Article
Chemistry, Analytical
Zoran Djinovic, Milos Tomic, Agnes Kocsis
Summary: This paper presents a method that combines micromachined optofluidic platforms with fiberoptic sensing configuration for simultaneous measurement of the refractive index of liquids and autocalibration. The method is based on low-coherence interferometry and an algorithm is used to calculate the refractive index from raw interference signals.
Article
Materials Science, Multidisciplinary
Shaokang Yan, Shengli Pu, Yuxiu Zhang, Min Yuan, Chencheng Zhang
Summary: The graphene oxide (GO) coating improved the performance of the sensor in glycerin solution, resulting in a refractive-index (RI) sensitivity of 496.823 nm/RIU. However, the GO coating reduced the magnetic field sensitivity of the sensor in magnetic fluid solution. The mechanism behind the enhanced RI sensitivity and decreased magnetic field sensitivity was clarified.
RESULTS IN PHYSICS
(2021)
Article
Optics
Wei Cheng, Shuhui Liu, Shengguo Zhao, Litong LI
Summary: An optofluidic sensor based on a Bragg grating in hollow core fiber (HCF) is demonstrated. The grating is inscribed into the HCF using femtosecond laser illumination, causing cladding mode resonance. The refractive index sensing of high index liquid and temperature sensitivity are achieved with this device.
Article
Optics
Ayda Aray, Saeed Ghavami Sabouri
Summary: The study presents a detailed design of a plasmonic refractive index sensor based on a metal-insulator-metal Bragg microcavity, utilizing high field confinement and resonant assisted multiple-pass of plasmonic waves to enhance sensing performance. By investigating the effect of structural parameters on plasmonic spectral properties, the sensor performance can be optimized with great significance.
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS
(2021)
Article
Optics
Xuyang Zhao, Yi Zhou, Yuxiang LI, Junhong Guo, Zhiran Liu, Man Luo, Zhihe Guo, Xi Yang, Meng Zhang, You Wang, Xiang Wu
Summary: This study proposes an ultrasensitive optofluidic coupled Fabry-Perot (FP) capillary sensor based on the Vernier effect for refractive index (RI) sensing and biomolecular detection. The sensor demonstrates a high RI sensitivity and low detection limit, making it suitable for practical and low-cost applications.
Article
Chemistry, Physical
Shengxi Jiao, Xiaolei Ren, Hanrui Yang, Shibo Xu, Xinzhi Li
Summary: A dual-core photonic crystal fiber with dual-channel-based surface plasmon resonance sensor is developed for highly sensitive detection of two analytes simultaneously, achieving average spectral sensitivities of 4280 and 3940 nm/RIU and RI resolutions of 2.34 x 10(-5) and 2.54 x 10(-5) RIU for left and right channels, respectively. The designed sensor shows potential for wide application in biomedical analysis and environmental monitoring.
Article
Engineering, Electrical & Electronic
Shuang Zhou, Yuyang Yan, Meiduan Fan, Chengcheng Xu, Yunlong Wang, Di Shen, Yunqi Liu, Longfei Ma, Xiaolan Sun, Alan R. Kost
Summary: The glucose sensor based on HLPG coupling demonstrates a linear response to glucose concentration in different pH environments, exhibiting different sensitivities at pH 7.4 and pH 9 respectively.
OPTICAL FIBER TECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Yiling Liu, Yanqiong Wang, Xi Yang, Chao-Yang Gong, Yuan Gong
Summary: This review article summarizes the recent advances in optofluidic lasers (OFLs) and their applications in biochemical analysis. OFLs achieve high performance in bio-chemical sensing due to the strong light-matter interaction in the laser cavity. The physical mechanisms, structure, and materials used in OFLs to achieve high sensitivity, disposability, fast response, and high throughput are discussed, as well as the inter-relationship between these performance indicators. The effects of new materials and a comparison with other optical biochemical sensors are also presented, along with the prospects of OFLs.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Qianying Feng, Jixuan Wu, Hua Bai, Binbin Song, Cheng Zhang, Wei Lin, Haifeng Liu, Shaoxiang Duan
Summary: In this study, a square coreless fiber functionalized with a Ti3C2Tx MXene layer is proposed for highly sensitive refractometric measurement. The sensitivity of the refractometric sensor is improved by more than 12% compared to the pristine fiber. The Ti3C2Tx modified square coreless fiber provides a promising platform for general ultra-low concentration analytical detection.
