Article
Biochemistry & Molecular Biology
Qun Wang, Jing Wu, Hua Wei, Hui Huang, Ying Huang, Hongyan Fang, Xiaojun Gong, Jun Sun, Yujuan Wu, Changjiang Lei, Jinming Yu, Desheng Hu
Summary: Increased stemness and drug resistance in lung cancer are linked to upregulation of JARID2, which also correlates with poor clinical outcomes. Targeting JARID2 may provide a promising approach to overcome drug resistance in NSCLC.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ling Ding, Yuning Yang, Qin Lu, Dongfeng Qu, Parthasarathy Chandrakesan, Hailan Feng, Hong Chen, Xuzheng Chen, Zhuhui Liao, Jian Du, Zhiyun Cao, Nathaniel Weygant
Summary: This study investigates the function and mechanism of bufalin against colorectal cancer stemness. The results demonstrate that bufalin inhibits CRC stemness by targeting the C-Kit/Slug signaling axis, leading to inhibited CRC growth and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Yu Han, Panyue Wen, Junjie Li, Kazunori Kataoka
Summary: Cisplatin is a successful chemotherapy drug, but its resistance and toxicity limit its clinical application. Targeted nanomedicine offers hope for maximizing efficacy and minimizing toxicity. This article reviews the recent progress and challenges in managing cisplatin resistance and toxicity and highlights future directions for development.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Oncology
Nasim Ebrahimi, Maral Afshinpour, Siavash Seifollahy Fakhr, Paniz Ghasempour Kalkhoran, Vida Shadman-Manesh, Samaneh Adelian, Sheida Beiranvand, Fatemeh Rezaei-Tazangi, Roya Khorram, Michael R. Hamblin, Amir Reza Aref
Summary: Colorectal cancer (CRC) is a major cause of cancer death worldwide. The presence of cancer stem cells (CSCs) contributes to therapy resistance and recurrence. This review examines the role of signaling pathways in colorectal CSCs and discusses potential drugs for treatment of resistant CRC.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Haijing Wang, Jinbao Chen, Sen Li, Jiahua Yang, Donghao Tang, Wentao Wu, Kun Yu, Yijun Cao, Ke Xu, Peihao Yin, Yi Chen, Wei Li
Summary: Currently, recurrence and metastasis remain significant factors leading to poor prognosis in colorectal cancer (CRC) patients. Cancer-associated fibroblasts (CAFs) play a crucial role in promoting tumorigenesis and development. Bufalin, the main active monomer of the clinical drug cinobufacini, has exhibited anti-tumor activity in various cancers. However, limited research has investigated the effect of bufalin in inhibiting metastasis from the perspective of the tumor microenvironment. This study isolated CAFs from freshly resected CRC patient specimens and observed their effect on CRC cell invasion. The study also explored the physiological activity of CRC mediated by CAFs and the inhibitory effect of bufalin on CAF-mediated CRC invasion and metastasis through the STAT3 pathway.
Review
Pharmacology & Pharmacy
Qingmei Ye, Xin Zhou, Han Ren, Fangxuan Han, Rong Lin, Juan Li
Summary: Significant progress has been made in cancer treatment over the past three decades, but drug resistance remains a challenge. Bufalin, a compound found in Chinese traditional medicine toad venom, has been extensively studied for its potential in overcoming drug resistance in cancer treatments. Bufalin has shown high potential in killing drug-resistant cancer cells through multiple mechanisms and enhancing the sensitivity of certain therapies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Jinbao Chen, Haijing Wang, Linlin Jia, Jing He, Yue Li, Huan Liu, Ruixin Wu, Yanyan Qiu, Yueping Zhan, Zeting Yuan, Yijun Cao, Wei Li, Ke Xu, Peihao Yin
Summary: Bufalin can reduce the polarization of M2 macrophages induced by chemoresistant cells, but has no direct effect on M2 macrophage polarization itself. Bufalin targets the SRC-3 protein to reduce MIF release and regulate the polarization of M2 macrophages. Additionally, Cinobufacini, which contains Bufalin as its main active monomer, can enhance the anti-tumour effect of oxaliplatin by regulating M2 macrophage polarization in vivo and in the clinic.
