Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma

TORC2 Structure and Function

(2016) Christl Gaubitz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells

(2015) Y. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer

(2015) A. Wiegering et al.   Cancer Discovery

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

(2015) P. Liu et al.   Cancer Discovery

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

(2015) Guang Yang et al.   Cell Reports

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

(2014) Andrew L. Wolfe et al.   NATURE

An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4

(2014) Olesja Fehler et al.   NUCLEIC ACIDS RESEARCH

SIN1, a critical component of the mTOR-Rictor complex, is overexpressed and associated with AKT activation in medullary and aggressive papillary thyroid carcinomas

(2014) Dimitrios Moraitis et al.   SURGERY

SIN1 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition

(2013) Jiangfeng Xu et al.   CANCER

Down-regulation of programmed cell death 4 leads to epithelial to mesenchymal transition and promotes metastasis in mice

(2013) Qing Wang et al.   EUROPEAN JOURNAL OF CANCER

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

(2013) Pengda Liu et al.   NATURE CELL BIOLOGY

Therapeutic Potential of the Translation Inhibitor Silvestrol in Hepatocellular Cancer

(2013) Takayuki Kogure et al.   PLoS One

Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc

(2012) Qing Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tumor Suppressor PDCD4 Represses Internal Ribosome Entry Site-Mediated Translation of Antiapoptotic Proteins and Is Regulated by S6 Kinase 2

(2012) U. Liwak et al.   MOLECULAR AND CELLULAR BIOLOGY

Tumour Suppressive Function and Modulation of Programmed Cell Death 4 (PDCD4) in Ovarian Cancer

(2012) Na Wei et al.   PLoS One

mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways

(2011) P. Gulhati et al.   CANCER RESEARCH

Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein

(2011) Emily J. Glidden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mTOR (Mammalian Target of Rapamycin) Kinase Maintains Integrity of mTOR Complex 2

(2011) Chien-Hung Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo

(2010) Didier Roulin et al.   Molecular Cancer

Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion

(2010) A N Santhanam et al.   ONCOGENE

PDCD4 inhibits the malignant phenotype of ovarian cancer cells

(2009) Zeng-Tao Wei et al.   CANCER SCIENCE

Targeted Inhibition of Mammalian Target of Rapamycin Signaling Inhibits Tumorigenesis of Colorectal Cancer

(2009) P. Gulhati et al.   CLINICAL CANCER RESEARCH

Structural basis for translational inhibition by the tumour suppressor Pdcd4

(2009) Portia G Loh et al.   EMBO JOURNAL

Downregulation of E-cadherin is an essential event in activating β-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells

(2009) Q Wang et al.   ONCOGENE

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

(2009) Regina Cencic et al.   PLoS One

Crystal structure of the eIF4A-PDCD4 complex

(2009) J. H. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line

(2008) Brigitte Lankat-Buttgereit et al.   BIOLOGY OF THE CELL

Programmed Cell Death 4 inhibits breast cancer cell invasion by increasing Tissue Inhibitor of Metalloproteinases-2 expression

(2008) René Nieves-Alicea et al.   BREAST CANCER RESEARCH AND TREATMENT

PI3K/Akt: getting it right matters

(2008) T F Franke   ONCOGENE