Article
Environmental Sciences
Min Ye, Jiaqi Du, Xiaowei Wang, Lijuan Xiu, Xuan Liu, Yufang Gu, Bei Pei, Dazhi Sun, Xiaoqiang Yue
Summary: This study investigated the anti-colorectal cancer effects of Xiaotansanjiefang, a traditional Chinese medicine, and its potential mechanism. The results showed that Xiaotansanjiefang inhibited the proliferation and migration, and promoted apoptosis of HCT116 colorectal cancer cells. The expression of Jagged 1, Notch 3, Snail, and Hes 1 were also affected by Xiaotansanjiefang treatment. The findings suggest that Xiaotansanjiefang may be a promising strategy for the treatment and prevention of colorectal cancer.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Zimei Dong, Jinrui Huo, Ang Liang, Jinzi Chen, Guangwen Chen, Dezeng Liu
Summary: The study found that the inhibition of the Notch pathway by DAPT is time- and concentration-dependent, leading to asymmetric growth and multi-eye anomalies in planarians. Exposure to DAPT induces cell proliferation and apoptosis, resulting in neurodevelopmental defects and changes in marker genes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Oncology
Fan Wu, Fang-Yong Zhang, Guo-Qian Tan, Wei-Jia Chen, Biao Huang, Lun Yan, Hao-Lu Zhang, Shi Chen, Yang Jiao, Bai-Lin Wang
Summary: The down-regulation of EGFL8 in hepatocellular carcinoma (HCC) is associated with tumor progression and poor prognosis, and is involved in regulating HCC cell migration, invasion, and apoptosis through activating the Notch signaling pathway.
Article
Plant Sciences
Rohit Kumar Tiwari, Afza Ahmad, Mohd Shahnawaz Khan, S. D. Shahanawaz, Saheem Ahmad, Irfan Ahmad Ansari
Summary: The study found that Pinostrobin (PN) can induce apoptosis in human lung cancer A549 cells and achieve this through mechanisms such as reactive oxygen species generation, activation of apoptotic regulators, cell cycle arrest, and downregulation of the Notch pathway.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Immunology
Anqi Lin, Jiarong Yao, Quan Cheng, Zaoqu Liu, Peng Luo, Jian Zhang
Summary: This study found that the status of NOTCH pathway mutation is closely associated with the efficacy of immunotherapy in colorectal cancer (CRC) patients, and it may serve as a novel biomarker and therapeutic target for CRC.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
Jiuyan Zhang, Yuan Zhao, Ning Sun, Manyu Song, Yongping Chen, Lin Li, Hailin Cui, Haotian Yang, Chuqiao Wang, Haiyang Zhang, Honggang Fan
Summary: This study reveals that lycopene (LYC) can alleviate spleen injury induced by chronic stress. LYC reduces splenocyte apoptosis and immunosuppression by inhibiting the death receptor apoptotic pathway and Notch pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Stefania Scicchitano, Maria Concetta Faniello, Maria Mesuraca
Summary: The human zinc finger protein 521 (ZNF521) plays a crucial role in the regulation of human ovarian cancer, affecting proliferation, progression, and cancer stem cell properties. This study also reveals the influence of ZNF521 on the NRF2-NOTCH signaling pathway in ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Luigi Borzacchiello, Roberta Veglia Tranchese, Roberta Grillo, Roberta Arpino, Laura Mosca, Giovanna Cacciapuoti, Marina Porcelli
Summary: Recent research has found a correlation between dysregulated Notch and tumor metastasis in colorectal cancer (CRC). The study also showed that S-adenosyl-L-methionine (AdoMet) could act as a potential antimetastatic agent by modulating the expression of miRNA-34a/-34c/-449a and inhibiting the migration of CRC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bin Li, Liang Wang, Xinwei Qi, Yumei Liu, Jiajun Li, Jie Lv, Xuan Zhou, Xuanlin Cai, Jiaoyu Shan, Xiumin Ma
Summary: In this study, the changes in NOTCH signaling pathway, as well as the fibrotic and inflammatory response of the liver after E. multilocularis infection, were analyzed using liver tissue samples from AE patients and an infected mouse model. It was found that blocking NOTCH signaling pathway exacerbates hepatic fibrosis levels and alters the polarization and origin of hepatic macrophages, suggesting the involvement of NOTCH3/DLL3 pathway in regulating macrophage polarization and fibrosis caused by AE.
