]
Nontuberculous mycobacteria (NTM) are troublesome pathogens that can cause significant pulmonary disease in patients with cystic fibrosis (CF). Diagnosis can be difficult in the setting of underlying CF and treatment regimens are burdensome on both patients and providers. Recent consensus guidelines for treatment of NTM in CF have provided a guide for the CF community, however research is lagging regarding accuracy of our diagnostic abilities and treatment efficacy. In this review, we provide new insights into the complexity of NTM from emerging whole genome sequencing data, a summary of current NTM diagnosis and treatment guidelines, highlight new treatment options, and discuss future research projects which aim to better define which patients to treat and timing and duration of treatment.
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