期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 15, 期 42, 页码 8985-8989出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob02267k
关键词
-
资金
- National Natural Science Foundation of China [21202090]
- Zhejiang Provincial Natural Science Foundation of China [LY12B02001, LQ13B010004, LY17B020004]
- Zhejiang Provincial Project of Applied Public Welfare Technology [2016C33254]
- Ningbo Natural Science Foundation [2016A610234, 2016A610237, 2016A610097]
- National Training Programs for Innovation and Entrepreneurship for Undergraduates [201611058006]
- Ningbo University of Technology (NBUT)
A general and robust protocol for the synthesis of terminal alpha-substituted vinylphosphonates via Suzuki coupling of alpha-bromovinylphosphonates with organotrifluoroborates has been successfully developed. This method features a broad substrate scope, great functional group compatibilities, and easy scale-up ability. In addition to easy access of nucleophiles, a straightforward synthesis of electrophiles was also realized with diethyl alpha-bromoethenylphosphonate as the starting material. With a combination of Pd-2(dba)(3)/SPhos as the catalyst, a range of alpha-alkyl, aryl, heteroaryl, and alkynyl substituted ethenylphosphonates could be nicely accessed under mild conditions. As a synthetic application, the terminal vinylphosphonate was utilized as an effective Michael acceptor in the visible-light-promoted Giese reaction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据