The ratio of pericardial to subcutaneous adipose tissues is associated with insulin resistance

ObjectiveTo examine the association between pericardial adipose tissue (PAT) and the ratio of PAT to subcutaneous adipose tissue (SAT) with insulin resistance in adults with and without type 1 diabetes (T1D). MethodsData for this report came from a substudy of the Coronary Artery Calcification in Type 1 Diabetes cohort (n=83; 38 with T1D, 45 without T1D). Insulin resistance was measured by hyperinsulinemic-euglycemic clamp. Abdominal computed tomography (CT) was used to measure visceral adipose tissue (VAT) and SAT. PAT was measured from CT scans of the heart. ResultsPAT and the ratio of PAT to SAT was higher in males compared to females. After adjustment for demographics, diabetes, blood pressure and lipid factors, BMI, VAT, and log PAT/SAT ratio, log PAT was positively associated with the glucose infusion rate (GIR) in females only (=3.361.96, P=0.097, P for sex interaction=0.055). Conversely, the log PAT/SAT ratio was significantly associated with decreased GIR in both males and females (=-2.08 +/- 1.03, P=0.047, P for sex interaction=0.768). ConclusionsA significant association between the PAT/SAT ratio and insulin resistance was found, independent of BMI, VAT, and PAT. These results highlight the importance of considering fat distribution independent of volume.