Article
Surgery
Molly Kobritz, Colleen Nofi, Maria Sfakianos, Gene Coppa, Monowar Aziz, Ping Wang
Summary: H151 has the potential to therapeutically reduce acute intestinal injury in sepsis.
Editorial Material
Microbiology
Nuria Balanza, Elisa Lopez-Varela, Barbara Baro, Quique Bassat
Summary: This study investigated intestinal barrier dysfunction and injury in Ugandan children hospitalized with severe malaria and found that it is associated with increased mortality, acute kidney injury, acidosis, and endothelial activation. These findings have important implications for improving outcomes in children with malaria.
Review
Chemistry, Medicinal
Yi-Feng Wang, Jia-Wei Li, Da-Peng Wang, Ke Jin, Jiao-Jie Hui, Hong-Yang Xu
Summary: Intestinal barrier injury and hyperglycemia are common in patients with sepsis. Hyperglycemia is an independent risk factor for intestinal barrier injury. Some anti-hyperglycemic agents can improve intestinal barrier function and are beneficial in managing sepsis-induced organ dysfunction.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Pediatrics
Colleen M. Badke, Anoop Mayampurath, L. Nelson Sanchez-Pinto
Summary: This study aimed to determine whether certain combinations of organ system dysfunctions are associated with a higher risk of morbidity or mortality in critically ill children. The results showed that interactions between cardiovascular and endocrinologic, cardiovascular and neurologic, and cardiovascular and respiratory dysfunctions were significantly associated with the highest number of deaths.
FRONTIERS IN PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Masashi Mukohda, Takanori Yano, Toshiyasu Matsui, Sho Nakamura, Jiro Miyamae, Kensuke Toyama, Ryoji Mitsui, Risuke Mizuno, Hiroshi Ozaki
Summary: This study found that hypertension in rats is associated with an imbalance in gut microbiota and increased intestinal permeability. The administration of Ligilactobacillus murinus improved blood pressure and endothelium-dependent vasodilation, while also reversing the intestinal morphological changes and tight junction protein expression caused by increased intestinal permeability.
SCIENTIFIC REPORTS
(2023)
Article
Pediatrics
Sanjukta N. Bose, Joseph L. Greenstein, James C. Fackler, Sridevi V. Sarma, Raimond L. Winslow, Melania M. Bembea
Summary: The study aims to build early prediction models for pediatric PICU patients at risk of developing MOD. Using machine learning methods, the models achieved high accuracy in predicting MOD onset with over 22 hours of lead time. Spectral clustering on risk-score trajectories identified a high-risk group with a high positive predictive value.
FRONTIERS IN PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Mara L. Leimanis-Laurens, Karen Ferguson, Emily Wolfrum, Brian Boville, Dominic Sanfilippo, Todd A. Lydic, Jeremy W. Prokop, Surender Rajasekaran
Summary: This study investigated the plasma lipidome in critically ill children, finding stratification in lipid profiles between patients with multi-organ dysfunction syndrome (MODS) and those requiring veno-arterial extracorporeal membrane oxygenation (ECMO) support. Nutrition intake did not correlate with changes in lipid profiles. Lipid measurement in the intensive care environment showed dynamic changes over an 8-day pediatric intensive care unit (PICU) course, suggesting potential new metabolic indicators for defining critically ill children.
Review
Biochemistry & Molecular Biology
Junghyun Park, Tae Joon Choi, Ki Sung Kang, Seo-Hyung Choi
Summary: This review explores the interrelationships between increased GI permeability and phlegm syndromes, discussing their similarities in symptoms, diseases, and herbal treatments. Both syndromes are related to inflammation and gut microbiota compositions, suggesting the need for further well-designed research in evidence-based integrative medicine.
