Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells

TRPV4 Is Required for Hypoxic Pulmonary Vasoconstriction

(2015) Neil M. Goldenberg et al.   ANESTHESIOLOGY

Interaction of SiO2 nanoparticles with neuronal cells: Ionic mechanisms involved in the perturbation of calcium homeostasis

(2015) Alessandra Gilardino et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling

(2015) Caixia Guo et al.   International Journal of Nanomedicine

Targeting TRP channels for chronic cough: from bench to bedside

(2015) Sara J. Bonvini et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia

(2015) Mathilde Delaval et al.   Particle and Fibre Toxicology

Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory

(2015) Marina E Vance et al.   Beilstein Journal of Nanotechnology

A Co-Culture System with an Organotypic Lung Slice and an Immortal Alveolar Macrophage Cell Line to Quantify Silica-Induced Inflammation

(2015) Falk Hofmann et al.   PLoS One

TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury

(2014) Shrilatha Balakrishna et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TRPV4: physiological role and therapeutic potential in respiratory diseases

(2014) Neil M. Goldenberg et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles

(2014) Virginie Rabolli et al.   Particle and Fibre Toxicology

Altered Gene Transcription in Human Cells Treated with Ludox® Silica Nanoparticles

(2014) Caterina Fede et al.   International Journal of Environmental Research and Public Health

TRPV4-Mediated Calcium Influx and Ciliary Activity in Human Native Airway Epithelial Cells

(2013) Lisa Alenmyr et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Transient receptor potential (TRP) channels in the airway: role in airway disease

(2013) M S Grace et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lack of correlation between the amplitudes of TRP channel-mediated responses to weak and strong stimuli in intracellular Ca2+ imaging experiments

(2013) Yeranddy A. Alpizar et al.   CELL CALCIUM

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

The toxicity outcome of silica nanoparticles (Ludox®) is influenced by testing techniques and treatment modalities

(2012) Caterina Fede et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Importance of transient receptor potential vanilloid 4 (TRPV4) in epidermal barrier function in human skin keratinocytes

(2012) Naoko Kida et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cytotoxic effects in 3T3-L1 mouse and WI-38 human fibroblasts following 72hour and 7day exposures to commercial silica nanoparticles

(2012) Maciej Stępnik et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Uptake and intracellular localization of submicron and nano-sized SiO2 particles in HeLa cells

(2011) Marco Al-Rawi et al.   ARCHIVES OF TOXICOLOGY

Model System to Study the Influence of Aggregation on the Hemolytic Potential of Silica Nanoparticles

(2011) Leen C. J. Thomassen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

TRPV4-Mediated Calcium Influx into Human Bronchial Epithelia upon Exposure to Diesel Exhaust Particles

(2011) Jinju Li et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes

(2011) Hiroshi Mihara et al.   JOURNAL OF PHYSIOLOGY-LONDON

Re: Inhibition of the Cation Channel TRPV4 Improves Bladder Function in Mice and Rats With Cyclophosphamide-Induced Cystitis

(2011) Anthony Atala   JOURNAL OF UROLOGY

Interaction of Spherical Silica Nanoparticles with Neuronal Cells: Size-Dependent Toxicity and Perturbation of Calcium Homeostasis

(2011) Paolo Ariano et al.   Small

Epithelial Barriers in Homeostasis and Disease

(2010) Amanda M. Marchiando et al.   Annual Review of Pathology-Mechanisms of Disease

Methodological Considerations to Understand the Sensory Function of TRP Channels

(2010) Víctor M. Meseguer et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The TRPV4 Channel Contributes to Intercellular Junction Formation in Keratinocytes

(2010) Takaaki Sokabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Size-Dependent Cytotoxicity of Monodisperse Silica Nanoparticles in Human Endothelial Cells

(2009) Dorota Napierska et al.   Small

TRPing on the Lung Endothelium: Calcium Channels That Regulate Barrier Function

(2008) Donna L. Cioffi et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation

(2008) Annemarieke E. Loot et al.   CARDIOVASCULAR RESEARCH

IP3sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5′-6′-epoxyeicosatrienoic acid

(2008) Jacqueline Fernandes et al.   JOURNAL OF CELL BIOLOGY

Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines

(2008) José M. Fernández-Fernández et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells

(2008) I. M. Lorenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA