Review
Biochemistry & Molecular Biology
Angelika Krol-Grzymala, Edyta Sienkiewicz-Szlapka, Ewa Fiedorowicz, Dominika Rozmus, Anna Cieslinska, Andrzej Grzybowski
Summary: This review investigates and analyzes the biomarkers for AD, PD, and MS in tears. Through analyzing the recent original studies, the biomarkers present in tears that can be used for the diagnosis and management of these diseases are shown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Clara Ballerini, Alfred K. Njamnshi, Sharon L. Juliano, Rajesh N. Kalaria, Roberto Furlan, Rufus O. Akinyemi
Summary: Traumatic brain injury, stroke, and neurodegenerative diseases are significant causes of disability and death in Africa. Neuroinflammation and neuroimmunology play important roles in the pathogenesis of these diseases, and further research is needed to better understand their contributions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Guangjin Gu, Jie Ren, Bin Zhu, Zhongju Shi, Shiqing Feng, Zhijian Wei
Summary: Spinal cord injury (SCI) is an irreversible disease process with a high disability and mortality rate. Curcumin, as the main active ingredient in turmeric, plays an important role in reducing inflammation and oxidation, protecting neurons, and ultimately reducing spinal cord injury by effectively curbing the process of secondary injury.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Evgeniy Kreydin, Hui Zhong, Igor Lavrov, V. Reggie Edgerton, Parag Gad
Summary: Spinal cord injury often leads to neurogenic bowel dysfunction, but spinal neuromodulation has been proven to improve sensation and movement in the bowel, and can stimulate the anorectal regions for beneficial effects on patients' bowel program.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Medicine, General & Internal
Willemijn Faber, Janneke Stolwijk-Swuste, Florian van Ginkel, Janneke Nachtegaal, Erwin Zoetendal, Renate Winkels, Ben Witteman
Summary: The review examined the gut microbiota in SCI and MS patients, suggesting that alpha diversity may be lower in chronic SCI patients compared to healthy controls, while it may be similar or lower in MS patients. Most studies did not account for potential confounding factors like diet, antibiotic use, and bowel function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Engineering, Environmental
Fang Wang, Jiaqiang Du, Hao Qiao, Dongfan Liu, Dong Guo, Jinjin Chen, Yanfeng Zhang, Yilong Cheng, Xijing He
Summary: Poly(lipoic acid-co-sodium lipoate) (PLL) hydrogels have been developed as an efficient treatment for spinal cord injury (SCI). The hydrogels exhibit injectability, tissue adhesiveness, and self-healing ability. They can scavenge reactive oxygen species (ROS), promote nerve fiber signal transmission, regulate inflammation, inhibit scar formation, and promote neural stem cell differentiation into neurons, contributing to fast functional recovery after SCI.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Clinical Neurology
Britta Matusche, Ludmila Litvin, Ruth Schneider, Barbara Bellenberg, Mark Muehlau, Viola Pongratz, Achim Berthele, Sergiu Groppa, Muthuraman Muthuraman, Frauke Zipp, Friedemann Paul, Heinz Wiendl, Sven G. Meuth, Philipp Saemann, Frank Weber, Ralf A. Linker, Tania Kuempfel, Ralf Gold, Carsten Lukas
Summary: The aim of this study was to analyze the extent of pseudoatrophy in the upper spinal cord during the first 2 years after therapy initiation and compare this to the brain. The results suggest that pseudoatrophy occurs not only in the brain, but also in the spinal cord during the first year of interferon-beta treatment.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Alfonso Delgado-Alvarez, Maria Diez-Cirarda, Cristina Delgado-Alonso, Laura Hernandez-Lorenzo, Constanza Cuevas, Maria Valles-Salgado, Paloma Montero-Escribano, Maria Jose Gil-Moreno, Jorge Matias-Guiu, Rocio Garcia-Ramos, Jordi A. Matias-Guiu
