Article
Oncology
Yingcui Zhang, Yuehui Su, Yujie Tang, Lihong Qin, Yan Shen, Bingjie Wang, Mengjiao Zhou, Yingying Zhou, Lili Cao, Ting Zhang, Mengzhen Zhang
Summary: This study compares the clinical efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and local surgical excision in the treatment of high-grade vaginal intraepithelial neoplasia (VAIN). The results show that ALA-PDT has similar efficacy and fewer side effects compared to local surgical excision.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Oncology
Yuehui Su, Yingcui Zhang, Yutong Tong, Luoman Zhang, Panpan Li, Huiping Zhang, Xiaodong Zhang, Yujie Tang, Lihong Qin, Yan Shen, Bingjie Wang, Yingying Zhou, Lili Cao, Mengzhen Zhang, Ting Zhang
Summary: 5-ALA-PDT is a non-invasive, effective, and safe therapy for treating CIN & VAIN. However, its efficacy is relatively poor in patients with endocervical canal lesions involvement, atypical vessels, and HPV16/18 and other hrHPV infection.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Gastroenterology & Hepatology
R. L. Goetgebuer, J. E. Kreijne, C. A. Aitken, G. Dijkstra, F. Hoentjen, N. K. de Boer, B. Oldenburg, A. E. van der Meulen, C. I. J. Ponsioen, M. J. Pierik, F. J. van Kemenade, I. M. C. M. de Kok, A. G. Siebers, J. Mannien, C. J. van der Woude, A. C. de Vries
Summary: Women with inflammatory bowel disease are at increased risk for cervical intraepithelial neoplasia. The main risk factors include smoking and disease location. HPV vaccination and adherence to cervical cancer screening are crucial for these women.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Oncology
Stephan Polterauer, Olaf Reich, Andreas Widschwendter, Laudia Hadjari, Gerhard Bogner, Alexander Reinthaller, Elmar Joura, Gerda Trutnovsky, Alexandra Ciresa-Koenig, Julia Ganhoer-Schimboeck, Ina Boehm, Regina Berger, Eva Langthaler, Stephan W. Aberle, Georg Heinze, Andreas Gleiss, Christoph Grimm
Summary: This study investigates the non-inferiority of topical IMQ therapy compared to LLETZ in patients diagnosed with HSIL. The results show that IMQ treatment leads to lower HPV clearance rates compared to LLETZ, suggesting that LLETZ remains the standard treatment for HSIL patients.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Hyun-Woong Cho, Jin Hwa Hong, Jae Kwan Lee
Summary: The study identified hrHPV genotypes associated with high-grade VaIN and found that HPV16 and HPV31 infections were significantly correlated with high-grade VaIN. Ablative or excisional treatments showed good efficacy against pathologic regression of high-grade VaIN.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Oncology
Nikki B. Thuijs, Willemijn A. M. Schonck, Linde L. J. Klaver, Guus Fons, Marc van Beurden, Renske D. M. Steenbergen, Maaike C. G. Bleeker
Summary: In this exploratory study, biomarker profiles in patients with multiple high-risk HPV-associated vulvar precursor lesions were compared. While the biomarkers generally showed similar expression between lesions, marked differences were occasionally observed, indicating heterogeneity within multifocal lesions. This study contributes to a better understanding of the potential diagnostic, prognostic, and predictive value of biomarkers in patients with multifocal HSIL.
