Role of HSPA1L as a cellular prion protein stabilizer in tumor progression via HIF-1α/GP78 axis

Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition

(2016) Heather A. Ward et al.   BRITISH JOURNAL OF NUTRITION

BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS-Mutant Colorectal Cancer

(2016) A. Bartolini et al.   CLINICAL CANCER RESEARCH

An investigation of the potential for epigenetic inactivation by transcription read-through in a sporadic colorectal cancer

(2016) Sameer Srivastava et al.   GENE

HSP90 inhibits apoptosis and promotes growth by regulating HIF-1α abundance in hepatocellular carcinoma

(2016) XIN LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Renal Cell Carcinoma

(2016) Thomas Powles et al.   JOURNAL OF CLINICAL ONCOLOGY

Colorectal Cancer on the Decline — Why Screening Can’t Explain It All

(2016) H. Gilbert Welch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells

(2016) Alessandro Corsaro et al.   Oncotarget

Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis

(2015) Amal M. El-Naggar et al.   CANCER CELL

The role of heat shock proteins in cancer

(2015) Georgios D. Lianos et al.   CANCER LETTERS

Hypoxia-Inducible Factor 1-Alpha Regulates Cancer-Inhibitory Effect of Human Mesenchymal Stem Cells

(2015) Yuan Hu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Trimethylamine-N-Oxide Treatment Induces Changes in the ATP-Binding Cassette Transporter A1 and Scavenger Receptor A1 in Murine Macrophage J774A.1 cells

(2015) Abbas Mohammadi et al.   INFLAMMATION

Domain-Specific Activation of Death-Associated Intracellular Signalling Cascades by the Cellular Prion Protein in Neuroblastoma Cells

(2015) Silvia Vilches et al.   MOLECULAR NEUROBIOLOGY

Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer

(2015) Y-W Chang et al.   ONCOGENE

The CDX1–microRNA-215 axis regulates colorectal cancer stem cell differentiation

(2015) Matthew F. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated level of HSPA1L mRNA correlates with graft-versus-host disease

(2015) Sadaf Atarod et al.   TRANSPLANT IMMUNOLOGY

Cellular prion protein contributes to LS 174T colon cancer cell carcinogenesis by increasing invasiveness and resistance against doxorubicin-induced apoptosis

(2015) Cornelius Kwang-Lee Chieng et al.   TUMOR BIOLOGY

Induction of cellular prion protein (PrPc) under hypoxia inhibits apoptosis caused by TRAIL treatment

(2015) Jin-Young Park et al.   Oncotarget

FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15

(2015) Ningning Li et al.   Oncotarget

Gp78, an E3 Ubiquitin Ligase Acts as a Gatekeeper Suppressing Nonalcoholic Steatohepatitis (NASH) and Liver Cancer

(2015) Tianpeng Zhang et al.   PLoS One

18F-FAZA PET Imaging Response Tracks the Reoxygenation of Tumors in Mice upon Treatment with the Mitochondrial Complex I Inhibitor BAY 87-2243

(2014) E. Chang et al.   CLINICAL CANCER RESEARCH

Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth

(2014) Nan Li et al.   GENES & DEVELOPMENT

Heat shock protein 90 promotes epithelial to mesenchymal transition, invasion, and migration in colorectal cancer

(2014) Ganji Purnachandra Nagaraju et al.   MOLECULAR CARCINOGENESIS

Targeting heat shock proteins in metastatic castration-resistant prostate cancer

(2014) Arun A. Azad et al.   Nature Reviews Urology

Disruption of prion protein–HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival

(2014) M H Lopes et al.   ONCOGENE

Hsp70 in cancer: back to the future

(2014) M Y Sherman et al.   ONCOGENE

Ubiquitin Ligase gp78 Targets Unglycosylated Prion Protein PrP for Ubiquitylation and Degradation

(2014) Jia Shao et al.   PLoS One

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation

(2014) Ivano Amelio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD44-Positive Cancer Stem Cells Expressing Cellular Prion Protein Contribute to Metastatic Capacity in Colorectal Cancer

(2013) L. Du et al.   CANCER RESEARCH

CD44/Cellular prion protein interact in multidrug resistant breast cancer cells and correlate with responses to neoadjuvant chemotherapy in breast cancer patients

(2013) Yuanyuan Cheng et al.   MOLECULAR CARCINOGENESIS

Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of Hypoxia-Inducible Factor 1 and RNA-Binding Protein HuR

(2012) V. L. Gabai et al.   MOLECULAR AND CELLULAR BIOLOGY

Atorvastatin stimulates neuroblastoma cells to induce neurite outgrowth by increasing cellular prion protein expression

(2012) Takuya Watanabe et al.   NEUROSCIENCE LETTERS

Cellular prion protein accelerates colorectal cancer metastasis via the Fyn-SP1-SATB1 axis

(2012) QIANWEI WANG et al.   ONCOLOGY REPORTS

CHIP and gp78-mediated ubiquitination of CYP3A4

(2011) Cody J. Peer et al.   CANCER BIOLOGY & THERAPY

HIF-1α and HSP90: Target molecules selected from a tumorigenic papillary thyroid carcinoma cell line

(2011) Ji-Hun Mo et al.   CANCER SCIENCE

Cell surface proteomics identifies glucose transporter type 1 and prion protein as candidate biomarkers for colorectal adenoma-to-carcinoma progression

(2011) Meike de Wit et al.   GUT

Midkine prevented hypoxic injury of mouse embryonic stem cells through activation of Akt and HIF-1α via low-density lipoprotein receptor-related protein-1

(2011) Sang Hun Lee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cancer theory faces doubts

(2011) Heidi Ledford   NATURE

Making sense of ubiquitin ligases that regulate p53

(2010) Abhinav K. Jain et al.   CANCER BIOLOGY & THERAPY

JNK1 Mediates Degradation HIF-1  by a VHL-Independent Mechanism that Involves the Chaperones Hsp90/Hsp70

(2010) D. Zhang et al.   CANCER RESEARCH

Cellular prion protein promotes glucose uptake through the Fyn-HIF-2α-Glut1 pathway to support colorectal cancer cell survival

(2010) Qing-Quan Li et al.   CANCER SCIENCE

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

(2010) William B Pratt et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α

(2009) Weibo Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

Cancer Statistics, 2008

(2008) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract

(2008) Ammar Natalwala et al.   WORLD JOURNAL OF GASTROENTEROLOGY