OPTICAL MATERIALS EXPRESS
(2023)
Article
Instruments & Instrumentation
Xi Yang, Chaoyang Gong, Yiling Liu, Yunjiang Rao, Mateusz Smietana, Yuan Gong
Summary: Fiber optofluidic laser (FOFL) combines the advantages of optical fiber microcavity and microfluidic channel, providing high sensitivity, signal-to-noise ratio, and ease of integration. With advancements in fiber structures and fabrication technologies, FOFL has become a crucial branch of optical fiber sensors, particularly in biochemical detection. The FOFL sensor holds promising potential for biomedical analysis and environmental monitoring.
Article
Optics
Yingxuan Liu, Ya-nan Zhang, Bo Han, Jincheng Zhao, Xuegang Li, Yong Zhao
Summary: This study proposes a gourd-type hollow-core fiber based Mach-Zehnder interferometer (MZI) and investigates its sensing properties. The MZI splices both ends of a section of HCF with single-mode fibers and forms a gourd-shaped structure. The MZI exhibits high refractive index sensitivity and low cross-sensitivity to temperature, making it suitable for biochemical sensing and physical sensing.
OPTICS AND LASERS IN ENGINEERING
(2023)
Article
Optics
Darcy L. Smith, Linh Nguyen, David J. Ottaway, Thiago D. Cabral, Eric Fujiwara, Cristiano M. B. Cordeiro, Stephen C. Warren-Smith
Summary: In this paper, we demonstrate that deep learning improves the analysis of fiber specklegrams for sensing, and apply it to measurements of air temperature and water immersion length. We compare deep neural networks (DNNs) including a convolutional neural network and a multi-layer perceptron network with a traditional correlation technique using data from a multimode fiber exposed-core fiber. We also show the ability of the DNNs to be trained against random noise sources like specklegram translations.
Article
Engineering, Electrical & Electronic
Md. Aslam Mollah, Md. Saiful Islam
Summary: A novel single air hole exposed core PCF sensor based on localized surface plasmon resonance (LSPR) for bio-analyte sensing is proposed in this study. The sensor utilizes a gold (Au) nano strip and a thin layer of titanium oxide (TiO2) for improved sensing performance and low loss. Numerical results demonstrate that the sensor shows high amplitude sensitivity, wavelength sensitivity, and resolution in a wide range of refractive index variations.
IEEE SENSORS JOURNAL
(2021)
Article
Biochemical Research Methods
Jiukai Tang, Guangyu Qiu, Xiaole Zhang, Jing Wang
Summary: A 3D-cascade-microlens optofluidic chip was fabricated for RI sensing, demonstrating adjustable sensitivity through different configurations of cascaded microlenses. The seven-microlens configuration achieved excellent sensitivity and resolution with a narrow linear dynamic range, whereas the single-microlens configuration had an extended linear dynamic range but lower sensitivity and resolution. The chip was also examined for real-time salinity sensing and urine specific gravity analysis.
Article
Optics
Fenghong Chu, Pengfei Han, Shi Feng, Shuangjiao Wei, Huyong Ma, Zhenglan Bian
Summary: This study presents an aluminum ions sensor based on hydrogel optical fiber doped with lumogallion, showing good linearity and stability in detecting aluminum ions concentration. The sensor has potential applications in the field of biology and medicine due to its biocompatible PEGDA core and cladding.
Article
Optics
Darcy L. Smith, Linh Nguyen, David J. Ottaway, Thiago D. Cabral, Eric Fujiwara, Cristiano M. B. Cordeiro, Stephen C. Warren-Smith
Summary: In this paper, we demonstrate that deep learning improves the analysis of fiber specklegrams for sensing, and apply it to measurements of air temperature and water immersion length. We compare deep neural networks (DNNs) including a convolutional neural network and a multi-layer perceptron network with a traditional correlation technique using data from a multimode fiber exposed-core fiber. We also show the ability of the DNNs to be trained against random noise sources like specklegram translations.
