Article
Dentistry, Oral Surgery & Medicine
Kaixin Wangzhou, Wanren Fu, Mengmeng Li, Zishao Lu, Zhiying Lai, Cheng Liu, Yi Tan, Chunbo Hao
Summary: This study reveals that LSD1 promotes the development and survival of oral squamous cell carcinoma by catalyzing demethylation of miR-17 and activating the KPNA2/PI3K/AKT pathway.
Article
Oncology
Lin Shi, Weiliang Zhu, Yuanyuan Huang, Lin Zhuo, Siyun Wang, Shaobing Chen, Bei Zhang, Bin Ke
Summary: This study found that exosomes released by cancer-associated fibroblasts (CAFs) can promote the progression and chemoresistance of non-small-cell lung cancer (NSCLC). Mechanistically, the exosomes transmit miR-20a to tumor cells, enhancing chemoresistance and proliferation by targeting PTEN.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Ke Wan, Ziwei Tu, Zhentian Liu, Yun Cai, Yinglan Chen, Chunhua Ling
Summary: This study found that the expression levels of OPG in the serum of patients with non-small cell lung cancer were upregulated compared to healthy individuals, and may play a role in promoting lung cancer cell invasion. Additionally, OPG promoted lung cancer cell invasion by regulating miR-20a, providing a potential new target for lung cancer treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, General & Internal
Sora Kim, Gwang Ha Kim, Su Jin Park, Chae Hwa Kwon, I Hoseok, Moon Won Lee, Bong Eun Lee
Summary: Exosomal miRNAs have the potential to serve as biomarkers for esophageal squamous cell carcinoma (ESCC). This study identified specific exosomal miRNAs that were differentially expressed in ESCC, and validated their expression levels in the plasma of healthy controls and ESCC patients. The results showed that plasma exosomal miR-205-5p, miR-429, and miR-375-3p could be potential biomarkers for the diagnosis of ESCC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jaroslav Nunvar, Lucie Pagacova, Zuzana Vojtechova, Nayara Trevisan Doimo de Azevedo, Jana Smahelova, Martina Salakova, Ruth Tachezy
Summary: Our study found that the degree of miRNA deregulation varies significantly among tumors at different locations, and the deregulated miRNAs are largely tumor-specific, with no miRNA shared by all four types of HPV-positive tumors.
Article
Biochemistry & Molecular Biology
Jeffrey Coon, Karl Kingsley
Summary: miR-365 expression was confirmed in oral cancers, with some cells also expressing NKX2.1 and MMP-2. The transfection of miR-365 led to increased proliferation, particularly in the fastest growing oral cancers. Further research is needed to understand the pathways underlying these effects.
Review
Oncology
Viji Remadevi, Parvathy Muraleedharan, Sreeharshan Sreeja
Summary: This article examines the role of FOXO1 proteins in oral squamous cell carcinoma, including their regulation of cell cycle, apoptosis, oxidative stress, and their positive impact on tumor suppression, angiogenesis, and metastasis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Junlei Han, Jianping Hu, Fang Sun, Hongzhi Bian, Bingxiang Tang, Xiang Fang
Summary: miR-20a suppresses NSCLC growth by inhibiting the RRM2-mediated PI3K/Akt signaling pathway, serving as a potential tumor suppressor and molecular target for NSCLC treatment.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Bo Zhou, Yue Zhou, Ying Liu, Hailin Zhang, Huangxing Mao, Mingjing Peng, Anji Xu, Zan Li, Hui Wang, Haolei Tan, Huayi Ren, Xiao Zhou, Ying Long
Summary: A novel CASC18/miR-20a-3p/TGFB2 ceRNA axis was identified in OLNM of TSCC. Higher CASC18 expression was positively correlated with the presence of OLNM and worse outcome of TSCC patients, while knockdown of CASC18 inhibited cell migration and invasion.
