Article
Psychiatry
C. Jameson, K. A. Boulton, N. Silove, A. J. Guastella
Summary: Growing evidence suggests that genetic, neurological, and environmental factors contribute to the development of autism spectrum disorder (ASD). Interestingly, children with ASD often have skin disorders, possibly due to the shared embryonic origin of skin and neural tissue. This study found that atopic disorders, especially comorbid eczema, are associated with increased ASD symptom severity in children.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Allergy
Laura Maintz, Thomas Welchowski, Nadine Herrmann, Juliette Brauer, Claudia Traidl-Hoffmann, Regina Havenith, Svenja Mueller, Claudio Rhyner, Anita Dreher, Matthias Schmid, Thomas Bieber
Summary: This study found that many patients with mild-to-moderate atopic dermatitis have elevated levels of biomarkers, suggesting a systemic impact of skin inflammation. Identifying different patient subtypes can better predict their response to specific treatments.
Review
Biochemistry & Molecular Biology
Caterina Anania, Giulia Brindisi, Ivana Martinelli, Edoardo Bonucci, Miriam D'Orsi, Sara Ialongo, Anna Nyffenegger, Tonia Raso, Mattia Spatuzzo, Giovanna De Castro, Anna Maria Zicari, Carlo Carraro, Maria Grazia Piccioni, Francesca Olivero
Summary: Atopic dermatitis is a chronic inflammatory skin disorder with increasing prevalence in children and adults. The potential role of probiotics in preventing atopic dermatitis has generated considerable interest, as they can modulate systemic inflammation and immune responses. However, the molecular mechanisms and efficacy of probiotics in anti-allergic effects are still unclear and controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Takashi Hashimoto, Hiroo Yokozeki, Hajime Karasuyama, Takahiro Satoh
Summary: This study found that macrophages are the main source of IL-31 in atopic dermatitis (AD) skin lesions. It demonstrated the association of macrophages, TSLP, and periostin with AD itch, and the attenuation of itch symptoms with macrophage depletion. The study suggests that a network comprising IL-31-expressing macrophages, TSLP, periostin, and basophils plays a significant role in AD itch.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yung-Sen Chang, Chih-Chen Tsai, Pang-Yan Yang, Chih-Yu Tang, Bor-Luen Chiang
Summary: Oral melatonin supplement has been shown to improve dermatitis severity in children with AD. This study investigated the mechanism and immunomodulatory effect of topical melatonin treatment in mice and cell models of AD. The results suggest that melatonin may have a direct immunomodulatory effect on AD and could be a potential treatment for patients with AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Haengdueng Jeong, Nakyum Lee, Chanyang Uhm, Kyungrae Cho, Heeju Oh, Yeseul Oh, KeLun Zhang, Hye Li Kim, James R. Goldenring, Kyung-Min Lim, Chang Ook Park, Ki Taek Nam
Summary: Rab-25 plays an important role in maintaining skin barrier function and keratinization in atopic dermatitis (AD).
Article
Dermatology
Trine Gerner, Maria Rasmussen Rinnov, Anne-Sofie Halling, Nina Haarup Ravn, Mette Hjorslev Knudgaard, Caroline Ewertsen, Simon Trautner, Ivone Jakasa, Sanja Kezic, Lone Skov, Jacob P. Thyssen
Summary: This prospective birth cohort study found that term newborns are more susceptible to infantile atopic dermatitis compared to preterm newborns, with an earlier age of onset and more severe symptoms. The environmental risk factors for atopic dermatitis were generally similar between preterm and term newborns, except for winter and autumn births. Filaggrin gene mutations were less prevalent in preterm newborns than term newborns.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Allergy
Angeline S. L. Tay, Chenhao Li, Tannistha Nandi, Kern Rei Chng, Anand Kumar Andiappan, Vijaya Saradhi Mettu, Camille de Cevins, Aarthi Ravikrishnan, Charles-Antoine Dutertre, X. F. Colin C. Wong, Amanda Hui Qi Ng, Sri Anusha Matta, Florent Ginhoux, Olaf Rotzschke, Fook Tim Chew, Mark B. Y. Tang, Yik Weng Yew, Niranjan Nagarajan, John E. A. Common
Summary: Different microbial profiles on AD skin were identified, with dermotype B showing reduced microbial richness, depletion of certain species, individual-specific outlier abundance of Staphylococcus species, and enrichment in metabolic pathways and virulence genes. These microbial configurations were associated with more severe itching, frequent flares, and increased disease severity in patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Jocelyn M. Biagini, John W. Kroner, Asel Baatyrbek Kyzy, Alexandra Gonzales, Hua He, Mariana Stevens, Brittany Grashel, Daniel Spagna, Samuel Paul, Rahul Patel, Angelo Bucci, Michael G. Sherenian, Liza Bronner Murrison, Lisa J. Martin, Gurjit K. Khurana Hershey
Summary: This study investigates the atopic march in Black and White children and identifies distinct allergic trajectories in these populations. It reveals that Black children have a higher risk of asthma despite a more intact skin barrier and less sensitization, food allergy, and allergic rhinitis. Conversely, White children have a lower risk of asthma despite a more dysfunctional skin barrier and higher rates of sensitization, food allergy, and allergic rhinitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Moriom Khatun, Abu Eabrahim Siddique, Abdus Wahed, Nazmul Haque, Selim Reza Tony, Jahidul Islam, Shahnur Alam, Md. Khalequzzaman Sarker, Isabela Kabir, Shakhawoat Hossain, Daigo Sumi, Zahangir Alam Saud, Aaron Barchowsky, Seiichiro Himeno, Khaled Hossain
Summary: This study found that excessive intake of arsenic can lead to skin lesions, particularly hyperkeratosis, which may be precancerous. Periostin, a matricellular protein, plays an important role in the development of these lesions through its presence and increased levels.
