Article
Biotechnology & Applied Microbiology
Yuxin Li, Lei Tian, Li-Li Guo, Yiran Hao, Ying Jie
Summary: This study evaluated the repeatability and reproducibility of 36 DCR parameters and bIOP parameters derived from Corvis ST in healthy eyes, and investigated their relationship with demographic and ocular characteristics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yuwei Zheng, Chao Xue, Jing Wang, Xuan Chen, Xiaohui Wang, Yan Wang
Summary: This study investigated the correlation between corneal biomechanical properties (in vitro and in vivo) and corneal densitometry in myopic patients. CD values and in vivo biomechanical parameters were obtained through Pentacam corneal densitometry and Corvis ST exams. Results showed a negative correlation between biomechanical properties and corneal densitometry in myopic patients.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Ophthalmology
Tomoya Nishida, Takashi Kojima, Takahiro Kataoka, Naoki Isogai, Yoko Yoshida, Tomoaki Nakamura
Summary: The study compared the effects of C-CXL and A-CXL on corneal biomechanical properties and morphology, with results showing that C-CXL had a more significant impact on improving corneal biomechanical parameters and shape than A-CXL.
Article
Biotechnology & Applied Microbiology
Mohammad-Reza Sedaghat, Hamed Momeni-Moghaddam, Abbas Azimi, Zohreh Fakhimi, Mohammed Ziaei, Zeynad Danesh, Cynthia J. Roberts, Naeemeh Monfared, Alireza Jamali
Summary: The study investigated corneal biomechanical response parameters in varying degrees of myopia and their correlation with corneal geometrical parameters and axial length. The results showed significant relationships between corneal biomechanical parameters with level of myopia, indicating a progressive reduction in corneal stiffness with increasing myopia, independent of IOP and CCT. Dynamic corneal response assessed by Corvis ST indicates biomechanical changes consistent with decreasing stiffness with increasing levels of myopia.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Ophthalmology
Min-Xin Liu, Dan-Lin Li, Zhi-Jian Yin, Yue-Zu Li, Ya-Jie Zheng, Yu Qin, Gang Liang, Chen-Wei Pan
Summary: This study investigated the association between smoking and alcohol consumption with corneal biomechanical parameters in university students. The findings showed that smoking was significantly associated with stiffer corneas, characterized by slower second applanation velocity and lower integrated radius. However, no significant association was found between alcohol consumption or passive smoking and corneal biomechanics.
Article
Biotechnology & Applied Microbiology
Xia Li, Anji Wei, Yujing Yang, Jiaxu Hong, Jianjiang Xu
Summary: This study aimed to investigate the short-term effects of eye rubbing on corneal biomechanical properties in myopia and emmetropia. The results showed that eye rubbing made the cornea softer, especially in myopic patients. All parameters returned to baseline levels after one week.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
M. Marinescu, D. Dascalescu, M. Constantin, V. Coviltir, M. Burcel, D. Darabus, R. Ciuluvica, D. Stanila, L. Voinea, V. Potop
Summary: This study investigated the relationship between corneal biomechanics and ocular morphology in myopic children and adolescents. The results showed that myopic eyes had lower corneal hysteresis and corneal resistance factor, and higher axial length and central corneal thickness compared to emmetropic eyes. There were also significant correlations between these parameters.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Vannarut Satitpitakul, Parichart Taweekitikul, Vilavun Puangsricharern, Ngamjit Kasetsuwan, Usanee Reinprayoon, Thanachaporn Kittipibul
Summary: This study evaluated the association between symptoms and signs of dry eye diseases (DED) with corneal biomechanical parameters, finding that as the severity of DED increased, corneal biomechanics worsened, but there was no significant difference in tear production levels.