Article
Oncology
Feline O. Voss, Nikki B. Thuijs, Sylvia Duin, Mujde Ozer, Marc van Beurden, Johannes Berkhof, Renske D. M. Steenbergen, Maaike C. G. Bleeker
Summary: This study aimed to validate the accuracy of previously identified DNA methylation markers for detection of high-grade vulvar intraepithelial neoplasia (VIN). The best-performing individual marker was found to be SST, detecting 80% of high-grade VIN cases, with excellent detection of HPV-independent VIN, known to have the highest cancer risk. Selection of a marker panel including ZNF582, SST, and miR124-2 also yielded high accuracy for detection of high-grade VIN.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Huei-Jean Huang, Hsiu-Jung Tung, Lan-Yan Yang, Angel Chao, Yun-Hsin Tang, Hung-Hsueh Chou, Wei-Yang Chang, Ren-Chin Wu, Chu-Chun Huang, Chiao-Yun Lin, Min-Jie Liao, Wei-Chun Chen, Cheng-Tao Lin, Min-Yu Chen, Kuan-Gen Huang, Chin-Jung Wang, Ting-Chang Chang, Chyong-Huey Lai
Summary: This observational study investigated the long-term outcomes and HPV genotype changes after conization for high-grade cervical intraepithelial neoplasia (HG-CIN). Results showed that active surveillance may reduce the severity of progression to cancer, and a majority of patients with recurrent CIN2+ had persistent type-specific HPV infections. Effective therapeutic vaccines for such cases are still needed.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Public, Environmental & Occupational Health
Jacqueline M. Mix, Mona Saraiya, Virginia Senkomago, Elizabeth R. Unger
Summary: This study analyzed the incidence rates of high-grade vulvar, vaginal, and anal precancers among individuals aged 15-39 years using data from select cancer registries in the U.S. The results showed a significant decrease in high-grade vulvar and vaginal precancer rates among females aged 15-29 years after the introduction of the human papillomavirus vaccine, while anal precancer rates stabilized in both females aged 15-29 years and males aged 30-39 years.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Review
Oncology
Yoshihide Inayama, Yukio Yamanishi, Eiji Nakatani, Junichi Aratake, Nanayo Sasagasako, Kaori Yamada, Rei Gou, Atsuko Kawamura, Megumi Yamanishi, Kenzo Kosaka
Summary: The study revealed that Imiquimod has a certain efficacy in treating vaginal intraepithelial neoplasia 2-3, with a high complete response rate and response rate regardless of whether patients have a history of hysterectomy.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Immunology
Chunlei Guo, Wenkui Dai, Qian Zhou, Liming Gui, Han Cai, Di Wu, Jun Hou, Changzhong Li, Shuaicheng Li, Hui Du, Ruifang Wu
Summary: The microbial community in the lower female genital tract is associated with the risk of genital infection. This study found significant changes in the microbial community when squamous intraepithelial lesion (SIL) developed into high-grade SIL (HSIL).
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biology
Georgios Panagakis, Ioannis K. Papapanagiotou, Charalampos Theofanakis, Paraskevi Tsetsa, Adamantia Kontogeorgi, Nikolaos Thomakos, Alexandros Rodolakis, Dimitrios Haidopoulos
Summary: The study evaluates the effectiveness of combining electrical impedance spectroscopy (EIS) with colposcopy in detecting high-grade cervical lesions. The results demonstrate that EIS exhibits high sensitivity and specificity in detecting high-grade lesions.
