Use of AlCl3 in Friedel Crafts arylation type reactions and beyond: an overview on the development of unique methodologies leading to N-heteroarenes

Metal catalyst free cyclization of 3-alkynyl substituted 2-(indol-3-yl)quinoxalines in TFA alone: a new synthesis of indolophenazines

(2017) K. Shiva Kumar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and anticancer potential of novel xanthone derivatives with 3,6-substituted chains

(2016) Chaomei Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Semisynthetic routes to PF1022H—A precursor for new derivatives of the anthelmintic cyclooctadepsipeptide PF1022A

(2016) Sivatharushan Sivanathan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 3-substituted 5-benzylidene-1-methyl-2-thiohydantoins as potent NADPH oxidase (NOX) inhibitors

(2016) Yun Soo Bae et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery, design and synthesis of 6 H -anthra[1,9- cd ]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification

(2016) Wei-Lin Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Advances in Transition-Metal-Catalysed Alkyne Hydroarylations

(2016) Andrea Biffis et al.   CHEMICAL RECORD

Alkenylation of Arenes and Heteroarenes with Alkynes

(2016) Vadim P. Boyarskiy et al.   CHEMICAL REVIEWS

Synthesis and biological evaluation of novel 2,3-disubstituted quinoxaline derivatives as antileishmanial and antitrypanosomal agents

(2015) Juliana Cogo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Reactions of nitrilium salts with indole and pyrrole and their derivatives in the synthesis of imines, ketones and secondary amines

(2015) Robert G. Giles et al.   TETRAHEDRON

Synthesis of 1,2-dihydro-1-oxophthalazin-4-yl trifluoromethanesulfonate and its application in the synthesis of 4-(aryl/heteroaryl/alkynyl)phthalazin-1(2H)-one

(2015) Ganesh Raosaheb Dhage et al.   RSC Advances

Lewis Acid-Catalyzed Generation of CC and CN Bonds on π-Deficient Heterocyclic Substrates

(2014) Matteo Staderini et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of indenes via aluminum chloride-promoted tandem Friedel–Crafts alkylation of arenes and cinnamaldehydes

(2014) Haiouani Kheira et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

Selective synthesis of 4-(sulfonyl)-methyl-1H-pyrazoles and (E)-4,5-dihydro-1H-pyrazoles from N-allenic sulfonylhydrazones

(2014) Yu Zhu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Arylation of 1,2,4-Triazines in the Presence of AlCl3

(2014) Ilya N. Egorov   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES

Comparison of Oxidative Aromatic Coupling and the Scholl Reaction

(2013) Marek Grzybowski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

AlCl3-mediated hydroarylation–heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest

(2013) Ali Nakhi et al.   CHEMICAL COMMUNICATIONS

Gold-Catalyzed Domino Aminocyclization/1,3-Sulfonyl Migration of N-Substituted N-Sulfonyl-aminobut-3-yn-2-ols to 1-Substituted 3-Sulfonyl-1H-pyrroles

(2013) Wan Teng Teo et al.   JOURNAL OF ORGANIC CHEMISTRY

Ligand/PTC-free intramolecular Heck reaction: synthesis of pyrroloquinoxalines and their evaluation against PDE4/luciferase/oral cancer cell growth in vitro and zebrafish in vivo

(2013) P. Vijaya Babu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

C–C bond formation at C-2 of a quinoline ring: Synthesis of 2-(1H-indol-3-yl)quinoline-3-carbonitrile derivatives as a new class of PDE4 inhibitors

(2012) K. Shiva Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

AlCl3 induced (hetero)arylation of 2,3-dichloroquinoxaline: A one-pot synthesis of mono/disubstituted quinoxalines as potential antitubercular agents

(2012) K. Shiva Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pyrrolo[2,3-b]quinoxalines as inhibitors of firefly luciferase: Their Cu-mediated synthesis and evaluation as false positives in a reporter gene assay

(2012) Ali Nakhi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

AlCl3 mediated unexpected migration of sulfonyl groups: regioselective synthesis of 7-sulfonyl indoles of potential pharmacological interest

(2012) Bagineni Prasad et al.   CHEMICAL COMMUNICATIONS

Heterocycles in drugs and drug discovery

(2012) A. Gomtsyan   Chemistry of Heterocyclic Compounds

Efficient Synthesis of β-Acetamido Ketones and Esters Using Aluminum Chloride as an Inexpensive and Green Catalyst

(2012) Zolfigol Mohammad Ali et al.   CHINESE JOURNAL OF CHEMISTRY

Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues : A novel DYRK1A inhibitor class

(2012) Cleopatra Neagoie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Diazine Indole Acetic Acids as Potent, Selective, and Orally Bioavailable Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases

(2012) Neelu Kaila et al.   JOURNAL OF MEDICINAL CHEMISTRY

Facile synthesis of dihydrochalcones via the AlCl3-promoted tandem Friedel–Crafts acylation and alkylation of arenes with 2-alkenoyl chlorides

