Article
Medicine, Research & Experimental
Liwen Ren, Yihui Yang, Wan Li, Xiangjin Zheng, Jinyi Liu, Sha Li, Hong Yang, Yizhi Zhang, Binbin Ge, Sen Zhang, Weiqi Fu, Dexin Dong, Guanhua Du, Jinhua Wang
Summary: High expression of CDK1 is associated with adverse clinical outcomes in adrenocortical carcinoma (ACC), and CurE shows potential as a candidate drug. CDK1 promotes ACC cell proliferation and transformation through multiple mechanisms, while CurE effectively inhibits tumor development and shows better efficacy in combination with Mtn, highlighting its significance for ACC patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Hieu-Huy Nguyen-Tran, Thi-Ngoc Nguyen, Chen-Yun Chen, Tien Hsu
Summary: A novel mechanism of cross-talk between VHL-deficient kidney tubules and endothelial cells is discovered, which stimulates inflammation and tumorigenesis in clear-cell renal cell carcinoma. The activation of oncostatin M signaling plays a critical role in initiating and promoting the microenvironment that supports ccRCC development.
Article
Biochemistry & Molecular Biology
Shigeaki Sunada, Hiroko Saito, Doudou Zhang, Zeyu Xu, Yoshio Miki
Summary: CDK1 inhibitors regulate cellular sensitivity to DNA damage by controlling cell cycle progression and DNA repair inhibition, providing insights for developing clinical strategies targeting CDK1 inhibition in tumor cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Shoumin Zhu, Marwah Al-Mathkour, Longlong Cao, Shayan Khalafi, Zheng Chen, Julio Poveda, Dunfa Peng, Heng Lu, Mohammed Soutto, Tianling Hu, Oliver G. McDonald, Alexander Zaika, Wael El-Rifai
Summary: Infection with Helicobacter pylori is the main risk factor for gastric cancer. CDK1 plays a critical role in gastric tumorigenesis by promoting inflammation and activation of 0-catenin through NF-kappa B signaling pathway. Inhibition of CDK1 could reverse these effects and impair tumor organoids and spheroid formation.
Article
Biochemistry & Molecular Biology
Huifeng Li, Ying Zhong, Guangxu Cao, Hezhan Shi, Yiyao Liu, Lingfeng Li, Peidi Yin, Jialing Chen, Zhendong Xiao, Bin Du
Summary: This study identifies the crucial roles of METTL3 and CDC25B in cell cycle regulation, and reveals the significance of the METTL3/m(6)A/CDC25B pathway in the cell cycle.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Xudan Wang, Yang Wang, Long Yang, Juzheng Yuan, Weiwei Shen, Wenjie Zhang, Jianlin Wang, Kaishan Tao
Summary: ASRGL1 is highly expressed in hepatocellular carcinoma (HCC) and is associated with poor overall survival. Knockdown of ASRGL1 inhibits cell proliferation, migration, and invasion, and promotes apoptosis in HCC cells. ASRGL1 may be involved in the regulation of the cell cycle in HCC. These findings demonstrate that ASRGL1 blockade functions through cell cycle inhibition to suppress tumor growth in HCC.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Jie Zhang, Hailin Tu, Zheyu Zheng, Xueqiang Zhao, Xin Lin
Summary: The study reveals that LUBAC and its component RNF31 play a crucial role in promoting tumorigenesis in the tumor microenvironment through regulating RIPK1 kinase activity. Inhibition of RNF31 could enhance antitumor toxicity during tumor immunotherapy.
