Non-Monotonic Endocrine-Disrupting Effects of Bisphenol-A on Vitellogenin Expression in Juvenile Freshwater Cyprinid, Catla catla

Endocrine-disrupting chemicals e.g. bisphenol-A can alter fish reproduction. Vitellogenin (vtg) is the egg yolk precursor and used as a biomarker for estrogenic endocrine disruption. To elucidate the endocrine disrupting effect of bisphenol-A, juvenile Catla catla was exposed to graded concentrations of bisphenol-A (10,100,1000 therefore mu g/l) for 14 days. BPA exposure strongly elevates rig mRNA level in fish exposed to 100 mu g/l but at 1000 mu g/l exposure of BPA, vtg level decreased compared to 100 mu g/l exposed fish. These results showed that BPA has estrogenic action and cause endocrine disruption in juvenile C. catla at environmentally relevant concentration. Moreover, these results also depict the non-monotonic, biphasic dose response to BPA.