Article
Oncology
Xiaojie Liu, Mingjing He, Linlin Li, Xiya Wang, Shuhua Han, Jinzhu Zhao, Yalong Dong, Mushtaq Ahmad, Leilei Li, Xueyan Zhang, Junfeng Huo, Yunfan Liu, Chengxue Pan, Cong Wang
Summary: Our study revealed the presence of cancer cell stemness characteristics in drug-resistant esophageal cancer cells, expressing stem cell biomarkers and undergoing epithelial-mesenchymal transition (EMT). The increased expression of EMT biomarkers and stemness-related proteins in esophageal cancer cells after prolonged exposure to chemotherapeutic drugs suggests that targeting EMT and stemness simultaneously could be an effective strategy for treating esophageal cancer drug resistance.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sae Hamaya, Kyoko Oura, Asahiro Morishita, Tsutomu Masaki
Summary: Hepatocellular carcinoma is often diagnosed at an advanced stage where surgery is not an option. Treatment options include systemic chemotherapy, transarterial chemoembolization, and hepatic arterial infusion chemotherapy. Cisplatin is used for local treatment via transhepatic arterial administration. In cases of cisplatin resistance, systemic therapy with a different mechanism of action is recommended.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Linjuan Huang, Jing Zhang, Youling Deng, Hao Wang, Piao Zhao, Guozhi Zhao, Wei Zeng, Yonghui Wang, Connie Chen, William Wagstaff, Rex C. Haydon, Russell R. Reid, Tong-Chuan He, Le Shen, Hue H. Luu, Ling Zhao
Summary: Ovarian cancer is a highly lethal malignancy, often diagnosed at advanced stages due to the lack of early diagnosis methods. The standard treatment includes surgery and chemotherapy, but many patients develop chemoresistant tumors. Therefore, there is a need to develop new therapeutic agents to overcome chemoresistance. Niclosamide, an anti-parasite agent, has shown potent anti-cancer activities in ovarian cancer and other types of human cancers. This study investigates the potential of repurposing niclosamide as a therapeutic agent.
Review
Medicine, Research & Experimental
Rahul Bhattacharjee, Tanima Dey, Lamha Kumar, Sulagna Kar, Ritayan Sarkar, Mimosa Ghorai, Sumira Malik, Niraj Kumar Jha, Balachandar Vellingiri, Kavindra Kumar Kesari, Jose M. Perez de la Lastra, Abhijit Dey
Summary: This review discusses the causes, mechanisms, and potential therapeutic strategies for cisplatin resistance in cervical cancer. Strategies such as the use of nanocarriers, miRNA, CRISPR/Cas system, and combination therapy with chemotherapeutics show promise in overcoming drug resistance and improving the efficacy of cisplatin. Furthermore, the review examines the signaling network of cisplatin-resistant cells in cervical cancer and the impact of tumor microenvironment on drug resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Yuanyuan Shang, Zhe Zhu, Yuanyuan Zhang, Fang Ji, Lian Zhu, Mengcheng Liu, Yewei Deng, Guifen Lv, Dan Li, Zhuqing Zhou, Bing Lu, Chuan-gang Fu
Summary: Resistance to radiotherapy is a major challenge in the treatment of locally advanced rectal cancer. This study investigated the role of a specific microRNA, miR-7-5p, in regulating radioresistance and cancer stem cell (CSC) properties in colorectal cancer (CRC). The findings showed that low miR-7-5p expression was associated with poor prognosis in CRC patients and that overexpression of miR-7-5p could reverse radioresistance and attenuate CSC properties in radioresistant CRC cells. The study also demonstrated that miR-7-5p targeted the stemness-associated transcription factor KLF4 and that delivery of miR-7-5p mimics using magnetic nanoparticles inhibited tumor growth in a mouse model of radioresistant CRC. These findings suggest that miR-7-5p could be a potential target for overcoming resistance to radiotherapy in CRC patients.
CELL DEATH DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Shaoran Song, Yaochun Wang, Peijun Liu
Summary: Replication licensing factors play a crucial role in regulating DNA replication and may be involved in the occurrence and development of cancer, as well as impacting the resistance of cancer cells to chemotherapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Zuxiong Tang, Jun He, Jiayue Zou, Shufei Yu, Xiaoming Sun, Lei Qin
Summary: The study found that exosomes derived from HepG2/DDP cells can transfer cisplatin resistance to HepG2 and other HCC cell lines, offering new insights into improving the effectiveness of cisplatin in treating HCC.