Article
Allergy
Loreen Thuermann, Gunda Herberth, Bettina Seiwert, Linda Schlittenbauer, Ulrike Rolle-Kampczyk, Stefan Roeder, Ulrich Sack, Michael Borte, Martin von Bergen, Saskia Trump, Thorsten Reemtsma, Irina Lehmann
Summary: The study found that prenatal exposure to ethylparaben and n-butylparaben can increase the risk of children developing persistent atopic dermatitis at a very early age, especially in children without a maternal history of atopic dermatitis.
Review
Dermatology
Maddalena Napolitano, Gabriella Fabbrocini, Fabrizio Martora, Lucia Genco, Matteo Noto, Cataldo Patruno
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin condition that causes itching and has a significant psychosocial impact on patients and their relatives. It presents with various clinical phenotypes, with varying severity and course. Diagnosis relies on experienced dermatologists, and misdiagnosis and delayed treatment can have negative effects on the patient's health.
DERMATOLOGIC THERAPY
(2022)
Article
Medicine, General & Internal
Murat Cansever, Cigdem Oruc
Summary: The study identified early disease onset, food sensitivity, rural residence, familial atopy history, and passive smoking exposure as factors contributing to severe AD. Eosinophil count showed a significant correlation with SCORAD scores, suggesting its potential use as a marker for assessing AD severity in children.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Xiang Lu, Hao Wang, Jingqi Zhang, Kexin Jin, Ling Ma, Yan Wang, Shixing Yang, Xiaochun Wang, Quan Shen, Tianji Zhou, Hui Xu, Wen Zhang
Summary: The imbalance of gut microbiota affects the immune development and regulation of individuals, leading to immune dysregulation and the development of atopic dermatitis (AD). This study assessed the composition of the virome in the gut of AD patients and healthy controls, revealing differences in diversity between the two groups. Finds provide a new perspective for understanding the effect of the gut microecological environment on AD.
FRONTIERS IN MEDICINE
(2022)
Article
Allergy
Anna B. Fishbein, Brian T. Cheng, Caroline C. Tilley, Wendy Smith Begolka, Adam C. Carle, Christopher B. Forrest, Phillis C. Zee, Amy S. Paller, James W. Griffith
Summary: The study estimated a prevalence rate of 66.9% for sleep disturbance in children aged 5 to 17 with AD, with the highest odds of severe sleep disturbance in moderate to severe AD. It was found that itch intensity and low income were predictors of parent proxy-reported sleep disturbance. Sleep disturbance was associated with neuropsychiatric impairment, including depression, anxiety, and inattention, in children with AD.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Ju Hee Kim, Eun Kyo Ha, Seung Won Lee, Hye Ryeong Cha, Hey-Sung Baek, Man Yong Han
Summary: This study found that low birth weight, high BMI during childhood, and the interaction between BMI during childhood and weight change during infancy are associated with an increased risk of childhood asthma.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Nutrition & Dietetics
Eun Kyo Ha, Ju Hee Kim, Hey-Sung Baek, Eun Lee, Ji Hyeon Baek, Somin Shim, Young Hyeon Kim, Luis A. Moreno, Seung Won Lee, Man Yong Han
Summary: This longitudinal cohort study found an association between early introduction of complementary foods (before 4 months) and increased BMI in children aged 5-7 years.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2023)
Letter
Allergy
Rosie Kwon, Youn Ho Shin, Jae Il Shin, So Min Kang, Jimin Hwang, Jung U. Shin, Hyungrye Noh, Chan Yeong Heo, Ai Koyanagi, Louis Jacob, Lee Smith, Jonas F. Ludvigsson, Stephen Turner, Ju-Young Shin, Han Eol Jeong, Jung-Hyun Kim, Sang Youl Rhee, Chanyang Min, Dong In Suh, Min Ji Koo, Katrina Abuabara, Sunyeup Kim, Seung Won Lee, Dong Keon Yon, Seong Ho Cho
