Article
Nanoscience & Nanotechnology
Xincong Li, Shuangshuang Ren, Lutong Song, Deao Gu, Haoran Peng, Yue Zhao, Chao Liu, Jie Yang, Leiying Miao
Summary: Black phosphorus nanosheets (BPNSs) can eliminate the side effects of reactive oxygen species (ROS) and scavenge ROS to produce an antibacterial effect, providing a solution to the oxidative pressure caused by aPDT on surrounding tissue.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Biomedical
Yilun Luo, Peiqi Yuan, Sentao Hu, Hanwen Wang, Haiqi Zhang, Lie Ma
Summary: Designing biomaterials with precise immunomodulation is important for understanding the dynamic interactions between macrophages and biomaterials in tissue repair. This study developed an immunomodulatory biomaterial with an inflammation-adaptive patterned surface that can recognize abnormal signals, change its properties in response to microenvironment triggers, and modulate macrophages in different stages. The surface adapts to microenvironment changes, matches cell behavior and tissue healing process, and achieves a balance of pro- and anti-inflammatory macrophage phenotypes.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Zunjing Liu, Zihao Liu, Yi Shan, Chen Xu, Bingran Yu, Fu-Jian Xu
Summary: This study introduced a ROS scavenger and a targeted peptide to construct a nucleic acid delivery system for treating atherosclerosis. The system effectively reduced inflammation and reactive oxygen species production, alleviating the progression of atherosclerosis, and displayed good biosafety.
Article
Immunology
Susana Lopez-Lopez, Maria Jose Romero de Avila, Natalia Carolina Hernandez de Leon, Francisco Ruiz-Marcos, Victoriano Baladron, Maria Luisa Nueda, Jorge Laborda, Jose Javier Garcia-Ramirez, Eva M. Monsalve, Maria Jose M. Diaz-Guerra
Summary: NOTCH4 acts as a negative regulator in macrophage activation by interfering with proinflammatory cytokine expression and signaling pathways such as IFN-gamma and STAT1. It also modulates the balance between STAT1 and STAT3 activation, impacting the transcriptional activity of macrophages. Moreover, NOTCH4 affects NF-kappa B and TLR signaling pathways, revealing new insights into the regulation of macrophage-specific effector functions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Paola Brun, Anna Piovan, Rosy Caniato, Vanessa Dalla Costa, Anthony Pauletto, Raffaella Filippini
Summary: The study demonstrated that fractionated extracts obtained from E. gracilis can reduce LPS-induced intestinal inflammation, with pheophytin a and b and canthaxanthin increasing intracellular reducing potential and reducing the generation of oxidative stress and lipid peroxidation induced by LPS.
Article
Integrative & Complementary Medicine
Jiha Byun, Su Kang Kim, Ju Yeon Ban
Summary: The study evaluated the protective effects of Korean ginseng berry extract (KGB) on LPS-induced inflammation and found that KGB can inhibit cytokine production, reduce expression of inflammation-related genes, and decrease oxidative stress through multiple pathways. These results suggest that KGB may have the potential to be a therapeutic agent for inflammatory and oxidative stress-related diseases.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Min Jeong Kim, Dae Won Kim, Ju Gyeong Kim, Youngjae Shin, Sung Keun Jung, Young-Jun Kim
Summary: Pink pepper demonstrates higher antioxidant effects and contains richer phenolic substances, showing significant effects in suppressing inflammation and oxidative stress.
Review
Oncology
Can Huang, Lanlan Dong, Baohua Zhao, Yifei Lu, Shurun Huang, Zhiqiang Yuan, Gaoxing Luo, Yong Xu, Wei Qian
Summary: Hydrogel dressings have shown promising potential in the biomedical field, particularly in promoting wound healing. In recent years, significant progress has been made in addressing excessive inflammation and promoting wound healing with hydrogel dressings. Excessive inflammation is a common issue in chronic wounds, hindering the repair process. Therefore, resolving excessive inflammation is crucial for effective wound healing.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Namkyung Kim, Seunghun Lee, Soyoung Lee, Jinjoo Kang, Young-Ae Choi, Jeongsu Park, Chul-Kyu Park, Dongwoo Khang, Sang-Hyun Kim
Summary: A cold atmospheric plasma (CAP) patch was developed for the treatment of skin diseases, especially psoriasis. The patch induces the opening of calcium channels in keratinocytes and generates ROS/RNS, improving psoriatic symptoms. It can be used as a combination therapy with existing drugs, reducing side effects.
Review
Environmental Sciences
Madhuri Grover, Tapan Behl, Simona Bungau, Lotfi Aleya
Summary: This study focuses on investigating the anti-inflammatory properties of vetiver, revealing that its plant extract can stimulate the antioxidant enzyme system network, reduce oxidative stress, exhibit antimicrobial activity, and have a CNS depressant effect, showing potential benefits in treating inflammation-related disorders.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, Hyun-Kyu Kang, Chang-Gu Hyun
Summary: Spiramycin has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators and cytokines in macrophages, suggesting its potential as a candidate for topical anti-inflammatory agents.
Article
Developmental Biology
Karina Geurtzen, Alejandra Cristina Lopez-Delgado, Ankita Duseja, Anastasia Kurzyukova, Franziska Knopf
Summary: In zebrafish, a model organism, immune cell behavior during bone repair after osteoblast loss has been studied. Osteoblast loss triggers recruitment of neutrophils and macrophages, which leads to the generation of osteoclasts. Glucocorticoid signaling inhibits macrophage recruitment and changes their phenotype. Although osteoblast loss can be compensated for by committed osteoblasts, macrophages continue to populate the region.
Article
Geriatrics & Gerontology
Pengfei Liu, Quansheng Gao, Lei Guan, Weixuan Sheng, Yanting Hu, Teng Gao, Jingwen Jiang, Yongxing Xu, Hui Qiao, Xinying Xue, Sanhong Liu, Tianzuo Li
Summary: Atorvastatin can attenuate oxidative stress and apoptosis induced by isoflurane, and ameliorate the activation of the p38MAPK/ATF-2 signaling pathway. The results suggest that p38MAPK/ATF-2 may be a potential target for the treatment of postoperative cognitive dysfunction.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Emergency Medicine
Chao Liu, Zhao-Rui Sun, Meng-Meng Wang, Zhi-Zhou Yang, Wei Zhang, Yi Ren, Xiao-Qin Han, Rui Liu, Quan Li, Shi-Nan Nie
Summary: This study found that arctigenin has a protective effect on PQ-induced lung injury by attenuating cell apoptosis and suppressing ROS/p38 MAPK signaling. Arctigenin may be considered as a potential candidate drug for PQ-induced ALI.
WORLD JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Puneet Kaur, Jin Gao, Zhenjia Wang
Summary: Dietary omega 3 polyunsaturated fatty acids (PUFAs), including DHA and EPA, have beneficial effects on cardiovascular diseases and cancer due to their anti-inflammatory properties. This study introduces a novel liposomal formulation of EPA (EPA-liposomes) that shows significant reduction in inflammation-related molecules, providing potential therapeutic applications.