4.8 Article

Transition-Metal-Free Lactonization of sp2 C-H Bonds with CO2

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ORGANIC LETTERS
卷 19, 期 2, 页码 396-399

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03601

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资金

  1. National Natural Science Foundation of China [21502124]
  2. 1000-Youth Talents Program
  3. Sichuan University
  4. 973 Project from the MOST of China [2015CB856600]

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The transition-metal-free lactonization of heteroaryl and alkenyl C-H bonds with carbon dioxide is reported to synthesize important coumarin derivatives in moderate to excellent yields. These redox-neutral reactions feature a broad substrate scope, good functional group tolerance, facile scalability, and easy product derivatization.

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