MOLECULAR MEDICINE
(2021)
Article
Oncology
Zhimou Cai, Bingjie Tang, Lin Chen, Wenbin Lei
Summary: This study identified a prognostic mast cell gene signature (MCS) using single-cell RNA sequencing analysis to assess the prognosis and immunotherapy response of patients with head and neck squamous cell carcinoma (HNSCC). The MCS effectively distinguished survival outcomes and could be used as a predictive indicator for immunotherapy response and decision-making.
Article
Biochemistry & Molecular Biology
Cheng-Mei Yang, Tian-Huei Chu, Kuo-Wang Tsai, Shuchen Hsieh, Mei-Lang Kung
Summary: Zingerone nanoparticles (NPs), derived from phytochemical substances, have demonstrated significant inhibition of cell invasion and metastasis, making them a promising adjuvant for cancer treatment.
Article
Cell Biology
Yingcheng Lyu, Binghua Tan, Lin Li, Ruihao Liang, Kai Lei, Kefeng Wang, Duoguang Wu, Huayue Lin, Minghui Wang
Summary: In this study, a highly expressed circRNA with protein-coding ability, circUBE4B, was identified in esophageal squamous carcinoma (ESCC) tissues. The expression level of circUBE4B was correlated with tumor size and differentiation level of ESCC patients, and higher levels were associated with poorer prognosis. Functionally, circUBE4B promoted ESCC cell proliferation by encoding a novel cancer-promoting protein, circUBE4B-173aa. Mechanistically, circUBE4B-173aa interacted with MAPK1, leading to increased phosphorylation and activation of the MAPK/ERK signaling pathway. In a xenograft model, overexpression of circUBE4B-173aa significantly promoted tumor growth. This study provides new insights into the role of circRNAs in ESCC development and suggests circUBE4B-173aa as a potential biomarker and therapeutic target for ESCC.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Sara Capolla, Monica Argenziano, Sara Bozzer, Tiziana D'Agaro, Tamara Bittolo, Luigina De Leo, Tarcisio Not, Davide Busato, Michele Dal Bo, Giuseppe Toffoli, Roberta Cavalli, Valter Gattei, Riccardo Bomben, Paolo Macor
Summary: miR-17 is an onco-miRNA overexpressed in B-cell non-Hodgkin lymphoma (B-NHL). This study utilized CD20 targeted chitosan nanobubbles (NBs) for the delivery of antagomiR17 to B-NHL cells, resulting in down-regulation of miR-17 and reduction in tumor burden.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Fu Chen, Zheng Lao, Haiyan Zhang, Jie Wang, Shengzi Wang
Summary: This study revealed that circ_0001883 inhibited cell migration, invasion, and EMT of LSCC by sponging miR-125b-5p. Additionally, circ_0001883 and miR-125b-5p influenced the phosphorylation of PI3K and AKT signaling pathways.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Nevena Ladjevac, Marija Milovanovic, Andra Jevtovic, Dragana Arsenijevic, Bojana Stojanovic, Milica Dimitrijevic Stojanovic, Bojan Stojanovic, Nebojsa Arsenijevic, Aleksandar Arsenijevic, Jelena Milovanovic
Summary: Elucidating the inflammatory mechanisms underlying formation and progression of oral squamous cell carcinoma (OSCC) is crucial for discovering new targeted therapeutics. The proinflammatory cytokine IL-17 has proven roles in tumor formation, growth, and metastasis. The presence of IL-17 is demonstrated in both in vitro and in vivo models, and in OSCC patients, is mostly accompanied by enhanced proliferation and invasiveness of cancer cells. Here we review the known facts regarding the role of IL-17 in OSCC pathogenesis, namely the IL-17 mediated production of proinflammatory mediators that mobilize and activate myeloid cells with suppressive and proangiogenic activities and proliferative signals that directly induce proliferation of cancer cells and stem cells. The possibility of a potential IL-17 blockade in OSCC therapy is also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yun-Jen Chou, Hsiang-Ying Lin, Bruce A. Cooper, Been-Ren Lin, Jeng-Kai Jiang, Hui-Ying Yang, Christine Miaskowski, Shiow-Ching Shun
Summary: This study evaluated a proposed resilience model for patients with colorectal cancer (CRC) and found that depressive symptoms partially mediate the relationship between protective factors and resilience.
Article
Oncology
Kuo-Hsing Chen, Liang-In Lin, Chang-Tsu Yuan, Li-Hui Tseng, Yu-Liang Chao, Yi-Hsin Liang, Jin-Tung Liang, Been-Ren Lin, Ann-Lii Cheng, Kun-Huei Yeh
Summary: In Taiwan, distinct clinicopathological features were identified for CIMP-high CRC among different age groups. Our data suggest the association between BMI >= 27.5 kg/m(2) and CIMP-high CRC in patients younger than 50 years.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Yen-Ju Huang, Tsung-Chun Lee, Yu-Chen Pai, Been-Ren Lin, Jerrold R. Turner, Linda Chia-Hui Yu
Summary: The study found that human CRC showed lower levels of MLCK1/2 and higher expression of CD44, but no significant change in CD133 or LGR5. MLCK(-/-) mice in a chemical-induced CRC model exhibited a 3-fold increase in tumor burden. The MLCK1/2 variants act as tumor suppressors by reducing the nuclear translocation of specific transcriptional coactivators and inhibiting the TEAD4/CD44 axis in CRC.
Review
Environmental Sciences
Cheng-Kuan Lin, Yuan-Ting Chang, Fu-Shiuan Lee, Szu-Ta Chen, David Christiani
Summary: The study reviewed the impact of prenatal and early childhood exposure to ambient particulate matters on the risk of autism spectrum disorder in children, finding a positive association between PM2.5 exposure and ASD risk.
ENVIRONMENTAL RESEARCH LETTERS
(2021)
Article
Oncology
Li-Chun Chang, Chia-Tung Shun, Been-Ren Lin, Silvia Sanduleanu, Weng-Feng Hsu, Ming-Shiang Wu, Han-Mo Chiu
Summary: A study conducted at the National Taiwan University Hospital from 2005 to 2014 compared the disease-free survival of T1 cancer arising from the rectum versus the colon. The results showed that T1 rectal cancer had a higher risk of recurrence compared to T1 colon cancer, with rectal location being an independent risk factor for recurrence. Further research is needed to explore whether adjuvant therapy or closer surveillance can reduce the risk of recurrence in T1 rectal cancer.
Article
Biology
Yo-Ping Lai, Lu-Cheng Kuo, Been-Ren Lin, Hung-Ju Lin, Chih-Yu Lin, Yi-Ting Chen, Pei-Wen Hsiao, Huan-Tsung Chang, Patrick Chow-In Ko, Hsiao-Chin Chen, Hsiang-Yu Chang, Jean Lu, Hong-Nerng Ho, Betty A. Wu-Hsieh, John T. Kung, Shu-Ching Chen
Summary: CD28 costimulation inhibits CD73 upregulation in CD8(+) T cells, thereby preventing them from becoming suppressive. Lack of CD28 costimulation renders CD8(+) T cells immunosuppressive and less effective in eliminating solid tumors.