Article
Ophthalmology
Bandar Alenezi, Ahmed Kazaili, Riaz Akhtar, Hema Radhakrishnan
Summary: The study found that age has an impact on corneal biomechanical properties following corneal cross-linking, with younger age groups showing greater corneal elastic enhancement. Cross-linking treatment effectively strengthened the stroma, particularly in the anterior and mid stroma, with minimal impact on the posterior stroma.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Dan-Lin Li, Min-Xin Liu, Zhi-Jian Yin, Yue-Zu Li, Rong Ma, Ya-Jie Zheng, Yu Qin, Gang Liang, Chen-Wei Pan
Summary: This study found significant associations between corneal biomechanical properties and axial length, suggesting that myopic eyes have more deformable corneas.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Mohammad-Reza Sedaghat, Hamed Momeni-Moghaddam, Asieh Ehsaei, Riccardo Vinciguerra, Omid Zamani, Hassan Robabi
Summary: The purpose of this study was to compare corneal biomechanical parameters between normal thin corneas and matched keratoconus eyes. The results showed significant differences in softness between keratoconus corneas and healthy thin corneas of matched thickness. However, the clinical use of standard and combined biomechanical parameters is limited by the cutoff points in these particular cases.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2023)
Article
Ophthalmology
Chao Xue, Yaoqi Xiang, Yi Song, Min Shen, Di Wu, Yan Wang
Summary: This study used fresh human corneal tissue to confirm the assumption that the corneal biomechanical properties are similar between the eyes of the same individual. The results showed no significant difference in biomechanical parameters between the left and right eyes, and the LSTM and HSTM were significantly correlated with spherical equivalent.
JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Riccardo Vinciguerra, Robert Herber, Yan Wang, Fengju Zhang, Xingtao Zhou, Ji Bai, Keming Yu, Shihao Chen, Xuejun Fang, Frederik Raiskup, Paolo Vinciguerra
Summary: This study aimed to evaluate the difference in Corvis ST dynamic corneal response parameters between Caucasian and Chinese healthy subjects. After matching for age, IOP, and CCT, significant differences were found in SPA1, ARTh, and SSI values between the two ethnic groups, while other parameters did not show significant differences.
FRONTIERS IN MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Yan Liu, Chenjiu Pang, Shuai Ming, Qi Fan
Summary: The purpose of this study was to investigate the differences in corneal biomechanical parameter stress-strain index (SSI) among different degrees of myopic eyes in Chinese individuals and to analyze the relevant factors of the SSI. The results showed that the SSI decreased with increasing myopia and astigmatism, especially in high and ultra-high myopia.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Usanee Reinprayoon, Monthira Jermjutitham, Ngamjit Kasetsuwan
Summary: This study found that with the increasing severity of Fuchs' endothelial corneal dystrophy (FECD), the rate of endothelial cell loss increased and the corneal biomechanical properties changed. In the advanced stage, the corneas significantly altered their viscoelastic behavior by decreasing resistance.
FRONTIERS IN MEDICINE
(2021)
Article
Ophthalmology
Mijie Li, Carla Lanca, Chuen-Seng Tan, Li-Lian Foo, Chen-Hsin Sun, Fabian Yap, Raymond P. Najjar, Charumathi Sabanayagam, Seang-Mei Saw
Summary: This study evaluated the association between reported time outdoors and light exposure patterns with myopia in 9-year-old Singaporean children. The findings showed that greater reported time outdoors was associated with a lower risk of myopia, while light levels and specific light measures did not have an impact.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Anna C. S. Tan, Miao Li Chee, Beau J. Fenner, Paul Mitchell, Yih Chung Tham, Tyler Rim, Kelvin Teo, Shaun S. Sim, Ching Yu Cheng, Tien Yin Wong, Usha Chakravarthy, Chui Ming Gemmy Cheung
Summary: This study aimed to report the incidence of age-related changes in drusen volume detected by optical coherence tomography (OCT) over a span of 6 years and their systemic and ocular associations. The results showed that the incidence of age-related macular degeneration (AMD) detected at 6 years was low. Drusen volume in the macular region either decreased, remained stable, or increased over the 6-year period. Older age, smoking, and chronic kidney disease were associated with decreased drusen volume, while older age and hypertension were associated with increased drusen volume.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Yi Xuen Chai, Alfred Tau Liang Gan, Eva K. Fenwick, Abraham Y. Sui, Benjamin Kye Jyn Tan, Debra Q. Y. Quek, Chaoxu Qian, Tien Yin Wong, Ching-Yu Cheng, Ecosse Luc Lamoureux, Ryan Eyn Kidd Man
