Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates

Resolution of single and double Holliday junction recombination intermediates by GEN1

(2017) Rajvee Shah Punatar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1

(2016) Gizem Ölmezer et al.   Nature Communications

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GEN1 promotes Holliday junction resolution by a coordinated nick and counter-nick mechanism

(2015) Ying Wai Chan et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA

(2015) Yijin Liu et al.   Cell Reports

Holliday junction resolution: Regulation in space and time

(2014) Joao Matos et al.   DNA REPAIR

Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe

(2014) S. Sarbajna et al.   GENES & DEVELOPMENT

GEN1 from a Thermophilic Fungus Is Functionally Closely Similar to Non-Eukaryotic Junction-Resolving Enzymes

(2014) Alasdair D.J. Freeman et al.   JOURNAL OF MOLECULAR BIOLOGY

The Cdk/Cdc14 Module Controls Activation of the Yen1 Holliday Junction Resolvase to Promote Genome Stability

(2014) Christie L. Eissler et al.   MOLECULAR CELL

Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair

(2014) Michael R.G. Hodskinson et al.   MOLECULAR CELL

Spatial control of the GEN1 Holliday junction resolvase ensures genome stability

(2014) Ying Wai Chan et al.   Nature Communications

Mus81-Mms4 and Yen1 resolve a novel anaphase bridge formed by noncanonical Holliday junctions

(2014) Jonay García-Luis et al.   Nature Communications

Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

(2013) Dennis Castor et al.   MOLECULAR CELL

Coordinated Actions of SLX1-SLX4 and MUS81-EME1 for Holliday Junction Resolution in Human Cells

(2013) Haley D.M. Wyatt et al.   MOLECULAR CELL

Human GEN1 and the SLX4-Associated Nucleases MUS81 and SLX1 Are Essential for the Resolution of Replication-Induced Holliday Junctions

(2013) Elizabeth Garner et al.   Cell Reports

Cell-Cycle Kinases Coordinate the Resolution of Recombination Intermediates with Chromosome Segregation

(2013) Joao Matos et al.   Cell Reports

The Development of a Monoclonal Antibody Recognizing the Drosophila melanogaster Phosphorylated Histone H2A Variant (γ-H2AV)

(2013) Cathleen M. Lake et al.   G3-Genes Genomes Genetics

Combinatorial Regulation of Meiotic Holliday Junction Resolution in C. elegans by HIM-6 (BLM) Helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 Nucleases

(2013) Ana Agostinho et al.   PLoS Genetics

Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange

(2012) S. Munoz-Galvan et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

(2011) Joao Matos et al.   CELL

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

Three Structure-Selective Endonucleases Are Essential in the Absence of BLM Helicase in Drosophila

(2011) Sabrina L. Andersen et al.   PLoS Genetics

Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiae

(2010) Miguel G. Blanco et al.   DNA REPAIR

Mechanism of Holliday junction resolution by the human GEN1 protein

(2010) U. Rass et al.   GENES & DEVELOPMENT

Overlapping Roles for Yen1 and Mus81 in Cellular Holliday Junction Processing

(2010) Ye Dee Tay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylated DNA Causes a Physical Block to Replication Forks Independently of Damage Signalling, O6-Methylguanine or DNA Single-Strand Breaks and Results in DNA Damage

(2010) Petra Groth et al.   JOURNAL OF MOLECULAR BIOLOGY

Mus81 and Yen1 Promote Reciprocal Exchange during Mitotic Recombination to Maintain Genome Integrity in Budding Yeast

(2010) Chu Kwen Ho et al.   MOLECULAR CELL

The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant

(2009) Alexander Lorenz et al.   NUCLEIC ACIDS RESEARCH

Identification of Holliday junction resolvases from humans and yeast

(2008) Stephen C. Y. Ip et al.   NATURE

Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonuclease

(2008) K. T. Ehmsen et al.   NUCLEIC ACIDS RESEARCH