Editorial Material
Clinical Neurology
Kristina Simonyan, Julie Barkmeier-Kraemer, Andrew Blitzer, Mark Hallett, John F. Houde, Teresa Jacobson Kimberley, Laurie J. Ozelius, Michael J. Pitman, Robert Mark Richardson, Nutan Sharma, Kristine Tanner
Summary: Research priorities for improving clinical management of laryngeal dystonia should focus on identifying disorder-specific biomarkers, elucidating critical nodes within neural networks, and fostering collaborations to facilitate rapid progress in understanding and treatment of this rare disorder.
Review
Medicine, General & Internal
Maja Rogic Vidakovic, Ivana Gunjaca, Josipa Bukic, Vana Kosta, Josko Soda, Ivan Konstantinovic, Braco Boskovic, Irena Bilic, Nikolina Rezic Muzinic
Summary: This narrative review provides a summary of the patho-neuro-physiological and genetic background of focal laryngeal dystonia (LD), as well as the standard treatment options and potential future therapies. It also presents two LD cases and discusses the diagnostic procedures and achievements in treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
VyVy N. Young, Joseph Kidane, Grant E. Gochman, David J. Bracken, Yue Ma, Clark A. Rosen
Summary: This study is the first to objectively assess laryngopharyngeal sensation in AdLD. The findings demonstrate increased laryngopharyngeal sensation in AdLD patients compared to controls. The identification of increased laryngeal hypersensitivity in these patients may improve understanding of AdLD pathophysiology and identify future targets for intervention.
Review
Food Science & Technology
Winnie Yeung, Amanda L. Richards, Daniel Novakovic
Summary: Laryngeal dystonia is a chronic disorder affecting laryngeal movement, primarily interfering with phonation and speech, significantly diminishing patients' quality of life. Botulinum neurotoxin is the standard treatment for LD, with this article providing a comprehensive overview of its clinical application and therapeutic injection techniques in managing LD.
Article
Clinical Neurology
Dongren Yao, Lena C. O'Flynn, Kristina Simonyan
Summary: DystoniaBoTXNet is a deep learning algorithm that identifies a neural network biomarker for predicting the efficacy of botulinum toxin treatment in patients with isolated dystonia, achieving high accuracy and fast computation.
ANNALS OF NEUROLOGY
(2023)
Article
Otorhinolaryngology
Nikita Kohli, Michael Lerner, Jamie Rashty, Diana Kirke, Thomas Stewart, Andrew Blitzer
Summary: This study demonstrates the efficacy of incobotulinumtoxinA in the treatment of adductor spasmodic dysphonia and its potential as an alternative for non-responders to onabotulinumtoxinA.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Clinical Neurology
Lena C. O'Flynn, Kristina Simonyan
Summary: This study investigated the short-term and long-term effects of BoNT treatment on brain function in patients with LD. The results suggest that BoNT-treated patients who benefited from the treatment had reduced activity in the left precuneus compared to untreated patients and patients who did not benefit from the treatment. Additionally, BoNT-treated patients with adductor LD showed decreased activity in the right thalamus, while patients with abductor LD showed reduced activity in the left inferior frontal cortex. There were no significant differences in brain activity between patients with shorter and longer treatment durations. However, patients with intermediate treatment duration of 6-12 years showed reduced activity in the right cerebellum and right prefrontal cortex compared to patients with shorter treatment duration.
Article
Audiology & Speech-Language Pathology
Amy Rutt, Kathleen D. Kennelly, Jhon F. Martinez-Paredes
Summary: This study explores nonbiological factors that can affect the patient experience during Laryngeal Botulinum Toxin injection (LBTX) therapy for Adductor Spasmodic Dysphonia. The study identifies preprocedure education, body position, pain, and stress sensation as potential factors influencing treatment outcomes.
