Article
Multidisciplinary Sciences
Jian Wang, Peirong Xu, Yeyong Zhang, Shuai Han, Gongteng Wang, Hangxiang Wang, Haihan Song, Shufeng Li
Summary: The study develops injectable anticancer nanoassemblies through self-assembly technique, which exhibit tumor-restricted pharmacology and can be self-activated without exogenous stimuli. The anticancer agent cabazitaxel is covalently dimerized to form the prodrug diCTX, which is further coassembled with an ROS generator diDHA. The refined nanoparticles show durable antitumor efficacy in a preclinical model and lower toxicity compared to free drug combinations, suggesting great potential for clinical translation.
Article
Chemistry, Multidisciplinary
Kosmas Vamvakidis, Nikolaos Maniotis, Catherine Dendrinou-Samara
Summary: In this study, a series of magneto-fluorescent nanocomposites were synthesized and optimized through experimental and theoretical studies. The inclusion of an orange-emitting platinum complex was confirmed by spectroscopic techniques, and a theoretical model based on linear response theory was developed to analyze the composites' power losses. Theoretical estimations on optimal concentration and size were validated by experimental data, demonstrating the potential for nanotheranostic applications.
Article
Nanoscience & Nanotechnology
Marcus Vinicius-Araujo, Navadeep Shrivastava, Ailton A. Sousa-Junior, Sebastiao A. Mendanha, Ricardo Costa De Santana, Andris F. Bakuzis
Summary: This study introduces a trimodal system that combines magnetic nanoparticle hyperthermia, photothermal therapy, and luminescent nanothermometry properties into a single nanoplatform, showing potential for multifunctionality. By optimizing zinc-manganese ferrite NPs for low-field magnetic hyperthermia, superior performance was achieved, as well as enhanced photothermal therapy through silica coating and Nd3+ doping.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Catia T. Perciani, Lewis Y. Liu, Lawrence Wood, Sonya A. MacParland
Summary: The use of engineered nanoparticles has shown promise in enhancing vaccine efficacy and host immune responses to viral and tumor antigens. By harnessing the properties of nanoparticles, it may be possible to overcome current obstacles in vaccinology and oncology.
Article
Chemistry, Multidisciplinary
Thibaut Blondy, Julien Poly, Camille Linot, Joanna Boucard, Emilie Allard-Vannier, Steven Nedellec, Phillipe Hulin, Celine Henoumont, Lionel Larbanoix, Robert N. Muller, Sophie Laurent, Elena Ishow, Christophe Blanquart
Summary: The surface chemistry of nanoparticles has a significant impact on their cellular uptake, and the residual groups of chain transfer agents (CTAs) introduced in the main chain can modulate the cell uptake of nanoparticles. This study demonstrates that the cellular internalization of functionalized nanoparticles can be controlled by the compaction of the PEG comb-like shell incorporating CTAs with a long alkyl chain, without changing the overall surface potential.
Article
Environmental Sciences
Nelofer Jan, Neelofar Majeed, Muneeb Ahmad, Waseem Ahmad Lone, Riffat John
Summary: Nanoparticles are highly diverse in quality and sources of emission. The lack of rules and regulations has led to severe impacts on the environment and human health, with only a few studies assessing their toxic effects. Further research is needed to determine the actual impacts of nanoparticles on the environment and human health.
