Resveratrol Prevents ROS-Induced Apoptosis in High Glucose-Treated Retinal Capillary Endothelial Cells via the Activation of AMPK/Sirt1/PGC-1α Pathway

Oxidative stress induces loss of pericyte coverage and vascular instability in PGC-1α-deficient mice

(2016) Nieves García-Quintans et al.   ANGIOGENESIS

Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats

(2016) Hnin Ei Phyu et al.   BRITISH JOURNAL OF NUTRITION

Resveratrol via activation of LKB1-AMPK signaling suppresses oxidative stress to prevent endothelial dysfunction in diabetic mice

(2016) Min Hu et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Regulation of endothelial dynamics by PGC-1α relies on ROS control of VEGF-A signaling

(2016) Nieves García-Quintans et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overexpression of uncoupling protein 2 inhibits the high glucose-induced apoptosis of human umbilical vein endothelial cells

(2016) YING HE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults

(2016) Małgorzata Nita et al.   Oxidative Medicine and Cellular Longevity

Resveratrol and Ophthalmic Diseases

(2016) Khaled Abu-Amero et al.   Nutrients

Application of Resveratrol in Diabetes: Rationale, Strategies and Challenges

(2015) P.K. Bagul et al.   CURRENT MOLECULAR MEDICINE

Anti-inflammatory properties of resveratrol in the retinas of type 2 diabetic rats

(2014) Farhad Ghadiri Soufi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Control of endothelial function and angiogenesis by PGC-1α relies on ROS control of vascular stability

(2014) Nieves García-Quintans et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol improves diabetic retinopathy possibly through oxidative stress – nuclear factor κB – apoptosis pathway

(2014) Farhad Ghadiri Soufi et al.   Pharmacological Reports

Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits?

(2013) Silvie Timmers et al.   Annals of the New York Academy of Sciences

Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart

(2013) Wenjun Yan et al.   BASIC RESEARCH IN CARDIOLOGY

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1

(2013) Gnanapragasam Arunachalam et al.   BRITISH JOURNAL OF PHARMACOLOGY

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Finding a Target for Resveratrol

(2012) Ruth I. Tennen et al.   CELL

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice

(2012) M. Y. Kim et al.   DIABETOLOGIA

Role of the retinal vascular endothelial cell in ocular disease

(2012) Arpita S. Bharadwaj et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway

(2011) M. Kitada et al.   DIABETES

Sirtuin 1-Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin

(2011) Z. Zheng et al.   DIABETES

AMP-activated protein kinase and its downstream transcriptional pathways

(2010) Carles Cantó et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Improvement of Retinal Vascular Injury in Diabetic Rats by Statins Is Associated With the Inhibition of Mitochondrial Reactive Oxygen Species Pathway Mediated by Peroxisome Proliferator-Activated Receptor   Coactivator 1 

(2010) Z. Zheng et al.   DIABETES

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation

(2010) Valérie Vingtdeux et al.   FASEB JOURNAL

Diabetic retinopathy

(2010) Ning Cheung et al.   LANCET

AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

(2009) J.-H. Um et al.   DIABETES

Diabetes-Enhanced Tumor Necrosis Factor-α Production Promotes Apoptosis and the Loss of Retinal Microvascular Cells in Type 1 and Type 2 Models of Diabetic Retinopathy

(2008) Yugal Behl et al.   AMERICAN JOURNAL OF PATHOLOGY