Review
Oncology
Xiangrong Liu, Dimitri Papukashvili, Zhixiang Wang, Yan Liu, Xiaoxia Chen, Jianrong Li, Zhiyuan Li, Linjie Hu, Zheng Li, Nino Rcheulishvili, Xiaoqing Lu, Jinfeng Ma
Summary: Breast cancer is the most common malignancy in women, and traditional cancer detection methods are insufficient in detecting the complete cancer genomic landscape, necessitating the development of new strategies. Liquid biopsy has gained attention for its simplicity, early detection, and effective monitoring, with miRNAs potentially playing a crucial role in the diagnosis and prognosis of breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Marcel Kemper, Carolin Krekeler, Kerstin Menck, Georg Lenz, Georg Evers, Arik Bernard Schulze, Annalen Bleckmann
Summary: Liquid biopsy is a novel method in cancer diagnostics that is less invasive for patients compared to conventional tissue biopsies. This review provides an overview of lung cancer biomarkers identified in liquid biopsy assays and discusses the differences, current applications, and future perspectives of liquid biopsies in lung cancer.
Article
Oncology
Lei Wang, Jinxiang Wu, Naikuan Ye, Feng Li, Hanxiang Zhan, Shihong Chen, Jianwei Xu
Summary: Plasma-derived Exo-miR-19b is a promising diagnostic marker for pancreatic cancer, showing superior diagnostic value when normalized using miR-1228 in differentiating patients with Pca from healthy volunteers. The study suggests that Exo-miR-19b may be a potential alternative or supplement to serum CA19-9 for diagnosing Pca.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Kota Nakamura, Goretti Hernandez, Geeta G. Sharma, Yuma Wada, Jasjit K. Banwait, Natalia Gonzalez, Jose Perea, Francesc Balaguer, Hiroyuki Takamaru, Yutaka Saito, Yuji Toiyama, Yasuhiro Kodera, C. Richard Boland, Luis Bujanda, Enrique Quintero, Ajay Goel
Summary: A circulating miRNA signature has been developed as a potential noninvasive diagnostic tool for early-onset colorectal cancer (EOCRC), with high accuracy and clinical application potential.
Review
Biochemistry & Molecular Biology
Alexandra Roi, Simina Boia, Laura-Cristina Rusu, Ciprian Ioan Roi, Eugen Radu Boia, Mircea Rivis
Summary: Oral cancer is a challenging disease with a high incidence and poor survival rate. The use of liquid biopsy and identification of potential biomarkers, particularly miRNAs, in body fluids such as serum, plasma, and saliva samples offer promising perspectives for early diagnosis of oral cancer. These biomarkers can provide important information about the initiation, development, progression, and metastasis of oral malignancy, and can contribute to the development of personalized medicine and targeted therapies.
Review
Oncology
Amaia Sandua, Estibaliz Alegre, Alvaro Gonzalez
Summary: Lung cancer is a major cause of cancer-related deaths globally, with late detection and frequent treatment resistance being common issues. Exosomes, as microvesicles secreted by cells, especially tumor cells, play a crucial role in lung cancer development and can be utilized for diagnosis, prognosis, and follow-up. However, the isolation and analysis of exosomes can be challenging, yet their cargo proteins, RNA, and DNA provide valuable insights into lung cancer progression and management.
Review
Oncology
Elvan Wiyarta, Darrin Ananda Nugraha, Muhammad Indera Ramadani, Gita Fajri Gustya, Muhammad Farrasy Ammar, Hana Dzakira Edwar, Nildza Kheirizzad, Mutiah Nurul Mukhlisah, Erlina Burhan, Elisna Syahruddin
Summary: This review addresses the diagnostic value and clinical utility of tumor-educated platelets (TEPs) in adult patients with lung cancer. The findings suggest that TEPs have high sensitivity and specificity, indicating their potential as an effective diagnostic biomarker for lung cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Jingwei Li, Qiran Zhang, Decheng Jiang, Jun Shao, Weimin Li, Chengdi Wang
Summary: Lung cancer has the highest mortality rate among malignancies worldwide. Circular RNAs (circRNAs), a type of covalently closed molecules, show potential clinical application prospects in lung cancer. This review explains the biogenesis, biological functions, and pathophysiology of circRNAs, and highlights their forefront in the diagnosis, prognosis, and therapy of lung cancer.