Article
Materials Science, Biomaterials
Hongsen Wang, Yu Wang, Zhaohui Zheng, Fang Yang, Xiaobin Ding, Aiguo Wu
Summary: In this study, four donor-acceptor compounds were synthesized to develop a multifunctional single molecule phototherapeutic agent with excellent fluorescence imaging, photothermal therapy, and photodynamic therapy. The compounds exhibited aggregation-induced emission characteristics and had long emission wavelengths, photostability, biocompatibility, photothermal stability, and singlet oxygen generation performance. The photothermal conversion efficiency of one of the compounds reached 84.5%. Cellular internalization and therapy demonstrated the compounds' good biocompatibility, excellent cell bioimaging, and cancer phototherapy capabilities in vitro.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Multidisciplinary
Xiao Wei, Shen Zhang, Tong Wang, Aixia Chen, Jifeng Guo, Bo Bai, Shengke Yang, Yaqian Li, Xinyi Wang, Xinni Liu
Summary: This study reported a fluorescent sensor that combines luminescent CsPbBr3 quantum dots and molecularly imprinted polymers for trace tetracycline detection in aqueous environments. The sensor showed good linear correlation and low detection limit under optimal conditions. The results pave the way for the practical application of IPQDs in detection environments.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Engineering, Electrical & Electronic
Y. S. Rammah, Hesham M. H. Zakaly, Shams A. M. Issa, H. O. Tekin, M. M. Hessien, H. A. Saudi, A. M. A. Henaish
Summary: The study investigated the impact of Nd3+ ion doping on the fabrication, physical, structure, and optical characteristics of cadmium lead-borate glass systems. The results showed that increasing the Nd2O3 content led to higher density and energy gaps in the fabricated glasses.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Xiaoyun Liu, Chunyan Sun, Mingxia Chai, Weijun Song
Summary: The leaf-like zeolitic imidazolate framework (ZIF-L) is a promising porous nanomaterial that can be used as a host to encapsulate functional fluorescent nanoparticles for designing fluorescent sensors. A simple and rapid synthetic method using polyethyleneimine (PEI)-modified ZIF-L as a host was reported, which solved the precipitation problem and constructed a dual-emitting system combining its fluorescence with carbon dots (CDs). The resulting CDs@ZIF-L/PEI sensor exhibited excellent dispersibility and good selectivity for sensing Hg2+ ions.
Article
Chemistry, Multidisciplinary
Xiaohua Wang, Haiyue Lu, Baicheng Liao, Gen Li, Liyong Chen
Summary: In this study, a facile synthetic method for preparing LDH-based self-assembly structures via a metal ions-mediated zeolitic imidazolate framework-8 (ZIF-8) transformation process is proposed. The loading and release of small molecular weight drugs using hierarchical porous ZIF-8@LDHs core-shell structures and porous cages of LDHs (PC-LDHs) in drug delivery systems are studied. The results show that PC-LDHs outperform ZIF-8@LDHs core-shell structures in terms of drug delivery performance, indicating the decisive role of LDH nanosheets in the drug delivery process. This study provides the preliminary preparation for an LDH-based nanomedicine platform in the field of cancer therapy.
Article
Nanoscience & Nanotechnology
Madalitso M. Mlozen, Jacqueline Van Marwijk, Brendan Shane Wilhelmi, Chris Whiteley
Summary: The increasing number of reported cases of human African trypanosomiasis (HAT) is mainly due to drug resistant Trypanosoma brucei (Tb). Therefore, finding new anti-trypanosomal drugs is crucial. A study showed that silver nanoparticles (AgNPs) selectively inhibited TbHK, which could be used for the development of new drugs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Pharmacology & Pharmacy
Hannah S. Newton, Marina A. Dobrovolskaia
Summary: Pharmaceutical products can activate, suppress, or modify immune responses. Nanoparticles, depending on their physicochemical properties, can have immunostimulatory, immunosuppressive, or immunomodulatory effects. Immunophenotyping is a valuable method for evaluating immune cell changes and activation status.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Spectroscopy
Chao Yang, Ting Li, Qin Yang, Yongming Guo, Tao Tao
Summary: We have developed a hydrothermal method for synthesizing fluorescent silicon nanoparticles (F-SiNPs) with yellow-green emission, which showed excellent stability and good biocompatibility. By utilizing the specific reaction between S2- and 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB), a colorimetric assay for S2- was achieved. The F-SiNPs could be combined with the colorimetric detection system to construct a probe for fluorescence turn-off sensing S2- in aqueous solution due to inner filter effect.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Biochemistry & Molecular Biology
Francesca Roda, Riccardo Caraffi, Silvia Picciolini, Giovanni Tosi, Maria Angela Vandelli, Barbara Ruozi, Marzia Bedoni, Ilaria Ottonelli, Jason Thomas Duskey
Summary: Nanoparticles have potential as a strategy to improve the treatment of glioblastoma by enhancing drug delivery and targeting specific receptors or pathways. This review explores the latest strategies for drug delivery to glioblastoma, with a focus on the importance of surface functionalization for blood-brain barrier crossing and tumor specific targeting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
James M. Begeng, Wei Tong, Blanca del Rosal, Michael Ibbotson, Tatiana Kameneva, Paul R. Stoddart
Summary: Patients with photoreceptor degeneration-caused blindness can partially regain vision through artificial stimulation of surviving retinal ganglion cells (RGCs). Nanoparticle-based optical sensors, specifically nanoparticle-enhanced infrared neural modulation (NINM), show potential in stimulating and inhibiting RGCs, which is important for modulating different types of RGCs. Gold nanorods with tunable absorption in the near-infrared range could be well-suited for retinal prosthesis applications but have not been demonstrated in RGCs before.
