期刊
ORGANIC LETTERS
卷 19, 期 5, 页码 976-979出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03652
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-
资金
- National Natural Science Foundation of China [21072055]
Although deprotonation of electron-poor C-H bonds to carbon anions with bases has long been known and widely used in organic synthesis, the hydride elimination from electron-rich C-H bonds to carbon cations or partial carbocations for the introduction of nucleophiles is a comparatively less explored area. Here we report that the carbonyl beta-C(sp(3))-H bond hydrogens of ortho-acyl phenols could be substituted by intramolecular phenolic hydroxyls to form O-heterocycles, followed by dehydrogenation of the O-heterocycle into flavonoids. The cascade reaction is catalyzed by Pd/C without added oxidants andsacrificing hydrogen acceptors.
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