Review
Pharmacology & Pharmacy
Zohreh Yaghobi, Aliakbar Movassaghpour, Mehdi Talebi, Mahdi Abdoli Shadbad, Khalil Hajiasgharzadeh, Shiva Pourvahdani, Behzad Baradaran
Summary: CD44, overexpressed on cancer stem cells, interacts with hyaluronan to influence tumor development and chemoresistance, inhibiting the cytotoxic effect of chemotherapy medications. Therefore, high expression of CD44 is associated with poor prognosis in cancer patients.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Lucie M. Frerichs, Bastian Frerichs, Patrick Petzsch, Karl Koehrer, Joachim Windolf, Bernd Bittersohl, Michele J. Hoffmann, Vera Grotheer
Summary: Patients with muscle-invasive bladder cancer have a poor prognosis. The tumor microenvironment plays a key role in tumor development and therapy resistance. This study found that mesenchymal stromal cells and fibroblasts have tumor-promoting effects on bladder cancer cells and increase chemoresistance.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhanhong Liu, Pengbo Hou, Jiankai Fang, Jingyu Zhu, Juanmin Zha, Rui Liu, Yayun Ding, Muqiu Zuo, Peishan Li, Lijuan Cao, Chao Feng, Gerry Melino, Changshun Shao, Yufang Shi
Summary: Chemotherapy resistance in breast cancer can be induced by mesenchymal stromal cells (MSCs) through reducing the intratumoral accumulation of doxorubicin. This resistance is mediated by hyaluronan (HA), a major extracellular matrix (ECM) product of MSCs, which can bind with doxorubicin and inhibit its entry into breast cancer cells. High levels of HA in the serum are positively associated with chemoresistance in breast cancer patients.
Article
Oncology
Abdel-Rahman N. Zekri, Abeer Bahnassy, Magda Mourad, Ibrahim Malash, Ola Ahmed, Mona S. Abdellateif
Summary: This study characterized breast cancer stem cells (BCSCs) through genetic profiling, revealing specific molecular profiles that differ according to their phenotypes. These profiles could potentially impact patients' prognosis and outcome.
CANCER CELL INTERNATIONAL
(2022)
Article
Environmental Sciences
Yunhe Lu, Wei Wang, Shubin Tan
Summary: This study identified that EHD1 was upregulated in glioma cells and played a role in promoting cancer stem cell-like traits through enhancing CD44 stability and preventing ubiquitination. The study also revealed a higher expression of EHD1 in glioma tissues, which correlated with the expression of CSC markers and patient survival.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Dongliang Wang, Chaoshuai Zhao, Fei Xu, Aimi Zhang, Mingming Jin, Kunchi Zhang, Liu Liu, Qian Hua, Jian Zhao, Jianjun Liu, Hao Yang, Gang Huang
Summary: Hypoxia exacerbates cisplatin resistance in NSCLC cells by increasing the expression of PKM2 in exosomes secreted by hypoxic cisplatin-resistance cells. Exosomal PKM2 transmits cisplatin resistance to sensitive NSCLC cells by promoting glycolysis and inhibiting apoptosis. Additionally, exosomal PKM2 remodels CAFs to create an acidic microenvironment that promotes NSCLC cell proliferation and cisplatin resistance.
Article
Biochemistry & Molecular Biology
Haili Wu, Jin'e Du, Chenglu Li, Hanqing Li, Huiqin Guo, Zhuoyu Li
Summary: Resistance to 5-Fluorouracil (5-Fu) chemotherapy is a major obstacle in colon cancer treatment. This study found that the dietary flavonoid kaempferol can reverse the drug resistance of colorectal cancer cells to 5-Fu, suggesting a potential treatment option. The mechanism behind this reversal involves the regulation of the miR-326-hnRNPA1/A2/PTBP1-PKM2 axis and inhibition of glycolysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kanakaraju Manupati, Ragini Yeeravalli, Komal Kaushik, Digvijay Singh, Bhupendra Mehra, Nitin Gangane, Anupama Gupta, Kalyan Goswami, Amitava Das
Summary: Breast cancer stem cells with high CD44 expression play a key role in tumorigenesis by activating PSTAT3, SNAI3, and LPL genes. Inhibiting CD44 or targeting LPL can effectively prevent tumor progression and neoangiogenesis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Kenly Wuputra, Pi-Jung Hsiao, Wen-Tsan Chang, Po-Hsuan Wu, Lin-Ann Chen, Jian-Wei Huang, Wen-Lung Su, Ya-Han Yang, Deng-Chyang Wu, Kazunari K. Yokoyama, Kung-Kai Kuo
Summary: This study found a close relationship between the overexpression of FOXM1 and regorafenib resistance in liver cancer cells, which were correlated with the survival of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Rakshita Grover, Sahil Drall, Neelam Poonia, Gaurav Kumar Jain, Geeta Aggarwal, Viney Lather, Prashant Kesharwani, Deepti Pandita, Ramesh K. Goyal
Summary: Cancer stem cells (CSCs) contribute to tumor onset, progression, chemotherapy resistance, and relapse. CD44 and CD133 are commonly expressed markers used to identify aggressive CSCs. Targeting these markers with aptamers conjugated nanocarriers can overcome the limitations of antibodies and has proven to be beneficial in targeting CSCs. This article reviews the recent advancements in aptamers and their conjugation with nanocarriers for specific targeting of CSCs and improved cancer therapy efficacy.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Oncology
