Article
Chemistry, Applied
Loveleen Kaur Gulati, Gurleen Kaur Gulati, Satish Kumar
Summary: This article discusses the use of photochromism in photodynamic therapy, highlighting the potential of photochromic substances in three different roles to enhance efficacy: as photosensitizers, switches to conventional photosensitizers, and reserves of singlet oxygen.
Article
Spectroscopy
Jin Bai, Lei Zhang, Ying Qian
Summary: In this study, a novel NIR and lysosomal targeting thiophene-BODIPY photosensitizer SBOP-Lyso was synthesized to explore its potential applications in photodynamic therapy. SBOP-Lyso demonstrated high singlet oxygen yield, good biocompatibility, and effective inhibition of A549 cells migration. The unique lysosome-targeted properties of SBOP-Lyso make it a promising candidate for cancer cell PDT.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Multidisciplinary
Ezel Ozturk Gunduz, Berkan Tasasiz, M. Emre Gedik, Gurcan Gunaydin, Elif Okutan
Summary: Three multifunctional targeted NI-BODIPYs and GO nanocarriers were fabricated for specific recognition of cancer cells and efficient singlet oxygen production. Detailed characterization, photophysical/ photochemical properties, and interactions with GO were studied. Formation of nanohybrids with GO promoted singlet oxygen formation and showed no dark toxicity, as evaluated with human chronic myelogenous leukemia cells.
Review
Chemistry, Inorganic & Nuclear
Jun Wang, Qingbao Gong, Lijuan Jiao, Erhong Hao
Summary: Photodynamic therapy (PDT) is a promising approach for anticancer and antibacterial treatment by generating reactive oxygen species (ROS) through light activation. BODIPY dyes, as the most important element of PDT, face challenges of poor water solubility, low tumor selectivity, and limited biocompatibility.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Engineering, Environmental
Ziyong Li, Si Chen, Yurou Huang, Hui Zhou, Shuren Yang, Haining Zhang, Mingxing Wang, Hui Guo, Jun Yin
Summary: Researchers have developed a novel photosensitizer system that allows for reversible control over singlet oxygen generation. This photosensitizer exhibits excellent aggregation-induced emission properties and photoswitching behavior, making it suitable for precise photodynamic therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Feng Xu, Haoying Ge, Ning Xu, Cheng Yang, Qichao Yao, Saran Long, Wen Sun, Jiangli Fan, Xinsheng Xu, Xiaojun Peng
Summary: In this study, a quartet photosensitizer Cy-DENT with high singlet oxygen quantum yield was reported, achieved through a radical enhanced inter-system crossing process. By introducing a TEMPO radical, over 20-fold enhancement of singlet oxygen quantum yield compared to Cy-DEN could be achieved under near infrared light irradiation. The electron-donating ability of the terminal substituent group can effectively control the production of singlet oxygen.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Chemistry, Applied
Serdal Kaya, Yahya A. Ismaiel, Nahyun Kwon, Gyoungmi Kim, Jose L. Bila, Juyoung Yoon, Ozlem Seven, Engin U. Akkaya
Summary: Singlet oxygen is a cytotoxic reactive species involved in cancer photodynamic therapy. Bodipy-based fluorescent dyes with singlet oxygen reactive modules can signal the intracellular generation of singlet oxygen through photosensitization. Long wavelength probes of singlet oxygen based on this approach are expected to be highly valuable.
Article
Pharmacology & Pharmacy
Isabel Wen Badon, Jun-Pil Jee, Temmy Pegarro Vales, Chanwoo Kim, Seungbin Lee, Jaesung Yang, Si Kyung Yang, Ho-Joong Kim
Summary: The straightforward synthesis of three cationic boron-dipyrromethene (BODIPY) derivatives and their mitochondria-targeting and photodynamic therapeutic (PDT) capabilities are reported. The halogenated BODIPY dyes exhibit lower fluorescence quantum yields and enable the efficient production of singlet oxygen species. The synthesized dyes displayed good PDT capabilities against cancer cell lines, with low cytotoxicity in the dark, demonstrating the potential of cationic BODIPY-based dyes as therapeutic drugs for anticancer photodynamic therapy.