Article
Critical Care Medicine
Christina Cheung, Kate F. Kernan, Robert A. Berg, Athena F. Zuppa, Daniel A. Notterman, Murray M. Pollack, David Wessel, Kathleen L. Meert, Mark W. Hall, Christopher Newth, John C. Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick E. Harrison, Russell K. Banks, Ron W. Reeder, Richard Holubkov, Joseph A. Carcillo, Ericka L. Fink
Summary: This study found that approximately one out of five children with severe sepsis and organ failure experienced acute disorders of consciousness (DoC) during their PICU stay. Older age and presence of any multiple organ failure (MOF) were associated with DoC.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Review
Virology
Wenbin Zhao, Hanmeng Li, Jianghua Li, Bin Xu, Jian Xu
Summary: COVID-19 is a respiratory disease caused by SARS-CoV-2. It not only affects the respiratory system but also leads to systemic symptoms and multiple organ dysfunction syndromes (MODS). The entry of SARS-CoV-2 into cells is mediated by the human angiotensin-converting enzyme 2 protein, which plays a role in maintaining fluid and electrolyte balance and the stability of the internal environment.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Medicine, Research & Experimental
Hiong-Ping Hii, Whai-Zer Lo, Yung-Hui Fu, Ming-Hua Chen, Chia -Ching Shih, Cheng-Ming Tsao, Shuk-Man Ka, Yi-Lin Chiu, Chin-Chen Wu, Chih-Chin Shih
Summary: This study suggests that misoprostol can alleviate intestinal and organ damage caused by heat stroke, making it a potential treatment for heat-related illnesses.
Article
Multidisciplinary Sciences
K. E. Huus, T. T. Hoang, A. Creus-Cuadros, M. Cirstea, S. L. Vogt, K. Knuff-Janzen, P. J. Sansonetti, P. Vonaesch, B. B. Finlay
Summary: Child undernutrition is a global health issue that is associated with an overabundance of intestinal pathogens. This study shows that disease-inducing human isolates of Enterobacteriaceae and Bacteroidales are capable of multi-species symbiotic cross-feeding, leading to synergistic growth of a mixed community. This diet-specific bacterial crossfeeding contributes to the overgrowth of intestinal pathogens during child malnutrition, exacerbating growth stunting.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Mariusz Sikora, Albert Stec, Magdalena Chrabaszcz, Joanna Giebultowicz, Emilia Samborowska, Radoslaw Jazwiec, Michal Dadlez, Malgorzata Olszewska, Lidia Rudnicka
Summary: The study showed an association between altered gut barrier in psoriasis patients and gastrointestinal symptoms, systemic inflammatory profile, and increased blood concentration of gut microbiota-derived metabolite TMAO. Modulation of intestinal barrier represents a potential therapeutic approach.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Health Care Sciences & Services
Mara Leimanis-Laurens, Emily Wolfrum, Karen Ferguson, Jocelyn R. Grunwell, Dominic Sanfilippo, Jeremy W. Prokop, Todd A. Lydic, Surender Rajasekaran
Summary: The study found that a ceramide metabolite Hex-Cer was elevated in critically ill patients, potentially associated with viral infection, while the lipid species GPC(36:01) was increased in all MODS patients, indicating a relationship with inflammation and brain injury.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Jeffrey D. Salomon, Haowen Qiu, Dan Feng, Jacob Owens, Ludmila Khailova, Suzanne Osorio Lujan, John Iguidbashian, Yashpal S. Chhonker, Daryl J. Murry, Jean -Jack Riethoven, Merry L. Lindsey, Amar B. Singh, Jesse A. Davidson
Summary: The intestinal microbiome plays a crucial role in human health and disease. Cardiac surgery with cardiopulmonary bypass (CPB) can lead to systemic inflammation, but limited research exists on how it affects the microbiome. In this study, a piglet model of CPB was used to replicate the changes in the human intestinal microbiome. Significant alterations were found in the microbiome, intestinal barrier function, metabolites, and cytokines, indicating the potential for gut interventions to reduce inflammation after CPB.
DISEASE MODELS & MECHANISMS
(2022)