Hiroko Ishii, Yuki Mimura, Maram H. Zahra, Shota Katayama, Ghmkin Hassan, Said M. Afify, Masaharu Seno
Summary: In this study, stem-like cells were isolated and characterized from the human glioblastoma cell line U-251MG, resulting in the establishment of the U-251MGSC1 cell line with high expression of stem cell markers and enhanced tumorigenicity and sphere-forming ability. The U-251MGSC1 cells exhibited properties of cancer stem cells and could serve as a valuable tool for developing therapeutic agents against CSCs and studying the mechanism of tumor development in brain gliomas.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Yingying Liu, Peisheng Chen, Liufei Xu, Bo Wang, Shengping Zhang, Xiangpeng Wang
Summary: In this study, researchers found that the expression level of GALNT2 is elevated in GBM, IDH1 wildtype glioma, and GSCs. GALNT2 expression is correlated with unfavorable clinical outcomes in GBM patients. Targeting GALNT2 can block GSCs cell proliferation, self-renewal, and malignant invasion through repressing CD44 expression.
Review
Cell & Tissue Engineering
Hamed Rezayatmand, Mahboobeh Razmkhah, Iman Razeghian-Jahromi
Summary: Drug resistance caused by cancer stem cells (CSCs) is the main reason for the failure and relapse of cancer therapy. CSCs possess the ability to self-renew and differentiate into heterogeneous cancer cells, and play a significant role in metastatic dissemination. Although chemotherapy can destroy most tumor cells, CSCs are left mostly intact, leading to resistance to treatment. It is crucial to understand the key features of drug resistance caused by CSCs in order to develop effective treatment strategies, but there are challenges in differentiating CSCs from normal cells.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Karina Lindbog Madsen, Oke Gerke, Poul F. Hoilund-Carlsen, Birgitte Brinkmann Olsen
Summary: Cancer stem cells (CSCs) are resistant to conventional therapy and responsible for cancer relapse. Auger electron emitters show promising potential in eradicating resistant lung cancer CD44(+) populations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Mahdi Abdoli Shadbad, Negar Hosseinkhani, Zahra Asadzadeh, Afshin Derakhshani, Noora Karim Ahangar, Nima Hemmat, Parisa Lotfinejad, Oronzo Brunetti, Nicola Silvestris, Behzad Baradaran
Summary: CD44 and CD44(+)CD24(-/low) phenotype are associated with poor prognosis in TNBC patients, and these cancer stem cell markers are linked to advanced tumor stage, size, grade, metastasis, and lymphatic involvement in TNBC patients. Additionally, chemoradiotherapy-treated TNBC patients show an upregulation of CD44(+)CD24(-/low) phenotype, which inversely correlates with androgen receptor (AR) and leads to inferior prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Anatomy & Morphology
Mahmoud Osman Khalifa, Mahmoud Abd-El Kareem, Wafaa Gaber, Taosheng S. Li, Abdelmohaimen Mostafa Saleh
Summary: The study on the development of the mucous preglottal salivary gland in Japanese quails revealed distinct stages of differentiation and the presence of highly alcianophilic mucous in the secretory materials.
MICROSCOPY RESEARCH AND TECHNIQUE
(2022)
Article
Cell & Tissue Engineering
Lan Luo, Chen Yan, Naoki Fuchi, Yukinobu Kodama, Xu Zhang, Goto Shinji, Kiyonori Miura, Hitoshi Sasaki, Tao-Sheng Li
Summary: The study explored the hypothesis that altered secretion of extracellular vesicles (EVs) from mesenchymal stem cells (MSCs) triggered radiation-induced heart disease. Results indicated that EVs from irradiated MSCs exhibited changed miRNA profiles and harmful effects on heart cells.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Gastroenterology & Hepatology
Zisheng Huang, Mahmoud Osman Khalifa, Peilin Li, Yu Huang, Weili Gu, Tao-Sheng Li
Summary: Our study found that low-dose losartan can alleviate liver fibrosis by modulating the mechanotransduction properties of hepatic stellate cells.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Cell Biology
Mhd Yousuf Yassouf, Xu Zhang, Zisheng Huang, Da Zhai, Reiko Sekiya, Tsuyoshi Kawabata, Tao-Sheng Li
Summary: Mechanical stress can have a biphasic effect on lymphocyte activation, either promoting or inhibiting the immune response. This provides insight into the role of mechanical stress in immune-related pathologies.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Oncology
Lina Abdelghany, Xu Zhang, Tsuyoshi Kawabata, Shinji Goto, Nageh El-Mahdy, Keiichi Jingu, Tao-Sheng Li
Summary: Nicaraven effectively prevents the rapid growth of inflamed tumors by reducing the levels of macrophages and neutrophils in the tumor, as well as regulating the p38 MAPK pathway.