Summary: This study aims to examine the relationship between vision impairment (VI) and employment outcomes in a multiethnic Asian population. The results suggest that even mild VI is associated with unemployment and underemployment.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Natalia Porporato, Rachel Chong, Benjamin Y. Xu, Tin A. Tun, Joanne HuiMin Quah, Marcus Tan, Mani Baskaran, Ching Yu Cheng, Tin Aung
Summary: There is an association between the extent of iridotrabecular contact and other quantitative anterior segment dimensions with intraocular pressure (IOP). ITC index and ACD have significant effects on IOP, and their joint association is particularly significant. These parameters have important implications for predicting elevated IOP, especially in women with gonioscopic angle closure.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Li Lian Foo, Lingqian Xu, Charumathi Sabanayagam, Hla M. Htoon, Han Nian Marcus Ang, Jingwen Zhang, Kyoko Ohno-Matsui, Ching Yu Cheng, Quan Hoang, Chuen-Seng Tan, Seang-Mei Saw, Chee Wai Wong
Summary: The purpose of this study was to investigate the predictive factors for myopic macular degeneration (MMD) and progression in adults with myopia. The study found that in adults without MMD, tessellated fundus, age, spherical equivalent (SE), and axial length (AL) were good predictors for incident MMD. In adults with MMD, older age, more severe myopia, and longer AL were independent risk factors for progression.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Chaoxu Qian, Simon Nusinovici, Sahil Thakur, Zhi Da Soh, Shivani Majithia, Miao Li Chee, Hua Zhong, Yih-Chung Tham, Charumathi Sabanayagam, Pirro G. Hysi, Ching-Yu Cheng
Summary: This study identifies several blood metabolites that are associated with intraocular pressure (IOP). The findings provide insights into the physiological and pathological processes underlying IOP control.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
David Ziyou Chen, Charlene Wong, Janice Sing Harn Lam, Chen-Hsin Sun, Yien Lai, Victor Teck Chang Koh, Yap-Seng Chong, Seang-Mei Saw, Yih-Chung Tham, Cheryl Ngo
Summary: This study aimed to determine axial length elongation profiles in children aged 3-6 years in an Asian population. The study found that the average axial length increased by 0.80 mm from 3 to 6 years, with myopic eyes showing the greatest elongation. Furthermore, an increase in birth weight was associated with greater axial length elongation in children.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Li Lian Foo, Chuen-Seng Tan, Brennan Noel, Hla M. Htoon, Raymond P. Najjar, Biten Kathrani, Charumathi Sabanayagam, Seang-Mei Saw
Summary: The purpose of this study was to evaluate factors influencing myopia stabilisation in Singapore. The longitudinal natural history of 424 myopic participants from 1999 to 2022 was evaluated, and it was found that 82.3% of people had stabilisation of myopia within 10 years. The study also found that males and non-Chinese ethnicities were more likely to achieve myopia stabilisation.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Yu Huang, Carol Y. Cheung, Dawei Li, Yih Chung Tham, Bin Sheng, Ching Yu Cheng, Ya Xing Wang, Tien Yin Wong
Summary: Cardiovascular disease (CVD) is a major cause of death globally, and the use of artificial intelligence (AI) in analyzing ocular images has the potential to enhance CVD risk prediction. This review provides an overview of AI-based ocular image analysis for predicting CVD and discusses the limitations in AI research and the challenges in clinical practice.
Article
Biology
Charumathi Sabanayagam, Feng He, Simon Nusinovici, Jialiang Li, Cynthia Lim, Gavin Tan, Ching Yu Cheng
Summary: This study compares the accuracy of different machine learning algorithms in predicting diabetic kidney disease. The results show that machine learning models outperform logistic regression and identify novel risk factors.
Article
Ophthalmology
Kai Xiong Cheong, Hengtong Li, Yih Chung Tham, Kelvin Yi Chong Teo, Anna Cheng Sim Tan, Leopold Schmetterer, Tien Yin Wong, Chui Ming Gemmy Cheung, Ching-Yu Cheng, Qiao Fan
Summary: This study evaluated the relationship between genetic susceptibility to AMD and retinal thickness, finding that certain genetic variants were associated with thinner retinal layers, particularly the photoreceptor layers. These findings suggest that retinal thickness could serve as a potential risk marker for prodromal AMD, highlighting the importance of considering topographic variation.
OPHTHALMOLOGY SCIENCE
(2023)