Review
Oncology
Rinad Mahmoud, Paloma Ordonez-Moran, Cinzia Allegrucci
Summary: Triple Negative Breast Cancer (TNBC) is a cancer type with an unmet clinical need, characterized by its aggressiveness, high heterogeneity, and absence of therapeutic targets. Chemotherapy is the standard treatment, but many patients develop resistance and metastatic disease. The stratification into different molecular subtypes and identification of resistant cells is crucial for effective and precise therapies.
Article
Medicine, Research & Experimental
Kai Fang, Yueping Zhan, Ruiqiu Zhu, Yuqian Wang, Chengqi Wu, Min Sun, Yanyan Qiu, Zeting Yuan, Xin Liang, Peihao Yin, Ke Xu
Summary: This study found that bufalin inhibits tumor microenvironment-mediated angiogenesis by targeting the STAT3 signaling pathway in vascular endothelial cells. This suggests that bufalin may be used as a new antiangiogenic adjuvant therapy for treating colorectal cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Jun Yang, Juan Wang, Yuan Liu, Yu Zhang, Wenjing Huang, Yu Zou, Yanyan Qiu, Weiyang Cai, Jing Gao, Hu Zhou, Yingli Wu, Weijun Liu, Qingqing Ding, Yanjie Zhang, Pei-hao Yin, Wenfu Tan
Summary: The study reveals that colorectal cancer cells exploit PGE2 to promote Hh activity in a non-canonical manner, leading to Gli-dependent proliferation. Mechanistically, PGE2 activates JNK, enabling Gli2 to evade degradation by phosphorylating Gli2 at Thr1546.
CELL DEATH & DISEASE
(2021)
Article
Mathematical & Computational Biology
Lingxia Li, Yunjiu Wang, Xiaowan Huang, Jian Sun, Jue Zhang
Summary: Xiaoyutang combined with intraperitoneal heat perfusion chemotherapy has a good postoperative effect on patients with colorectal cancer, effectively improving immune function and circulating Mir, reducing tumor recurrence, and improving patient prognosis.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Gang Wang, Yu Yang, Du Yi, Lu Yuan, Pei-Hao Yin, Xu Ke, Wang Jun-Jie, Min-Fang Tao
Summary: This study developed polymer-coated pH-responsive liposomes loaded with betulinic acid for chemotherapy of colorectal cancer, showing superior antitumor effects and immune regulation properties in vivo.
JOURNAL OF LIPOSOME RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Zeting Yuan, Guohua Fan, Honglei Wu, Chaolian Liu, Yueping Zhan, Yanyan Qiu, Chenting Shou, Feng Gao, Jun Zhang, Peihao Yin, Ke Xu
Summary: Recent studies show that photodynamic therapy (PDT) can enhance the therapeutic effects of PD-L1 blockade in colorectal cancer (CRC) by inducing tumor cell death, stimulating immune response, and preventing tumor recurrence through upregulation of PD-L1 expression via the hypoxia-inducible factor 1a (HIF-1a) signaling pathway. This combination therapy using multifunctional nanoparticles loaded with photosensitized mTHPC (mTHPC@VeC/T-RGD NPs) shows promise in improving the response rate of anti-PD-L1 checkpoint blockade immunotherapies in CRC.
Article
Oncology
Jinbao Chen, Wentao Wu, Xue He, Linlin Jia, Jiahua Yang, Xianke Si, Kun Yu, Sen Li, Yanyan Qiu, Ke Xu, Peihao Yin, Yijun Cao, Qiong Li, Wei Li
Summary: This study utilized small RNA sequencing and RT-qPCR techniques to find that the expression level of exosomal miR122-5p correlates with the severity of myelosuppression after chemotherapy, and this miRNA can inhibit the cell cycle by targeting CDK4.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Yingying Jiang, Jiadong Li, Xu Xue, Zhifeng Yin, Ke Xu, Jiacan Su
Summary: Extracellular vesicles (EVs) have emerged as a promising cell-free strategy in the treatment of bone-related diseases. However, challenges such as uncertain distribution, unfavorable therapeutic efficiency, and low yields hinder their clinical application. Internal and external engineering of EVs can address these issues and improve their bone-targeting capacity.