Article
Chemistry, Multidisciplinary
Ahmed Refaat, Blanca del Rosal, Viktoria Bongcaron, Aidan P. G. Walsh, Geoffrey Pietersz, Karlheinz Peter, Simon E. Moulton, Xiaowei Wang
Summary: Acute thrombosis is a significant cause of death and illness globally. Researchers have discovered that targeted photothermal therapy using liposomes can effectively dissolve blood clots without major side effects. Liposomes targeted to activated platelets can selectively accumulate in thrombi, leading to enhanced treatment efficacy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhuolei Zhang, Artiom Skripka, Jakob C. Dahl, Chaochao Dun, Jeffrey J. Urban, Daniel Jaque, P. James Schuck, Bruce E. Cohen, Emory M. Chan
Summary: This article demonstrates the controllable synthesis of low-phonon-energy KPb2X5 (X=Cl, Br) nanoparticles and the ability to tune nanocrystal phonon energies as low as 128 cm(-1). KPb2Cl5 nanoparticles are moisture resistant and can be efficiently doped with lighter lanthanides. The low phonon energies of KPb2X5 nanoparticles promote upconversion luminescence from higher lanthanide excited states and enable highly nonlinear, avalanche-like emission from KPb2Cl5 : Nd3+ nanoparticles. The realization of nanoparticles with tunable, ultra-low phonon energies facilitates the discovery of nanomaterials with phonon-dependent properties, precisely engineered for applications in nanoscale imaging, sensing, luminescence thermometry and energy conversion.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemical Research Methods
Jose Lifante, Maria de la Fuente-Fernandez, Marta Roman-Carmena, Nuria Fernandez, Daniel Jaque Garcia, Miriam Granado, Erving Ximendes
Summary: The prevalence of nonalcoholic fatty liver (NAFLD) is increasing worldwide, and accurate diagnosis is crucial to prevent complications. Ultrasonography may underestimate NAFLD prevalence, hence a need for a noninvasive method. In this study, an integrated approach using autofluorescence and reflectance signals accurately estimated triglyceride density in the livers of mice.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Materials Science, Multidisciplinary
Wojciech M. Piotrowski, Riccardo Marin, Maja Szymczak, Emma Martin Rodriguez, Dirk H. Ortgies, Paloma Rodriguez-Sevilla, Miroslav D. Dramicanin, Daniel Jaque, Lukasz Marciniak
Summary: Lifetime-based luminescence thermometry enables accurate deep-tissue monitoring of temperature changes, but short lifetimes and poor brightness limit its performance. A solution to these limitations is the design and optimization of luminescent nanothermometers co-doped with transition metal and lanthanide ions, which exhibit strong near-infrared emission and long temperature-dependent photoluminescence lifetime. These nanothermometers, combined with a custom-made instrument, allow for obtaining 2D thermal maps for deep-tissue thermal mapping. This study provides foundations for the deployment of lifetime-based thermometry for accurate deep-tissue temperature monitoring.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Oncology
Gabriel Lopez-Pena, Silvia Simon-Fuente, Dirk H. Ortgies, Maria Angeles Moline, Emma Martin Rodriguez, Francisco Sanz-Rodriguez, Maria Ribagorda
Summary: This work presents a nanoplatform for deep-tissue photodynamic therapy and imaging using upconverting nanoparticles functionalized with eosin Y (EY) as photosensitizers. The nanoparticles can be excited by 800 nm near infrared light, allowing better penetration and minimal thermal load. Additionally, the combination with UCNPs enables the transport of EY into the cell and the generation of reactive oxygen species (ROS) under 800 nm light. The functionalized UCNPs also exhibit deep tissue NIR-II fluorescence under 808 nm excitation, making them potential bioimaging agents.