Article
Gastroenterology & Hepatology
Kota Nakamura, Zhongxu Zhu, Souvick Roy, Eunsung Jun, Haiyong Han, Ruben M. Munoz, Satoshi Nishiwada, Geeta Sharma, Derek Cridebring, Frederic Zenhausern, Seungchan Kim, Denise J. Roe, Sourat Darabi, In-Woong Han, Douglas B. Evans, Suguru Yamada, Michael J. Demeure, Carlos Becerra, Scott A. Celinski, Erkut Borazanci, Susan Tsai, Yasuhiro Kodera, Joon Oh Park, John S. Bolton, Xin Wang, Song Cheol Kim, Daniel Von Hoff, Ajay Goel
Summary: This study developed an exosome-based liquid biopsy signature for the noninvasive and robust detection of patients with PDAC, showing high accuracy and specificity through genome-wide profiling and qRT-PCR assays.
Review
Medicine, Research & Experimental
Runzhang Liang, Xiaosong Li, Weiquan Li, Xiao Zhu, Chen Li
Summary: DNA methylation, catalyzed by DNMT, plays a role in lung cancer pathogenesis and progression, with smoking influencing gene methylation status and increasing the risk of central lung cancer. It is crucial in the mechanisms of lung cancer, early diagnosis, and treatment, but faces challenges in clinical application due to limitations in methylation markers and sample tests. The future development of DNA methylation may need to focus on improving efficiency and sensitivity in liquid biopsy for lung cancer diagnosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jun Lu, Wei Zhang, Keke Yu, Lele Zhang, Yuqing Lou, Ping Gu, Wei Nie, Jie Qian, Jun Xu, Huimin Wang, Hua Zhong, Baohui Han
Summary: This study identified potential plasma biomarkers for stratification of anlotinib treatment response in NSCLC patients using proteomic analysis, suggesting the importance of proteomic examination in biomarker screening and the potential predictive value of ARHGDIB, FN1, CDH1, and KNG1 levels.
Article
Multidisciplinary Sciences
Jiyoun Seo, Mihir Kumar, Jeremy Mason, Fiona Blackhall, Nicholas Matsumoto, Caroline Dive, James Hicks, Peter Kuhn, Stephanie N. Shishido
Summary: This study aimed to explore the potential of liquid biopsy for stratified treatment of small cell lung cancer (SCLC) based on phenotypic heterogeneity. The study observed phenotypic heterogeneity of circulating rare cells in SCLC and established a classification model to differentiate SCLC patients from non-cancerous donors. Single-cell genomic analysis confirmed the plasticity of cancer cells in these rare cell groups.
SCIENTIFIC REPORTS
(2023)
Review
Pharmacology & Pharmacy
Hang Yan, Shengjie Tang, Shoujun Tang, Jun Zhang, Haiyang Guo, Chao Qin, Haiyang Hu, Chuan Zhong, Li Yang, Yunhe Zhu, Haining Zhou
Summary: Non-small cell lung cancer (NSCLC) is a common malignant tumor with suboptimal clinical success due to late diagnosis, limited treatment options, high recurrence rates, and drug resistance. MicroRNAs (miRNAs), small non-coding RNAs, have emerged as important players in NSCLC initiation, progression, and drug resistance. This review provides an overview of miRNA dysregulation and resistance in NSCLC and discusses their potential applications in different anti-cancer treatments.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Jing Li, Na Gao, Zhengfan Gao, Wei Liu, Bairen Pang, Xingli Dong, Yong Li, Tianli Fan
Summary: Exosomes play critical roles in promoting chemoresistance in cancer through various mechanisms. Due to their stability, specificity, and sensitivity, exosomes can serve as biomarkers in liquid biopsies to monitor the current status and progression of cancer chemoresistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yasushi Sato, Koichi Okamoto, Tomoyuki Kawaguchi, Fumika Nakamura, Hiroshi Miyamoto, Tetsuji Takayama
Summary: Neoadjuvant chemotherapy (NAC) is an effective therapeutic option for locally advanced gastric cancer (LAGC), but its therapeutic effect is unpredictable due to tumor heterogeneity and a lack of predictive biomarkers. Researchers are focusing on biomarkers such as metabolic enzymes, nucleotide excision repair, and microsatellite instability, as well as noninvasive liquid biopsy detection methods such as miRNA and exosome detection, to guide the choice of preoperative treatment.
Article
Medicine, General & Internal
Iwona Bojar, Radoslaw Mlak, Iwona Homa-Mlak, Monika Prendecka, Alfred Owoc, Teresa Malecka-Massalska
Summary: This study examined the relationship between body fat level and serum concentration of myostatin protein in peri- and postmenopausal women. The results showed that a decreased level of myostatin is associated with higher body fat in these women.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Review
Environmental Sciences
Aneta Szudy-Szczyrek, Sylwia Chocholska, Oliwia Bachanek-Mitura, Olga Czabak, Radoslaw Mlak, Michal Szczyrek, Justyna Muzyka-Kasietczuk, Marek Hus
Summary: This study aimed to evaluate the safety and efficacy of IRd therapy in patients with RRMM and unfavorable cytogenetics. Preliminary results suggest potentially high efficacy and good safety profile of IRd therapy in these patients.
ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Oncology
Katarzyna Sedlak, Karol Rawicz-Pruszynski, Radoslaw Mlak, Katarzyna Geca, Magdalena Skorzewska, Zuzanna Pelc, Teresa Malecka-Massalska, Wojciech P. Polkowski
Summary: The textbook oncological outcome (TOO) of multimodal treatment has a significant impact on the prognosis of patients with advanced gastric cancer. Patients who received multimodal treatment had lower risk of death compared to those who only received preoperative chemotherapy. Additionally, patients with pathological response in the primary tumor also had a lower risk of death. Thus, TOO can serve as an evaluation parameter for the quality of multimodal treatment in advanced gastric cancer patients.
Article
Biochemistry & Molecular Biology
Tomasz Powrozek, Dominika Pigon-Zajac, Marcin Mazurek, Michael Ochieng Otieno, Mansur Rahnama-Hezavah, Teresa Malecka-Massalska
Summary: This study aimed to evaluate the impact of inflammatory conditions on the expression of long non-coding RNAs (lncRNAs) in a mouse skeletal muscle cell line. Three lncRNAs (Gm4117, Ccdc41os1, and 5830418P13Rik) were found to be significant in inflammatory-related myotube atrophy. The expression of lncRNAs varied depending on the concentration of the inflammatory factor and the treatment time. Bioinformatics analysis identified potential target genes and miRNAs for these lncRNAs, further implicating their involvement in molecular processes related to muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Jaromir Jarecki, Teresa Malecka-Masalska, Ewa Kosior-Jarecka, Wojciech Widuchowski, Piotr Krasowski, Martina Gutbier, Maciej Dobrzynski, Tomasz Blicharski
Summary: The aim of this study was to evaluate the levels of MMPs and osteocalcin in the serum and synovial fluid of obese women with osteoarthritis and their correlations with clinical status. The results showed that the levels of MMP3, MMP9, and pro-MMP13 were increased in more advanced stages of osteoarthritis, indicating an underlying inflammatory process.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Katarzyna Geca, Magdalena Skorzewska, Karol Rawicz-Pruszynski, Radoslaw Mlak, Katarzyna Sedlak, Zuzanna Pelc, Wojciech P. Polkowski
Summary: This study evaluated the prognostic value of the One-Step Nucleic Acid Amplification (OSNA) assay in advanced gastric cancer patients. The results showed that a positive OSNA assay result was a significant unfavorable prognostic factor in these patients. The OSNA assay of peritoneal washings could be considered as an adjunct tool to provide precise intraoperative staging and additional prognostic information.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Iwona Homa-Mlak, Marcin Mazurek, Aleksandra Majdan, Radoslaw Mlak, Maria Majdan, Teresa Melecka-Massalska
Summary: This study aimed to evaluate the potential of serum calprotectin as a rapid diagnostic biomarker for systemic lupus erythematosus (SLE). Comparing 59 SLE patients with 52 healthy controls, it was found that the study group had significantly higher levels of calprotectin. Calprotectin showed high sensitivity and specificity in differentiating SLE patients from healthy volunteers, as well as in detecting moderate to severe SLE patients.
MEDICAL SCIENCE MONITOR
(2022)
Article
Oncology
Iwona Homa-Mlak, Radoslaw Mlak, Marcin Mazurek, Anna Brzozowska, Tomasz Powrozek, Mansur Rahnama-Hezavah, Teresa Malecka-Massalska
Summary: This study found that the TT genotype of the TNFRSF1A gene (-610 T > G) is independently associated with a higher risk of nutritional disorders in head and neck cancer patients undergoing radiotherapy. This suggests that this genetic polymorphism may be useful in assessing the risk of nutritional deficiencies in these patients.
Review
Nutrition & Dietetics
Marcin Mazurek, Radoslaw Mlak, Agata Kot, Mansur Rahnama-Hezavah, Teresa Malecka-Massalska
Summary: The research suggests that HPV infection may increase the risk of malnutrition, significant weight loss, and the need for gastrostomy in head and neck cancer patients. However, the data on the influence of HPV infection on the occurrence and severity of nutritional disorders in HNC patients is still limited and inconclusive.
Article
Medicine, Research & Experimental
Iwona Homa-Mlak, Radoslaw Mlak, Anna Brzozowska, Marcin Mazurek, Tomasz Powrozek, Monika Prendecka-Wrobel, Aneta Szudy-Szczyrek, Piotr Dreher, Katarzyna Kaminska, Teresa Malecka-Massalska, Alicja Wojcik-Zaluska
Summary: This study found that there is a correlation between malnutrition and weight loss with the increase in irisin concentration in patients with head and neck cancers. Higher levels of irisin may serve as a useful marker for malnutrition in HNC patients.
