Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease

Mitochondrial Cytochrome c Oxidase Biogenesis Is Regulated by the Redox State of a Heme-Binding Translational Activator

(2016) Iliana C. Soto et al.   ANTIOXIDANTS & REDOX SIGNALING

Overexpression of NDUFA4L2 is associated with poor prognosis in patients with colorectal cancer

(2016) Yun Lv et al.   ANZ JOURNAL OF SURGERY

The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits

(2016) J. Cesnekova et al.   BIOCHEMICAL JOURNAL

Supercomplex-associated Cox26 protein binds to cytochrome c oxidase

(2016) Valentina Strecker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure of Mammalian Respiratory Supercomplex I 1 III 2 IV 1

(2016) Meng Wu et al.   CELL

Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein

(2016) Ricarda Richter-Dennerlein et al.   CELL

NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma

(2016) R. K.-H. Lai et al.   CLINICAL CANCER RESEARCH

Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma

(2016) D. R. Minton et al.   CLINICAL CANCER RESEARCH

Mitochondrial cytochrome c oxidase deficiency

(2016) M. Rak et al.   CLINICAL SCIENCE

The Mg2+-containing Water Cluster of Mammalian CytochromecOxidase Collects Four Pumping Proton Equivalents in Each Catalytic Cycle

(2016) Naomine Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leigh syndrome associated with a novel mutation in the COX15 gene

(2016) Mohammad Miryounesi et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Mechanism of super-assembly of respiratory complexes III and IV

(2016) Sara Cogliati et al.   NATURE

The Role of Mitochondrial Reactive Oxygen Species in Cardiovascular Injury and Protective Strategies

(2016) Danina M. Muntean et al.   Oxidative Medicine and Cellular Longevity

Systems proteomics of liver mitochondria function

(2016) E. G. Williams et al.   SCIENCE

Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice

(2016) Tara R. Richman et al.   Nature Communications

COX7AR is a Stress-inducible Mitochondrial COX Subunit that Promotes Breast Cancer Malignancy

(2016) Kezhong Zhang et al.   Scientific Reports

COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation

(2016) Rafael Pérez-Pérez et al.   Cell Reports

Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPRMT and increased resistance to oxidative stress in primary cultures of fibroblasts

(2016) Gavin Pharaoh et al.   Redox Biology

Evolution of the oxygen sensitivity of cytochrome c oxidase subunit 4

(2015) K. M. Kocha et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes

(2015) Hye Jin Hwang et al.   BIOCHEMISTRY

Loss of the smallest subunit of cytochromecoxidase, COX8A, causes Leigh-like syndrome and epilepsy

(2015) Kerstin Hallmann et al.   BRAIN

Maintaining Ancient Organelles: Mitochondrial Biogenesis and Maturation

(2015) R. B. Vega et al.   CIRCULATION RESEARCH

Improving executive function using transcranial infrared laser stimulation

(2015) Nathaniel J. Blanco et al.   Journal of Neuropsychology

MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism

(2015) Siddhesh Aras et al.   MITOCHONDRION

Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochromecoxidase

(2015) Vivek Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas

(2015) Claudia R Oliva et al.   Oncotarget

The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice

(2015) Stefanie F. Maurer et al.   Scientific Reports

MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly

(2015) Sven Dennerlein et al.   Cell Reports

A Mutation of COX6A1 Causes a Recessive Axonal or Mixed Form of Charcot-Marie-Tooth Disease

(2014) Gen Tamiya et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Comparisons of subunit 5A and 5B isoenzymes of yeast cytochromecoxidase

(2014) Raksha Dodia et al.   BIOCHEMICAL JOURNAL

Complex IV-deficientSurf1−/−mice initiate mitochondrial stress responses

(2014) Daniel A. Pulliam et al.   BIOCHEMICAL JOURNAL

Re-evaluation of the near infrared spectra of mitochondrial cytochrome c oxidase: Implications for non invasive in vivo monitoring of tissues

(2014) Maria G. Mason et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Respiratory Chain Supercomplex Organization Is Independent of COX7a2l Isoforms

(2014) Arnaud Mourier et al.   Cell Metabolism

Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy

(2014) Ulla Najwa Abdulhag et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase

(2014) Myriam Bourens et al.   HUMAN MOLECULAR GENETICS

mRNA degradation: an underestimated factor in steady-state transcript levels of cytochrome c oxidase subunits?

(2014) K. Bremer et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The Pet309 pentatricopeptide repeat motifs mediate efficient binding to the mitochondrialCOX1transcript in yeast

(2014) Angélica Zamudio-Ochoa et al.   RNA Biology

The thioredoxin antioxidant system

(2013) Jun Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

hCOA3 Stabilizes CytochromecOxidase 1 (COX1) and Promotes CytochromecOxidase Assembly in Human Mitochondria

(2013) Paula Clemente et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased in vitro Mitochondrial Function is Associated with Enhanced Brain Metabolism, Blood Flow, and Memory in Surfl-Deficient Mice

(2013) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Heme a Synthase Cox15 Associates with Cytochrome c Oxidase Assembly Intermediates during Cox1 Maturation

(2013) B. Bareth et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2

(2013) Siddhesh Aras et al.   NUCLEIC ACIDS RESEARCH

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

(2013) E. Lapuente-Brun et al.   SCIENCE

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

(2013) Ryan J. Mailloux et al.   TRENDS IN BIOCHEMICAL SCIENCES

NDUFA4 Mutations Underlie Dysfunction of a Cytochrome c Oxidase Subunit Linked to Human Neurological Disease