Article
Chemistry, Multidisciplinary
Tamara Munoz-Ortiz, Idoia Alayeto, Jose Lifante, Dirk H. Ortgies, Riccardo Marin, Emma Martin Rodriguez, Maria del Carmen Iglesias de la Cruz, Gines Lifante-Pedrola, Jorge Rubio-Retama, Daniel Jaque
Summary: Nanothermometry utilizes nanoparticles as thermal probes, enabling remote and minimally invasive sensing. It has emerged as a powerful tool in biomedicine. However, the lack of 3D thermal imaging capability and readily available tools in clinic hinders its translation to the bedside.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Liyan Ming, Irene Zabala-Gutierrez, Paloma Rodriguez-Sevilla, Jorge Rubio Retama, Daniel Jaque, Riccardo Marin, Erving Ximendes
Summary: This article introduces a luminescence lifetime estimation method based on U-NET to improve the estimation accuracy under extremely low signal-to-noise ratio conditions. The effectiveness of U-NET is demonstrated in luminescence lifetime thermometry and its sensing performance improvement is verified through two experiments under extreme measurement conditions.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Carlos D. S. Brites, Riccardo Marin, Markus Suta, Albano N. Carneiro Neto, Erving Ximendes, Daniel Jaque, Luis D. Carlos
Summary: Luminescence (nano)thermometry is a remote sensing technique that utilizes the temperature dependency of luminescence features to measure temperature. It has potential applications in various fields and requires the establishment of a theoretical background, standardized practices, and improved readouts through multiparametric analysis and artificial intelligence algorithms. Challenges in luminescence thermometry and the need for continuous innovation are also discussed.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Amalia Coro, Ada Herrero Ruiz, Mateo Pazo-Gonzalez, Alonso Sanchez-Cruz, Tobias Busch, Alejandro Hernandez Medel, Erving C. Ximendes, Dirk H. Ortgies, Rosalia Lopez-Mendez, Ana Espinosa, Dorleta Jimenez de Aberasturi, Daniel Jaque, Nuria Fernandez Monsalve, Enrique J. de la Rosa, Catalina Hernandez-Sanchez, Emma Martin Rodriguez, Beatriz H. Juarez
Summary: In this study, the application of Ag2S nanoparticles in ocular imaging was extended by preparing them with a biocompatible amphiphilic block copolymer. This method protects the photoluminescence properties of the nanoparticles and allows for the controlled preparation of submicrometric scattering centers, enhancing colloidal stability and biocompatibility. The resulting nanoparticles exhibit improved contrast for optical coherence tomography and near-infrared imaging.
Article
Chemistry, Multidisciplinary
Ana C. C. Soares, Tasso O. Sales, Erving C. Ximendes, Daniel Jaque, Carlos Jacinto
Summary: In recent years, there has been significant interest in infrared emitting luminescent nanothermometers due to their potential for new diagnosis and therapy procedures. However, concerns have been raised regarding their reliability, as tissues can induce spectral distortions even in the commonly used second biological window. In this study, the effectiveness of shifting the operation range of these nanothermometers to the third biological window is demonstrated, showing minimal distortion by tissue and opening the path to reliable luminescence thermometry. Advanced analysis of emission spectra allows for sub-degree thermal uncertainties.
