Article
Oncology
Xin Zhao, Xiaoshi Zhang, Xinxue Zhang, Tao Jiang, Jialei Zhai, Huaguang Wang, Mengxiu Huang, Ren Lang, Qiang He
Summary: This study revealed that miR-374b-5p is downregulated in pancreatic cancer (PC) and its overexpression can inhibit the proliferation, migration, and invasion of PC cells by suppressing the expression of KDM5B, thereby reducing epithelial-mesenchymal transition (EMT) in PC. The findings suggest that miR-374b-5p could potentially serve as a prognostic biomarker and therapeutic target for EMT induced by KDM5B in PC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Pathology
Ning-Lei Li, Gang Xiao, Yi-Yi Jin, Yun-Yao Deng, Yu-Jiao Liu, Liang-Chun Yin
Summary: This study revealed the interactions between long non-coding RNA LINC00992, miR-361-5p, and transcription factor Twist1 in the progression of hepatocellular carcinoma (HCC). The results showed that LINC00992 upregulated the expression of Twist1 by downregulating miR-361-5p, leading to increased proliferation, migration, and invasion of HCC cells.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biotechnology & Applied Microbiology
Zhenglei Xu, Zeming Chen, Minsi Peng, Zhuliang Zhang, Weixiang Luo, Ruiyue Shi, Lisheng Wang, Yingcai Hong
Summary: Pancreatic cancer is difficult to treat, and the main reasons for poor prognosis are cell invasion and migration. In this study, researchers found that miR-490-5p is abnormally low-expressed in pancreatic cancer and downregulation of miR-490-5p enhances the viability, migration, and invasion of pancreatic cancer cells. Additionally, miR-490-5p regulates the protein expression of MMP2, MMP9, and N-cadherin, and upregulates the protein expression of E-cadherin. The expression of MAGI2-AS3 is also associated with cell viability, migration, and invasion in pancreatic cancer. The study reveals that miR-490-5p plays an anti-cancer role in pancreatic cancer by targeting MAGI2-AS3 and regulating EMT.
Article
Oncology
Deheng Li, Liangdong Li, Xin Chen, Wentao Yang, Yiqun Cao
Summary: A novel upregulated circRNA, circSERPINE2, was identified in glioblastoma, promoting tumor cell proliferation and progression by sponging miRNAs and enhancing the expression of the anti-apoptosis gene BCL2. This study reveals the biological function and mechanism of circSERPINE2 in glioblastoma progression, suggesting its potential as a therapeutic target.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Medicine, Research & Experimental
Ke-Da Yang, Ying Wang, Fan Zhang, Bai-Hua Luo, De-Yun Feng, Zhi-Jun Zeng
Summary: This study found that circN4BP2L2 acts as an oncogene in CRC, promoting tumor growth and metastasis by regulating the miR-340-5p/CXCR4 axis. The authors revealed a novel mechanism in the ceRNA regulatory network for CRC progression and identified a potential therapeutic target for CRC treatment.
LABORATORY INVESTIGATION
(2022)
Article
Biotechnology & Applied Microbiology
Xiaobo He, Xiao Cheng, Jianfeng Ding, Maoming Xiong, Bo Chen, Guodong Cao
Summary: This study found that the overexpression of PFKFB3 is associated with poor prognosis in gastric cancer patients. Hyperglycemia stimulates the high expression of PFKFB3 and enhances proliferation, migration, and epithelial-mesenchymal transition in gastric cancer cells. Down-regulation of PFKFB3 by miR-26-5p inhibits the malignant phenotype of gastric cancer with hyperglycemia.
