Pathophysiological characteristics of preproinsulin-specific CD8+ T cells in subjects with juvenile-onset and adult-onset type 1 diabetes: A 1-year follow-up study

Peripheral Proinsulin Expression Controls Low-Avidity Proinsulin-Reactive CD8 T Cells in Type 1 Diabetes

(2016) Terri C. Thayer et al.   DIABETES

Detection, phenotyping, and quantification of antigen-specific T cells using a peptide-MHC dodecamer

(2016) Jun Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preproinsulin specific CD8+ T cells in subjects with latent autoimmune diabetes show lower frequency and different pathophysiological characteristics than those with type 1 diabetes

(2015) Naresh Sachdeva et al.   CLINICAL IMMUNOLOGY

Targeting Memory T Cells in Type 1 Diabetes

(2015) Mario R. Ehlers et al.   Current Diabetes Reports

Heterogeneity in recent-onset type 1 diabetes - a clinical trial perspective

(2015) Jennifer B. Bollyky et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Effects of High-Dose Oral Insulin on Immune Responses in Children at High Risk for Type 1 Diabetes

(2015) Ezio Bonifacio et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Differences in B7 and CD28 family gene expression in the peripheral blood between newly diagnosed young-onset and adult-onset type 1 diabetes patients

(2015) K. Pruul et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Population dynamics of islet-infiltrating cells in autoimmune diabetes

(2015) Angela M. Magnuson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

(2014) G. Dolton et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+T Cells Infiltrate Islets in Type 1 Diabetes

(2014) Vimukthi Pathiraja et al.   DIABETES

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

(2014) Ania Skowera et al.   DIABETES

Prevalence of Detectable C-Peptide According to Age at Diagnosis and Duration of Type 1 Diabetes

(2014) Asa K. Davis et al.   DIABETES CARE

Biomarkers for immune intervention trials in type 1 diabetes

(2013) Roberto Mallone et al.   CLINICAL IMMUNOLOGY

T-lymphocyte recognition of beta cells in type 1 diabetes: Clinical perspectives

(2013) C. Boitard   DIABETES & METABOLISM

Targeting proinsulin-reactive CD8+ T cells: a new direction for Type 1 diabetes treatment

(2013) Joana RF Abreu et al.   Expert Review of Clinical Immunology

Tolerogenic Vaccination Reduced Effector Memory CD4 T Cells and Induced Effector Memory Treg Cells for Type I Diabetes Treatment

(2013) Jingyao Zhang et al.   PLoS One

Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes

(2013) B. O. Roep et al.   Science Translational Medicine

Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial

(2013) Mark R Rigby et al.   Lancet Diabetes & Endocrinology

Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity

(2012) Robin R. Knight et al.   DIABETES

Circulating Preproinsulin Signal Peptide-Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill  -Cells

(2012) D. Kronenberg et al.   DIABETES

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes

(2012) Anna M Bulek et al.   NATURE IMMUNOLOGY

Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice

(2012) Wendy W. J. Unger et al.   PLoS One

Single Insulin-Specific CD8+ T Cells Show Characteristic Gene Expression Profiles in Human Type 1 Diabetes

(2011) S. Luce et al.   DIABETES

Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell-Associated Epitopes Using Combinatorial MHC Multimers

(2010) J. H. Velthuis et al.   DIABETES

Monitoring of antigen-specific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies

(2009) Simona Cernea et al.   CLINICAL IMMUNOLOGY

Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy

(2009) Tihamer Orban et al.   JOURNAL OF AUTOIMMUNITY

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Recognition of Human Proinsulin Leader Sequence by Class I-Restricted T-Cells in HLA-A*0201 Transgenic Mice and in Human Type 1 Diabetes

(2008) A. Toma et al.   DIABETES

The Frequency and Immunodominance of Islet-Specific CD8+ T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment

(2008) E. Martinuzzi et al.   DIABETES

The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression

(2008) P. K. Chattopadhyay et al.   JOURNAL OF LEUKOCYTE BIOLOGY