MEDICAL SCIENCE MONITOR
(2022)
Article
Cell Biology
Weronika Domerecka, Anna Kowalska-Kepczynska, Iwona Homa-Mlak, Agata Michalak, Radoslaw Mlak, Marcin Mazurek, Halina Cichoz-Lach, Teresa Malecka-Massalska
Summary: This study investigated the role of Extended Inflammation Parameters (EIP) and systemic inflammatory response markers in diagnosing autoimmune hepatitis (AIH). Results showed higher values in AIH patients compared to controls, indicating potential diagnostic value. Additionally, certain markers were also found to be important in detecting liver fibrosis in the course of AIH.
Review
Health Care Sciences & Services
Iwona Homa-Mlak, Dominika Pigon-Zajac, Pawel Wawrejko, Teresa Malecka-Massalska, Radoslaw Mlak
Summary: According to the World Health Organization, cancer remains one of the main causes of mortality globally. Cancer cachexia is a complex disorder characterized by muscle mass loss and inflammation. miRNAs have potential as valuable biomarkers in the diagnosis, treatment, and prognosis of cancer cachexia due to their ability to regulate multiple genes and biological processes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Aneta Szudy-Szczyrek, Radoslaw Mlak, Marcin Mazurek, Tomasz Krajka, Sylwia Chocholska, Paulina Bitkowska, Marta Jutrzenka, Michal Szczyrek, Iwona Homa-Mlak, Andrzej Krajka, Teresa Malecka-Massalska, Marek Hus
Summary: The functional single nucleotide polymorphism (SNP) of the KIAA1524 gene (rs2278911, 686C > T) is associated with disease progression and survival in patients with multiple myeloma (MM). The TT genotype is linked to shorter progression-free survival (PFS) and overall survival (OS). Therefore, evaluating the SNP 686C > T of the KIAA1524 gene could serve as a diagnostic tool for identifying MM patients at risk of early disease progression and death.
Article
Biochemistry & Molecular Biology
Michal Mielnik, Aneta Szudy-Szczyrek, Iwona Homa-Mlak, Radoslaw Mlak, Martyna Podgajna-Mielnik, Aneta Goracy, Teresa Malecka-Massalska, Marek Hus
Summary: This study assessed the correlation between pretreatment serum concentrations of IL-6, IL-8, MCP-1, and VEGF and the clinical outcomes of MM patients. Results showed that IL-8 was significantly correlated with age, staging, performance status, anemia, kidney disease, and VEGF. Chemotherapy responders had lower IL-8, IL-6, and VEGF concentrations compared to non-responders. High levels of IL-6 were associated with a higher risk of disease progression and reduced overall survival.
Article
Pathology
Xiaobo Zhang, Chen Wang, Danhua Shen
Summary: This study investigated the Clinicopathological features and FH mutation in FH-dUL. FH-dUL is rare and the combination of predictive Clinicopathological evaluation, FH and 2SC IHC test, and molecular test were helpful for the screening of FH-dUL or even HLRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Gaurav Dubey, Mithilesh Singh, Himmat Singh, Mohit Agarwal, Shailendra Singh Chandel, Anurag Mishra, Ravindra Pal Singh, Neelima Kukreti
Summary: SnoRNAs play a crucial role in autoimmune diseases, influencing gene expression, immune cell development, and immune regulation. They have the potential to be biomarkers or therapeutic targets for disease management. However, further research is needed to elucidate their precise molecular mechanisms.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
P. Suhaj, D. Do, T. Olejar, R. Pichova, O. Lang, R. Matej
Summary: Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H still need to be further elucidated. This study analyzed 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN) and found that gastrointestinal symptoms may be more related to PPY-H rather than NEN hormonal production. Strong SSTR2 expression in PPY-H suggests the potential utility of radiotracers in clinical diagnostics, but further studies are needed.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ruyun Zhang, Xiaofei Liao, Bin Zhang, Xiaohong Huang, Guanjie Qin, Xiangyun Kong, Yuan Xie, Yunyan Mo, Jinxuan Dai, Chunqiao Gan, Zan Luo, Jingyan Lu, Wei Jiang
Summary: This study found that patients with high COV+TIL score had worse prognosis in nasopharyngeal carcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Waleed Hassan Almalki
Summary: Understanding the molecular pathways behind cardiovascular illnesses is crucial. Recent studies have revealed the role of Xist RNA in cardiovascular diseases, including epigenetic changes, gene expression, cellular identity, and sex chromosomal inactivation. Dysregulation of Xist RNA expression is associated with conditions such as atherosclerosis, hypertrophy, and cardiac fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A. Halawi, Thaifallah Munahi Alotaibi
Summary: Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
