期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 21, 期 12, 页码 2068-2072出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.7b00312
关键词
-
资金
- National Institutes of Health [GM110382]
- Alfred P. Sloan Foundation [FG-2015-65240]
We report herein a process safety assessment of the iron-catalyzed direct olefin diazidation for the preparation of a broad range of synthetically valuable vicinal primary diamines. Differential scanning calorimetry analysis of the corresponding reagents, intermediates, and a list of representative diazide/diaminium salt products revealed that all of them are thermal stable at the reaction temperature. The drop weight test of the diazides suggested that they are moderately impact-sensitive. Guided by this assessment, an optimized olefin diazidation/diamination procedure has been developed which allows for the gram-scale diaminium salt synthesis without purification of the diazide intermediate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据