Summary: The study validated the effectiveness of the Rowland Universal Dementia Assessment Scale (RUDAS) in patients with Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). The results showed that RUDAS performed well in diagnosing cognitive impairment associated with AD, PD, and MS, with minimal influence from education and cultural biases.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Medicine, General & Internal
Jeffery S. Johns, Klaus Krogh, Karen Ethans, Joanne Chi, Matthew Queree, Janice J. Eng
Summary: The study investigated the current pharmacological management of neurogenic bowel dysfunction in patients with SCI and MS, revealing a discrepancy between the number of prescribed agents and the limited amount of literature, especially for MS where literature was almost nonexistent.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Lei Liu, Changjun Yang, Eduardo Candelario-Jalil
Summary: BET proteins play a crucial role in regulating the inflammatory response by interacting with NF-κB and Nrf2 signaling pathways. Research suggests that BET proteins are essential regulators of inflammation and neuropathology in various CNS diseases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Chemistry, Analytical
Andreas Triantafyllidis, Sofia Segkouli, Stelios Zygouris, Christina Michailidou, Konstantinos Avgerinakis, Evangelia Fappa, Sophia Vassiliades, Anastasia Bougea, Nikos Papagiannakis, Ioannis Katakis, Evangelos Mathioudis, Alexandru Sorici, Lidia Bajenaru, Valentina Tageo, Francesco Camonita, Christoniki Magga-Nteve, Stefanos Vrochidis, Ludovico Pedulla, Giampaolo Brichetto, Panagiotis Tsakanikas, Konstantinos Votis, Dimitrios Tzovaras
Summary: Central nervous system diseases (CNSDs) cause significant disability globally, and mobile app interventions have shown potential in monitoring and managing these diseases. This systematic review focuses on the characteristics and clinical effectiveness of mobile app interventions for three major CNSDs: Parkinson's disease, multiple sclerosis, and stroke. Out of 21 included studies, most had weak-to-moderate methodological quality and small sample sizes. The majority of mobile apps targeted exercise and physical rehabilitation, and positive outcomes were reported in terms of physical activity, motor function, cognition, quality of life, and education.
Review
Medicine, General & Internal
Fredrika S. Magnuson, Peter Christensen, Andrei Krassioukov, Gianna Rodriguez, Anton Emmanuel, Steven Kirshblum, Klaus Krogh
Summary: Neurogenic bowel dysfunction is a common problem among individuals with spinal cord injury or multiple sclerosis, often resulting in constipation, difficulty with bowel evacuation, and fecal incontinence. The current treatment algorithm does not fully align with clinical practice, calling for an updated version to guide healthcare professionals in treating NBD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Michael Poppell, Grace Hammel, Yi Ren
Summary: Macrophages are a highly versatile cell type that exhibit various phenotypes and functions in different disease states. Recent studies have shown a possible link between macrophage activation and the development of autoimmune disorders. The exact role of macrophages and microglia in the adaptive immune response and the progression of neurodegenerative diseases and neural injuries is still not fully understood. This review aims to provide evidence on the initiation of adaptive immune response by macrophages and microglia in various CNS diseases, including the types of immune responses, antigen presentation processes, receptors involved in phagocytosis, and the implications on disease pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Rakib Uddin Ahmed, Chase A. Knibbe, Felicia Wilkins, Leslie C. Sherwood, Dena R. Howland, Maxwell Boakye