(2012) Yang Zhou et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

A new approach to construct a fused 2-ylidene chromene ring: highly regioselective synthesis of novel chromeno quinoxalines

(2012) K. Shiva Kumar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

AlCl3 induced C–N bond formation followed by Pd/C–Cu mediated coupling–cyclization strategy: synthesis of pyrrolo[2,3-b]quinoxalines as anticancer agents

(2012) Bagineni Prasad et al.   TETRAHEDRON LETTERS

Structure–activity relations on [1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone. The effect of methoxy substitution on aldose reductase inhibitory activity and selectivity

(2011) Maria Chatzopoulou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D

(2011) Salvatore Cananzi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

AlCl3 induced C-arylation/cyclization in a single pot: a new route to benzofuran fused N-heterocycles of pharmacological interest

(2011) K. Shiva Kumar et al.   TETRAHEDRON LETTERS

Design, synthesis and biological evaluation of new 2,3-diarylquinoline derivatives as selective cyclooxygenase-2 inhibitors

(2010) Razieh Ghodsi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles

(2010) Abdelouahid Samadi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II

(2010) Vanessa Desplat et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Direct Synthesis of 6-Arylpurines by Reaction of 6-Chloropurines with Activated Aromatics

(2010) Hai-Ming Guo et al.   JOURNAL OF ORGANIC CHEMISTRY

A simple synthesis of aminopyridines: use of amides as amine source

(2010) Arumugam Kodimuthali et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Evaluation of Novel 7-(hetero)aryl-substituted Pyrazolo[1, 5-a]pyrimidines as Phosphodiesterase-4 Inhibitors

(2010) Arumugam Kodimuthali et al.   Letters in Drug Design & Discovery

Synthesis of 1-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones

(2010) Ekaterina Shinkevich et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

AlCl3-catalyzed oxidation of alcohol

(2010) Shang Wu et al.   TETRAHEDRON

One-pot synthesis of 1,2-disubstituted pyrrolo[2,3-b]quinoxalines via palladium-catalyzed heteroannulation in water

(2010) Ali Keivanloo et al.   TETRAHEDRON LETTERS

AlCl3-induced (hetero)arylation of thienopyrimidine ring: a new synthesis of 4-substituted thieno[2,3-d]pyrimidines

(2010) K. Shiva Kumar et al.   TETRAHEDRON LETTERS

Synthesis and biological evaluation of novel 4-(hetero) aryl-2-piperazino quinazolines as anti-leishmanial and anti-proliferative agents

(2009) Shailesh Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Friedel-Crafts heteroarylation of (hetero)arenes: A facile entry to 4-(hetero)aryl quinazolines and quinolines

(2009) Shailesh Kumar et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Tacripyrines, the First Tacrine−Dihydropyridine Hybrids, as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease

(2009) José Marco-Contelles et al.   JOURNAL OF MEDICINAL CHEMISTRY

An efficient method for the synthesis of α-arylated nitroalkanes and α-arylated hydroximoyl chlorides mediated by AlCl3

(2009) Zhijay Tu et al.   TETRAHEDRON

Synthesis of functionalized 2-arylpyridines from 2-halopyridines and various aryl halides via a nickel catalysis

(2009) Corinne Gosmini et al.   TETRAHEDRON

A new synthesis of 2-(hetero)aryl-substituted pyrazines

(2009) Arumugam Kodimuthali et al.   TETRAHEDRON LETTERS

Computer based design, synthesis and biological evaluation of novel indole derivatives as HCV NS3-4A serine protease inhibitors

(2008) Nasser S.M. Ismail et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of New Pyrrolo[1,2-a]quinoxaline Derivatives as Potential Inhibitors of Akt Kinase

(2008) Vanessa Desplat et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Recent Advances on Phosphodiesterase 4 Inhibitors for the Treatment of Asthma and Chronic Obstructive Pulmonary Disease

(2008) Arumugam Kodimuthali et al.   JOURNAL OF MEDICINAL CHEMISTRY

AlCl3-Mediated Direct Carbon−Carbon Bond-Forming Reaction of α-Hydroxyketene-S,S-acetals with Arenes and Synthesis of 3,4-Disubstituted Dihydrocoumarin Derivatives

(2008) Cheng-Ri Piao et al.   JOURNAL OF ORGANIC CHEMISTRY

Reactivity of the –C(Cl)C–CN– moiety towards AlCl3-induced C–C bond forming reactions: a new synthesis of 7-(hetero)aryl-substituted pyrazolo[1,5-a]pyrimidines

(2008) Arumugam Kodimuthali et al.   TETRAHEDRON LETTERS

A simple, green and one-pot four-component synthesis of 1,4-dihydropyridines and their aromatization

(2007) Saikat Das Sharma et al.   CATALYSIS COMMUNICATIONS