Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like lesions in mice through activation of STAT pathway

The NF-kB regulates the SHP-1 expression in monocytes in congestive heart failure

(2017) Sara Franceschelli   Frontiers in Bioscience-Landmark

Effects of Ergosterol on COPD in Mice via JAK3/STAT3/NF-κB Pathway

(2017) Wang Huan et al.   INFLAMMATION

Involvement of the cytokine–IDO1–AhR loop in zinc oxide nanoparticle-induced acute pulmonary inflammation

(2017) Chia-Chi Ho et al.   Nanotoxicology

Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury

(2016) Jiping Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Therapeutic Effects of Resveratrol in a Mouse Model of LPS and Cigarette Smoke-Induced COPD

(2016) Jinlong Chen et al.   INFLAMMATION

Role of engineered metal oxide nanoparticle agglomeration in reactive oxygen species generation and cathepsin B release in NLRP3 inflammasome activation and pulmonary toxicity

(2016) Tina M. Sager et al.   INHALATION TOXICOLOGY

Impact of air pollution on the burden of chronic respiratory diseases in China: time for urgent action

(2016) Wei-Jie Guan et al.   LANCET

Integrative functional transcriptomic analyses implicate specific molecular pathways in pulmonary toxicity from exposure to aluminum oxide nanoparticles

(2016) Xiaobo Li et al.   Nanotoxicology

Simplein vitromodels can predict pulmonary toxicity of silver nanoparticles

(2016) Hedwig M. Braakhuis et al.   Nanotoxicology

Organ burden and pulmonary toxicity of nano-sized copper (II) oxide particles after short-term inhalation exposure

(2016) Ilse Gosens et al.   Nanotoxicology

Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice

(2016) Suzanne M Cloonan et al.   NATURE MEDICINE

JAK–STAT pathway activation in COPD

(2015) Liang Yew-Booth et al.   EUROPEAN RESPIRATORY JOURNAL

Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment

(2015) Anika Stadtmann et al.   JOURNAL OF IMMUNOLOGY

Gender differences in murine pulmonary responses elicited by cellulose nanocrystals

(2015) Anna A. Shvedova et al.   Particle and Fibre Toxicology

An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles

(2015) Xiaobo Li et al.   Particle and Fibre Toxicology

Small molecule 1′-acetoxychavicol acetate suppresses breast tumor metastasis by regulating the SHP-1/STAT3/MMPs signaling pathway

(2014) Jieqiong Wang et al.   BREAST CANCER RESEARCH AND TREATMENT

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

(2014) Calvin C. Willhite et al.   CRITICAL REVIEWS IN TOXICOLOGY

Pdcd4 modulates markers of macrophage alternative activation and airway remodeling in antigen-induced pulmonary inflammation

(2014) Bo Zhong et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Novel Carbazole Inhibits Phospho-STAT3 through Induction of Protein–Tyrosine Phosphatase PTPN6

(2014) Shujie Hou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Zinc oxide nanoparticles affect the expression of p53, Ras p21 and JNKs: an ex vivo/in vitro exposure study in respiratory disease patients

(2014) Ashutosh Kumar et al.   MUTAGENESIS

Assessment of acute bronchodilator effects from specific airway resistance changes in stable COPD patients

(2014) Pierachille Santus et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Interleukin-6 neutralization alleviates pulmonary inflammation in mice exposed to cigarette smoke and poly(I:C)

(2013) Cedric Hubeau et al.   CLINICAL SCIENCE

Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease

(2013) Derek E. Byers et al.   JOURNAL OF CLINICAL INVESTIGATION

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

(2013) John R. Lukens et al.   NATURE

Elastase induced lung epithelial cell apoptosis and emphysema through placenta growth factor

(2013) H-H Hou et al.   Cell Death & Disease

Bacterial Pathogens Activate a Common Inflammatory Pathway through IFNλ Regulation of PDCD4

(2013) Taylor S. Cohen et al.   PLoS Pathogens

Titanium oxide nanoparticle instillation induces inflammation and inhibits lung development in mice

(2012) Namasivayam Ambalavanan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation

(2012) Kuen-Feng Chen et al.   CANCER LETTERS

Anti-interleukin-33 inhibits cigarette smoke-induced lung inflammation in mice

(2012) Chuan Qiu et al.   IMMUNOLOGY

Murine pulmonary responses after sub-chronic exposure to aluminum oxide-based nanowhiskers

(2012) Andrea Adamcakova-Dodd et al.   Particle and Fibre Toxicology

Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown

(2010) Saskia Braber et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The tyrosine phosphatase, SHP-1, is involved in bronchial mucin production during oxidative stress

(2010) Min Kyoung Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein Tyrosine Phosphatases, TC-PTP, SHP1, and SHP2, Cooperate in Rapid Dephosphorylation of Stat3 in Keratinocytes Following UVB Irradiation

(2010) Dae Joon Kim et al.   PLoS One

Assessment of air space size characteristics by intercept (chord) measurement: an accurate and efficient stereological approach

(2009) Lars Knudsen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Pulmonary Toxicity and Fate of Agglomerated 10 and 40 nm Aluminum Oxyhydroxides following 4-Week Inhalation Exposure of Rats: Toxic Effects are Determined by Agglomerated, not Primary Particle Size

(2009) Jürgen Pauluhn   TOXICOLOGICAL SCIENCES

Retrospective analysis of 4-week inhalation studies in rats with focus on fate and pulmonary toxicity of two nanosized aluminum oxyhydroxides (boehmite) and pigment-grade iron oxide (magnetite): The key metric of dose is particle mass and not particle surface area

(2009) Jürgen Pauluhn   TOXICOLOGY

Tyrosine Phosphatase SHP-1 in Oxidative Stress and Development of Allergic Airway Inflammation

(2008) You Sook Cho et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Manufactured Aluminum Oxide Nanoparticles Decrease Expression of Tight Junction Proteins in Brain Vasculature

(2008) Lei Chen et al.   Journal of Neuroimmune Pharmacology