Article
Chemistry, Analytical
Xuegang Li, Ning Chen, Xue Zhou, Yanan Zhang, Yong Zhao, Linh Viet Nguyen, Heike Ebendorff-Heidepriem, Stephen C. Warren-Smith
Summary: A label-free DNA biosensor based on exposed core microstructured optical fiber has been presented and experimentally demonstrated for in-situ real-time DNA detection. The sensor, with high sensitivity, is fabricated by splicing a section of tapered exposed core fiber between two single-mode fibers. The experimental results show that the sensor can be used for specific and label-free sensing of DNA hybridization.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Optics
Qi Yu, Xuegang Li, Xue Zhou, Xinjie Gao, Riqing Lv, Linh Nguyen, Stephen C. Warren-Smith, Yong Zhao
Summary: This paper proposes and verifies a highly sensitive temperature compensated fiber optic magnetic field sensor using Sagnac and Mach-Zehnder combination interference (SMZI). The sensor relies on microstructured exposed core fiber filled with ethanol and magnetic fluid. It achieves high magnetic sensitivity and temperature sensitivity, with good repeatability and low detection limits.
Article
Chemistry, Analytical
Fei Li, Xuegang Li, Xue Zhou, Pengqi Gong, Yanan Zhang, Yong Zhao, Linh Viet Nguyen, Heike Ebendorff-Heidepriem, Stephen C. Warren-Smith
Summary: A Fabry-Perot interference biosensor based on the Vernier effect is developed for label-free DNA hybridization detection, showing high sensitivity and specificity in refractive index range.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemical Research Methods
Stephen C. Warren-Smith, Adam D. Kilpatrick, Kabish Wisal, Linh V. Nguyen
Summary: This study introduces a fiber optic sensor array that can be embedded into a mattress to detect movement on a bed. The results show that the sensor array has high sensitivity to various movements on the bed, including breathing. This technology has potential applications in healthcare settings for monitoring physiological parameters and patient movement.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Engineering, Electrical & Electronic
Xuegang Li, Fei Li, Xue Zhou, Yanan Zhang, Linh Viet Nguyen, Stephen C. Warren-Smith, Yong Zhao
Summary: This article introduces a label-free DNA sensor based on the double microcavities Fabry-Perot (FP) interference and Vernier effect. The sensor can simultaneously monitor the temperature to avoid interference with the process of measuring DNA. The proposed sensor has good specificity, high sensitivity, dual-parameter detection, real-time response, and simple fabrication. It is proven by experiments that the temperature sensitivity and refractive index (RI) sensitivity of the sensor are -2.79 nm/°C and -7122.63 nm/RIU, respectively. This is of great significance to solve the problem of the temperature sensitivity of biosensors.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Chemistry, Analytical
Kwang Jun Lee, Patrick K. Capon, Heike Ebendorff-Heidepriem, Emerson Keenan, Fiona Brownfoot, Erik P. Schartner
Summary: Optical fiber pH sensors detect pH by observing changes in the indicator's optical signal. The composition of the polymer matrix used to immobilize the indicator on the fiber surface affects the working pH ranges of these sensors. AAm-based sensors have a pH range of 6.6 - 8.0, while NIPAM-based sensors have a shifted range towards basic pH.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Electrochemistry
Yahia A. A. Yahia, Mohamed W. W. Tawfik, Wolfgang Fritzsche, Hassan M. E. Azzazy
Summary: This review classifies interleukin electrochemical biosensors developed since 2015 into noble metals, ceramics, and carbon-based materials based on the material of the working electrode. The advantages and limitations of each material are discussed and compared, including hybrid ones. Additionally, the designs and performance criteria of these biosensors are compared.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Stephan Kastner, Anne-Kathrin Dietel, Florian Seier, Shaunak Ghosh, Daniel Weiss, Oliwia Makarewicz, Andrea Csaki, Wolfgang Fritzsche
Summary: The need for rapid, simple, and accurate bioassays for nucleic acid detection has increased in recent years. This study utilized localized surface plasmon resonance (LSPR) spectroscopy to detect the antimicrobial resistance gene, sulfhydryl variable beta-lactamase (blaSHV), which confers resistance against a broad spectrum of beta-lactam antibiotics. The system was able to detect a 23 nucleotide DNA sequence at a limit of 25 nm, with signal intensity inversely correlated to sequence length. It was also capable of real-time monitoring and distinguishing single nucleotide polymorphism (SNP) variants of blaSHV.