Article
Chemistry, Physical
Fangyu Jin, Shiqin Liao, Qingqing Wang, Huiying Shen, Chenyu Jiang, Jiawen Zhang, Qufu Wei, Reza A. Ghiladi
Summary: In this study, a scalable and facile method to immobilize long persistent phosphor and photosensitizer onto cotton fabric was reported. The resulting composite material exhibited superior antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus under visible-light illumination. Mechanistic studies showed enhanced singlet oxygen production, resulting in effective pathogen inactivation. In addition, the composite fabric possessed excellent abrasion resistance, mechanical strength, and color fastness. These findings suggest the potential of using long persistent phosphors in composite fabrics for infection control applications.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Xiaolong Hu, Shuna Wang, Qinghua Luo, Binghui Ge, Qin Cheng, Chen Dong, Jiahui Xu, Haizhen Ding, Mingsheng Xu, Antonio Claudio Tedesco, Xin Huang, Renquan Zhang, Hong Bi
Summary: A new core-shell structured Sn nanocluster@carbon dots photosensitizer with high O-1(2) quantum yield and fluorescence intensity is proposed. Upon light irradiation, this photosensitizer can effectively reduce cancer cell viability, with minimal impact on healthy cells and liver tissue.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Oleg A. Yeshchenko, Nataliya Kutsevol, Anastasiya Tomchuk, Pavlo S. Khort, Pavlo A. Virych, Vasyl A. Chumachenko, Yulia Kuziv, Andrey Marinin, Lili Cheng, Guochao Nie
Summary: The thermoresponsive ZnTPP/D-g-PNIPAM/AuNPs triple hybrid nanosystem was synthesized for thermally driven and controlled photodynamic therapy applications. The nanosystem demonstrated excellent stability and plasmonic enhancement of electronic processes in the photosensitizer molecules. In vitro experiments on Staphylococcus aureus proved the high potential of the nanosystem for rapid photodynamic inactivation of microorganisms in wounds or ulcers.
Article
Chemistry, Applied
Ruth Prieto-Montero, Alejandro Prieto-Castaneda, Alberto Katsumiti, Rebeca Sola-Llano, Antonia R. Agarrabeitia, Miren P. Cajaraville, Maria J. Ortiz, Virginia Martinez-Martinez
Summary: Three different molecular designs based on BODIPY dye have been proposed as photosensitizers for photodynamic therapy, showing a good balance between singlet oxygen generation and fluorescence for potential applications. In vitro experiments in HeLa cells were conducted to elucidate the best potential candidate for PDT.