Article
Medicine, Research & Experimental
Yu-gang Huang, Dan Li, Li Wang, Xiao-min Su, Xian-bin Tang
Summary: The study revealed that CENPF is significantly overexpressed in ACC patients, which is positively correlated with tumor stage and associated with unfavorable overall survival in ACC patients. GSEA analysis suggested that CENPF is mainly involved in regulating the G2/M phase of the cell cycle and the p53 signaling pathway. Experimental findings indicated that the interaction between CENPF and CDK1 facilitates the G2/M phase transition, cell proliferation, and potentially induces a p53-mediated anti-tumor effect in ACC. Additionally, immune infiltration analysis highlighted the potential use of CENPF inhibitors like Cisplatin, Sunitinib, and Etoposide for ACC therapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Guangya Xu, Xueling Yan, Zhongjia Hu, Lulu Zheng, Ke Ding, Yamei Zhang, Yi Qing, Tao Liu, Lijia Cheng, Zheng Shi
Summary: Glucocappasalin (GCP) from Descurainia sophia seeds shows potential antitumor activity in HeLa cervical carcinoma cells. GCP induces cell cycle G2/M-phase arrest, apoptosis, and autophagy by acting on the PI3K/AKT/mTOR signaling pathways, making it a promising agent for cervical cancer eradication.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Suhang Guo, Yi Peng, Yan Lou, Lijuan Cao, Junqing Liu, Nengming Lin, Sheng Cai, Yu Kang, Su Zeng, Lushan Yu
Summary: The downregulation of FXR in colorectal cancer results in dysregulation of bile acid metabolism, affecting the concentration of secretory immunoglobulin A and gut microbiome, thereby increasing the risk of colorectal tumor development.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hong Zhou, Qixiang Zhao, Chengcheng Yue, Jiadong Yu, Huaping Zheng, Jing Hu, Zhonglan Hu, Haozhou Zhang, Xiu Teng, Xiao Liu, Xiaoqiong Wei, Yuxi Zhou, Fanlian Zeng, Yan Hao, Yawen Hu, Xiaoyan Wang, Chen Zhang, Linna Gu, Wenling Wu, Yifan Zhou, Kaijun Cui, Nongyu Huang, Wei Li, Zhen Wang, Jiong Li
Summary: IL-38 is downregulated in cutaneous squamous cell carcinoma and its knockout suppresses skin tumor formation and malignant progression. Deletion of IL-38 leads to reduced expression of inflammatory cytokines and myeloid cell infiltration in the tumor microenvironment. IL-38 activates the JNK/AP-1 pathway in an IL-1Rrp2-dependent manner to promote cancer-related inflammatory cytokines expression, tumor cell proliferation, and migration.
Article
Immunology
Rebecca Metzger, Lis Winter, Nassim Bouznad, Debora Garzetti, Benedikt von Armansperg, Matjaz Rokavec, Konstantin Lutz, Yvonne Schafer, Sabrina Krebs, Elena Winheim, Verena Friedrich, Dana Matzek, Rupert Oellinger, Roland Rad, Barbel Stecher, Heiko Hermeking, Thomas Brocker, Anne B. Krug
Summary: CCL17 plays a significant role in the development of colorectal cancer by influencing the composition of the intestinal microbiome and reducing apoptosis during tumor initiation.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Yi-Jie Zhang, De-Hui Yi
Summary: This study analyzed multiomics data to construct a regulatory network involving kinases, transcription factors, and immune genes in hepatocellular carcinoma (HCC) prognosis. The study identified key immune genes and their relationships, and validated the effects of the CDK1-SRC-HSP90AB1 network on HCC progression and antitumor immunity. The findings highlight the importance of this network in HCC prognosis and immune regulation.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Cell Biology
Shuo Chen, Wu Wu, Qian-hui Li, Bu-min Xie, Fan Shen, Yu-ping Du, Zhi-hong Zong, Li-li Wang, Xiao-qing Wei, Yang Zhao
Summary: Circ-NOLC1 plays a role in promoting tumorigenesis and development in epithelial ovarian cancer by binding to ESRP1 and modulating CDK1 and RhoA expression levels.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Poshan Yugal Bhattarai, Garam Kim, Sung-Chul Lim, Ramesh Mariappan, Takbum Ohn, Hong Seok Choi
Summary: PIN1 interacts with METTL3 to stabilize it, increasing the m(6)A modification of mRNA. Loss of PIN1 disrupts mRNA distribution and affects cell proliferation and cycle. In clinical settings, METTL3 expression is correlated with breast cancer progression and positively associated with PIN1 expression.
