期刊
ORGANIC LETTERS
卷 19, 期 18, 页码 4718-4721出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01969
关键词
-
资金
- NSFC [21402200, 21502191, 21672213, 21232001]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- 100 Talents Program
- 1000 Youth Talents Program
gamma-Amino butyric acid (GABA) is the chief inhibitory neurotransmitter in the mammalian central nervous system. Many GABA derivatives are used clinically to prevent or treat neurodegenerative diseases. Copper-catalyzed carboamination of alkenes offers an efficient method to fashion the core structure of GABA derivatives from alkenes. In this reaction, acetonitrile serves as the source of the carbon and nitrogen functionalities used to difunctionalize alkenes. Experimental and density functional theory (DFT) studies were carried out to investigate the mechanism of the reaction, and a copper-catalyzed radical polar crossover mechanism is proposed.
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