Article
Chemistry, Medicinal
Yanjun Wang, Xiangchao Shi, Hongbao Fang, Zhong Han, Hao Yuan, Zhenzhu Zhu, Lei Dong, Zijian Guo, Xiaoyong Wang
Summary: PtPAN is a platinum-based photosensitizer that is unreactive to DNA in the dark but highly cytotoxic upon near-infrared irradiation for oxygen-independent photodynamic therapy. With its two-photon excitation property, PtPAN may be suitable for the treatment of deep solid tumors.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Wenbin Hu, Xian-Fu Zhang, Mingyu Liu
Summary: The newly synthesized thioalkyl and thiophenyl BODIPYs are much more efficient in generating the excited triplet state and singlet oxygen compared to the unsubstituted BODIPY parent. The presence of thioalkyl and thiophenyl remarkably decreases the quantum yield of fluorescence and shortens the fluorescence lifetime of BODIPYs, leading to the efficient formation of triplet state and singlet oxygen. This finding provides a new method to develop heavy atom free photosensitizers for various applications in photodynamic therapy, solar cell technology, and photoredox catalysis.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Review
Chemistry, Inorganic & Nuclear
Hande Gunduz, Safacan Kolemen, Engin U. Akkaya
Summary: The detection and imaging of singlet oxygen is a challenging task due to its short half-life and solvent sensitivity. Selective probes for singlet oxygen are crucial in the presence of other oxidizing species, and smart designs are already making progress in pushing signalling events towards longer wavelengths of the visible spectrum.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Physical
Erman Karakus
Summary: This rhodamine-based fluorescent probe, integrated with a phosphonate group, shows high selectivity and sensitivity towards copper (II) ions through a ring opening reaction, offering properties such as turn-on fluorescence response, naked-eye detection, low detection limit (15 nM), and fast response time. Successful detection of copper (II) ions in living cells as a biological application is also reported.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Analytical
Nursel Olgac, Erman Karakus, Yucel Sahin, Lokman Liv
Summary: A novel voltammetric method using a disposable bare pencil graphite electrode was developed for determining ferric ions with quercetin in water samples and iron supplements. The method showed high sensitivity with a detection limit of 3.6 nM and an analytical range of 17.9-716.0 nM. The accuracy of the method was confirmed through comparison with potentiometric auto-titration system and testing with certified reference material, and the complex stoichiometry and electrode reaction were systematically investigated using various techniques.
Article
Biochemical Research Methods
Erman Karakus, Eda Erdemir, Garen Suna, Lokman Liv, Simay Gunduz, Sevval Arzu Can
Summary: The novel fluorescein-based fluorescent chemosensor FL-In, functionalised with an indole moiety, can sensitively detect CO32- ions in aqueous media with excellent selectivity and a low detection limit.
JOURNAL OF FLUORESCENCE
(2021)
Article
Chemistry, Analytical
Eda Erdemir, Garen Suna, Simay Gunduz, Musa Sahin, Songul Eglence-Bakir, Erman Karakus
Summary: In this study, a novel fluorescent probe TPE-TSC with high selectivity and low limit of detection for ClO- was designed and synthesised. It was successfully used in determining the quality of milk and water contaminated with ClO- and trace amounts of ClO- in disinfectants.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Applied
Eda Erdemir, Garen Suna, Simay Gunduz, Musa Sahin, Songul Eglence-Bakir, Erman Karakus
Summary: The novel fluorescent probe TPA-TSC showed excellent selectivity for Hg2+ ions with a low detection limit, offering a promising method for accurately determining the quality of seafood and water samples polluted with mercury.
Article
Chemistry, Analytical
Garen Suna, Eda Erdemir, Lokman Liv, Simay Gunduz, Turan Ozturk, Erman Karakus
Summary: This work presents a novel probe that shows high selectivity in detecting Au(III) ions compared to other metal species. The probe offers various advantages such as naked-eye detection, fluorescence responses, low detection limit, and rapid response.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Materials Science, Multidisciplinary
Nursel Olgac, Erman Karakus, Yucel Sahin, Lokman Liv
Summary: This article presents a newly developed voltammetric biosensor that uses a glassy carbon electrode functionalised with an anti-cortisol antibody to measure cortisol in hormone tablets and artificial bodily fluids. The biosensor exhibited a linear increase in anodic signal at -60 mV with increasing cortisol amount. Characterisation techniques such as cyclic voltammetry, scanning electron microscopy, energy dispersive X-ray spectroscopy, UV-visible spectrophotometry, and Fourier transform infrared spectroscopy were performed. The biosensor detected 2 pM of cortisol within a linear range of 0.025 nM to 5 μM, while demonstrating high recovery values and low relative standard deviations in real samples, indicating its efficiency regardless of sample matrix.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Biochemical Research Methods
Muhammed Ucuncu
Summary: A phenalenone-based turn-on probe was developed for selective and sensitive detection of Fe3+ ions in aqueous solutions. The probe showed remarkable characteristics such as rapid response time, high analyte selectivity, and low limit of detection. Importantly, this study is the first example of a phenalenone-based sensor developed for metal ion sensing in literature.