Review
Pharmacology & Pharmacy
Jiadong Li, Zhifeng Yin, Biaotong Huang, Ke Xu, Jiacan Su
Summary: Stat3 is a key player in bone-related diseases, influencing disease progression through regulation of cellular proliferation, intercellular interactions, and other processes. Targeting Stat3 with drugs could be a potential therapeutic strategy for bone-related diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zeting Yuan, Chaolian Liu, Yuji Sun, Yue Li, Honglei Wu, Shuli Ma, Jing Shang, Yueping Zhan, Peihao Yin, Feng Gao
Summary: This study designed iRGD-modified nanoparticles to co-deliver mTHPC and BU, aiming to enhance the efficacy of photodynamic therapy (PDT) in colorectal cancer (CRC). The nanoparticles passively accumulated in tumor cells, with mTHPC inducing apoptosis and death under laser irradiation, while the sustained release of BU inhibited hypoxia and angiogenesis by targeting the SRC-3/HIF-1α pathway.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Yicheng Wei, Jialuo Cai, Ruiqiu Zhu, Ke Xu, Hongchang Li, Jianxin Li
Summary: This review focuses on the role of TRPA1 channel in fibroblasts, exploring its interactions with inflammatory factors and its different functions in the fibrosis process in different organs. The aim of this review is to describe the function of TRP channels in controlling fibrosis through fibroblasts in various inflammatory and immune-mediated diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haijing Wang, Jinbao Chen, Sen Li, Jiahua Yang, Donghao Tang, Wentao Wu, Kun Yu, Yijun Cao, Ke Xu, Peihao Yin, Yi Chen, Wei Li
Summary: Currently, recurrence and metastasis remain significant factors leading to poor prognosis in colorectal cancer (CRC) patients. Cancer-associated fibroblasts (CAFs) play a crucial role in promoting tumorigenesis and development. Bufalin, the main active monomer of the clinical drug cinobufacini, has exhibited anti-tumor activity in various cancers. However, limited research has investigated the effect of bufalin in inhibiting metastasis from the perspective of the tumor microenvironment. This study isolated CAFs from freshly resected CRC patient specimens and observed their effect on CRC cell invasion. The study also explored the physiological activity of CRC mediated by CAFs and the inhibitory effect of bufalin on CAF-mediated CRC invasion and metastasis through the STAT3 pathway.
Article
Oncology
Jinbao Chen, Jian Xu, Jiahua Yang, Yueping Zhan, Sen Li, Linlin Jia, Wentao Wu, Xianke Si, Die Zhang, Kun Yu, Peihao Yin, Yijun Cao, Wanli Deng, Ke Xu, Wei Li
Summary: Chemoresistance is a significant challenge for patients with colorectal cancer (CRC), and hypoxia is associated with poor prognosis and therapeutic resistance in cancer patients. Alpha-hederin has shown antitumour effects and can inhibit hypoxia-mediated drug resistance in CRC, but the underlying mechanism is still unclear. This study reveals that alpha-hederin inhibits drug resistance in hypoxic CRC cells by reducing AKT phosphorylation and Bcl2 expression, promoting apoptosis. These findings suggest that alpha-hederin may be a promising adjuvant for reversing drug resistance in CRC.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jun Yang, Juan Wang, Yu Zhang, Wenjing Huang, Shaoqing Zhang, Peihao Yin, Wenfu Tan
Summary: In colorectal cancer, PGE2-JNK can activate the Hh signaling pathway non-canonically. This study demonstrates that c-Jun prevents Gli2 protein from degradation by protease through phosphorylation by PGE2. Suppression of c-Jun decreases Gli2 expression and ubiquitination, and restricts PGE2-induced Hh activity and colorectal cancer cell proliferation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Oncology
Lan Xu, Shuli Ma, Bozhen Fan, Zeting Yuan, Peihao Yin
Summary: In this study, vitamin E succinate (VES)-grafted chitosan oligosaccharide (CSO)/arginine-glycine-aspartic acid peptide (RGD)-conjugated d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) mixed micelles (VeC/T-RGD MMs) were used to deliver bufalin (BU) to ovarian cancer cells to inhibit intraperitoneal metastasis. The BU-loaded VeC/T-RGD MMs (BU@MMs) effectively inhibited cell proliferation, induced apoptosis, and reduced the migration and invasion of ovarian cancer cells. The BU@MMs also showed better biocompatibility and biosafety for in vivo applications.
CANCER NANOTECHNOLOGY
(2023)