Article
Chemistry, Analytical
Xuegang Li, Pengqi Gong, Xue Zhou, Shankun Wang, Yingxuan Liu, Yanan Zhang, Linh V. Nguyen, Stephen C. Warren-Smith, Yong Zhao
Summary: This paper demonstrates an advanced multi-parameter optical fiber sensing technology for EGFR gene detection based on DNA hybridization technology. The proposed multi-parameter detection technology can simultaneously detect complementary DNA, temperature, and pH based on a single optical fiber probe, overcoming the limitations of traditional DNA hybridization detection methods. The designed sensor has a sensitivity of 0.07 nm nM-1 for exon-20 concentration and a detection limit of 3.27 nM, providing a fast response, high sensitivity, and low detection limit that is important for DNA hybridization research and addressing the issues of biosensor susceptibility to temperature and pH.
ANALYTICA CHIMICA ACTA
(2023)
Article
Engineering, Electrical & Electronic
Xue Zhou, Shankun Wang, Xuegang Li, Yong Zhao, Yanan Zhang, Linh Viet Nguyen, Stephen C. Warren-Smith
Summary: This paper proposes a novel optical fiber sensor using exposed-core fiber (ECF) to excite whispering gallery modes (WGMs) within a high refractive index barium titanate glass microsphere for achieving label-free real-time specific DNA detection. The microsphere is encapsulated into the exposed channel of the ECF, allowing for physical stability while excited WGMs via the evanescent field. The sensor shows promising results in aqueous environment with high Q-factor levels and potential applications in disease diagnostics, chemical analysis, and environmental protection.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Shaghayegh Baghapour, Jasmine Nehema, Wen Qi Zhang, Stephen C. Warren-Smith, Shane M. Hickey, Sally E. Plush, Shahraam Afshar Vahid
Summary: Dysregulated production of hydrogen sulphide in the human body has been associated with various diseases including cancer, underlining the importance of accurate detection of this molecule. In this study, researchers developed a method to detect hydrogen sulphide using fluorescence-emission enhancement and optical fibres. The results showed a fast response time and pH insensitivity of the fluorophore coated on the optical fibre, suggesting the potential for developing a sensing system for hydrogen sulphide detection.
Review
Polymer Science
Esmat Ebadati, Eliza Switalska, Enzo Lombi, Stephen C. Warren-Smith, Drew Evans
Summary: Soil nutrients are essential for plant growth, but their availability can be influenced by soil pH. This review focuses on the development of polymer materials for in-ground pH sensing and discusses the importance of pH in nutrient availability and toxicity control.
JOURNAL OF POLYMER SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Stephan Kastner, Matthias Urban, Anne-Kathrin Dietel, Andrea Csaki, Wolfgang Fritzsche
Summary: This paper introduces a simple and reliable device setup for time-resolved LSPR measurements using inexpensive array sensor chips. Gold nanoparticles are spotted onto glass substrates under different conditions to achieve optimal signal-to-noise ratio. Bulk sensitivity measurements with solutions of varying refractive index and surface sensitivity measurements with layer-by-layer deposition are performed to verify the setup and sensor chips. The presented cost-effective system allows parallel reading of more than 100 spots in a label-free platform, providing an interesting alternative for the development of future on-site diagnostics.
ADVANCED PHOTONICS RESEARCH
(2023)
Article
Chemistry, Analytical
Xuegang Li, He Zhang, Yanan Zhang, Yong Zhao, Linh Viet Nguyen, Xue Zhou, Stephen C. Warren-Smith
Summary: A label-free isothermal DNA amplification method based on refractive index quantification is proposed and demonstrated for the first time in this paper by combining optical fiber sensing, microfluidics, and isothermal amplification. The experimental results show that this method can achieve real-time label-free monitoring of DNA amplification.
