Article
Pharmacology & Pharmacy
Nabil A. Alhakamy, Gamal A. Mohamed, Usama A. Fahmy, Basma G. Eid, Mohammed W. Al-Rabia, Amgad I. M. Khedr, Mohammed Z. Nasrullah, Sabrin R. M. Ibrahim, Ashraf B. Abdel-Naim, Osama A. A. Ahmed, Shadab Md
Summary: This study aimed to design a hydrogel formula loaded with thioctamer, a nanoconjugate of thioctic acid (TA) and glatiramer acetate (GA), and evaluate its efficacy in expedited wound healing in a rat model of diabetic wound. The results demonstrated that thioctamer significantly enhanced wound healing and inhibited inflammation markers, showing its potential as a promising treatment for diabetic wounds.
Review
Nutrition & Dietetics
Ruey-Yu Hsieh, I-Chen Huang, Chiehfeng Chen, Jia-Ying Sung
Summary: Alpha-lipoic acid (ALA) improves symptoms in patients with diabetic sensorimotor peripheral neuropathy (DSPN) by reducing oxidative stress and improving microcirculation. A meta-analysis of randomized controlled trials (RCTs) evaluated the effects of orally-administered ALA versus placebo in patients with DSPN, finding that ALA treatment had favorable effects on sensory symptoms, total symptoms' score (TSS), neurological disability score (NDS), and global satisfaction. However, it did not produce favorable results for vibration perception, nerve conduction, and neuropathy impairment.
Article
Chemistry, Medicinal
E. E. Karmanova, A. Chernikov, V. E. Ivanov, A. M. Usacheva, V. Bruskov
Summary: Alpha-lipoic acid is an effective antioxidant that neutralizes water radiolysis products and reduces oxidative damage caused by x-ray exposure. It can eliminate oxidative damage to DNA in vitro and reduce micronuclei formation in vivo after irradiation.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Kaio Murilo Monteiro Espindola, Everton Luiz Pompeu Varela, Rosyana de Fatima Vieira de Albuquerque, Rosiane Araujo Figueiredo, Savio Monteiro dos Santos, Nivea Silva Malcher, Pamela Suelen da S. Seabra, Andreia do Nascimento Fonseca, Karla Marcely de Azevedo Sousa, Susan Beatriz Batista de Oliveira, Agnaldo da Silva Carneiro, Michael D. Coleman, Marta Chagas Monteiro
Summary: This study evaluated the protective effect of racemic alpha lipoic acid (ALA) and its enantiomers on methemoglobin induction caused by Dapsone (DDS) therapy. The results showed that ALA could effectively inhibit the formation of methemoglobin induced by DDS-NOH and reduce DNA damage. This study suggests that ALA could be used as a treatment in patients who chronically use DDS, including leprosy patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Vijay Bhasker Reddy, Lakmal Boteju, Asela Boteju, Li Shen, Kelem Kassahun, Nageshwar Reddy, Adrian Sheldon, Sanjeev Luther, Ke Hu
Summary: This study highlights the clearance mechanism of CPI-613 via beta-oxidation, species differences in their ability to carry out beta-oxidation, and subsequent elimination routes. Structural limitations for completion of terminal cycle of beta-oxidation is discussed against the backdrop of its endogenous counterpart lipoic acid.
DRUG METABOLISM AND DISPOSITION
(2022)
Article
Biochemistry & Molecular Biology
Aaron Priester, Richard Waters, Ashleigh Abbott, Krista Hilmas, Klaus Woelk, Hunter A. Miller, Aria W. Tarudji, Connor C. Gee, Brandon McDonald, Forrest M. Kievit, Anthony J. Convertine
Summary: This study designed a material that can rapidly bind and neutralize reactive oxygen species (ROS) and lipid peroxidation product (LPOx) after traumatic brain injury (TBI). These neuroprotective copolymers (NPCs) showed promise for improved target engagement of multiple biochemical derangements and reduction of post-traumatic oxidative stress, potentially leading to improved TBI therapeutic outcomes.
Article
Biochemistry & Molecular Biology
Ilenia Martinelli, Daniele Tomassoni, Proshanta Roy, Lorenzo Di Cesare Mannelli, Francesco Amenta, Seyed Khosrow Tayebati
Summary: Hypertension leads to organ damage through oxidative stress, which can be reduced by antioxidant supplementation such as (+)-ALA. In spontaneously hypertensive rats, (+)-ALA showed greater effectiveness in reducing oxidative stress, cardiac, and renal damages compared to (+/-)-ALA. Therefore, (+)-ALA is proposed as a more appropriate antioxidant to prevent renal and cardiac alterations associated with hypertension.