Article
Biochemistry & Molecular Biology
Kai-Xuan Wang, Chen Yan, Xu Yang, Pei-Yan Zhu, Wen-Wen Cui, Cong Ye, Kan Hu, Ting Lan, Lin-Yan Huang, Wan Wang, Ping Ma, Su-Hua Qi, Bing Gu, Lan Luo
Summary: In this study, we found that autophagy-mediated Sirt1 downregulation may be a promising therapeutic target for prostate cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Han Nie, Chen Yan, Weimin Zhou, Tao-sheng Li
Summary: This study elucidated the characteristics of immune cells and inflammation-related gene expression in the development of atherosclerosis. The results showed differences between atherosclerosis occurring at different sites, including variations in the infiltration proportion and sensitivity of immune cells. Key immune cells and immune marker genes were found to play important roles in atherosclerosis and plaque formation.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Zisheng Huang, Mahmoud Osman Khalifa, Weili Gu, Tao-Sheng Li
Summary: Elevated interstitial fluid hydrostatic pressure in diseased livers can induce hepatic stellate cells to acquire profibrotic properties, promoting liver fibrosis. This process is mediated by the RhoA/ROCK signaling pathway.
Article
Cardiac & Cardiovascular Systems
Wen-Wen Cui, Cong Ye, Kai-Xuan Wang, Xu Yang, Pei-Yan Zhu, Kan Hu, Ting Lan, Lin-Yan Huang, Wan Wang, Bing Gu, Chen Yan, Ping Ma, Su-Hua Qi, Lan Luo
Summary: This study found that Momordica.charantia-derived EVs-like nanovesicles (MCELNs) can protect cardiomyocytes from radiation-induced damage and have antioxidant effects. MCELNs promote cell proliferation, alleviate cell apoptosis and DNA damage, and protect mitochondrial function. Moreover, MCELNs can restore the phosphorylation levels of ROS-related proteins and mitigate myocardial injury and fibrosis caused by thoracic radiation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Oncology
Kai-Xuan Wang, Cong Ye, Xu Yang, Ping Ma, Chen Yan, Lan Luo
Summary: Cancer patients receiving high-dose thoracic radiotherapy are at risk of developing radiation-induced heart disease (RIHD), which includes various complications such as coronary artery atherosclerosis, valvular disease, pericarditis, cardiomyopathy, and conduction defects. Although improved radiotherapy techniques have reduced these complications, they cannot completely avoid heart radiation exposure. Studies on atomic bomb survivors and occupational exposures have shown that even relatively low-dose radiation can increase the risk of RIHD. Understanding the mechanisms of RIHD at the cellular and molecular levels, including endothelial dysfunction, inflammation, fibrosis, and hypertrophy, is crucial in light of the increasing exposure to ionizing radiation.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Article
Cell Biology
Md. Mahmudul Hasan, Reiko Sekiya, Tao-Sheng Li
Summary: We have successfully grown high-quality primary cells from P. waltl limb tissue, with fibronectin coating providing the best environment for cell growth and attachment.
DEVELOPMENT GROWTH & DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Zisheng Huang, Han Nie, Geng Liu, Peilin Li, Yong-Hua Peng, Jie Xiao, Weili Gu, Tao-Sheng Li
Summary: This study investigated the effectiveness and mechanism of angiotensin receptor blockers (ARBs) in alleviating renal fibrosis. It found that losartan, even at a low dose, can attenuate renal fibrosis by inhibiting the epithelial to mesenchymal transition (EMT) of renal epithelial cells induced by biomechanical stress.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Mahmoud Osman Khalifa, Takahito Moriwaki, Shouhua Zhang, Wei Zhou, Kosei Ito, Tao-Sheng Li
Summary: Biomechanical forces have the ability to regulate cell behaviors. This study investigated the role of negative pressure in regulating the dedifferentiation of hepatocytes. It was found that exposure to -50 mmHg pressure quickly induced stress fiber formation and changes in cell morphology. Furthermore, the activation of RhoA/ROCK pathway and the upregulation of stemness markers were observed. Inhibition of ROCK abrogated these changes induced by -50 mmHg pressure.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Respiratory System
Yong Xu, Lina Abdelghany, Reiko Sekiya, Da Zhai, Keiichi Jingu, Tao-Sheng Li
Summary: Nicaraven has shown a positive effect in alleviating the side effects of radiotherapy, especially when administered at a relatively low dose after radiation.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2022)