NANOSCALE ADVANCES
(2023)
Article
Materials Science, Multidisciplinary
W. M. Piotrowski, R. Marin, M. Szymczak, E. Martin Rodriguez, D. H. Ortgies, P. Rodriguez-Sevilla, P. Bolek, M. D. Dramicanin, D. Jaque, L. Marciniak
Summary: Near-infrared (NIR) luminescence thermometry is a reliable method for remote thermal sensing and imaging. Lanthanide (Ln(3+))-based nanophosphors are commonly used as NIR nanothermometers, but the combination of Ln(3+) with transition metal (TM) ions can enhance the sensitivity of the thermometric approach. However, there are few examples of luminescence nanothermometers combining both TM and Ln(3+), leaving room for further exploration of these systems.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Marina Paris Ogayar, Diego Mendez-Gonzalez, Irene Zabala Gutierrez, Alvaro Artiga, Jorge Rubio-Retama, Oscar G. Calderon, Sonia Melle, Aida Serrano, Ana Espinosa, Daniel Jaque, Riccardo Marin
Summary: Luminescence nanothermometry is a technique that uses luminescence signals from nanosized materials to remotely and minimally invasively measure temperature. However, in a biomedical context, the reliability of temperature measurement is compromised by bias caused by environmental conditions. This study reveals an unexpected source of bias induced by metal ions, which enhances the emission of Ag2S nanothermometers. These findings highlight the need for caution when using luminescence nanothermometry in complex biological environments.
Article
Materials Science, Multidisciplinary
Yanbin Wang, Xinyou Huang, Ziqiu Cheng, Penghui Chen, Yuyang Chen, Junhao Ye, Haohong Chen, Zhenzhen Zhou, Denis Yu Kosyanov, Jiang Li
Summary: Uniform Al2O3-Ce:LuAG composite phosphor ceramics (CPCs) with excellent luminescent properties and thermal stability have been successfully synthesized in this study, showing great potential for application in solid-state laser lighting.
Article
Materials Science, Multidisciplinary
Syed Muhammad Ali Zaidi, Mazhar Ali Kalyar, Zulfiqar Ali Raza, Aayesha Shoukat, Rubaila Waseem, Muhammad Aslam
Summary: Polyvinyl alcohol (PVA) nanocomposite strips embedded with graphene nanosheets and copper-ferrite nanoparticles were synthesized using solution casting technique. Laser pulse irradiations were then applied to modify the structural, optical, and electrical properties of the strips, showing potential for optoelectronic devices.
Article
Materials Science, Multidisciplinary
Yunru Chen, Jialing Wu, Jiajia Wang, Shihui Ma, Hongwei Yu
Summary: This paper investigates the angular non-critical phase-matching second-harmonic-generation properties of Ba3(ZnB5O10)PO4 crystal and explores its potential applications in the output spectral regions.
Article
Materials Science, Multidisciplinary
Qun Jing, Menglin Zhu, Lu Li, Xu Ji, Haiming Duan, Henglei Chen, Ming-Hsien Lee
Summary: The paper introduces two new nonlinear optical materials, MZnPO4 (M = Rb, Cs), synthesized by cation substitution. These materials exhibit a honeycomb-like structure and show mild SHG responses with short absorption edges. The thermal properties, IR spectra, and theoretical calculations of the materials are also discussed.
Article
Materials Science, Multidisciplinary
Camila Ianhez-Pereira, Akhil Kuriakose, Ariano De Giovanni Rodrigues, Ana Luiza Costa Silva, Ottavia Jedrkiewicz, Monica Bollani, Marcio Peron Franco de Godoy
Summary: This study aims to evaluate the crystalline changes induced by ultrafast laser micromachining on manganese oxide thin films using micro-Raman spectroscopy. The results show that laser-writing is effective in locally modifying low-crystallinity films and increasing crystallite sizes, highlighting an interesting approach to evaluate laser-induced structural modifications on metal oxide thin films.
Article
Materials Science, Multidisciplinary
Kamal Bansal, Neeraj Kumar Mishra, Ibrahim Abdullahi, Param Jeet Singh, Mohit Tyagi, Sukhpal Singh
Summary: A novel Sm3+ activated oxyfluoride glass was synthesized and its structure and properties were analyzed. The glass showed potential applications in lasers, optical temperature sensing, and high-energy scintillators.
Article
Materials Science, Multidisciplinary
Xingjian Wang, Zhixu Wu, Jiawei Zhu, Yubin Kang, Mengqiang Cai, Yong Xia, Hui Deng
Summary: Antimony sulfide (Sb2S3) has been investigated as a promising material for visible light photodetectors due to its non-toxicity, stability, and high absorption coefficient. In this study, we systematically explored the impact of key parameters on the performance of Sb2S3 devices using simulation and successfully fabricated self-powered photodetectors with high responsivity and specific detectivity. Furthermore, we demonstrated the application of the Sb2S3 detector in a scanning imaging system, showcasing its potential for developing new types of visible light detectors and imaging systems.
Article
Materials Science, Multidisciplinary
O. I. Sallam, R. M. Ahmed
Summary: The 20NaF-60P2O5-20Na2O fluorophosphate glass systems doped with 3 wt% of CoO and NiO were investigated for their optical parameters before and after gamma irradiation. The presence of defects within the glass network and the addition of transition metals were found to affect the properties of the composites. After irradiation, a red shift was observed in the dissipation factor spectrum. The energy lost at the surface of the composites was larger than the energy lost within the constituent materials. All investigated composites showed insulating behavior and exhibited increased nonlinear optical parameters after irradiation, with the CoO-doped composite showing the highest values.
Article
Materials Science, Multidisciplinary
Fahimeh Ahmadi, Zeinab Ebrahimpour, Asghar Asgari, Bao Van
Summary: In this study, Er3+-doped sulfophosphate glasses containing titanium nanoparticles (TiO2 NPs) and different concentrations of silver nanoparticles (AgNPs) were synthesized. The impact of AgNPs on the physical and structural characteristics, optical absorption and emission features, and photocatalytic activity of the glasses were investigated. The results showed that the addition of AgNPs enhanced the emission intensity of the glasses, with the system containing 0.04 mol% of AgNPs exhibiting optimal performance. Furthermore, the presence of AgNPs and TiO2 NPs in the glass matrix positively affected the photocatalytic performance.
Article
Materials Science, Multidisciplinary
Zhuang Li, Rongfei Huang, Wei Yuan, Shaoqiang Zheng, Wenlu Liao, Huiying Xu, Zhiping Cai
Summary: This study reports the first realization of an 868 nm Pr:YLF laser pumped by an InGaN blue laser diode. The laser achieved a maximum power of 641 mW with stable output and good beam quality. The experimental results were in agreement with theoretical simulations.
Article
Materials Science, Multidisciplinary
Bhishma Karki, Youssef Trabelsi, Amrindra Pal, Sofyan A. Taya, Ram Bharos Yadav
Summary: This study proposes an SF11 Prism- Ag- ZnO nanowires-CeO2-Sensing layer-based surface plasmon resonance sensor for measuring dopamine concentration in human blood. The sensor demonstrates high sensitivity and detection accuracy, and holds significant importance for early diagnosis of neurological diseases.
Article
Materials Science, Multidisciplinary
M. Taoufiq, A. Soussi, A. Elfanaoui, A. Ait Hssi, S. Baoubih, A. Ihlal, K. Bouabid
Summary: In this study, the effect of copper doping within ZnS on glass substrates was investigated through experimental and theoretical approaches. Pure ZnS and Cu-doped ZnS films with varying copper concentrations were deposited on glass substrates using the SILAR technique. The structural, morphological, and optical properties of the films were characterized, and the theoretical FP-LAPW method based on density functional theory was employed to study the properties of copper-doped ZnS.
