Article
Gastroenterology & Hepatology
Joo Hyun Oh, Danbee Kang, Wonseok Kang, Eliseo Guallar, Juhee Cho, Yang Won Min
Summary: This study found an association between PPI use and increased risk of pyogenic liver abscess, emphasizing the importance of prescribing PPIs only when necessary and avoiding improper use.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Cardiac & Cardiovascular Systems
Hee Gyu Yang, Dong-Kyu Kim
Summary: Antiplatelet therapy combined with proton-pump inhibitors (PPIs) in patients with acute coronary syndrome increases the risk of mortality, myocardial infarction, and coronary revascularization events. The use of PPIs can alter the pharmacokinetics of antiplatelet agents. Middle-aged patients and those with shorter duration of concomitant use are at a higher risk. This study highlights the potential adverse cardiovascular effects of combining antiplatelet therapy with PPIs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Gastroenterology & Hepatology
Jeung Hui Pyo, Tae Jun Kim, Hyuk Lee, Sung Chul Choi, Soo-Jin Cho, Yoon-Ho Choi, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Minwoong Kang, Yeong Chan Lee, Jae J. Kim
Summary: This study found an association between PPI use and an increased risk of fatty liver disease, even after adjusting for multiple confounders. A dose-response effect was observed with PPI use for at least 180 days. Subgroup analysis also revealed a correlation between PPI use and an increased risk of fatty liver disease.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Jen-Hung Wang, Chih-Hsun Yi, Tso-Tsai Liu, Jui-Sheng Hung, Ming-Wun Wong, Ming-Jong Bair, Michael F. Vaezi, William C. Orr, Chien-Lin Chen
Summary: This large-scale cohort study found that the use of PPIs may increase the risk of CRC in a dose-dependent manner, with long-term use of PPIs for more than one year also leading to an increased risk. All PPIs, except pantoprazole and rabeprazole, were associated with an increased risk of CRC.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Man Yang, Qiangsheng He, Fang Gao, Krish Nirantharakumar, Tonny Veenith, Xiwen Qin, Amy T. Page, Martin C. S. Wong, Junjie Huang, Zi Chong Kuo, Bin Xia, Changhua Zhang, Yulong He, Wenbo Meng, Jinqiu Yuan, Yihang Pan
Summary: The study found that regular use of PPIs was associated with an increased risk of stroke, with a higher absolute risk observed in individuals with high baseline stroke risk. It is recommended that physicians exercise caution when prescribing PPIs and assess the underlying stroke risk for individualized use.
Article
Orthopedics
C. Zeng, T. Neogi, A. T. Chan, J. Wei, D. Misra, N. Lu, H. K. Choi, G. Lei, Y. Zhang
Summary: This study compares the risk of knee replacement among initiators of different proton pump inhibitors (PPIs) and histamine-2 receptor antagonist (H2RA) initiators in patients with knee osteoarthritis. The results show that the use of omeprazole and pantoprazole is associated with a higher risk of knee replacement compared to the use of H2RA.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Clinical Neurology
Nelsan Pourhadi, Janet Janbek, Christina Jensen-Dahm, Christiane Gasse, Thomas Munk Laursen, Gunhild Waldemar
Summary: The use of proton pump inhibitors (PPIs) may increase the risk of dementia in individuals aged 60 to 75 years, with a potential correlation to age.
ALZHEIMERS & DEMENTIA
(2023)
Article
Veterinary Sciences
Haemin Lee, Sanggu Kim, Dohee Lee, Yeon Chae, Taesik Yun, Mhan-Pyo Yang, Byeong-Teck Kang, Soochong Kim, Hakhyun Kim
Summary: The long-term use of omeprazole in a dog resulted in the development of fundic gland polyps, a phenomenon not previously described in veterinary literature.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Ophthalmology
E. Laura Wolpert, Harold Snieder, M. Nomdo Jansonius, P. Tor Utheim, J. Christopher Hammond, Jelle Vehof
Summary: This study revealed associations between dry eye symptoms and medication classes and individual drugs using a hypothesis-free approach. Medication use is highly informative of the risk of dry eye symptoms, but correction for underlying comorbidities is critical to avoid confounding effects. Several new associations were discovered, including the link between PPIs and dry eye symptoms.
Letter
Medicine, General & Internal
Ahhyung Choi, Yunha Noh, Dong Keon Yon, Ju-Young Shin
Summary: This cohort study investigates the potential link between prenatal exposure to proton pump inhibitors and the risk of low birth weight.
Article
Gastroenterology & Hepatology
Da Hee Park, Seung In Seo, Kyung Joo Lee, Jinseob Kim, Yerim Kim, Won-Woo Seo, Hyung Seok Lee, Woon Geon Shin, Jong Jin Yoo
Summary: This study aimed to evaluate the relationship between the use of proton pump inhibitors (PPIs) and the risk of osteoporosis and hip fractures. The results showed that long-term PPI use was significantly associated with osteoporosis, but the results for hip fractures were inconsistent.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pediatrics
Yun-Han Wang, Viktor Wintzell, Jonas F. Ludvigsson, Henrik Svanstrom, Bjorn Pasternak
Summary: In this cohort study, initiation of proton pump inhibitor (PPI) use in children was associated with a higher risk of asthma compared to non-use, with the highest impact seen in infants and toddlers. Individual PPIs also showed varying levels of risk, with pantoprazole demonstrating the highest risk among the PPIs studied.
Article
Gastroenterology & Hepatology
Nadim Mahmud, Marina Serper, Tamar H. Taddei, David E. Kaplan
Summary: The study found that PPI exposure in patients with cirrhosis is associated with increased risk of infection and decompensation, leading to higher liver-related mortality. However, in patients with prior gastrointestinal bleeding, PPI use is associated with reduced all-cause mortality, suggesting potential benefits.
Article
Health Care Sciences & Services
Chia-Jung Kuo, Cheng-Yu Lin, Chun-Wei Chen, Chiu-Yi Hsu, Sen-Yung Hsieh, Cheng-Tang Chiu, Wey-Ran Lin
Summary: This study demonstrates that gastric-acid-suppressive drug use is associated with an increased risk of enteric infection after adjusting for potential biases and confounders.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Peidong Zhang, Zhihao Li, Peiliang Chen, Ao Zhang, Yu Zeng, Xiru Zhang, Qingmei Huang, Dan Liu, Songtao Qi, Chen Mao
Summary: The use of proton pump inhibitors is associated with an increased risk of incident dementia, particularly among APOE epsilon 4 heterozygotes, according to the findings of this large population-based cohort study.