期刊
ORGANIC LETTERS
卷 19, 期 7, 页码 1682-1685出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b00471
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资金
- MEXT (Japan)
- JSPS
- Grants-in-Aid for Scientific Research [17H06447, 16K05680] Funding Source: KAKEN
An efficient synthesis of enantioenriched gamma-amino-alpha,beta-usaturated esters was developed by utilizing the palladium-catalyzed decarboxylative rearrangement of enantioenriched allylic carbamates possessing an ester moiety at the allylic position. The reaction proceeded in good yield with a high degree of chirality transfer by making use of Xantphos as a superior ligand for the catalyst. The products directly participated in the formal [3 + 2] cycloaddition reaction with tosyl isocyanate under Bronsted base catalysis to afford enantioenriched beta,gamma-diamino acid derived imidazolidin-2-ones as versatile chiral building blocks.
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