Review
Immunology
Sahar Sheikholeslami, Shaghayegh Khodaverdian, Masoumeh Dorri-Giv, Seyyed Mohammad Hosseini, Shokoufeh Souri, Razzagh Abedi-Firouzjah, Hamed Zamani, Leila Dastranj, Bagher Farhood
Summary: This study reviewed the potential role of alpha-lipoic acid in alleviating radiation-induced toxicities in healthy cells/tissues. Experimental results showed that this radio-protective agent could alleviate radiation-induced toxicities through mechanisms such as anti-oxidant, antiapoptosis, and anti-inflammatory effects. Co-treatment of alpha-lipoic acid with radiotherapy could ameliorate the radiation-induced toxicities in healthy cells/tissues.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
A. M. Usacheva, A. Chernikov, E. E. Karmanova, V. Bruskov
Summary: Lipoic acid is a natural compound that has multiple uses, including treating diseases and acting as a detoxifying agent. It has various effects on insulin receptors and protein levels in tissues, and it also triggers antioxidant responses and improves glycemia and inflammation markers.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2022)
Article
Neurosciences
Jian Zhang, Yuan Zhao, Yidan Zhang, Ya Gao, Shuyue Li, Cui Chang, Xuan Gao, Jingru Zhao, Guofeng Yang
Summary: This study found that alpha lipoic acid (ALA) can improve cognitive function and provide protection in aging mice. The Morris water maze test revealed improved cognitive function in mice that received ALA treatment. Proteomic analysis showed that ALA can modulate synaptic transmission, lipid transporter activity, and neuroinflammation, highlighting its potential mechanistic role in improving cognitive function in the aged brain.
NEUROSCIENCE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Xinyue Wang, Qiang Wang, Ping Wang, Man Zhou, Bo Xu, Ying Liu, Yuanyuan Yu
Summary: Chitosan was modified with thioctic acid to prepare soft films with improved physical-mechanical, antibacterial, and thermal properties. The modified films showed higher flexibility, good antibacterial activity, and resistance to harsh conditions, making them suitable for flexible devices and packaging.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Qingxiu Liu, Wenxiang Li, Shimeng Huang, Lihong Zhao, Jianyun Zhang, Cheng Ji, Qiugang Ma
Summary: The study investigated the effectiveness of alpha-lipoic acid with different optical rotation in alleviating inflammation and oxidative stress in laying hens induced by oxidized fish oil. The results showed that the addition of alpha-lipoic acid reduced the levels of inflammatory factors, increased the activity of antioxidant indexes, and decreased the content of oxidative factor MDA. Moreover, R-form of alpha-lipoic acid was more effective than S-form. These findings provide basic data for the potential development of alpha-lipoic acid as a chiral dietary additive for laying hens.
Review
Agriculture, Dairy & Animal Science
Reshma M. Anthony, Jennifer M. MacLeay, Kathy L. Gross
Summary: The review of studies on alpha-lipoic acid supplementation in dogs indicates that at concentrations of 2.7-4.94 mg/kg body weight/day, it can be utilized as a nutritive additive and improve antioxidant capacity effectively and without health risks.
Article
Anesthesiology
Ian Gilron, Sylvia Robb, Dongsheng Tu, Ronald Holden, Tanveer Towheed, Dan Ziegler, Louie Wang, Roumen Milev, Christopher Gray
Summary: The study examined the efficacy of alpha-lipoic acid (ALA) as a treatment for fibromyalgia, showing no significant differences in pain intensity compared to placebo. Interestingly, there was a favorable effect of ALA in pain relief for men, but not for women.
Article
Biochemistry & Molecular Biology
Sam Cho, Seok Jin Hong, Sung Hun Kang, YongKeun Park, Sung Kyun Kim
Summary: This study investigated the impact of alpha-lipoic acid on ferroptosis and lipid droplets (LDs) in auditory hair cells damaged by cisplatin. It was found that alpha-lipoic acid inhibited 4-HNE expression, restored xCT and GPX4 expression, and normalized LD levels in the cells. The research provides biological evidence of ferroptosis and offers insights for investigating molecular pathways using 3D optical diffraction tomography (3D-ODT) of LDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
E. Bestepe, M. Cabalar, S. Kucukgoncu, C. Calikusu, F. Ornek, V. Yayla, S. Erkoc
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2011)
Article
Clinical Neurology
Celal Calikusu, Suat Kucukgoncu, Emrem Bestepe
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
(2012)
Review
Psychiatry
Suat Kucukgoncu, Urska Kosir, Elton Zhou, Erin Sullivan, Vinod H. Srihari, Cenk Tek
EARLY INTERVENTION IN PSYCHIATRY
(2019)
Review
Psychiatry
Suat Kucukgoncu, Sinan Guloksuz, Kubra Celik, Mert Ozan Bahtiyar, Jurjen J. Luykx, Bart P. F. Rutten, Cenk Tek
SCHIZOPHRENIA BULLETIN
(2020)
Article
Medicine, General & Internal
Elif Ates Budak, Suat Kucukgoncu, Engin Emrem Bestepe
CUKUROVA MEDICAL JOURNAL
(2019)
Article
Psychiatry
Derya Ipekcioglu, Ozlem Cetinkaya, Ilker Kucukparlak, Hulya Guveli, Gamze Bozgeyik, Suat Kucukgoncu, Nesrin Karamustafalioglu, Ferhan Yener, Mehmet Cem Ilnem
ANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY
(2012)
Article
Psychology, Clinical
Celal Calikusu, Suat Kucukgoncu, Ozlem Tecer, Emrem Bestepe
BEHAVIOR MODIFICATION
(2012)
Article
Psychiatry
Suat Kucukgoncu, Evin Aktar, Ebru Erginbas, E. Emrem Bestepe, Celal Calikusu, Fulya Algin, Sahap Erkoc
DUSUNEN ADAM-JOURNAL OF PSYCHIATRY AND NEUROLOGICAL SCIENCES
(2010)
Article
Clinical Neurology
Sultan Dogan, Suat Kucukgoncu
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
(2009)
Article
Psychiatry
Sultan Dogan, Bedriye Oncu, Gamze Varol-Saracoglu, Suat Kucukgoncu
ANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY
(2009)