Article
Biochemical Research Methods
Xuejuan Gao, Qionghua Lian, Baiye Guan, Qiu-Yu Liu, Meng Meng, Yang Chen, Jingjie Jin, Huihua Li, Xiaohui Liu, Zhenghua Sun, Langxia Liu, Qing-Yu He, Gong Zhang
Summary: This study investigated the function and mechanism of ZSWIM1 in lung adenocarcinoma. ZSWIM1 was found to be upregulated in lung adenocarcinoma and correlated with poor prognosis. It promoted cancer cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition. The protein interactome of ZSWIM1 was identified, and its interaction with STK38 was verified. ZSWIM1 antagonized the function of STK38 and activated the MEKK2/ERK1/2 pathway. Overall, ZSWIM1 acts as an oncogene in lung adenocarcinoma and its effects are mediated through the STK38/MEKK2/ERK1/2 axis.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Multidisciplinary Sciences
Hui-Fang Hu, Gui-Bin Gao, Xuan He, Yu-Ying Li, Yang-Jia Li, Bin Li, Yunlong Pan, Yang Wang, Qing-Yu He
Summary: This study identifies the ARF1-IQGAP1 interaction-mediated reactivation of ERK signaling as critical for vemurafenib resistance and cancer metastasis. LY2835219 is shown to be a promising therapeutic agent for CRC, both alone and in combination with vemurafenib, with significant inhibitory effects on ARF1-mediated cancer.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Oncology
Chun-Miao Deng, Guo-Geng Zhang, Qin-Wen Liu, Jiao-Jiao Xu, Zhi-Chao Liu, Jing Yang, Tao-Yang Xu, Zhi-Gang Li, Fan Zhang, Bin Li
Summary: Tumor metastasis is a complex process. This study found that ANO1 is upregulated in primary esophageal squamous cell carcinoma (ESCC) and lymph node metastatic tissues. High expression of ANO1 is associated with poor patient survival, and ANO1 overexpression promotes cancer invasion and metastasis. ANO1 interacts with JUN to inhibit the transcription of cholesterol hydroxylase, leading to increased cholesterol accumulation. Additionally, ANO1 can activate fibroblasts through the secretion of IL1I3, enhancing invasion of ESCC cancer cells. The compound K786-4469 was identified as a potential ANO1 inhibitor that suppresses cancer metastasis in vitro and in vivo. These findings reveal the noncanonical role of ANO1 in regulating cholesterol metabolism and fibroblast function, and suggest ANO1 as a potential biomarker and therapeutic target for metastatic ESCC.
Article
Oncology
Kun Meng, Yuyu Hu, Dingkang Wang, Yuying Li, Fujin Shi, Jiangli Lu, Yang Wang, Yun Cao, Chris Zhiyi Zhang, Qing-Yu He
Summary: A seven-mitochondrial-gene signature was generated to predict prognosis of ccRCC patients, with EFHD1 being less studied but found to be correlated with unfavorable outcome. Overexpression of EFHD1 reduced mitochondrial Ca2+ and inhibited cell migration and tumor metastasis by binding to mitochondrial calcium uniporter (MCU) and deactivating the Hippo/YAP pathway. Upregulation of STARD13 induced by EFHD1 enhanced the phosphorylation of YAP at Ser-127. The EFHD1-MCU-STARD13 axis serves as a novel regulator in ccRCC progression.
Article
Biochemistry & Molecular Biology
Kun Meng, Shaohua Lu, Yu-Ying Li, Li-Ling Hu, Jing Zhang, Yun Cao, Yang Wang, Chris Zhiyi Zhang, Qing-Yu He
Summary: The study discovered a microprotein encoded by LINC00493, called SMIM26, which is localized in mitochondria and tends to be downregulated in ccRCC. SMIM26 suppresses ccRCC growth and metastasis by interacting with AGK and SLC25A11. This interaction increases the mitochondrial localization of AGK and inhibits AGK-mediated AKT phosphorylation. The study shows the importance of hidden proteins in human cancers.
Article
Infectious Diseases
Dan Lei, Linlin Cao, Tairan Zhong, Qing-Yu He, Xuesong Sun
Summary: In this study, the researchers found that the mutation of the key residue Lys219 leads to a conformational change in CpxR, resulting in loss of its regulatory ability in antibiotic resistance.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Instruments & Instrumentation
Lihui Zhou, Qingyu He, Xinglu Que, Andreas W. W. Rost, Hide Takagi
Summary: Cryogenic scanning tunneling microscopy and spectroscopy with a high vector magnetic field is used to image surface magnetic structures, study anisotropic superconductivity, and explore spin physics in quantum materials. This paper describes the design, construction, and performance of a low-temperature, ultra-high-vacuum spectroscopic imaging STM with a vector magnet capable of applying a field of up to 3 T in any direction. The STM can operate at variable temperatures and is suitable for studying layered compounds and thin films.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2023)
Review
Geosciences, Multidisciplinary
Min Li, Song Huang, Tianyao Hao, Miao Dong, Ya Xu, Jian Zhang, Qingyu He, Gui Fang
Summary: This paper reviews the initiation models of Neogene subduction in the western Pacific, including polarity-reversal, induced subduction re-initiation, and non-inherited subduction initiation. It also collates the parameters of different subduction zones to form five categories: basic features, subducting plate features, upper plate features, kinematic features, and subsequent activity. The regularity of the subduction processes, the specificity of different subduction cases, and the possible constraints between subduction initiation types and subduction zone parameters are discussed and analyzed. The compiled dataset of subduction zone parameters can provide data support for related studies.