Article
Oncology
Y. Y. Zhang, R. Xia, D. Chen, X. Zhang
Summary: This study aimed to explore the risk factors for and prevent misdiagnosis of cervical intraepithelial neoplasia (CIN) coexisting with vaginal intraepithelial neoplasia (VaIN). The results indicated that menopausal status and HPV load were related to the occurrence of VaIN in CIN patients, with menopausal patients at higher risk.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Immunology
Yichan Zhang, Xiaolin Xu, Liqun Yu, Xingxian Shi, Min Min, Lijuan Xiong, Jia Pan, Yong Zhang, Peipei Liu, Guizhen Wu, Guolan Gao
Summary: This study found that HPV infection is related to vaginal microbiota in Chinese women, and specific bacteria are associated with HPV infection and cervical neoplasia. Age is also a factor influencing HPV infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Obstetrics & Gynecology
Rikke Kamp Damgaard, David Jenkins, Mark H. Stoler, Miekel M. van de Sandt, Kathrine Dyhr Lycke, Maurits N. C. de Koning, Wim G. V. Quint, Torben Steiniche, Lone Kjeld Petersen, Anne Hammer
Summary: This study aimed to describe the distribution of HPV genotypes, age, and cytology in women undergoing active surveillance for CIN2. The results showed a high prevalence of HPV16 and high-grade cytology, implying that these women may be perceived as a high-risk population and non-eligible for active surveillance in countries outside Denmark.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Health Care Sciences & Services
Marilyn M. Schapira, Brian L. Sprague, Carrie N. Klabunde, Anna N. A. Tosteson, Asaf Bitton, Jane S. Chen, Elisabeth F. Beaber, Tracy Onega, Charles D. MacLean, Kimberly Harris, Kathleen Howe, Loretta Pearson, Sarah Feldman, Phyllis Brawarsky, Jennifer S. Haas
JOURNAL OF GENERAL INTERNAL MEDICINE
(2016)
Editorial Material
Obstetrics & Gynecology
Alan G. Waxman, Lee E. Buenconsejo-Lum, Miriam Cremer, Sarah Feldman, Kevin A. Ault, Joanna M. Cain, Maria Lina Diaz
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2016)
Article
Public, Environmental & Occupational Health
Caroline Nitschmann, Taymaa May, Jelena Mirkovic, Sarah Feldman
JOURNAL OF WOMENS HEALTH
(2016)
Article
Rheumatology
C. H. Feldman, J. Liu, S. Feldman, D. H. Solomon, S. C. Kim
Meeting Abstract
Oncology
S. Fiascone, A. Vitonis, S. Feldman
GYNECOLOGIC ONCOLOGY
(2017)
Meeting Abstract
Oncology
E. J. Diver, E. M. Hinchcliff, A. A. Gockley, A. Melamed, L. Contrino, S. Feldman, W. B. Growdon
GYNECOLOGIC ONCOLOGY
(2017)
Article
Health Care Sciences & Services
Sarah F. Feldman, Nathanael Lapidus, Jacques Cosnes, Emmanuel Tiret, Laurent Fonquernie, Jean Cabane, Olivier Chazouilleres, Laure Surgers, Marc Beaussier, Alain-Jacques Valleron, Fabrice Carrat, Gilles Hejblum
JOURNAL OF MEDICAL INTERNET RESEARCH
(2017)
Article
Obstetrics & Gynecology
Elisabeth Diver, Emily Hinchcliff, Allison Gockley, Alexander Melamed, Leah Contrino, Sarah Feldman, Whitfield Growdon
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2017)
Article
Multidisciplinary Sciences
Aude Carillion, Sarah Feldman, Na Na, Matthieu Biais, Wassila Carpentier, Aurelie Birenbaum, Nicolas Cagnard, Xavier Loyer, Dominique Bonnefont-Rousselot, Stephane Hatem, Bruno Riou, Julien Amour
Editorial Material
Medicine, General & Internal
Rebecca B. Perkins, Joanna M. Cain, Sarah Feldman
JAMA INTERNAL MEDICINE
(2017)
Meeting Abstract
Obstetrics & Gynecology
Rachel L. Wood, Danielle Panelli, Whitfield Growdon, Kevin Elias, Anjuli Kaimal, Sarah Feldman, Thomas McElrath
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2018)
Meeting Abstract
Obstetrics & Gynecology
Danielle Panelli, Rachel L. Wood, Kevin M. Elias, Whitfield B. Growdon, Anjali J. Kaimal, Sarah Feldman, Thomas F. McElrath
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2018)
Review
Oncology
Emily S. Wu, Jose Jeronimo, Sarah Feldman
JOURNAL OF GLOBAL ONCOLOGY
(2017)
Meeting Abstract
Obstetrics & Gynecology
Danielle M. Panelli, Ann M. Thomas, Sarah Feldman, Thomas F. McElrath
REPRODUCTIVE SCIENCES
(2017)