JOURNAL OF FLUORESCENCE
(2023)
Article
Chemistry, Analytical
Eda Erdemir, Garen Suna, Lokman Liv, Songul Eglence-Bakir, Musa Sahin, Erman Karakus
Summary: Heavy metal ions, such as mercury and copper, are well-known pollutants that cause long-term damage to humans. In this study, we developed an optical-electrochemical method using gold nanoparticles modified with 1-thioglycerol to selectively detect mercury and copper ions. The method involved changing the solution's medium and resulted in distinct color changes and absorbance peaks for each ion. The detection mechanism relied on the destabilization and aggregation of gold nanoparticles. The method's use of a smartphone for signal reading reduces the cost of detection and shows potential for on-site testing of these ions.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Garen Suna, Simay Gunduz, Sebahat Topal, Turan Ozturk, Erman Karakus
Summary: In this study, a novel triple-channel fluorescent probe, TTB, was developed for the detection and discrimination of cyanide, hydrazine, and hypochlorite in the same sensing medium. The probe exhibited different fluorescent colors (white, green, and orange) upon the addition of each analyte. It demonstrated excellent selectivity and sensitivity, as well as the capability to detect these ions in complex water samples and various food samples.
Article
Chemistry, Multidisciplinary
Garen Suna, Eda Erdemir, Simay Gunduz, Turan Ozturk, Erman Karakus
Summary: Hypochlorite/hypochlorous acid (ClO-/HOCl) plays a vital role in biological processes and is used as a sanitizer. However, excessive ClO- can cause oxidation of biomolecules and pose a threat to vital organs. This study developed a BODIPY-based fluorescent probe (BOD-CN) that can efficiently detect ClO-, showing excellent selectivity, sensitivity (LOD=83.3 nM), and rapid response (<30s). The probe successfully detected ClO- in various samples and offers a promising approach for quality evaluation.
Article
Chemistry, Multidisciplinary
Lokman Liv, Erman Karakus
Summary: A novel signal-enhanced electrochemical sensing strategy was developed using a poly(chromotrope fb)-modified activated pencil graphite electrode for the determination of quercetin in vegetables and fruits. The analytical response was based on the oxidation signal of quercetin at 118 mV in an alcoholic solution. The developed platform could detect 1.9 nM of quercetin in the range of 0.01-1.2 mu M, and it was compared with UV-visible spectroscopy for quercetin determination in various food samples, showing no significant difference.
Article
Chemistry, Organic
Merve Cevik Eren, Ahmet Eren, Suay Dartar, Beraat Umur Kaya, Muhammed Ucuncu, Canan Varlikli, Huseyin Caglar Karakaya, Mustafa Emrullahoglu
Summary: A BODIPY-based fluorophore decorated with a gold specific reactive handle showed exceptional selectivity towards Au3+ ions and could monitor the concentration of gold ions in a solution through a unique chemical transformation.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Merve Cevik Eren, Ahmet Eren, Suay Dartar, Beraat Umur Kaya, Muhammed Ucuncu, Canan Varlikli, Huseyin Caglar Karakaya, Mustafa Emrullahoglu
Summary: A BODIPY-based compound showed exceptional selectivity towards Au3+ ions and underwent a unique chemical transformation induced by gold catalysis, resulting in significant changes in fluorescence and absorption wavelength. The probe exhibited excellent analytical performance in solution and demonstrated potential for monitoring Au3+ ions in human cells and plants.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Suay Dartar, Muhammed Ucuncu, Erman Karakus, Yuqi Hou, Jianzhang Zhao, Mustafa Emrullahoglu
Summary: The new generation of halogen-based triplet sensitisers were developed by incorporating geminal dibromides into the pi-conjugation of BODIPY, enhancing intersystem crossing and excited triplet states.
CHEMICAL COMMUNICATIONS
(2021)