(2013) Robert D.S. Pitceathly et al.   Cell Reports

Mutations in COX7B Cause Microphthalmia with Linear Skin Lesions, an Unconventional Mitochondrial Disease

(2012) Alessia Indrieri et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cardiac mitochondrial matrix and respiratory complex protein phosphorylation

(2012) Raul Covian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Redox and Reactive Oxygen Species Regulation of Mitochondrial Cytochrome c Oxidase Biogenesis

(2012) Myriam Bourens et al.   ANTIOXIDANTS & REDOX SIGNALING

Adaptation of respiratory chain biogenesis to cytochrome c oxidase deficiency caused by SURF1 gene mutations

(2012) Nikola Kovářová et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain

(2012) Eduardo Balsa et al.   Cell Metabolism

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

(2012) Maik Hüttemann et al.   FASEB JOURNAL

A mutation in the FAM36A gene, the human ortholog of COX20, impairs cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia

(2012) Radek Szklarczyk et al.   HUMAN MOLECULAR GENETICS

High-resolution melting analysis of 15 genes in 60 patients with cytochrome-c oxidase deficiency

(2012) Alzbeta Vondrackova et al.   JOURNAL OF HUMAN GENETICS

Deletion of heart-type cytochromecoxidase subunit 7a1 impairs skeletal muscle angiogenesis and oxidative phosphorylation

(2012) Icksoo Lee et al.   JOURNAL OF PHYSIOLOGY-LONDON

Molecular Mechanisms of Ischemia–Reperfusion Injury in Brain: Pivotal Role of the Mitochondrial Membrane Potential in Reactive Oxygen Species Generation

(2012) Thomas H. Sanderson et al.   MOLECULAR NEUROBIOLOGY

Multiple phosphorylations of cytochrome c oxidase and their functions

(2012) Stefan Helling et al.   PROTEOMICS

Redox Regulation of Mitochondrial Function

(2011) Diane E. Handy et al.   ANTIOXIDANTS & REDOX SIGNALING

The O2 reduction and proton pumping gate mechanism of bovine heart cytochrome c oxidase

(2011) Shinya Yoshikawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial calcium handling during ischemia-induced cell death in neurons

(2011) Yves Gouriou et al.   BIOCHIMIE

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

(2011) Daniel Tello et al.   Cell Metabolism

Protein Phosphorylation and Prevention of Cytochrome Oxidase Inhibition by ATP: Coupled Mechanisms of Energy Metabolism Regulation

(2011) Rebeca Acin-Perez et al.   Cell Metabolism

Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy

(2011) Maik Hüttemann et al.   MITOCHONDRION

Mitochondrial disorders caused by mutations in respiratory chain assembly factors

(2011) Francisca Diaz et al.   Seminars in Fetal & Neonatal Medicine

Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H2O2 Signaling

(2010) Michel Rigoulet et al.   ANTIOXIDANTS & REDOX SIGNALING

Human mitochondrial mRNAs—like members of all families, similar but different

(2010) Richard J. Temperley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Assembly factors and ATP-dependent proteases in cytochrome c oxidase biogenesis

(2010) Lukas Stiburek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Dysfunction and Resuscitation in Sepsis

(2010) Albert J. Ruggieri et al.   CRITICAL CARE CLINICS

Signaling pathways in mitochondrial dysfunction and aging

(2010) Cristina Mammucari et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The energetics of genome complexity

(2010) Nick Lane et al.   NATURE

Gene Expression Patterns of Oxidative Phosphorylation Complex I Subunits Are Organized in Clusters

(2010) Yael Garbian et al.   PLoS One

Exocrine Pancreatic Insufficiency, Dyserythropoeitic Anemia, and Calvarial Hyperostosis Are Caused by a Mutation in the COX4I2 Gene

(2009) Eyal Shteyer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Loss of function of Sco1 and its interaction with cytochrome c oxidase

(2009) Lukas Stiburek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

(2009) Werner J.H. Koopman et al.   ANTIOXIDANTS & REDOX SIGNALING

From protons to OXPHOS supercomplexes and Alzheimer's disease: Structure–dynamics–function relationships of energy-transducing membranes

(2009) H. Seelert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cytochromecoxidase isoform IV-2 is involved in 3-nitropropionic acid-induced toxicity in striatal astrocytes

(2009) Shilpee Singh et al.   GLIA

Control of Respiration by CytochromecOxidase in Intact Cells

(2009) Maria Elena Dalmonte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Functions of Mss51 Couple Synthesis of Cox1 to Assembly of Cytochrome c Oxidase in Saccharomyces cerevisiae Mitochondria

(2009) Xochitl Perez-Martinez et al.   MOLECULAR BIOLOGY OF THE CELL

Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome

(2009) Woranontee Weraarpachai et al.   NATURE GENETICS

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources

(2009) Chunlei Wu et al.   GENOME BIOLOGY

Severe Infantile Encephalomyopathy Caused by a Mutation in COX6B1, a Nucleus-Encoded Subunit of Cytochrome C Oxidase

(2008) Valeria Massa et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Assembly of the oxidative phosphorylation system in humans: What we have learned by studying its defects

(2008) Erika Fernández-Vizarra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tumor Necrosis Factor α Inhibits Oxidative Phosphorylation through Tyrosine Phosphorylation at Subunit I of CytochromecOxidase

(2008) Lobelia Samavati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The F1F0-ATP Synthase Complex Influences the Assembly State of the Cytochromebc1-Cytochrome Oxidase Supercomplex and Its Association with the TIM23 Machinery

(2008) Sonika Saddar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY