Review
Biochemistry & Molecular Biology
Wei-Yi Ong, Deron R. Herr, Grace Y. Sun, Teng-Nan Lin
Summary: Recent studies on Clinacanthus nutans have shown its potential anti-inflammatory, anti-tumorigenic, and antiviral properties. The extraction of its leaves has yielded various C-glycosyl flavones, which have been studied for their anti-inflammatory effects. This review focuses on the effects of C. nutans extracts and its phytochemical components on inflammatory signaling pathways in the nervous system. The study highlights their role in targeting the TLR4-NF-kB pathway, antioxidant defense pathway, and PLA2-COX-2 pathway.
Article
Plant Sciences
Chao Xi, Mingyue Zhang, Bingtao Li, Xiaowei Meng, Shangcheng Xu, Hong Du, Xinyi Wang, Jingping Xu, Hong Ke, Yanru Cui, Fei Qu
Summary: The anti-inflammatory effects of Pueraria lobata and Pueraria thomsonii have been confirmed, and their mechanism of action involves regulating arachidonic acid metabolism and glutathione metabolism. These findings provide a scientific basis for the development of new drugs for inflammation-related diseases and lay a foundation for the utilization of herbal resources such as Pueraria lobata and Pueraria thomsonii.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yang Xu, Liangliang Xiong, Yushu Yan, Dejuan Sun, Yanwei Duan, Hua Li, Lixia Chen
Summary: Stemona tuberosa, a traditional medicine widely used in China and South Asian regions, was found to contain 29 alkaloids, including eight newly discovered compounds. These compounds showed inhibitory effects on NO production in experimental cells.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ying-Jie Sun, Shi-Jie Cao, Feng-Ni Liang, Jin-Yan Li, Xiang-Yu Zhang, Wei Li, Li-Qin Ding, Feng Qiu
Summary: Five undescribed puerols and puerosides, along with three known analogues, were isolated from the roots of Pueraria lobata. Their structures were determined through comprehensive analysis of spectroscopic data and chemical methods. The absolute configurations of racemic compounds puerol D and puerol C were determined using experimental and calculated ECD spectra. The inhibitory activities of six isolates on NO generation and expression of inflammatory factors were evaluated, with (S)-puerol C, (R)-puerol C, isokuzubutenolide A, and kuzubutenolide A showing significant inhibitory effects.
Article
Plant Sciences
Nalluri Vedasree, Kotha Peddanna, Allagadda Rajasekhar, Chinthirla ParthaSarathi, Pasupuleti Munirajeswari, Yallanki Sireesha, Appa Rao Chippada
Summary: This study confirmed the anti-diabetic effects of Cyanotis tuberosa root tubers (CTRT) in diabetic rats by improving insulin secretion, glycemic control, and restoring functional activities of the liver and kidney.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Saori Inui, Takahiro Hosoya, Kazuma Yoshizumi, Hajime Sato, Shigenori Kumazawa
Summary: Propolis is a chemically complex resinous product collected by honeybees from various plant sources, which has anti-inflammatory activity. Senegalese propolis contains phenolic compounds with high anti-inflammatory activity, indicating potential applications as anti-inflammatory agents.
Article
Chemistry, Applied
Cristiane Catela Martins de Jesus, Marlon Heggdorne de Araujo, Thatiana Lopes Bia Ventura Simao, Elena B. Lasunskaia, Thiago Barth, Michelle Frazao Muzitano, Shaft Correa Pinto
Summary: The compound orientin has been found to have antimycobacterial activity against drug-resistant strains of tuberculosis, as well as immunomodulatory effects and low cytotoxicity.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
Feihe Lian, Jun Chi, Qionglin Meng, Qingxia Li, Anying Chen, Zhimin Wang, Liping Dai
Summary: Six new cucurbitane-type triterpenes, hemchinins A-F (1-6), were isolated from Hemsleya chinensis tubers along with thirteen known compounds (7-19). Compounds 1-2 possess an infrequent pentacyclic framework and their structures were determined through comprehensive analyses. Bioassay results showed that most of the isolated compounds have anti-inflammatory activity, with compounds 13 and 15 exhibiting stronger activity at 6.25 μM, with NO inhibition rates of 49.00 +/- 0.05% and 48.40 +/- 0.10%, respectively.
Article
Biochemistry & Molecular Biology
Gui-Yang Xia, Dong-Jie Fang, Ling-Yan Wang, Huan Xia, Ya-Nan Wang, Hong-Cai Shang, Sheng Lin
Summary: Six new protoberberine derivatives, including yanhusanines H-L with a unique 13,13a-seco skeleton, were isolated from Corydalis yanhusuo tubers. Among them, yanhusanine J showed potent inhibitory effect against nitric oxide production and anti-inflammatory activity by suppressing NF-kappa B pathway. Molecular docking analysis suggested strong interaction of yanhusanine J with iNOS protein.
Article
Chemistry, Multidisciplinary
Trinh Nhat Thi Pham, Tuan Trong Nguyen, Thuy Le Thi Nguyen, An Minh Nguyen Tran, Tuan Ngoc Nguyen, Danh Thanh Tong, Dung Tien Le
Summary: In Vietnam, Ruellia tuberosa L. is used to treat stress oxidation and inflammatory symptoms in diabetes mellitus. This study found that the extract and compounds isolated from Ruellia tuberosa L. exhibited potent antioxidant and anti-inflammatory activities.
JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Taghrid S. AlOmar, Abdur Rauf, Umer Rashid, Sehrish Sarfaraz, Khurshid Ayub, Fahad Hussain, Najla Almasoud, Abdulaziz S. AlOmar, Gauhar Rehman, Zubair Ahmad, Naveed Muhammad, Zafar Ali Shah
Summary: This study evaluates the anti-inflammatory potential of peshawaraquinone, a compound isolated from Fernandoa adenophylla, and investigates its mode of action. The results demonstrate significant anti-inflammatory activity of peshawaraquinone in both in vitro and in vivo models, supported by computational analyses. These findings provide a solid foundation for further exploration and therapeutic applications of peshawaraquinone.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Edita Ritmejeryte, Rachael Y. M. Ryan, Brendan Byatt, Yoshimi Peck, Karma Yeshi, Norelle L. Daly, Guangzu Zhao, Darren Crayn, Alex Loukas, Stephen G. Pyne, Roland Ruscher, Phurpa Wangchuk
Summary: Two new compounds were isolated from Uromyrtus metrosideros leaf extract and showed significant suppression on proinflammatory cytokines involved in inflammatory bowel disease. These compounds have the potential to be candidates for IBD treatment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Xavier Capo, Miquel Martorell, Josep A. Tur, Antoni Sureda, Antoni Pons
Summary: Pork lard shows anti-inflammatory properties in a rat model of zymosan-induced inflammation, with the main components of the hydroalcoholic extract being 5-dodecanolide, oleamide, and resolvin D1. Both the extract and its components reduce the immune response and activities of inflammatory markers in immune cells, with 5-dodecanolide playing a significant role in the observed anti-inflammatory effects.
Article
Biochemistry & Molecular Biology
Priya Shree, Priyanka Mishra, Prateek Kumar, Harsh Pandey, Rajanish Giri, Radha Chaube, Neha Garg, Yamini Bhusan Tripathi
Summary: The study identified multiple phytochemicals from Pueraria tuberosa that may serve as potential inhibitors for the COVID-19 virus, with compounds like Robinin, Daidzin, and Hydroxytuberosone showing promise. Further analysis demonstrated the safety and potential utility of these plant compounds for inhibiting COVID-19 targets.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Plant Sciences
Bhanupriya Kanthaliya, Abhishek Joshi, Jaya Arora, Mashael Daghash Alqahtani, Elsayed Fathi Abd Allah
Summary: The present study evaluated the effects of different concentrations of biotic elicitors on the growth, antioxidant activity, and metabolite accumulation in in vitro propagated shoots of Pueraria tuberosa. The results showed that the elicitors significantly increased biomass and metabolite contents, with the best effect observed in cultures treated with 100 mg/L pectin. Furthermore, pectin treatment promoted the accumulation of isoflavonoids. Overall, the application of different biotic elicitors improved the growth and metabolite accumulation in P. tuberosa, providing potential phytopharmaceutical advantages in the future.
Article
Public, Environmental & Occupational Health
Faisal Ismail, Atiya Farag, Soghra Haq, Mohammad A. Kamal
Summary: This study reports the clinical features of suspected COVID-19 patients in Tobruk, Libya, and reflects on the challenges of diagnosis in low-resource settings. The most common symptoms among these patients were fever, cough, and dyspnea. Chest X-ray abnormalities were not observed in all patients.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2023)
Review
Neurosciences
Faijan Akhtar, Parth K. Patel, Md Belal Bin Heyat, Saba Yousaf, Atif Amin Baig, Rashenda Aziz Mohona, Muhamad Malik Mutoffar, Tanima Bhattacharya, Bibi Nushrina Teelhawod, Jian Ping Li, Mohammad Amjad Kamal, Kaishun Wu
Summary: This study aims to determine the research volume conducted on students who are affected by smartphone addiction and design a database. It also provides a comprehensive image of smartphone-addicted students and highlights critical problems for future research.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Biochemistry & Molecular Biology
Fariya Khan, Salman Akhtar, Mohammad Amjad Kamal
Summary: The emerging field of nanoinformatics, combining bioinformatics and nanotechnology, offers new research opportunities for the development of personalized nanomedicine in cancer therapy. This approach has the potential to revolutionize the field of precision medicine by providing non-invasive and versatile treatment options for cancer patients.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Athanasios Alexiou, Christos Tsagkaris, Stylianos Chatzichronis, Andreas Koulouris, Ioannis Haranas, Ioannis Gkigkitzis, Georgios Zouganelis, Nobendu Mukerjee, Swastika Maitra, Niraj Kumar Jha, Gaber El-Saber Batiha, Mohammad Amjad Kamal, Michail Nikolaou, Ghulam Md Ashraf
Summary: Even though cancer therapies have improved, the number of patients has increased, making cancer the fifth deadliest disease. Efficient drug delivery systems must overcome barriers and maximize drug delivery while limiting side effects. Quantum-inspired solutions, such as using quantum tunneling phenomenon in scanning tunneling microscopes, allow for accurate mapping of tumor surfaces and efficient nanodrug design.
CURRENT MEDICINAL CHEMISTRY
(2023)
Letter
Public, Environmental & Occupational Health
Faisal Ismail, Atiya Farag, Soghra Haq, Mohammad Amjad Kamal
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2023)
Review
Endocrinology & Metabolism
Nobendu Mukerjee, Swastika Maitra, Subhradeep Roy, Shaswata Modak, Mohammad Mehedi Hasan, Biswajit Chakraborty, Arabinda Ghosh, Asmita Ghosh, Mohammad Amjad Kamal, Abhijit Dey, Ghulam Md Ashraf, Sumira Malik, Md Habibur Rahman, Badrah S. Alghamdi, Adel Mohammad Abuzenadah, Athanasios Alexiou
Summary: Glioblastoma is an aggressive tumor that hinders normal brain function, and the inability of the skull to expand results in increased pressure in the brain. Recent studies have found that SNPs play a significant role in the development and spread of glioblastoma, with many GB-related SNPs being highly abundant in the promoter region, creating genetic vulnerability to glioma.
METABOLIC BRAIN DISEASE
(2023)
Editorial Material
Neurosciences
Mohammad Amjad Kamal, Athanasios Alexiou, Asma Perveen
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Syed Mohd Danish Rizvi, Talib Hussain, Farhan Alshammari, Hana Sonbol, Nabeel Ahmad, Syed Shah Mohammed Faiyaz, Mohammad Amjad Kamal, El-Sayed Khafagy, Afrasim Moin, Amr Selim Abu Lila
Summary: Infections caused by resistant bacterial pathogens have become more complicated for clinicians worldwide. Researchers have developed gold nanoparticles (AuNPs) that efficiently deliver cephalosporin antibiotics to resistant clinical pathogens. The synthesized AuNPs showed high stability and were effective against resistant strains of E. coli and K. pneumoniae. This study suggests that investing in a nano-antibiotic strategy may be a better approach to overcome resistance.
Review
Pharmacology & Pharmacy
Syed Mohd Danish Rizvi, Amr Selim Abu Lila, Afrasim Moin, Talib Hussain, Mohammad Amjad Kamal, Hana Sonbol, El-Sayed Khafagy
Summary: The advent of new antibiotics has helped control severe bacterial infections, but inappropriate use and resistance mechanisms still pose challenges. Extended-spectrum beta-lactamases (ESBLs) genes have become one of the most common approaches for bacteria to develop resistance. Nanotechnology, specifically gold nanoparticles (AuNPs), has shown potential in converting unresponsive antibiotics into potent ones against resistant strains.
Article
Pharmacology & Pharmacy
Shailja Singhal, Utsang Kumar, Taha Alqahtani, Igor Vladimirovich Rzhepakovsky, Rekha Khandia, Megha Pandey, Saud Alqahtani, Hanan Alharbi, Mohammad Amjad Kamal
Summary: Apoptosis and autophagy are two fundamental processes involved in maintaining homeostasis, and they can be initiated by a common stimulus. Autophagy has been implicated in various diseases, including viral infections. Genetic manipulations that alter gene expression could be a strategy to control viral infection.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Divyanshi Shukla, Amer M. Alanazi, Siva Prasad Panda, Vivek Dhar Dwivedi, Mohammad Amjad Kamal
Summary: In this study, a QSAR-based chemical library screening was conducted to identify potential RdRp inhibitors from the Meliaceae family. The top two hit compounds were further analyzed using molecular docking and molecular dynamics simulations, which showed stable binding interactions with RdRp and comparable binding energies to known inhibitors. Compound IMPHY009135 exhibited the strongest binding affinity, while compound IMPHY009276 showed the most stable structure. These findings suggest that these two compounds could be potential lead compounds for developing novel antiviral agents against ZIKV.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biology
Gnana Deepthi Medarametla, Ripudaman Singh Kahlon, Lampimukhi Mahitha, Sanobar Shariff, Naga Praneeth Vakkalagadda, Hitesh Chopra, Mohammad Amjad Kamal, Neil Patel, Yashendra Sethi, Nirja Kaka
Summary: Amyloidosis is a protein deposition disorder that damages organ function by causing the accumulation of insoluble fibrils in bodily tissues. Cardiac amyloidosis, a severe and under-reported condition, involves the accumulation of amyloid in the extracellular area of the myocardium, leading to thickening and stiffening of ventricular walls. The incidence of cardiac amyloidosis has been slowly increasing, and this study aims to provide a comprehensive understanding of its pathophysiology and clinical presentation, as well as offer up-to-date approaches for diagnosis and therapy. Genetic mutations and advancements in imaging and diagnostic methods contribute to the growing incidence of cardiac amyloidosis. Early detection can help improve treatment outcomes, and various therapeutic approaches are being explored to impede disease progression and enhance clinical outcomes.
Review
Biochemistry & Molecular Biology
Ligen Yu, Mohd Khanapi Abd Ghani, Alessio Aghemo, Debmalya Barh, Matteo Bassetti, Fausto Catena, Gaetano Gallo, Ali Gholamrezanezhad, Mohammad Amjad Kamal, Amos Lal, Kamal Kant Sahu, Shailendra K. Saxena, Ugo Elmore, Farid Rahimi, Chiara Robba, Yuanlin Song, Zhengyuan Xia, Boxuan Yu
Summary: This study analyzed keywords and found that factors such as the immune system and nutrition are related to COVID-19. It proposed that the human immune system is a complex system that employs self-destruct and rebuild strategies to fight microbial infections. Microbial infections may be self-limiting and provide essential nutrition for the patient. The study also discussed possible strategies to mitigate COVID-19, including vaccination.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Computer Science, Artificial Intelligence
Pongtep Weerapong, Kotaro Hashikura, Md Abdus Samad Kamal, Iwanori Murakami, Kou Yamada
Summary: This paper discusses a method to evaluate the prediction accuracy of a wheelchair-occupant simulation model by comparing it with real-world experimental results. Different types of seat cushions are used in the model to simulate the low-frequency vibration waves caused by the interaction between wheelchair tires and the ground. The analysis shows that the occupant's torso is most affected by the vibration, resulting in the maximum displacement of organs; and the foam-based cushion performs the best in reducing the amplitude of displacement responses.
INTERNATIONAL JOURNAL OF INNOVATIVE COMPUTING INFORMATION AND CONTROL
(2023)
Article
Computer Science, Artificial Intelligence
Sorawin Phukapak, Daisuke Koyama, Kotaro Hashikura, Md Abdus Samad Kamal, Kou Yamada
Summary: In this paper, the parameterization of all disturbance observers for periodic output disturbances is examined. Disturbance observers have been used to estimate disturbances in plants. While previous papers have clarified the parameterization of all disturbance observers for plants, none have focused on periodic output disturbances. This paper proposes a parameterization method for all disturbance observers for periodic output disturbances.
INTERNATIONAL JOURNAL OF INNOVATIVE COMPUTING INFORMATION AND CONTROL
(2023)