Article
Biophysics
Tianyi Wang, Yinpeng Huang
Summary: The study showed that hsa_circ_0001681 expression was increased in thyroid carcinoma, while miR-942-5p expression was decreased and negatively correlated with hsa_circ_0001681. Silencing hsa_circ_0001681 significantly inhibited the proliferation, migration, invasion, and EMT of TC cells. Downregulation of hsa_circ_0001681 suppressed tumor growth by repressing EMT through regulating the miR-942-5p/TWIST1 signaling pathway.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2021)
Article
Cell Biology
Dandan Wang, Liangyi Cui, Qing Yang, Jiao Wang
Summary: The up-regulated circZFPM2 in ectopic endometrial tissues can induce EMT through the miR-205-5p /ZEB1 signaling pathway, promoting cell proliferation, migration, and invasion. This may serve as a promising biomarker in the diagnosis and treatment of endometriosis.
CELLULAR SIGNALLING
(2021)
Article
Chemistry, Medicinal
Jia Yang, Gangdan Jiang, Kaiwen Ni, Liming Fan, Wang Tong, Junchao Yang
Summary: Emodin can attenuate pulmonary fibrosis and epithelial-mesenchymal transition (EMT) by regulating the c-MYC/miR-182-5p/ZEB2 axis, providing evidence for the application of Emodin in the treatment of pulmonary fibrosis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biology
Pingping Peng, Huamei Song, Chenghong Xie, Wenfei Zheng, Huigai Ma, Dandan Xin, Jingqiong Zhan, Xiaoqing Yuan, Aihua Chen, Jing Tao, Jufang Qin
Summary: This study reveals that miR-146a-5p mediates trophoblast cell proliferation and invasion by regulating the expression of Wnt2, thus influencing the development of preeclampsia.
BIOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Huiyan Niu, Anna Qu, Chunyan Guan
Summary: The study revealed that miR-188-5p inhibits invasion and migration of lung cancer cells by regulating the MGAT3 gene, thereby suppressing the EMT process, suggesting potential therapeutic value for the management of metastatic lung cancer.
BIOMEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Yanzhe Wang, Yuyuan Liu, Ling Zhang, Linnan Bai, Sijia Chen, Hao Wu, Linlin Sun, Xiaoxia Wang
Summary: The study investigated the effect of miR-30b-5p targeting SNAIL on epithelial-to-mesenchymal transition (EMT) in diabetic nephropathy (DN). The findings suggest that miR-30b-5p plays a protective role by targeting SNAI1 in renal EMT in DN.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Guo Yang, Yangyang Tian, Chao Li, Jiarui Xia, Yuanmeng Qi, Wu Yao, Changfu Hao
Summary: This study observed the changes and effects of UCA1 and miR-204-5p in silica-induced mouse silicosis model and in vitro EMT model of A549 cells. It was found that both models showed the presence of EMT process, and UCA1 was upregulated in the in vitro model. Silencing UCA1 inhibited EMT process, while intervention of miR-204-5p regulated EMT.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Oncology
Wenli Liu, Xuewei Gao, Xiaolong Chen, Na Zhao, Ying Sun, Yawen Zou, Yize Guan, Lin Yang, Xiaoxian Pei, Guozhen Wang, Bin Wang, Mingcheng Li, Wengang Song
Summary: The study revealed that WTAP is a potential oncogene in HCC and its expression is correlated with clinical features and patient prognosis. MiR-139-5p negatively regulates WTAP expression and affects the growth and invasion abilities of HCC cells. The miR-139-5p/WTAP axis controls HCC progression by regulating EMT.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Caihong Liu, Junjuan Lu, Ting Yuan, Lihua Xie, Li Zhang
Summary: This study aimed to investigate whether exosomes can influence the ferroptosis of bronchial epithelial cells (BECs) in chronic obstructive pulmonary disease (COPD) and the mechanisms involved. The researchers extracted and identified endothelial progenitor cells (EPCs) and EPC-Exo from blood samples of normal subjects and COPD patients, and established a COPD animal model. They found that EPCs could alleviate cigarette smoke-induced ferroptosis in BECs by transporting exosomes. In addition, exosomes also alleviated cigarette smoke-induced ferroptosis and airway remodeling in mice. The study revealed that the PTGS2/PGE2 pathway and miR-26a-5p played important roles in the regulation of ferroptosis and epithelial-mesenchymal transition in BECs.
SCIENTIFIC REPORTS
(2023)