COMMUNICATIONS BIOLOGY
(2021)
Editorial Material
Oncology
Yue-Ju Li, Cheng-Ning Yang, Mark Yen-Ping Kuo, Wei-Ting Lai, Tai-Sheng Wu, Been-Ren Lin
ANNALS OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Oncology
Yue-Ju Li, Cheng-Ning Yang, Yen-Ping Kuo, Wei-Ting Lai, Tai-Sheng Wu, Been-Ren Lin
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Yue-Ju Li, Cheng-Ning Yang, Mark Yen-Ping Kuo, Wei-Ting Lai, Tai-Sheng Wu, Been-Ren Lin
Summary: In mismatch repair-deficient colorectal carcinoma, decreased expression of ATMIN is positively correlated with disease progression and metastasis. Knockdown of ATMIN increases cell motility and influences the Wnt signaling pathway via PARP1, providing potential for PARP1 inhibitors in further clinical trials for MSI-high CRC.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Yun-Jen Chou, Kord M. Kober, Kun-Huei Yeh, Bruce A. Cooper, Ching-Hua Kuo, Been-Ren Lin, Tien-Chueh Kuo, Yufeng J. Tseng, Christine Miaskowski, Shiow-Ching Shun
Summary: This pilot study found that fatigue symptoms in colorectal cancer patients during chemotherapy are associated with pathways involved in galactose metabolism and phenylalanine, tyrosine, and tryptophan biosynthesis.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2022)
Article
Gastroenterology & Hepatology
Meng-Tzu Weng, Ko-Han Chao, Chien-Chih Tung, Hao-Chun Chang, I-Lun Shih, Been-Ren Lin, Ming-Jium Shieh, Chia-Tung Shun, Jau-Min Wong, Shu-Chen Wei
Summary: PSRCCR is a rare type of colon and rectal cancer, often diagnosed at an advanced stage with poor prognosis. Patients with PSRCCR tend to be younger, progress rapidly, exhibit unique clinical features, and require attention to diagnosis and treatment.
BMC GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Yi-Hsin Liang, Jin-Tung Liang, Ben-Ren Lin, John Huang, Ji-Shiang Hung, Shuo-Lun Lai, Tzu-Chun Chen, Jia-Huei Tsai, Yung-Ming Cheng, Ting-Han Tsao, Wen-Ling Hsu, Kuo-Hsing Chen, Kun-Huei Yeh
Summary: In this retrospective study, it was found that patients with metastatic colorectal cancer who received second-line ramucirumab treatment had better outcomes in terms of treatment discontinuation and overall survival compared to those who received third or later-line treatment. The study also identified second-line treatment and combination with triplet chemotherapy as independent predictive factors for longer treatment discontinuation time and overall survival.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Engineering, Biomedical
Shuo-Lun Lai, Chi-Sheng Chen, Been-Ren Lin, Ruey-Feng Chang
Summary: In this study, a neural network model using deep learning technology was proposed to detect the presence of surgical gauze from surgical videos, allowing real-time tracking of missing gauze in laparoscopic surgery.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Health Care Sciences & Services
Yun-Jen Chou, Ya-Ching Wang, Been-Ren Lin, Shiow-Ching Shun
Summary: The aim of this study was to explore the process of resilience in individuals with colorectal cancer (CRC). The findings revealed that resilience is a dynamic three-phase process, including the impact of CRC, adaptation or maladaptation following CRC, and growth from CRC experience. Resilience strategies, avoidance behaviors, and passive waiting strategy were shown across the resilience process. Some individuals used resilience strategies to promote positive adjustment and develop their resilience process.
QUALITY OF LIFE RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Li-Jun Chang, Chun-Jen Hsiao, Bing Chen, Tzu-Yu Liu, Julia Ding, Wan-Ting Hsu, Victor Su-Ortiz, Szu-Ta Chen, Ke-Ying Su, Han-Ping Wu, Chien-Chang Lee
Summary: The primary aim was to summarize the diagnostic accuracies of multiplex PCR gastrointestinal (GI) panels-BioFire FilmArray and Luminex xTAG on detecting gastroenteritis pathogens, while the secondary aim was to compare their performance head to head. The findings showed that both GI panels are highly accurate, potentially providing important diagnostic information for early identification of gastroenteritis. Although the FilmArray panel demonstrated higher sensitivity and post-test probability than xTAG GPP for most pathogens, the clinical implications remain uncertain.
BMJ OPEN GASTROENTEROLOGY
(2021)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.