SCIENCE CHINA-EARTH SCIENCES
(2023)
Article
Medicine, General & Internal
Wen Wen, Long Liao, Wei Dai, Can-Can Zheng, Xiang-Peng Tan, Yan He, Qi-Hua Zhang, Zhi-Hao Huang, Wen-You Chen, Yan-Ru Qin, Kui-Sheng Chen, Ming-Liang He, Simon Law, Maria Li Lung, Qing-Yu He, Bin Li
Summary: Through genome-wide CRISPR/Cas9 screening and gene profiling, the MEST-PURA-SRCIN1/RASAL1-ERK-snail signaling cascade was identified as an important mechanism underlying cancer metastasis in esophageal squamous cell carcinoma. Blocking the interaction between MEST and PURA could be a potential therapeutic approach for managing tumor metastasis.
Article
Pharmacology & Pharmacy
Xiao-Ling Liang, Lan Ouyang, Nan-Nan Yu, Zheng-Hua Sun, Zi-Kang Gui, Yu-Long Niu, Qing-Yu He, Jing Zhang, Yang Wang
Summary: This study identifies a potential anticancer therapy strategy by inducing cell death through shifting the scission position of mitochondria. The pan-HDAC inhibitor pracinostat is found to activate the CDK5-Drp1 signaling pathway, leading to mitochondrial fission and showing potential in CRC treatment.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Qianqian Yang, Lulu Wang, Yuehong Liang, Qingyu He, Qi Sun, Jing Luo, Hongdi Cao, Yi Fang, Yang Zhou, Junwei Yang, Ping Wen, Lei Jiang
Summary: Mitochondrial dysfunction, regulated by UCP2, plays a crucial role in the development of podocyte injury and proteinuria.
Article
Engineering, Electrical & Electronic
Xu Zhang, Honglin Ji, Ming Luo, Qingyu He, Chao Yang, Jie Li, Wu Liu, Chao Li, Qibing Wang, Zichen Liu, Chuyu Peng, Hao Guo, Huang Yu, Zhiwen Fan, Zhixue He, Xi Xiao, Shaohua Yu
Summary: We experimentally demonstrate a 3.61 Pbit/s estimated throughput of generalized mutual information (GMI) achieved through combined space division multiplexing (SDM) and wavelength division multiplexing (WDM) over a 19-core single-mode fiber. The transmission utilizes 680 wavelength channels covering a 17 THz bandwidth in the S, C, and L bands, delivering probabilistically constellation-shaped (PCS) 256 quadrature amplitude modulation (QAM) and PCS-64QAM signals at a data rate of 24.5 GBaud. The measured data rate shows significant potential for enhancing the achievable data rate in multi-core fibers.
IEEE PHOTONICS TECHNOLOGY LETTERS
(2023)
Article
Multidisciplinary Sciences
Shaohua Lu, Hong Lu, Tingkai Zheng, Huiming Yuan, Hongli Du, Youhe Gao, Yongtao Liu, Xuanzhen Pan, Wenlu Zhang, Shuying Fu, Zhenghua Sun, Jingjie Jin, Qing-Yu He, Yang Chen, Gong Zhang
Summary: The development of high-throughput omics technology has greatly promoted the development of biomedicine, but its poor reproducibility limits its application. The use of standard reference materials is necessary to test and calibrate the accuracy and reproducibility of omics workflows. In this study, we demonstrated that the human hepatocellular cell line MHCC97H has a very stable transcriptome and proteome after 9 subculturing generations, providing a steady standard sample for industrial-scale production in the long term. Furthermore, this stability was consistent across labs and platforms.
Review
Chemistry, Physical
Yisha Huang, Xuejuan Gao, Qing-Yu He, Wanting Liu
Summary: This article investigates the role of TRIM21 in intracellular immunity and proposes a model for how TRIM21 interacts with proteins. The model suggests that TRIM21 participates in inflammatory responses through ubiquitination and facilitates antibody destruction of target proteins by detecting antibody complexes. This systematic understanding of TRIM21's interactions provides insights into the pathogenesis of related diseases and potential applications.