Article
Nanoscience & Nanotechnology
Wei Chen, Xiaohong Yang
Summary: This study aimed to investigate the effect of dual antiplatelet therapy (DAPT) on cardiac dysfunction in psoriasis. The results showed that DAPT alleviated cardiac dysfunction caused by psoriasis by inhibiting angiogenesis and regulating the Notch/DLL4 pathway.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yan Wang, Fen-rong Chen, Chong-cao Wei, Lin-lang Sun, Chen-yu Liu, Long-bao Yang, Xiao-yan Guo
Summary: Zinc finger protein 671 (ZNF671) is a vital cancer inhibitor in multiple neoplasms, except its roles in colorectal carcinoma (CRC) are still unclear. This study investigated the relationship between ZNF671 and CRC. Low levels of ZNF671 were found in CRC tissue, which correlated with worse survival rate in CRC patients. The ZNF671 gene promoter region in CRC tissue showed high methylation levels, inversely correlated with ZNF671 expression. Treatment with demethylation agents restored ZNF671 levels in CRC cell lines. Up-regulation of ZNF671 inhibited cell proliferation, metastasis, and enhanced chemosensitivity of CRC cells. Mechanistic study showed ZNF671 as a vital mediator of Notch signaling. In summary, ZNF671 exerts a cancer-inhibiting function in CRC through deactivation of Notch signaling pathway, and can be a potential target for novel anti-CRC therapies.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Environmental Sciences
Ming-Yu Hsieh, Ming-Ju Hsieh, Yu-Sheng Lo, Chia-Chieh Lin, Yi-Ching Chuang, Mu-Kuan Chen, Ming-Chih Chou
Summary: The study found that Xanthohumol has a significant apoptotic effect and anticancer properties in human NPC cell lines, by regulating apoptosis-related proteins and the MAPK JNK pathway to promote cell apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Cell Biology
Fuli Li, Tinglei Huang, Yao Tang, Qingli Li, Jianzheng Wang, Xiaojiao Cheng, Wenhui Zhang, Baiwen Zhang, Cong Zhou, Shuiping Tu
Summary: UTD1, a novel microtubule stabilizing agent, has shown significant anti-tumor activity in colorectal cancer by inhibiting cell proliferation, inducing cell cycle arrest in G2/M phase, and triggering apoptosis. Additionally, UTD1 exhibits a stronger apoptosis-inducing effect in ABCB1 high-expression cells.
CELL DEATH & DISEASE
(2021)
Review
Pharmacology & Pharmacy
Yongguang Gao, Zhanda Fu, Junxia Guan, Xinhua Liu, Qing Zhang
Summary: Metabolic bone diseases are the third most common endocrine disorders, affecting over 500 million people worldwide. The Notch signaling pathway plays a crucial role in the development and regulation of bone metabolic diseases. Genetic mutations in Notch signaling genes can lead to various metabolic bone diseases. This review provides insights into the mechanisms and clinical manifestations of these diseases, aiming to raise awareness and offer new approaches for diagnosis and treatment of metabolic bone diseases.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Mengru Wang, Baopeng Tian, Jie Shen, Shilin Xu, Cong Liu, Ling Guan, Min Guo, Jie Dou
Summary: Bavachin, a compound derived from Psoralea corylifolia, has various pharmacological activities including antibacterial, anti-inflammatory, anti-tumor, and lipid-lowering effects. This study aimed to explore the anti-cancer effects and underlying mechanisms of bavachin in colorectal cancer. The results demonstrated that bavachin inhibited colorectal cancer cell proliferation and induced apoptosis. These effects were mediated through the activation of the MAPK signaling pathway and upregulation of Gadd45a expression. These findings suggest that bavachin has potential as a therapeutic agent for colorectal cancer by inducing apoptosis through the MAPK pathway.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
