Article
Multidisciplinary Sciences
Daijiro Haba, Gojiro Nakagami, Takeo Minematsu, Hiromi Sanada
Summary: The study found that a LFV of 50 Hz, 1000 mVpp, 40 min/d, over 5 days was optimal for accelerating AMPK-mediated GLUT4 translocation and glucose uptake in adipocytes.
Article
Biochemistry & Molecular Biology
Xiaoqin Liang, Shengping Deng, Yan Huang, Liwei Pan, Yanling Chang, Ping Hou, Chenyang Ren, Weifeng Xu, Ruiyun Yang, Kanyuan Li, Jun Li, Ruijie He
Summary: By analyzing the structures of natural compounds isolated from Cyclocarya paliurus leaves and conducting experiments, it was found that three of these compounds have stimulating effects on glucose uptake in adipocytes under insulin stimulation, showing a dose-dependent relationship. This suggests the potential application of abundant natural compounds from C. paliurus leaves in the treatment of diabetes.
Article
Biochemistry & Molecular Biology
Xue-Lin Chen, Kun Zhang, Xia Zhao, Han-Lei Wang, Mei Han, Ru Li, Zhen-Nan Zhang, Yu-Mei Zhang
Summary: Three new triterpenes and fourteen known triterpenoids were isolated from Kochiae Fructus, and their structures were elucidated. Compound 13 showed potent effect on glucose uptake in adipocytes. Compounds 3, 9, and 13 exhibited significant inhibitory activities against alpha-glucosidase, with their inhibitory activities and binding capacities with alpha-glucosidase reported for the first time. These compounds could have therapeutic potentials for type 2 diabetes mellitus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jennifer L. Bailey, Hardy Hang, Anik Boudreau, Carrie M. Elks
Summary: The study found that OSM induces adipocyte lipolysis via the p66Shc-ERK pathway, inhibiting the suppression of lipolysis by insulin, and inducing phosphorylation of inhibitory IRS1 residues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anjar P. Asmara, Anchalee Prasansuklab, Anchalee Chiabchalard, Hui Chen, Alison T. Ung
Summary: Methanolic extracts from various parts of Acacia saligna showed significant antioxidant activities. These extracts and isolated compounds were able to reduce cellular reactive oxygen species (ROS) levels and maintain mitochondrial function in 3T3-L1 adipocytes. They also activated the AMPK signaling pathway and enhanced glucose uptake.
Article
Biochemistry & Molecular Biology
Kyung Dong Lee, Soundharrajan Ilavenil, Muthusamy Karnan, Chul-Ju Yang, Dahye Kim, Ki Choon Choi
Summary: This study investigates the role of cell-free metabolites from Bacillus ginsengihumi-RO6 in adipogenesis and lipogenesis, suggesting a potential novel probiotic for treating obesity and metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Su Bu, Anran Xiong, Zhiying Yang, Faycal Aissa-Brahim, Ying Chen, Yichun Zhang, Xunyong Zhou, Fuliang Cao
Summary: Bilobalide exhibits beneficial bioactivities such as neuroprotection, anti-inflammation, and antioxidant effects. The study demonstrates that bilobalide can induce apoptosis in mature adipocytes through the ROS-mediated mitochondrial pathway.
Article
Food Science & Technology
In-Seon Bae, Jeong Ah Lee, Soo-Hyun Cho, Hyoun-Wook Kim, Yunseok Kim, Kangmin Seo, Hyun-Woo Cho, Min Young Lee, Ju Lan Chun, Ki Hyun Kim
Summary: This study demonstrates for the first time that rabbit meat extract induces browning of white adipocytes through activation of the AMPK pathway, leading to a reduction in adipocyte differentiation and triglyceride content, and an increase in hormone-sensitive lipase activity.
Article
Biotechnology & Applied Microbiology
Bo-Yang Hsu, Chia-Hui Chen, Ting-Jang Lu, Min-Hsiung Pan, Chi-Tang Ho, Lucy Sun Hwang, Wei-Lun Hung
Summary: The study investigated the hypoglycemic activities of American ginseng extraction residue (AmR) by fermentation with Ganoderma lucidum. Results showed that the total phenolic contents and beta-glucosidase activity of AmR increased significantly after fermentation. Fermented AmR (FAmR) exhibited insulin-like glucose-uptake-stimulatory effects, which were positively associated with the amount of deglycosylated minor ginsenosides Rg1, Rg3, and compound K. This suggests that bioconversion of AmR by fermentation with G. lucidum may be a feasible approach for managing diabetes and reducing ginseng waste.