Article
Clinical Neurology
Yi-Ling Kuo, Mo Chen, Teresa J. Kimberley
Summary: The pathophysiology of adductor laryngeal dystonia remains unknown, but there is evidence of disruptions in the inhibitory regulation of sensorimotor cortical areas. Using functional MRI and transcranial magnetic stimulation, an overly activated laryngeal motor cortex was found in dystonia-related tasks. In a dystonia-unrelated task, there was more broadly dispersed activation and reduced intracortical inhibition in adductor laryngeal dystonia compared to controls.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Otorhinolaryngology
Antonia Lagos-Villaseca, Neel K. Bhatt, Parirash Abdolhosseini, Leonel Quinonez, Marcus F. Paoletti, Grant Gochman, Michael M. Johns, Clark A. Rosen, Tzu-Cheg Kao, Tanya K. Meyer
Summary: This study found that despite insurance companies usually mandating a minimum 3-month interval for BoNT treatment injections, there are still many patients with LD and ETVT who choose to receive shorter interval injections to optimize their vocal function.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Review
Neurosciences
Alana B. McCambridge, Lynley V. Bradnam
Summary: This study provides a synthesized understanding of cortical neurophysiology associated with isolated dystonia through meta-analysis of TMS measures. The results indicate a reduction in cortical silent period, short-interval intracortical inhibition, and afferent-induced inhibition in isolated dystonia compared to controls, suggesting potential new treatment targets for this poorly understood movement disorder.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Christopher D. Dwyer, Andree-Anne Leclerc, Sanjeev D. Nandedkar, VyVy N. Young, Clark A. Rosen
Summary: The study of 45 AdSD patients revealed that aiming for an NSS value greater than 200 during phonation prior to BoNT-A toxin injection may reduce unfavorable voice outcomes.
Review
Clinical Neurology
Gamze Kilic-Berkmen, Laura J. Wright, Joel S. Perlmutter, Cynthia Comella, Mark Hallett, Jan Teller, Sarah Pirio Richardson, David A. Peterson, Carlos Cruchaga, Codrin Lungu, H. A. Jinnah
Summary: Dystonia is a rare movement disorder with heterogeneous subtypes and causes, posing challenges for research. The Dystonia Coalition, established in 2009, fosters international collaboration to advance research in defining, classifying, diagnosing, evaluating, and conducting multi-center studies on dystonia.
FRONTIERS IN NEUROLOGY
(2021)
Article
Audiology & Speech-Language Pathology
Robert Brinton Fujiki, Caitlin K. Croegaert-Koch, Susan L. Thibeault
Summary: The study aimed to examine the impact of patient voice-related diagnosis, dysphonia severity, and rater's experience on the correlation between laryngeal oscillation ratings obtained from videostroboscopic and high-speed videoendoscopic (HSV) exams. The results indicated that the correlation between the ratings was stronger for patients with benign vocal fold lesions compared to those with adductor spasmodic dysphonia (ADSD). Differences between the two exams were more significant for various ratings in ADSD patients, especially for raters with less experience. The study suggests further research is needed to understand the clinical implications of these differences.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2023)
Article
Audiology & Speech-Language Pathology
Victoria Vanderaa, Lisa A. Vinney
Summary: The objective of this research was to determine whether there is an association between laryngeal exploration and the prevalence of self-reported upper respiratory infection (URI) at the time of SD onset. Individuals with and without SD were recruited to complete an online survey measure. Significant associations were found between ADSD and LH, mixed SD and LH, and URI at time of SD onset and increased severity of LH symptoms.
Review
Otorhinolaryngology
Justin M. Hintze, Christy L. Ludlow, Stephen F. Bansberg, Charles H. Adler, David G. Lott
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2017)
Article
Engineering, Biomedical
Yourka D. Tchoukalova, Justin M. Hintze, Richard E. Hayden, David G. Lott
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2018)
Article
Audiology & Speech-Language Pathology
Justin M. Hintze, Sharon H. Gnagi, David G. Lott
Article
Surgery
Justin M. Hintze, Donal B. O'Connor, Peter Molony, Paul C. Neary
JOURNAL OF SURGICAL CASE REPORTS
(2017)
Article
Surgery
Justin M. Hintze, Brittany E. Howard, Carrlene B. Donald, Richard E. Hayden
CASE REPORTS IN SURGERY
(2016)