4.5 Article

Red-blood-cell-shaped chitosan microparticles prepared by electrospraying

期刊

PARTICUOLOGY
卷 30, 期 -, 页码 151-157

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.partic.2016.05.011

关键词

Chitosan microparticle; Red blood cell; Electrospraying; Solvent evaporation; Solvent diffusion

资金

  1. National Natural Science Foundation of China [21322605, 21276002, 81321002]
  2. Training Program of Sichuan Province Distinguished Youth Academic and Technology Leaders [2013JQ0035]
  3. State Key Laboratory of Polymer Materials Engineering, China [sklpme2014-3-02]

向作者/读者索取更多资源

Red-blood-cell-shaped chitosan microparticles with acid-triggered dissolution and auto-fluorescence were successfully fabricated by a simple strategy combining electrospraying with a solvent diffusion process controlled by solvent evaporation. The sizes of the prepared chitosan microparticles were relatively uniform. Control of the solvent diffusion process was crucial for the formation of microparticles with concave morphology. A chitosan aqueous solution containing 20 vol% ethanol as the evaporable solvent and 30 vol% dimethyl sulfoxide as the diffusible solvent was optimal for preparation of chitosan microparticles with the desired red-blood-cell-like size and shape. These chitosan microparticles will be highly attractive for many biological and biomedical applications. (C) 2016 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.

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