FERMENTATION-BASEL
(2021)
Article
Medicine, Research & Experimental
Trang Thi Huyen Dang, Jong Won Yun
Summary: Our study revealed a previously unknown mechanism in the regulation of browning by CYP2E1 in 3T3-L1 white adipocytes, suggesting that CYP2E1 is a promising molecular target for the treatment of obesity and its related diseases. It was found that deficiency of CYP2E1 results in reduced adipogenesis and lipogenesis as well as induction of brown adipocyte-like phenotype. Moreover, CYP2E1 inhibition deters the activation of the 83-adrenergic receptor and its downstream targets, highlighting its potential role in lipid metabolism and browning in white adipocytes.
Article
Pharmacology & Pharmacy
Sung Ho Lim, Jae Sik Yu, Ho Seon Lee, Chang-Ik Choi, Ki Hyun Kim
Summary: Rutin and Q3G isolated from Morus alba fruits have the potential to improve glucose uptake by activating the Akt and AMPK signaling pathways, making them potential therapeutic candidates for managing type 2 diabetes with fewer side effects.
Article
Biochemistry & Molecular Biology
Francisco J. Cimas, Miguel Angel De la Cruz-Morcillo, Carmen Cifuentes, Natalia Moratalla-Lopez, Gonzalo L. Alonso, Eduardo Nava, Silvia Llorens
Summary: CCT, a saffron-derived apocarotenoid, has anti-adipogenic, anti-inflammatory, and antioxidant activities. This study found that CCT decreased glycerol release and lipid accumulation, inhibited key lipolytic enzymes, and exhibited antioxidant and anti-inflammatory effects. These findings suggest that CCT may be a promising compound for improving lipid mobilisation in obesity.
Article
Pharmacology & Pharmacy
Chaiwat Monmai, Jin-Suk Kim, Hyun Bo Sim, Doh-Won Yun, Sung-Dug Oh, Eui-Shik Rha, Jong-Jin Kim, So-Hyeon Baek
Summary: This study evaluated the effects of extracts from transgenic rice on inhibiting adipogenesis and anti-inflammatory activity. The results showed that the extracts significantly reduced lipid accumulation in cells and inhibited the expression of adipogenesis-related mRNA and inflammation-related factors. Therefore, transgenic rice may have potential as an obesity-reducing and/or -preventing agent.
Article
Biochemistry & Molecular Biology
Jorge G. Garcia, Eduardo Ansorena, Fermin I. Milagro, Guillermo Zalba, Carlos de Miguel
Summary: This study suggests that endothelial NOX5 expression may regulate glucose sensitivity and lipid homeostasis in adipose tissue under conditions of high-calorie diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Subramani Manigandan, Sulagna Mukherjee, Jong Won Yun
Summary: The study identified FAM107A as a factor that interferes with fat browning in white adipocytes. Deficiency of FAM107A promoted mitochondrial biogenesis and significantly upregulated core fat-browning marker proteins, as well as beige-specific genes. The data revealed a previously unknown mechanism of FAM107A in the regulation of lipid metabolism and its significant role in metabolic homeostasis.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Nutrition & Dietetics
Charlotte Wernicke, Anne Pohrt, Laura Pletsch-Borba, Konstantina Apostolopoulou, Silke Hornemann, Nina Meyer, Jurgen Machann, Christiana Gerbracht, Frank Tacke, Andreas F. H. Pfeiffer, Joachim Spranger, Knut Mai
Summary: This study aimed to assess the long-term effects of a dietary intervention high in protein and unsaturated fatty acids on intrahepatic lipids and metabolism. The study found that in adherent older individuals following dietary recommendations, a high-protein and unsaturated fatty acids diet can have beneficial long-term effects on liver fat and lipid metabolism.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Robert Wagner, Martin Heni, Konstantinos Kantartzis, Arvid Sandforth, Juergen Machann, Fritz Schick, Andreas Peter, Louise Fritsche, Julia Szendroedi, Andreas F. H. Pfeiffer, Annette Schuermann, Matthias Blueher, Hans Hauner, Jochen Seissler, Stefan Bornstein, Michael Roden, Norbert Stefan, Andreas L. Birkenfeld, Morris F. White, Hans-Ulrich Haering, Andreas Fritsche
Summary: The objective of this study was to examine the effects of lifestyle intervention on impaired insulin secretion in specific subphenotypes of prediabetes. Participants from the Prediabetes Lifestyle Intervention Study were divided into six prediabetes clusters and assessed for insulin secretion, glycemia, insulin sensitivity, and liver fat changes during a 1-year intervention. The lifestyle intervention improved glycemic traits in all high-risk clusters, while insulin secretion increased only in clusters 3 and 5. However, high liver fat in cluster 5 hindered the improvement of insulin secretion.
