Article
Oncology
Jing Li Huang, Masanori Oshi, Itaru Endo, Kazuaki Takabe
Summary: Clinically, patients with high CD24 expression in colorectal cancer tumors have better disease-specific and overall survival rates, and tumors with high CD133, CD24, and CD44 expression are associated with increased EGFR, KRAS, and Ki67 expression. Moreover, CD133-high/CD24-low tumors show potential for predicting worse prognosis in colorectal cancer patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Pei-Yin Chen, Shih-Chi Chao, Pei-Ling Hsieh, Yi-Wen Liao, Pei-Ming Chu, Horng-Jyh Harn, Cheng-Chia Yu
Summary: Oral cancer is a common type of cancer worldwide, and targeting cancer stem cells (CSC) may lead to promising results in terms of tumor relapse and metastasis. This study found that butylidenephthalide, a compound from Angelica sinensis, has anti-CSC effects in oral cancer. It inhibited the proliferation, migration, invasion, and colony formation abilities of CSCs, and also delayed tumor development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ruizhi Geng, Niklas Harland, Ivonne A. Montes-Mojarro, Falko Fend, Wilhelm K. Aicher, Arnulf Stenzl, Bastian Amend
Summary: In this study, it was found through experiments that the expression of CD24 in bladder cancer cell organoids may serve as an indicator for the prolonged proliferation potential of the cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Natalia Izycka, Marcin Rucinski, Malgorzata Andrzejewska, Sebastian Szubert, Ewa Nowak-Markwitz, Karolina Sterzynska
Summary: Recurrent disease and treatment-associated chemoresistance are major contributors to poor clinical outcomes in ovarian cancer patients. This study investigated the expression of CSC-associated markers ALDH1A, CD44, and CD133 to predict patient prognosis. ALDH1A1-positive patients had significantly shorter overall survival (OS) and progression-free survival (PFS). Multivariate analysis revealed that ALDH1A1 expression, FIGO stage III-IV, and residual disease were associated with shorter OS. Targeting ALDH1A1-positive cancer cells may be a promising therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Rakshita Grover, Sahil Drall, Neelam Poonia, Gaurav Kumar Jain, Geeta Aggarwal, Viney Lather, Prashant Kesharwani, Deepti Pandita, Ramesh K. Goyal
Summary: Cancer stem cells (CSCs) contribute to tumor onset, progression, chemotherapy resistance, and relapse. CD44 and CD133 are commonly expressed markers used to identify aggressive CSCs. Targeting these markers with aptamers conjugated nanocarriers can overcome the limitations of antibodies and has proven to be beneficial in targeting CSCs. This article reviews the recent advancements in aptamers and their conjugation with nanocarriers for specific targeting of CSCs and improved cancer therapy efficacy.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biology
Xinbo Qiao, Yixiao Zhang, Lisha Sun, Qingtian Ma, Jie Yang, Liping Ai, Jinqi Xue, Guanglei Chen, Hao Zhang, Ce Ji, Xi Gu, Haixin Lei, Yongliang Yang, Caigang Liu
Summary: The study found that a higher frequency of CD44(-)/CD24(-) breast cancer cells was associated with delayed breast cancer metastasis, and that RHBDL2 may play a role in breast cancer metastasis and CSC formation.
Article
Multidisciplinary Sciences
Matias Blomqvist, Ilmari Koskinen, Eliisa Loyttyniemi, Tuomas Mirtti, Peter J. Bostrom, Pekka Taimen
Summary: In bladder cancer patients, the stem cell markers ALDH1, SOX2, and SSEA-4 show little prognostic or predictive value, with weak or negative cytoplasmic SOX2 staining being associated with lymphovascular invasion and cancer-specific survival but not significantly.
SCIENTIFIC REPORTS
(2021)
Review
Multidisciplinary Sciences
Agus Rizal Ardy Hariandy Hamid, Yasmina Zahra Syadza, Oliver Emmanuel Yausep, Roberto Bagaskara Indy Christanto, Bayu Hernawan Rahmat Muharia, Chaidir Arif Mochtar
Summary: Bladder cancer is associated with high recurrence rates and metastasis. Cancer stem cells (CSCs) contribute to these processes and may serve as prognostic markers for bladder cancer. This study reviewed 12 clinical studies and identified multiple CSC markers that are implicated in the recurrence and metastasis of bladder cancer. The detection of these markers offers a promising approach to determine the prognosis of bladder cancer.