Article
Medicine, General & Internal
Joo Young Song, Hye Ryeong Cha, Seung Won Lee, Eun Kyo Ha, Ju Hee Kim, Man Yong Han
Summary: This study found that the use of general anesthesia and endotracheal intubation in children may increase their risk of developing attention deficit hyperactivity disorder (ADHD) and have negative effects on neurodevelopment.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Virology
Seung Hyun Park, Sung Hwi Hong, Kwanghyun Kim, Seung Won Lee, Dong Keon Yon, Sun Jae Jung, Ziad Abdeen, Ramy Abou Ghayda, Mohamed Lemine Cheikh Brahim Ahmed, Abdulwahed Al Serouri, Waleed Al-Herz, Humaid O. Al-Shamsi, Sheeza Ali, Kosar Ali, Oidov Baatarkhuu, Henning Bay Nielsen, Enrico Bernini-Carri, Anastasiia Bondarenko, Ayun Cassell, Akway Cham, Melvin L. K. Chua, Sufia Dadabhai, Tchin Darre, Hayk Davtyan, Elena Dragioti, Barbora East, Robert Jeffrey Edwards, Martina Ferioli, Tsvetoslav Georgiev, Lilian A. Ghandour, Harapan Harapan, Po-Ren Hsueh, Saad I. Mallah, Aamer Ikram, Shigeru Inoue, Louis Jacob, Slobodan M. Jankovic, Umesh Jayarajah, Milos Jesenak, Pramath Kakodkar, Nathan Kapata, Yohannes Kebede, Yousef Khader, Meron Kifle, David Koh, Visnja Kokic Males, Katarzyna Kotfis, Ai Koyanagi, James-Paul Kretchy, Sulaiman Lakoh, Jinhee Lee, Jun Young Lee, Maria da Luz Lima Mendonca, Lowell Ling, Jorge Llibre-Guerra, Masaki Machida, Richard Makurumidze, Ziad A. Memish, Ivan Mendoza, Sergey Moiseev, Thomas Nadasdy, Chen Nahshon, Silvio A. Namendys-Silva, Blaise Nguendo Yongsi, Amalea Dulcene Nicolasora, Zhamilya Nugmanova, Hans Oh, Atte Oksanen, Oluwatomi Owopetu, Zeynep Ozge Ozguler, Konstantinos Parperis, Gonzalo Emanuel Perez, Krit Pongpirul, Marius Rademaker, Nemanja Radojevic, Anna Roca, Alfonso J. Rodriguez-Morales, Enver Roshi, Khwaja Mir Islam Saeed, Ranjit Sah, Boris Sakakushev, Dina E. Sallam, Brijesh Sathian, Patrick Schober, P. Shaik Syed Ali, Zoran Simonovic, Tanu Singhal, Natia Skhvitaridze, Marco Solmi, Kannan Subbaram, Kalthoum Tizaoui, John Thato Tlhakanelo, Julio Torales, Junior Smith Torres-Roman, Dimitrios Tsartsalis, Jadamba Tsolmon, Duarte Nuno Vieira, Sandro G. Viveiros Rosa, Guy Wanghi, Uwe Wollina, Ren-He Xu, Lin Yang, Kashif Zia, Muharem Zildzic, Jae Il Shin, Lee Smith
Summary: The novel coronavirus, SARS-CoV-2, has caused the highly contagious COVID-19 disease which has severely impacted developed and low- to middle-income countries. Nonpharmaceutical interventions (NPIs) such as social distancing, quarantine, and personal hygiene measures have been widely employed. A survey of 92 countries/territories found that quarantine and isolation at designated places were associated with lower incidence and mortality rates, while the use of sanitizer for personal hygiene reduced incidence. Mask deprivation was common regardless of economic level, and higher incidence and mortality were observed in countries/territories with higher economic levels.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Mathematics
S. M. A. Sharif, Rizwan Ali Naqvi, Zahid Mehmood, Jamil Hussain, Ahsan Ali, Seung-Won Lee
Summary: This study proposes an end-to-end scale-recurrent deep network for learning deblurring from multi-modal medical images. The proposed network includes a novel residual dense block and a module with spatial-asymmetric attention to recover salient information while learning medical image deblurring. Experimental results demonstrate that the proposed method can remove blur from medical images without visually disturbing artifacts and outperforms existing deep deblurring methods. The applicability of the proposed method has been verified by incorporating it into various medical image analysis tasks.