Editorial Material
Cardiac & Cardiovascular Systems
Oliver Schnell, Tadej Battelino, Richard Bergenstal, Andreas L. Birkenfeld, Antonio Ceriello, Alice Cheng, Melanie Davies, Steve Edelman, Thomas Forst, Francesco Giorgino, Jennifer Green, Per-Henrik Groop, Samy Hadjadj, Hiddo J. L. Heerspink, Marcus Hompesch, Baruch Izthak, Linong Ji, Naresh Kanumilli, Boris Mankovsky, Chantal Mathieu, Martin Miszon, Reem Mustafa, Michael Nauck, Roberto Pecoits-Filho, Jeremy Pettus, Kari Ranta, Helena W. Rodbard, Peter Rossing, Lars Ryden, Petra-Maria Schumm-Draeger, Scott D. Solomon, Jan Skrha, Pinar Topsever, Tina Vilsboll, John Wilding, Eberhard Standl
Summary: The 8th Cardiovascular Outcome Trial (CVOT) Summit focused on discussing and exchanging recently completed outcomes trials and key trials important to the cardiovascular field. Topics included the results of trials on heart failure, chronic kidney disease, and obesity, as well as consensus recommendations and guideline updates on diabetes and CKD management. The impact of cardiovascular outcomes on liver disease trials and the role of real-world evidence in confirming trial outcomes were also discussed. The 9th CVOT Summit will be held virtually on November 23-24, 2023.
CARDIOVASCULAR DIABETOLOGY
(2023)
Editorial Material
Cell Biology
Norbert Stefan, Fritz Schick, Andreas L. Birkenfeld, Hans-Ulrich Haering, Morris F. White
Summary: Non-alcoholic fatty liver disease (NAFLD) is both a consequence and a cause of insulin resistance and major non-communicable diseases (NCDs). The close relationship between NAFLD and visceral obesity has led to the overshadowing of fatty liver as the main pathomechanism of insulin resistance and NCDs. However, the concept of hepatokines provides a new perspective on the role of the liver in metabolism and offers potential for precision medicine in NAFLD and visceral obesity.
Article
Nutrition & Dietetics
Jiudan Zhang, Sylva Mareike Schaefer, Stefan Kabisch, Marta Csanalosi, Bettina Schuppelius, Margrit Kemper, Mariya Markova, Nina Marie Tosca Meyer, Olga Pivovarova-Ramich, Farnaz Keyhani-Nejad, Sascha Rohn, Andreas F. H. Pfeiffer
Summary: This study investigates the contribution of amino acids to postprandial hyper-glucagonemia in type 2 diabetes patients. The research shows that type 2 diabetes patients have excessive glucagon responses after mixed meals, while the obese control group only shows small initial and delayed greater glucagon responses. The role of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in mixed meals is unclear.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Carlotta Hoffmann, Peter E. Schwarz, Christos S. Mantzoros, Andreas L. Birkenfeld, Christian Wolfrum, Michele Solimena, Stefan R. Bornstein, Nikolaos Perakakis
Summary: This study aimed to compare the concentrations of GLP-1, glucagon, GIP, and glicentin during an OGTT in patients with different glycemic states. The results showed that hormonal levels did not differ between groups when all subjects were in a prediabetic state. However, one year later, patients progressing to diabetes had lower postprandial increases of glicentin and GLP-1, lower postprandial decrease of glucagon, and higher levels of fasting GIP compared to patients regressing to NGT. Changes in glicentin and GLP-1 were found to be negatively correlated with changes in glucose levels and beta-cell function markers.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Estela Lorza-Gil, Gabriele Kaiser, Christopher Carlein, Markus D. A. Hoffmann, Gabriele M. Koenig, Sieglinde Haug, Leticia Prates Roma, Elisabeth Rexen Ulven, Trond Ulven, Evi Kostenis, Andreas L. Birkenfeld, Hans-Ulrich Haering, Susanne Ullrich, Felicia Gerst
Summary: Research shows that NEFA plays an important role in the functional maturation and adaptive insulin secretion of neonatal beta cells, with FFA1 being a critical factor. FFA1 promotes insulin secretion and is essential in the adaptation of offspring beta cells to parental high-fat feeding.