Review
Oncology
Mahdi Abdoli Shadbad, Negar Hosseinkhani, Zahra Asadzadeh, Afshin Derakhshani, Noora Karim Ahangar, Nima Hemmat, Parisa Lotfinejad, Oronzo Brunetti, Nicola Silvestris, Behzad Baradaran
Summary: CD44 and CD44(+)CD24(-/low) phenotype are associated with poor prognosis in TNBC patients, and these cancer stem cell markers are linked to advanced tumor stage, size, grade, metastasis, and lymphatic involvement in TNBC patients. Additionally, chemoradiotherapy-treated TNBC patients show an upregulation of CD44(+)CD24(-/low) phenotype, which inversely correlates with androgen receptor (AR) and leads to inferior prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mariana Nunes, Francisca Pacheco, Ricardo Coelho, Dina Leitao, Sara Ricardo, Leonor David
Summary: Overexpression of MSLN in ovarian carcinomas does not affect the expression of cancer stem cell markers, indicating that MSLN is not involved in driving the cancer stem cell phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Eriko Nakagomi, Tetuo Mikami, Kimihiko Funahashi, Shinichi Okazumi, Kazutoshi Shibuya, Nobuyuki Hiruta, Yoshinori Igarashi
Summary: This study found that the expression of CSC markers CD133, CD44v9, and ALDH1A1 was higher in both sporadic and UC-associated colorectal tumors. ALDH1A1 expression was higher in the right colon of sporadic cancer and in those with longer disease duration of UC-associated cancer. CD44+/CD133-regions were commonly associated with low apoptosis in both sporadic and UC-associated cancers, indicating them as target areas for CSCs. The combination of CSC markers may differ between sporadic and UC-associated cancers.
HISTOLOGY AND HISTOPATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olga Pershina, Natalia Ermakova, Angelina Pakhomova, Darius Widera, Edgar Pan, Mariia Zhukova, Elena Slonimskaya, Sergey G. Morozov, Aslan Kubatiev, Alexander Dygai, Evgenii G. Skurikhin
Summary: This study found that breast cancer patients can be divided into two groups based on the frequency of ALDH1 cells, corresponding to different types of stem cells. Additionally, epithelial precursors associated with a positive effect of chemotherapy and remission in breast cancer patients were found in normal breast tissue.
Article
Biochemistry & Molecular Biology
Takahiro Kasai, Shoma Tamori, Yuta Takasaki, Izumi Matsuoka, Ayaka Ozaki, Chika Matsuda, Yohsuke Harada, Kazunori Sasaki, Shigeo Ohno, Kazunori Akimoto
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous cancer with poor prognosis, which leads to insensitivity to anticancer treatments. Cancer stem cells (CSCs) acquire phenotypic heterogeneity through asymmetric cell division, but the detailed mechanism is largely unknown.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Medicine, General & Internal
Wael Abdou Hassan, Mohamad Ayham Muqresh, Mohamed Omar
Summary: This study reviewed the literature related to CD44 and CD133 markers in colorectal cancer and discussed their roles in diagnosis, treatment, and prognosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yan S. Kim, Daria M. Potashnikova, Alisa M. Gisina, Irina Kholodenko, Arthur T. Kopylov, Olga Tikhonova, Leonid K. Kurbatov, Aleena A. Saidova, Anna Tvorogova, Roman Kholodenko, Pavel Belousov, Ivan A. Vorobjev, Victor G. Zgoda, Konstantin N. Yarygin, Alexey Yu Lupatov
Summary: CD133 plasma membrane expression is positively correlated with the proliferative activity of cancer cells. Transcriptomic and proteomic profiling revealed minor distinctions between different levels of CD133 expression. The TRIM28 transcription factor plays a prominent role in regulating CD133 expression. Knockout of the TRIM28 gene downregulates CD133 expression in Caco2 cell clones.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pathology
Xiaobo Zhang, Chen Wang, Danhua Shen
Summary: This study investigated the Clinicopathological features and FH mutation in FH-dUL. FH-dUL is rare and the combination of predictive Clinicopathological evaluation, FH and 2SC IHC test, and molecular test were helpful for the screening of FH-dUL or even HLRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Gaurav Dubey, Mithilesh Singh, Himmat Singh, Mohit Agarwal, Shailendra Singh Chandel, Anurag Mishra, Ravindra Pal Singh, Neelima Kukreti
Summary: SnoRNAs play a crucial role in autoimmune diseases, influencing gene expression, immune cell development, and immune regulation. They have the potential to be biomarkers or therapeutic targets for disease management. However, further research is needed to elucidate their precise molecular mechanisms.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
P. Suhaj, D. Do, T. Olejar, R. Pichova, O. Lang, R. Matej
Summary: Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H still need to be further elucidated. This study analyzed 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN) and found that gastrointestinal symptoms may be more related to PPY-H rather than NEN hormonal production. Strong SSTR2 expression in PPY-H suggests the potential utility of radiotracers in clinical diagnostics, but further studies are needed.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ruyun Zhang, Xiaofei Liao, Bin Zhang, Xiaohong Huang, Guanjie Qin, Xiangyun Kong, Yuan Xie, Yunyan Mo, Jinxuan Dai, Chunqiao Gan, Zan Luo, Jingyan Lu, Wei Jiang
Summary: This study found that patients with high COV+TIL score had worse prognosis in nasopharyngeal carcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Waleed Hassan Almalki
Summary: Understanding the molecular pathways behind cardiovascular illnesses is crucial. Recent studies have revealed the role of Xist RNA in cardiovascular diseases, including epigenetic changes, gene expression, cellular identity, and sex chromosomal inactivation. Dysregulation of Xist RNA expression is associated with conditions such as atherosclerosis, hypertrophy, and cardiac fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A. Halawi, Thaifallah Munahi Alotaibi
Summary: Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