Article
Gastroenterology & Hepatology
Sungchul Choi, Beom Kyung Kim, Dong Keon Yon, Seung Won Lee, Han Gyeol Lee, Ho Hyeok Chang, Seoyeon Park, Ai Koyanagi, Louis Jacob, Elena Dragioti, Joaquim Radua, Jae Il Shin, Seung Up Kim, Lee Smith
Summary: This study analyzed the temporal trends of liver cancer aetiologies and sociodemographic status in 204 countries and territories from 1990 to 2019. The study found that the crude numbers of liver cancer DALYs and deaths increased over the study period, but the age-standardized rates decreased. HBV remains the leading cause of liver cancer, followed by HCV, alcohol consumption, and NASH/NAFLD. The East Asia region had the highest age-standardized rates, while Central Asia showed an increase.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Review
Integrative & Complementary Medicine
Masoud Rahmati, Mahdieh Molanouri Shamsi, Wongi Woo, Ai Koyanagi, Seung Won Lee, Dong Keon Yon, Jae Il Shin, Lee Smith
Summary: This systematic review examines the outcomes of physical rehabilitation interventions in COVID-19 patients following discharge from the hospital. The results indicate that early physical rehabilitation interventions can improve functional capacity, pulmonary function, quality of life, and mental health status.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Multidisciplinary Sciences
Soo-Young Yoon, Hye Won Park, Hyeon Jin Kim, Andreas Kronbichler, Ai Koyanagi, Lee Smith, Jae Il Shin, Sang Youl Rhee, Seung Won Lee, Jin Sug Kim, Hyeon Seok Hwang, Dong Keon Yon, Kyunghwan Jeong
Summary: The prevalence of chronic kidney disease (CKD) decreased during the COVID-19 pandemic, particularly in 2020. This study provides the first large-scale investigation into the longitudinal prevalence of CKD from 2007 to 2020, and further research is needed to understand the reasons for this decline and develop healthcare policy strategies for CKD prevention and management.
SCIENTIFIC REPORTS
(2023)
Review
Pediatrics
Ji Eun Lim, Hye Min Kim, Ju Hee Kim, Hey Sung Baek, Man Yong Han
Summary: This study investigated the association between dyslipidemia and cholesterol levels in children and found that high cholesterol levels may be associated with the development of asthma in children.
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2023)
Article
Allergy
Ju Hee Kim, Eun Lee, Eun Kyo Ha, Jeewon Shin, Gi Chun Lee, Yeong Ho Rha, Man Yong Han
Summary: This study used national health insurance data to track individuals born in Korea between 2002 and 2003 and found that atopic dermatitis in children can lead to other diseases. The study identified 20 diseases that are associated with a higher risk of atopic dermatitis, and revealed a temporal sequence of interconnected comorbidities, starting with febrile seizures, constipation, and asthma in childhood and progressing to food allergy, allergic rhinitis, psychiatric disorders, and autoimmune diseases.
Article
Ophthalmology
Jihei Sara Lee, Yong Joon Kim, Sunyeup Kim, Hyoung Won Bae, Sung Soo Kim, Chan Yun Kim, Seung Won Lee
Summary: Hypertension is associated with open-angle glaucoma, but it is uncertain whether elevated blood pressure alone is associated with glaucoma. The risk of glaucoma is uncertain for stage 1 hypertension according to the American College of Cardiology/American Heart Association guidelines.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Chemistry, Medicinal
Ju Hee Kim, Hye Ryeong Cha, Eun Kyo Ha, Ji Hee Kwak, Hakjun Kim, Jeewon Shin, Hye Mi Jee, Man Yong Han
Summary: This study aimed to assess the association between first-generation H1-antihistamine use and cardiovascular events in a pediatric population. The findings showed an increased risk of cardiovascular events in children who were administered first-generation H1-antihistamines.
Review
Pediatrics
Eun Kyo Ha, Ju Hee Kim, Man Yong Han
Summary: Long COVID in children refers to the persistence of signs and symptoms for 4 weeks or even 6 months after the initial infection. It can manifest as respiratory symptoms, neuropsychiatric conditions, and general health issues. The pathophysiology of long COVID in children is still under investigation, but possible mechanisms include viral persistence, autoimmunity, and neuroinflammation. Evaluating respiratory symptoms and mental health problems is crucial in managing long COVID in children.
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2023)
