期刊
ORGANIC LETTERS
卷 19, 期 21, 页码 5936-5939出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02928
关键词
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资金
- National Research Foundation of Korea (NRF) grants - Korean government (MSIP) [2016R1A2B3007119, 2016R1A4A1011451]
- National Research Foundation of Korea [2016R1A2B3007119] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A catalytic enantioselective Roskamp reaction of silyl diazoalkane to synthesize a highly optically active alpha-silyl ketone from aldehydes is described. In the presence of a chiral oxazaborolidinium ion catalyst, the reaction provides alpha-chiral silyl ketones with good yields (up to 97%) and high enantioselectivities (up to >99% ee). In addition, a one-pot procedure using an asymmetric Roskamp/reduction strategy gives highly optically active syn-beta-hydroxysilane in good yields (up to 94%) with high enantioselectivities (up to 99% ee) and syn stereoselectivities (>20:1).
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