Article
Endocrinology & Metabolism
Simon I. I. Dreher, Martin Irmler, Olga Pivovarova-Ramich, Katharina Kessler, Karsten Juerchott, Carsten Sticht, Louise Fritsche, Patrick Schneeweiss, Juergen Machann, Andreas F. H. Pfeiffer, Martin Hrabe de Angelis, Johannes Beckers, Andreas L. L. Birkenfeld, Andreas Peter, Andreas M. M. Niess, Cora Weigert, Anja Moller
Summary: This study examined the response of subcutaneous adipose tissue (SAT) to exercise and compared it with skeletal muscle. The results showed that SAT responds differently to exercise, with reductions in transcripts related to lipid storage and lipogenesis, as well as modulation of the circadian rhythm, which can potentially prevent metabolic syndrome progression towards diabetes.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Viktor Rotbain Curovic, Nete Tofte, Morten Lindhardt, Katarina Adamova, Stephan J. L. Bakker, Joachim Beige, Joline W. J. Beulens, Andreas L. Birkenfeld, Gemma Currie, Christian Delles, Ingo Dimos, Lidmila Francova, Marie Frimodt-Moller, Peter Girman, Ruediger Goeke, Tine W. Hansen, Tereza Havrdova, Adriaan Kooy, Gozewijnw D. Laverman, Harald Mischak, Gerjan Navis, Giel Nijpels, Marina Noutsou, Alberto Ortiz, Aneliya Parvanova, Frederik Persson, John R. Petrie, Piero L. Ruggenenti, Femke Rutters, Ivan Rychlik, Justyna Siwy, Goce Spasovski, Marijn Speeckaert, Matias Trillini, Petra Zuerbig, Heiko von der Leyen, Peter Rossing
Summary: This study examines the relationship between baseline diabetic retinopathy (DR) and the risk of developing microalbuminuria, kidney function decline, and cardiovascular events (CVEs) in type 2 diabetes patients. The results show that the presence of DR is associated with an increased risk of developing microalbuminuria and CVEs, but not kidney function decline.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Qingqing Wang, Miriam Hoene, Chunxiu Hu, Louise Fritsche, Robert Ahrends, Gerhard Liebisch, Kim Ekroos, Andreas Fritsche, Andreas L. Birkenfeld, Xinyu Liu, Xinjie Zhao, Qi Li, Benzhe Su, Andreas Peter, Guowang Xu, Rainer Lehmann
Summary: Reliability, robustness, and interlaboratory comparability of quantitative measurements in clinical lipidomics studies are crucial. The different ex vivo stability of lipids in blood poses a risk to data interpretation. Clear recommendations for blood sample collection are necessary. In this study, we used UHPLC-high resolution mass spectrometry to investigate the stability of 417 lipid species in EDTA whole blood under different temperature conditions and time points. Our data suggest that cooling whole blood immediately and continuously, and separating plasma within 4 hours, unless focusing on robust lipids, are recommended. Lists of lipids' ex vivo (in)stability and potential biomarkers in whole blood are provided. Overall, our results contribute to the international efforts in achieving reliable and comparable clinical lipidomics studies in the future.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Medicine, General & Internal
S. E. E. Nissen, A. M. Lincoff, D. Brennan, K. K. K. Ray, D. Mason, J. J. P. Kastelein, P. D. D. Thompson, P. Libby, L. Cho, J. Plutzky, H. E. E. Bays, P. M. M. Moriarty, V Menon, D. E. E. Grobbee, M. J. J. Louie, C-F Chen, N. Li, L. A. Bloedon, P. Robinson, M. Horner, W. J. J. Sasiela, J. McCluskey, D. Davey, P. Fajardo-Campos, P. Petrovic, J. Fedacko, W. Zmuda, Y. Lukyanov, S. J. J. Nicholls
Summary: This study demonstrates that the ATP citrate lyase inhibitor Bempedoic acid can significantly reduce low-density lipoprotein cholesterol levels and is associated with a low incidence of muscle-related adverse events. Among patients unable or unwilling to take statins, Bempedoic acid treatment significantly reduces the risk of major adverse cardiovascular events.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Nutrition & Dietetics
Michael Kruse, Silke Hornemann, Anne-Cathrin Ost, Turid Frahnow, Daniela Hoffmann, Andreas Busjahn, Martin A. Osterhoff, Bettina Schuppelius, Andreas F. H. Pfeiffer
Summary: This study investigated the gene expression changes in white adipose tissue after an isocaloric high-fat diet in healthy human twins. The results showed that fatty acid transport was reduced, while fructose transport was increased, potentially leading to increased de novo lipogenesis. These gene expression changes were partially inherited.
Article
Endocrinology & Metabolism
Ruediger Landgraf, Jens Aberle, Andreas L. Birkenfeld, Baptist Gallwitz, Monika Kellerer, Harald Klein, Dirk Mueller-Wieland, Michael A. Nauck, Hans-Martin Reuter, Erhard Siegel
Article
Endocrinology & Metabolism
Katharina Schuett, Thomas Forst, Andreas L. Birkenfeld, Andreas Zirlik, Dirk Mueller-Wieland, Nikolaus Marx