2-Nitroimidazole based fluorescent probes for nitroreductase; monitoring reductive stress in cellulo

Glycosidase activated release of fluorescent 1,8-naphthalimide probes for tumor cell imaging from glycosylated ‘pro-probes’

(2016) Elena Calatrava-Pérez et al.   CHEMICAL COMMUNICATIONS

Bioreductive fluorescent imaging agents: applications to tumour hypoxia

(2016) Robert B. P. Elmes   CHEMICAL COMMUNICATIONS

Novel Biosensors Reveal a Shift in the Redox Paradigm From Oxidative to Reductive Stress in Heart Disease

(2016) Rhian M. Touyz et al.   CIRCULATION RESEARCH

Reductive Stress: A New Concept in Alzheimer's Disease

(2016) A. Lloret et al.   Current Alzheimer Research

Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting

(2016) Arnaud Chevalier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells

(2016) Stuart N. Berry et al.   Chemical Science

in vivo imaging and detection of nitroreductase in zebrafish by a new near-infrared fluorescence off–on probe

(2015) Zhao Li et al.   BIOSENSORS & BIOELECTRONICS

A turn-on fluorescent probe for tumor hypoxia imaging in living cells

(2015) Qi Cai et al.   CHEMICAL COMMUNICATIONS

A BODIPY-based ‘turn-on’ fluorescent probe for hypoxic cell imaging

(2015) Sisi Wang et al.   CHEMICAL COMMUNICATIONS

Ultrasensitive Near-Infrared Fluorescence-Enhanced Probe for in Vivo Nitroreductase Imaging

(2015) Yuhao Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient synthesis of 2-nitroimidazole derivatives and the bioreductive clinical candidate Evofosfamide (TH-302)

(2015) Liam J. O'Connor et al.   Organic Chemistry Frontiers

Biologically targeted probes for Zn2+: a diversity oriented modular “click-SNAr-click” approach

(2014) J. Pancholi et al.   Chemical Science

Nitroreductase Detection and Hypoxic Tumor Cell Imaging by a Designed Sensitive and Selective Fluorescent Probe, 7-[(5-Nitrofuran-2-yl)methoxy]-3H-phenoxazin-3-one

(2013) Zhao Li et al.   ANALYTICAL CHEMISTRY

7-((5-Nitrothiophen-2-yl)methoxy)-3H-phenoxazin-3-one as a spectroscopic off–on probe for highly sensitive and selective detection of nitroreductase

(2013) Zhao Li et al.   CHEMICAL COMMUNICATIONS

A highly sensitive long-wavelength fluorescence probe for nitroreductase and hypoxia: selective detection and quantification

(2013) Ting Guo et al.   CHEMICAL COMMUNICATIONS

Recent advances in the development of 1,8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents

(2013) Swagata Banerjee et al.   CHEMICAL SOCIETY REVIEWS

Hypoxia-Selective, Enzymatic Conversion of 6-Nitroquinoline into a Fluorescent Helicene: Pyrido[3,2-f]quinolino[6,5-c]cinnoline 3-Oxide

(2012) Anuruddha Rajapakse et al.   JOURNAL OF ORGANIC CHEMISTRY

A New Prodrug-Derived Ratiometric Fluorescent Probe for Hypoxia: High Selectivity of Nitroreductase and Imaging in Tumor Cell

(2011) Lei Cui et al.   ORGANIC LETTERS

“Alive” dyes as fluorescent sensors: fluorophore, mechanism, receptor and images in living cells

(2010) Xuhong Qian et al.   CHEMICAL COMMUNICATIONS

Colorimetric and fluorescent anion sensors: an overview of recent developments in the use of 1,8-naphthalimide-based chemosensors

(2010) Rebecca M. Duke et al.   CHEMICAL SOCIETY REVIEWS

Hypoxia-activated prodrugs in cancer therapy: progress to the clinic

(2010) William A Denny   Future Oncology

Imaging tumor hypoxia by magnetic resonance methods

(2010) Jesús Pacheco-Torres et al.   NMR IN BIOMEDICINE

Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia

(2009) Shinae Kizaka-Kondoh et al.   CANCER SCIENCE

4-Amino-1,8-naphthalimide-Based Tröger’s Bases As High Affinity DNA Targeting Fluorescent Supramolecular Scaffolds

(2009) Emma B. Veale et al.   ORGANIC LETTERS

Versatile Nitro-Fluorophore as Highly Effective Sensor for Hypoxic Tumor Cells: Design, Imaging and Evaluation

(2008) Min Dai et al.   JOURNAL OF FLUORESCENCE

Potent and Highly Selective Hypoxia-Activated Achiral Phosphoramidate Mustards as Anticancer Drugs

(2008) Jian-Xin Duan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Imaging of Hypoxia

(2008) K. A. Krohn et al.   JOURNAL OF NUCLEAR MEDICINE