4.8 Article

Highly Diastereoselective Crown Ether Catalyzed Arylogous Michael Reaction of 3-Aryl Phthalides

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ORGANIC LETTERS
卷 19, 期 16, 页码 4383-4386

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02113

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  1. University of Salerno (FARB), Regione Campania under POR Campania FESR O.O. 2.1 (Farma-BioNet) [CUP B25C13000230007, CUP B46D14002660009]

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The first arylbgous Michael reaction of 3-aryl phthalides has been, developed. The reaction, promoted by catalytic amounts of KOH or K3PO4 and dibeno-18-crown-6, affords the corresponding 3,3-disubstituted phthalides in good to high yields and as single diastereomers in nearly all studied cases.

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