Summary: Animal models are important for spinal cord injury research. Small animal models have advantages in terms of management and cost, but their neurologic and anatomical differences may limit their translation to humans. In contrast, large animal models are more similar to humans and have greater translational value in studying spinal cord injury.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Clinical Neurology
Simran Chhugani, Nivedita Agarwal, Faraz Sheikh, Florina Borca, Aginor Spanoulis, Ian Galea
Summary: The study found that cervical spinal degenerative disease (SDD) is more common in patients with progressive multiple sclerosis (MS), with foraminal stenosis being a significant feature. Therefore, a higher index of suspicion for cervical SDD is needed in progressive MS patients experiencing appropriate neurological symptoms, to guide appropriate treatment or monitoring.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Azimeh Izadi, Sara Ebrahimi, Shabnam Shirazi, Shiva Taghizadeh, Marziyeh Parizad, Laya Farzadi, Bahram Pourghassem Gargari
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Review
Biochemistry & Molecular Biology
Aynaz Mihanfar, Seyed Kazem Shakouri, Mohammad Hassan Khadem-Ansari, Amir Fattahi, Zeinab Latifi, Hamid Reza Nejabati, Mohammad Nouri
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Allergy
Alireza Pishgahi, Rozita Abolhasan, Seyed Kazem Shakouri, Mohammad Sadegh Soltani-Zangbar, Shahla Dareshiri, Sepideh Ranjbar Kiyakalayeh, Amirghasem Khoeilar, Majid Zamani, Farhad Motavalli Khiavi, Behzad Pourabbas Kheiraddin, Amir Mehdizadeh, Mehdi Yousefi
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Ahmad Mobed, Seyed Kazem Shakouri, Sanam Dolati
Editorial Material
Critical Care Medicine
Seyed Kazem Shakouri, Leila Roshangar, Ata Mahmoodpoor
JOURNAL OF CRITICAL CARE
(2020)
Review
Environmental Sciences
Madalyn Riley Higgins, Azimeh Izadi, Mojtaba Kaviani
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Biology
Seyed Kazem Shakouri, Neda Dolatkhah, Sepideh Omidbakhsh, Alireza Pishgahi, Maryam Hashemian
BMC RESEARCH NOTES
(2020)
Review
Cell Biology
Sanam Dolati, Mehdi Yousefi, Alireza Pishgahi, Salman Nourbakhsh, Behzad Pourabbas, Seyed Kazem Shakouri
Article
Medicine, General & Internal
Naser Aghamohammadzadeh, Neda Dolatkhah, Maryam Hashemian, Seyed Kazem Shakouri, Saeed Hasanpour
CASPIAN JOURNAL OF INTERNAL MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Sheyda Shaafi, Soraiya Ebrahimpour-Koujan, Mohammad Khalili, Seyad Morteza Shamshirgaran, Mazyar Hashemilar, Aliakbar Taheraghdam, Seyed Kazem Shakouri, Elyar Sadeghi Hokmabadi, Yaeghoub Ahmadi, Mehdi Farhoudi, Nasim Rezaeimanesh, Daryoush Savadi OsgoueiL
ADVANCED PHARMACEUTICAL BULLETIN
(2020)
Article
Food Science & Technology
Yalda Sadeghpour, Aliakbar Taheraghdam, Mohammad Khalili, Mazyar Hashemilar, Elyar Sadeghi Hokmabadi, Sheyda Shaafi, Mehdi Farhoudi, Seyed Kazem Shakouri, Nasim Rezaeimanesh, Daryoush Savadi Osgouei
NUTRITION & FOOD SCIENCE
(2020)
Article
Pharmacology & Pharmacy
Mazyar Hashemilar, Mohammad Khalili, Nasim Rezaeimanesh, Elyar Sadeghi Hokmabadi, Sevin Rasulzade, Seyed Morteza Shamshirgaran, Aliakbar Taheraghdam, Mehdi Farhoudi, Sheyda Shaafi, Seyed Kazem Shakouri, Daryoush Savadi Osgouei
ADVANCED PHARMACEUTICAL BULLETIN
(2020)
Article
Biology
Alireza Pishgahi, Neda Dolatkhah, Seyed Kazem Shakouri, Maryam Hashemian, Atefeh Amiri, Morteza Delkhosh Reihany, Fatemeh Jahanjou
BMC RESEARCH NOTES
(2019)
Article
Pharmacology & Pharmacy
Saeed Khamnei, Seyyed-Reza Sadat-Ebrahimi, Shaker Salarilak, Siavash Savadi Oskoee, Yousef Houshyar, Seyed Kazem Shakouri, Yaghoub Salekzamani, Masumeh Zamanlu